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The map label for this gene is serS

Identifier: 110834155

GI number: 110834155

Start: 1469117

End: 1470406

Strand: Direct

Name: serS

Synonym: ABO_1294

Alternate gene names: 110834155

Gene position: 1469117-1470406 (Clockwise)

Preceding gene: 110834154

Following gene: 110834156

Centisome position: 47.08

GC content: 54.03

Gene sequence:

>1290_bases
ATGCTGGATATTCGTGCCTTGCGGCAGGACGGTGAAGCGATCAAGGCGGCGTTGAGCAAACGCGGCTACACCCTGGACCT
GGAGGAATTTGCCGCTTTGGATGCCAAGCGCAAGCAAGCAGATATGCGCTCCCAGGAATTACAGGCGGATCGCAAGAAAG
CTTCCAAGCAGGTGGGCGAGTTGATTAAGTCCGGTATGGCGGTGGATGAGGCTAAGGCACAGGTGGCCGACGCCCTGCAG
ACCATTGATACAGAACTGGATAAGGAAGTGGCCAGTGCCAAGGCGATTCAGGACGAAATTCGTGAATACCTGATGGGCAT
TCCCAACGTCCCGCAAGAAGCCGTACCTGCAGGCAATGATGAAGACGACAATGTGGAAGTGCGCCGCTGGGGCACACCGA
AAACACTGCCGTTTGAGCCGAAGGACCATGTGGATATTGGTGAAGCGCTGGAGGGCGGGCTCGATTTTGAACGCGCGGCT
AAGCTTTCCGGTGCACGTTTTGCAGTGATGAGCGGTGGCCTAGCCCGCATGCACCGGGCGCTGATTGATTTTATGCTGGA
TATACACAGCGACGAGCATGGCTATCAGGAAGTGTACGTGCCTTTCCTAGTGGGGCCGGAAGCGCTACGAGGAACTGGCC
AGCTACCCAAGTTCGCTGAAGACCTGTTTAAAATAGAAGGTGAGCGTGAACTCTATTTGATTCCCACCGCTGAAGTGCCG
GTGACCAATCTGGCCGCGGATGAAATTCTCGAAGCGAACACCATGCCCCGTCGTTATACCTGTCATACACCGTGTTTTCG
TTCTGAAGCGGGCAGCCACGGTAGAGATACCCGCGGTATGATTCGCCAGCATCAGTTCGAAAAAGTGGAGCTGGTGCAGA
TGGTTCGCCCTGAAGAGTCCGATGCGGCGCTGGAGGCACTGACCGGCCATGCGGAAGCCATTTTACAGAAACTGGATTTG
CCATATCGAGTGGTGATTCTTTGTGGCGGTGATTTGGGCTTTTCGTCTTCCAAAACCTATGACATCGAAGTCTGGCTTCC
CAGCCAGCAGTGCTATCGGGAAATTTCTTCCTGTTCCAACTTCCGTGATTATCAATCACGTCGCATGCAGGCTCGCTGGC
GCAACCCGGAAACCGGTAAACCCGAATTGGTACATACCTTGAATGGGTCTGCTCTGGCAGTAGGGCGTACTTTAGTAGCG
ATACTGGAGAATTATCAGAACGATGATGGTTCAGTAACTGTTCCTGAGGCACTGCGTCCCTACATGAGAGGTCTGGAACG
CCTGAAATAG

Upstream 100 bases:

>100_bases
AGCGGGCCTAGCATTGGGTCGACTGTTTTTTGAATAACATTGGGAAGCTGAAAGTTTAAACTTTCAACTCAGCCTTTTCT
GATTTTGGAGTAAGAAATAC

Downstream 100 bases:

>100_bases
TGTTGCTCAGGCACAAACGACGACCATTGCGTTCGTCGCATGGCATGCCTTTAACGCAGGCTTGCCGCTTTTTGTGTCAG
GCATCATTCACTCAGCGTCT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLDIRALRQDGEAIKAALSKRGYTLDLEEFAALDAKRKQADMRSQELQADRKKASKQVGELIKSGMAVDEAKAQVADALQ
TIDTELDKEVASAKAIQDEIREYLMGIPNVPQEAVPAGNDEDDNVEVRRWGTPKTLPFEPKDHVDIGEALEGGLDFERAA
KLSGARFAVMSGGLARMHRALIDFMLDIHSDEHGYQEVYVPFLVGPEALRGTGQLPKFAEDLFKIEGERELYLIPTAEVP
VTNLAADEILEANTMPRRYTCHTPCFRSEAGSHGRDTRGMIRQHQFEKVELVQMVRPEESDAALEALTGHAEAILQKLDL
PYRVVILCGGDLGFSSSKTYDIEVWLPSQQCYREISSCSNFRDYQSRRMQARWRNPETGKPELVHTLNGSALAVGRTLVA
ILENYQNDDGSVTVPEALRPYMRGLERLK

Sequences:

>Translated_429_residues
MLDIRALRQDGEAIKAALSKRGYTLDLEEFAALDAKRKQADMRSQELQADRKKASKQVGELIKSGMAVDEAKAQVADALQ
TIDTELDKEVASAKAIQDEIREYLMGIPNVPQEAVPAGNDEDDNVEVRRWGTPKTLPFEPKDHVDIGEALEGGLDFERAA
KLSGARFAVMSGGLARMHRALIDFMLDIHSDEHGYQEVYVPFLVGPEALRGTGQLPKFAEDLFKIEGERELYLIPTAEVP
VTNLAADEILEANTMPRRYTCHTPCFRSEAGSHGRDTRGMIRQHQFEKVELVQMVRPEESDAALEALTGHAEAILQKLDL
PYRVVILCGGDLGFSSSKTYDIEVWLPSQQCYREISSCSNFRDYQSRRMQARWRNPETGKPELVHTLNGSALAVGRTLVA
ILENYQNDDGSVTVPEALRPYMRGLERLK
>Mature_429_residues
MLDIRALRQDGEAIKAALSKRGYTLDLEEFAALDAKRKQADMRSQELQADRKKASKQVGELIKSGMAVDEAKAQVADALQ
TIDTELDKEVASAKAIQDEIREYLMGIPNVPQEAVPAGNDEDDNVEVRRWGTPKTLPFEPKDHVDIGEALEGGLDFERAA
KLSGARFAVMSGGLARMHRALIDFMLDIHSDEHGYQEVYVPFLVGPEALRGTGQLPKFAEDLFKIEGERELYLIPTAEVP
VTNLAADEILEANTMPRRYTCHTPCFRSEAGSHGRDTRGMIRQHQFEKVELVQMVRPEESDAALEALTGHAEAILQKLDL
PYRVVILCGGDLGFSSSKTYDIEVWLPSQQCYREISSCSNFRDYQSRRMQARWRNPETGKPELVHTLNGSALAVGRTLVA
ILENYQNDDGSVTVPEALRPYMRGLERLK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=440, Percent_Identity=33.8636363636364, Blast_Score=222, Evalue=5e-58,
Organism=Homo sapiens, GI8923421, Length=452, Percent_Identity=29.2035398230088, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI225579074, Length=454, Percent_Identity=29.0748898678414, Blast_Score=164, Evalue=1e-40,
Organism=Escherichia coli, GI1787120, Length=434, Percent_Identity=55.2995391705069, Blast_Score=492, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17539260, Length=433, Percent_Identity=31.1778290993072, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=29.6969696969697, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=450, Percent_Identity=32.4444444444444, Blast_Score=209, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=400, Percent_Identity=31.75, Blast_Score=203, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24581334, Length=434, Percent_Identity=32.258064516129, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI17737985, Length=268, Percent_Identity=33.5820895522388, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ALCBS (Q0VQ06)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693014.1
- ProteinModelPortal:   Q0VQ06
- SMR:   Q0VQ06
- STRING:   Q0VQ06
- GeneID:   4213632
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1294
- NMPDR:   fig|393595.12.peg.1306
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q0VQ06
- BioCyc:   ABOR393595:ABO_1294-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47945; Mature: 47945

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 290-290 BINDING 390-390

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIRALRQDGEAIKAALSKRGYTLDLEEFAALDAKRKQADMRSQELQADRKKASKQVGE
CCCHHHHHHCHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIKSGMAVDEAKAQVADALQTIDTELDKEVASAKAIQDEIREYLMGIPNVPQEAVPAGND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCC
EDDNVEVRRWGTPKTLPFEPKDHVDIGEALEGGLDFERAAKLSGARFAVMSGGLARMHRA
CCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEECCCCHHHHHHH
LIDFMLDIHSDEHGYQEVYVPFLVGPEALRGTGQLPKFAEDLFKIEGERELYLIPTAEVP
HHHHHHHHCCCCCCCCEEEEEEEECHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
VTNLAADEILEANTMPRRYTCHTPCFRSEAGSHGRDTRGMIRQHQFEKVELVQMVRPEES
CHHHHHHHHHHCCCCCCCEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
DAALEALTGHAEAILQKLDLPYRVVILCGGDLGFSSSKTYDIEVWLPSQQCYREISSCSN
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHHHHC
FRDYQSRRMQARWRNPETGKPELVHTLNGSALAVGRTLVAILENYQNDDGSVTVPEALRP
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHHH
YMRGLERLK
HHHHHHHCC
>Mature Secondary Structure
MLDIRALRQDGEAIKAALSKRGYTLDLEEFAALDAKRKQADMRSQELQADRKKASKQVGE
CCCHHHHHHCHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIKSGMAVDEAKAQVADALQTIDTELDKEVASAKAIQDEIREYLMGIPNVPQEAVPAGND
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCC
EDDNVEVRRWGTPKTLPFEPKDHVDIGEALEGGLDFERAAKLSGARFAVMSGGLARMHRA
CCCCEEEEECCCCCCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCCEEEECCCCHHHHHHH
LIDFMLDIHSDEHGYQEVYVPFLVGPEALRGTGQLPKFAEDLFKIEGERELYLIPTAEVP
HHHHHHHHCCCCCCCCEEEEEEEECHHHHCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
VTNLAADEILEANTMPRRYTCHTPCFRSEAGSHGRDTRGMIRQHQFEKVELVQMVRPEES
CHHHHHHHHHHCCCCCCCEECCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
DAALEALTGHAEAILQKLDLPYRVVILCGGDLGFSSSKTYDIEVWLPSQQCYREISSCSN
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHHHHC
FRDYQSRRMQARWRNPETGKPELVHTLNGSALAVGRTLVAILENYQNDDGSVTVPEALRP
HHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEECHHHHHH
YMRGLERLK
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA