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The map label for this gene is eif

Identifier: 110834305

GI number: 110834305

Start: 1647252

End: 1648292

Strand: Direct

Name: eif

Synonym: ABO_1444

Alternate gene names: 110834305

Gene position: 1647252-1648292 (Clockwise)

Preceding gene: 110834304

Following gene: 110834306

Centisome position: 52.79

GC content: 58.6

Gene sequence:

>1041_bases
ATGGCCGTTAACAGCGCCGCAATCCGCTGGCTTGGTGATCACCTGCAATTGCTAGATCAACGTTGTCTGCCCACCGAAAC
GCTGTGGTTGGACATTTGCGATAGCCAACAAGCAGCCGACGCCATCCGTAACATGGTCGTGCGTGGCGCCCCCGCCATTG
GCATCACTGCAGCCTATGGCCTAGCCCTAGAAGCTCAAATCATGGGCAATGACGCATCCTGGGTTACACTGCAAAATGCG
GTTGCCACCCTAGCAGACAGCCGGCCAACGGCGGTGAACCTTTTCTGGGCACTTGAACGCCTGCAGCGCTATGCGGGGGA
CTTACAAGGTAAGGCGCTGGCACAGGCTCTGGCCGAGGACGCTGAAGCGATTCATCGCGAAGACCTCGCCGCTAACCAGG
CCATGGGCGAATTCGGTGCCGACCTGTTGCCCAGCGGCGCCACCGTCTACACCCACTGCAATACCGGTGCTCTAGCGACC
GGCGGGCATGGCACCGCTCTGGGCATCATTCGCAGTGCCTGGGCGCGAAATCAACTCACTGGCGTGTTTGCCGGCGAAAC
CCGCCCTTGGTTACAGGGCAGCCGGCTGACCAGCTGGGAGCTGCTAAACGATGGCATTCCTGTGACGCTGGTGGCGGACA
GCTGTGCCGGCCAACTGATGCAGCAGGGGAAAATCCAAGCCGTTATCGTAGGCGCAGACCGTATCACCGCCAATGGTGAT
ACTGCCAACAAAATCGGCACCTACAATCTGGCCGTTTTGGCCCAACATCACAATATTCCCTTCATCGTGGCTGCTCCCGT
CTCAACGCTGGACCCGGCCCTGCCCAATGGCAGCCATATTGTGATTGAAGAACGGGACGCTAACGAAGTGCGCAACGTGC
AAGGCAAGTCATTAGCCCCTGAACATTGCCCGGTATATAACCCAGCCTTTGATATCACCCCCGCGCAATTGATCACCGCC
ATCGTTACCGAACGAGGCGTGGTCCACCGCCCGGATACGGCCAAAATTAACAGCCATCTGGCTCAGACCAAGGAAAGCTA
G

Upstream 100 bases:

>100_bases
ATGCGCCGCCCCGGGGTTTTCCGGGCCGCCAACTGGATCCGGGCCAAATACCACCACCGCCCGCTGGAACACCCTGATGC
CTATAACAAGGAGCCTACCC

Downstream 100 bases:

>100_bases
CATGCCTGAGCGCCCCTACTCTACCACTGTCTTCCGCGACGCTGCCCGAGCATTGGCGGCCACCGGACAACGGATTTACG
CTAATGGCTGGTCGCCTGCC

Product: initiation factor eIF-2B

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MAVNSAAIRWLGDHLQLLDQRCLPTETLWLDICDSQQAADAIRNMVVRGAPAIGITAAYGLALEAQIMGNDASWVTLQNA
VATLADSRPTAVNLFWALERLQRYAGDLQGKALAQALAEDAEAIHREDLAANQAMGEFGADLLPSGATVYTHCNTGALAT
GGHGTALGIIRSAWARNQLTGVFAGETRPWLQGSRLTSWELLNDGIPVTLVADSCAGQLMQQGKIQAVIVGADRITANGD
TANKIGTYNLAVLAQHHNIPFIVAAPVSTLDPALPNGSHIVIEERDANEVRNVQGKSLAPEHCPVYNPAFDITPAQLITA
IVTERGVVHRPDTAKINSHLAQTKES

Sequences:

>Translated_346_residues
MAVNSAAIRWLGDHLQLLDQRCLPTETLWLDICDSQQAADAIRNMVVRGAPAIGITAAYGLALEAQIMGNDASWVTLQNA
VATLADSRPTAVNLFWALERLQRYAGDLQGKALAQALAEDAEAIHREDLAANQAMGEFGADLLPSGATVYTHCNTGALAT
GGHGTALGIIRSAWARNQLTGVFAGETRPWLQGSRLTSWELLNDGIPVTLVADSCAGQLMQQGKIQAVIVGADRITANGD
TANKIGTYNLAVLAQHHNIPFIVAAPVSTLDPALPNGSHIVIEERDANEVRNVQGKSLAPEHCPVYNPAFDITPAQLITA
IVTERGVVHRPDTAKINSHLAQTKES
>Mature_345_residues
AVNSAAIRWLGDHLQLLDQRCLPTETLWLDICDSQQAADAIRNMVVRGAPAIGITAAYGLALEAQIMGNDASWVTLQNAV
ATLADSRPTAVNLFWALERLQRYAGDLQGKALAQALAEDAEAIHREDLAANQAMGEFGADLLPSGATVYTHCNTGALATG
GHGTALGIIRSAWARNQLTGVFAGETRPWLQGSRLTSWELLNDGIPVTLVADSCAGQLMQQGKIQAVIVGADRITANGDT
ANKIGTYNLAVLAQHHNIPFIVAAPVSTLDPALPNGSHIVIEERDANEVRNVQGKSLAPEHCPVYNPAFDITPAQLITAI
VTERGVVHRPDTAKINSHLAQTKES

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily

Homologues:

Organism=Homo sapiens, GI72534748, Length=346, Percent_Identity=44.2196531791908, Blast_Score=252, Evalue=4e-67,
Organism=Homo sapiens, GI23943880, Length=326, Percent_Identity=39.2638036809816, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4503503, Length=217, Percent_Identity=28.110599078341, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7657058, Length=184, Percent_Identity=29.8913043478261, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI78000158, Length=263, Percent_Identity=23.574144486692, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI78000156, Length=263, Percent_Identity=23.574144486692, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI187607323, Length=263, Percent_Identity=23.574144486692, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557462, Length=328, Percent_Identity=40.2439024390244, Blast_Score=217, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17557123, Length=146, Percent_Identity=34.2465753424658, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6325375, Length=384, Percent_Identity=36.1979166666667, Blast_Score=209, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6322878, Length=269, Percent_Identity=24.907063197026, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357667, Length=344, Percent_Identity=40.9883720930233, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24651647, Length=344, Percent_Identity=40.9883720930233, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI18543295, Length=182, Percent_Identity=23.6263736263736, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNA_ALCBS (Q0VPK6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693164.1
- ProteinModelPortal:   Q0VPK6
- SMR:   Q0VPK6
- STRING:   Q0VPK6
- GeneID:   4213345
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1444
- NMPDR:   fig|393595.12.peg.1450
- eggNOG:   COG0182
- HOGENOM:   HBG682649
- OMA:   RPRNQGA
- PhylomeDB:   Q0VPK6
- BioCyc:   ABOR393595:ABO_1444-MONOMER
- HAMAP:   MF_01678
- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559
- PANTHER:   PTHR10233
- TIGRFAMs:   TIGR00524
- TIGRFAMs:   TIGR00512

Pfam domain/function: PF01008 IF-2B

EC number: =5.3.1.23

Molecular weight: Translated: 36806; Mature: 36675

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: NA

Important sites: ACT_SITE 233-233 BINDING 88-88 BINDING 192-192

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVNSAAIRWLGDHLQLLDQRCLPTETLWLDICDSQQAADAIRNMVVRGAPAIGITAAYG
CCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHC
LALEAQIMGNDASWVTLQNAVATLADSRPTAVNLFWALERLQRYAGDLQGKALAQALAED
EEEEEEEECCCCCEEEHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AEAIHREDLAANQAMGEFGADLLPSGATVYTHCNTGALATGGHGTALGIIRSAWARNQLT
HHHHHHHHHHHHHHHHHHCHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCC
GVFAGETRPWLQGSRLTSWELLNDGIPVTLVADSCAGQLMQQGKIQAVIVGADRITANGD
EEEECCCCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHCCCEEEEEEECCEEECCCC
TANKIGTYNLAVLAQHHNIPFIVAAPVSTLDPALPNGSHIVIEERDANEVRNVQGKSLAP
CCCCCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCC
EHCPVYNPAFDITPAQLITAIVTERGVVHRPDTAKINSHLAQTKES
CCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
AVNSAAIRWLGDHLQLLDQRCLPTETLWLDICDSQQAADAIRNMVVRGAPAIGITAAYG
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHC
LALEAQIMGNDASWVTLQNAVATLADSRPTAVNLFWALERLQRYAGDLQGKALAQALAED
EEEEEEEECCCCCEEEHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHH
AEAIHREDLAANQAMGEFGADLLPSGATVYTHCNTGALATGGHGTALGIIRSAWARNQLT
HHHHHHHHHHHHHHHHHHCHHHCCCCCEEEEECCCCCEEECCCCHHHHHHHHHHHHCCCC
GVFAGETRPWLQGSRLTSWELLNDGIPVTLVADSCAGQLMQQGKIQAVIVGADRITANGD
EEEECCCCCCCCCCCCCCHHHHCCCCCEEEEECHHHHHHHHCCCEEEEEEECCEEECCCC
TANKIGTYNLAVLAQHHNIPFIVAAPVSTLDPALPNGSHIVIEERDANEVRNVQGKSLAP
CCCCCCCEEEEEEEECCCCCEEEECCHHHCCCCCCCCCEEEEECCCCHHHHCCCCCCCCC
EHCPVYNPAFDITPAQLITAIVTERGVVHRPDTAKINSHLAQTKES
CCCCCCCCCCCCCHHHHHHHHHHCCCCEECCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA