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The map label for this gene is cysG

Identifier: 110834156

GI number: 110834156

Start: 1470527

End: 1471912

Strand: Direct

Name: cysG

Synonym: ABO_1295

Alternate gene names: 110834156

Gene position: 1470527-1471912 (Clockwise)

Preceding gene: 110834155

Following gene: 110834165

Centisome position: 47.13

GC content: 56.49

Gene sequence:

>1386_bases
ATGGAATTTCTACCGATCAGCTGGCGTTTACAAGGCAAGGTGGCTTTGTTGGCCGGCGGCGGCGAAGTGGCGTTGCGCAA
GGGGCGCCTTCTGCACCGATCAGGTGCGATTTTGACTGTAGTTGCCCCGCAAGTATGCGATGAGCTGCTCGATATTGTGG
TGCGTAGCGGCGGTTCCTGCGTGGTCAGGGCGTTTGAAAGCGCAGATCTAGACGGGGTCGCTCTGGTTATTTGTGCCACC
GATGATCGCAGTACCAATGCTGAGATAGCAAAACAGGCCCAGCAACGGGGTTTGCCCGTGAATGTGGTCGACGATCCTTC
GCTGGGTGATTTCATCTTTCCGGCCATTGTCGACCGTTCCCCGGTGTTAATCAGTATCAGCTCCTCCGGTGCTTCGCCAG
TGCTGGCCAGGAAACTAAGAGCCCAGCTGGAATCCACTTTGCCGGCGCGCTGGGGAAGACTGGCTGACCTGATGGCGCGT
TTCCGTCAGCCCTTGAAAGACAAGCTCAGTAACATCGGTGCCCGGCGTTTATTCTGGGAGCAAACACTGGATAGCCCAGT
CGTGGAAAAAGTGCTGGCCGGCAAGGACAGTGAGGCAGAAGCCATGCTCGCCGCTGCGATCGAATCTGCCGACGCAACAA
CCCTGAGCCGAGGCGAAGTGTATCTGGTGGGTGCTGGCCCTGGGGATCCGGACTTGCTCACGTTCCGAGCGCTGCGTTTG
CTGCAAAAAGCCGATGTGGTGCTCTACGATCGCCTGGTCGGCAAGGGTATTGTAGATCTGGCCCGTCGCGATGCGGAGCT
GGTGTATGTGGGTAAAGCCCGTGACAAGCACGCGCTGCCCCAGGACAACATCAACGAGTTGCTGGTTCATTACGCTAAAC
AAGGCAAGAAGGTTTGCCGGTTGAAAGGCGGGGATCCTTTTATCTTTGGCCGTGGCGGTGAAGAAATTGACCTGATTGTG
GCGGAAGGTATCGATTTTCAGGTGGTGCCAGGCATTACTGCGGCCAGCGGCTGCGCTTCCTATGCGGGTATTCCACTAAC
CCATCGTGACCATGCTCAATCCGTGCGATTCGTCACCGGGCATCGTAAAGATGGCTCGGTGGATCTGGATTGGAAACATT
TAGTCAGCGAAACCGAGACAGTGGTATTTTATATGGGGTTGGTGGGCTTGCGAGAAATCTGCAGCCAGCTGATCGCCCAC
GGCCGTGGGGGCGACACACCCATCGCGCTGGTGTCACGAGGCACGACTAACCTTCAGGAGGTGATTACCGGTAGGCTAGA
TCAGCTACCTGACGATATCGAAGGCCGTGAAATTCACGCCCCCACCCTGATAATTGTTGGCAGCGTGGTCAGCCTGCATC
CTAAATTTGGTTGGTTCAAACCCTGA

Upstream 100 bases:

>100_bases
CGACCATTGCGTTCGTCGCATGGCATGCCTTTAACGCAGGCTTGCCGCTTTTTGTGTCAGGCATCATTCACTCAGCGTCT
GGCGTTTACTGGGAGCAAGC

Downstream 100 bases:

>100_bases
TCGCTTCAATACCGCATTACGGCTACGTTTGACACGCCCTACAACGCACTGTTTGTAGGGCGAATACCTAAGAGCACAAT
TCGCACAATTCGCACAATTC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase

Number of amino acids: Translated: 461; Mature: 461

Protein sequence:

>461_residues
MEFLPISWRLQGKVALLAGGGEVALRKGRLLHRSGAILTVVAPQVCDELLDIVVRSGGSCVVRAFESADLDGVALVICAT
DDRSTNAEIAKQAQQRGLPVNVVDDPSLGDFIFPAIVDRSPVLISISSSGASPVLARKLRAQLESTLPARWGRLADLMAR
FRQPLKDKLSNIGARRLFWEQTLDSPVVEKVLAGKDSEAEAMLAAAIESADATTLSRGEVYLVGAGPGDPDLLTFRALRL
LQKADVVLYDRLVGKGIVDLARRDAELVYVGKARDKHALPQDNINELLVHYAKQGKKVCRLKGGDPFIFGRGGEEIDLIV
AEGIDFQVVPGITAASGCASYAGIPLTHRDHAQSVRFVTGHRKDGSVDLDWKHLVSETETVVFYMGLVGLREICSQLIAH
GRGGDTPIALVSRGTTNLQEVITGRLDQLPDDIEGREIHAPTLIIVGSVVSLHPKFGWFKP

Sequences:

>Translated_461_residues
MEFLPISWRLQGKVALLAGGGEVALRKGRLLHRSGAILTVVAPQVCDELLDIVVRSGGSCVVRAFESADLDGVALVICAT
DDRSTNAEIAKQAQQRGLPVNVVDDPSLGDFIFPAIVDRSPVLISISSSGASPVLARKLRAQLESTLPARWGRLADLMAR
FRQPLKDKLSNIGARRLFWEQTLDSPVVEKVLAGKDSEAEAMLAAAIESADATTLSRGEVYLVGAGPGDPDLLTFRALRL
LQKADVVLYDRLVGKGIVDLARRDAELVYVGKARDKHALPQDNINELLVHYAKQGKKVCRLKGGDPFIFGRGGEEIDLIV
AEGIDFQVVPGITAASGCASYAGIPLTHRDHAQSVRFVTGHRKDGSVDLDWKHLVSETETVVFYMGLVGLREICSQLIAH
GRGGDTPIALVSRGTTNLQEVITGRLDQLPDDIEGREIHAPTLIIVGSVVSLHPKFGWFKP
>Mature_461_residues
MEFLPISWRLQGKVALLAGGGEVALRKGRLLHRSGAILTVVAPQVCDELLDIVVRSGGSCVVRAFESADLDGVALVICAT
DDRSTNAEIAKQAQQRGLPVNVVDDPSLGDFIFPAIVDRSPVLISISSSGASPVLARKLRAQLESTLPARWGRLADLMAR
FRQPLKDKLSNIGARRLFWEQTLDSPVVEKVLAGKDSEAEAMLAAAIESADATTLSRGEVYLVGAGPGDPDLLTFRALRL
LQKADVVLYDRLVGKGIVDLARRDAELVYVGKARDKHALPQDNINELLVHYAKQGKKVCRLKGGDPFIFGRGGEEIDLIV
AEGIDFQVVPGITAASGCASYAGIPLTHRDHAQSVRFVTGHRKDGSVDLDWKHLVSETETVVFYMGLVGLREICSQLIAH
GRGGDTPIALVSRGTTNLQEVITGRLDQLPDDIEGREIHAPTLIIVGSVVSLHPKFGWFKP

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family

Homologues:

Organism=Escherichia coli, GI1789768, Length=461, Percent_Identity=47.0715835140998, Blast_Score=398, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6322922, Length=234, Percent_Identity=35.042735042735, Blast_Score=129, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CYSG_ALCBS (Q0VQ05)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693015.1
- ProteinModelPortal:   Q0VQ05
- STRING:   Q0VQ05
- GeneID:   4212573
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1295
- NMPDR:   fig|393595.12.peg.1307
- eggNOG:   COG0007
- HOGENOM:   HBG730212
- OMA:   MCRRDAE
- PhylomeDB:   Q0VQ05
- BioCyc:   ABOR393595:ABO_1295-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01646
- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043
- Gene3D:   G3DSA:3.40.1010.10
- Gene3D:   G3DSA:3.30.950.10
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.8.210
- TIGRFAMs:   TIGR01469
- TIGRFAMs:   TIGR01470

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase; SSF53790 Cor/por_Metransf

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4

Molecular weight: Translated: 49742; Mature: 49742

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00839 SUMT_1; PS00840 SUMT_2; PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFLPISWRLQGKVALLAGGGEVALRKGRLLHRSGAILTVVAPQVCDELLDIVVRSGGSC
CCCCCEEEEECCEEEEEECCCCEEEECCCEEECCCCEEEEECHHHHHHHHHHHHHCCCCE
VVRAFESADLDGVALVICATDDRSTNAEIAKQAQQRGLPVNVVDDPSLGDFIFPAIVDRS
EEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHCCC
PVLISISSSGASPVLARKLRAQLESTLPARWGRLADLMARFRQPLKDKLSNIGARRLFWE
CEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QTLDSPVVEKVLAGKDSEAEAMLAAAIESADATTLSRGEVYLVGAGPGDPDLLTFRALRL
HHCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHH
LQKADVVLYDRLVGKGIVDLARRDAELVYVGKARDKHALPQDNINELLVHYAKQGKKVCR
HHHCCHHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEE
LKGGDPFIFGRGGEEIDLIVAEGIDFQVVPGITAASGCASYAGIPLTHRDHAQSVRFVTG
ECCCCEEEECCCCCEEEEEEECCCCEEEECCCCHHHCCHHHCCCCCCCCHHHCCEEEEEC
HRKDGSVDLDWKHLVSETETVVFYMGLVGLREICSQLIAHGRGGDTPIALVSRGTTNLQE
CCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
VITGRLDQLPDDIEGREIHAPTLIIVGSVVSLHPKFGWFKP
HHHHHHHCCCCCCCCCEECCCEEEEECHHHHCCCCCCCCCC
>Mature Secondary Structure
MEFLPISWRLQGKVALLAGGGEVALRKGRLLHRSGAILTVVAPQVCDELLDIVVRSGGSC
CCCCCEEEEECCEEEEEECCCCEEEECCCEEECCCCEEEEECHHHHHHHHHHHHHCCCCE
VVRAFESADLDGVALVICATDDRSTNAEIAKQAQQRGLPVNVVDDPSLGDFIFPAIVDRS
EEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHCCC
PVLISISSSGASPVLARKLRAQLESTLPARWGRLADLMARFRQPLKDKLSNIGARRLFWE
CEEEEECCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
QTLDSPVVEKVLAGKDSEAEAMLAAAIESADATTLSRGEVYLVGAGPGDPDLLTFRALRL
HHCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCEECCCCEEEEECCCCCCHHHHHHHHHH
LQKADVVLYDRLVGKGIVDLARRDAELVYVGKARDKHALPQDNINELLVHYAKQGKKVCR
HHHCCHHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEE
LKGGDPFIFGRGGEEIDLIVAEGIDFQVVPGITAASGCASYAGIPLTHRDHAQSVRFVTG
ECCCCEEEECCCCCEEEEEEECCCCEEEECCCCHHHCCHHHCCCCCCCCHHHCCEEEEEC
HRKDGSVDLDWKHLVSETETVVFYMGLVGLREICSQLIAHGRGGDTPIALVSRGTTNLQE
CCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
VITGRLDQLPDDIEGREIHAPTLIIVGSVVSLHPKFGWFKP
HHHHHHHCCCCCCCCCEECCCEEEEECHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA