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The map label for this gene is pdxB [H]

Identifier: 110834038

GI number: 110834038

Start: 1337956

End: 1339116

Strand: Direct

Name: pdxB [H]

Synonym: ABO_1177

Alternate gene names: 110834038

Gene position: 1337956-1339116 (Clockwise)

Preceding gene: 110834037

Following gene: 110834040

Centisome position: 42.88

GC content: 56.85

Gene sequence:

>1161_bases
GTGGCTCTAAATTTTTTCATAGGCAGCCTAACTCCGAGGACAATGATGCACATTATTGCTGATGCCAATATGCCGGGGCT
GGAGCCCTTTGAGGCGTTTGCTACCGTTGAGCGAGTAGATGGTCGTTCCCTGACTCGGGAGCAACTGGGTGACGCTGATG
TTCTATTGGTGCGTTCAGTCACCCGTGTTGATAGGGCCTTGCTAGCCGGCTCGCAGGTGAAATTTGTGGGGTCTGCGACC
ATTGGCACAGACCATGTAGACCTGGCGTATCTTAGTGAGGCGGGAATTCAATTCGCTCACGCGCCGGGGTGCAATGCTCG
TGCAGTGGCAGAATACGTCCTGCAGGCGGTGTTGTTGCTGTGTGCTAGGCAGGGACGAGAAGTGCAAGGTGCCCGTGTGG
CGGTGGTCGGCCTAGGTAATGTGGGACGGCGGGTGGCGGATTGGCTCAGCGCCCTCGGCATGGAGGTGCGCGGCTGTGAC
CCTCTGTTGGATGCTCAGGGCTACGCGGGCCCGGTGGCACTGGCACCGTTGGATGATTTGCTGGATGCGGACATTATCAC
CTTGCATGTGCCGCTAACCCAGAGTGGAGAGCATGCCACCGGGCATTTGCTGGATGCTTCTAGGCTGTCCCGCCTTGGGC
CTGGGCAGATGCTGATCAATACCTGTCGGGGGCCAGTTATCGATAATCTGGCGCTGTCACAGCAGTTGGCCAGTGGCACT
GGGCCGATGACGGTGCTGGATGTGTGGGAAACGGAACCGCAGGTACCAGCCACCCTGTATCAGCAGGTAGTGATGGGGTC
ACCACATATTGCGGGGTACAGTCTTGAAGGCAAGCTCAAAGGCACGAGCATGCTCTACGACGCCGTGTGCCAATGGTCCG
GGCAGGGGATTGCATCAGGAACTGCGATGGCAGATGCTCCGCCGCTGAATCCTGCAGTGAACAGTGAGGCTGATTTATTG
GCGTTACTACAGGTGGCTTATCGGCTTGAAGACGATCATCGGCGATTGGGCGAAAGCCTGCATGATACAGACCCTAGCGC
TGCCTTTGATCGCTTACGCAAGCACTATCCGGTTCGCCATGAACTGCACTATTGGCAATATGACGGAAGTGTGGACGATA
CTTGGAGGGCTATTATTAGCCGTCTTTTTGAGCCCGATTGA

Upstream 100 bases:

>100_bases
GGCTATGATCGAGGTATAAAGCAGTCATACCGACAGTAAAAAAGTAGCGAGCCCATAGCCATAATATAGGTCGACTTAGG
CGTAGCCGTAAGCCGACACA

Downstream 100 bases:

>100_bases
ATTGCGCAGTGGGGTATTGCCAATGATTTTCCAAGTGTTCACAGGCGCGCTGGATCATTTCTTCAGTGATGGGAATTTCC
CGGCCTTGCTCATCAATGAT

Product: erythronate-4-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MALNFFIGSLTPRTMMHIIADANMPGLEPFEAFATVERVDGRSLTREQLGDADVLLVRSVTRVDRALLAGSQVKFVGSAT
IGTDHVDLAYLSEAGIQFAHAPGCNARAVAEYVLQAVLLLCARQGREVQGARVAVVGLGNVGRRVADWLSALGMEVRGCD
PLLDAQGYAGPVALAPLDDLLDADIITLHVPLTQSGEHATGHLLDASRLSRLGPGQMLINTCRGPVIDNLALSQQLASGT
GPMTVLDVWETEPQVPATLYQQVVMGSPHIAGYSLEGKLKGTSMLYDAVCQWSGQGIASGTAMADAPPLNPAVNSEADLL
ALLQVAYRLEDDHRRLGESLHDTDPSAAFDRLRKHYPVRHELHYWQYDGSVDDTWRAIISRLFEPD

Sequences:

>Translated_386_residues
MALNFFIGSLTPRTMMHIIADANMPGLEPFEAFATVERVDGRSLTREQLGDADVLLVRSVTRVDRALLAGSQVKFVGSAT
IGTDHVDLAYLSEAGIQFAHAPGCNARAVAEYVLQAVLLLCARQGREVQGARVAVVGLGNVGRRVADWLSALGMEVRGCD
PLLDAQGYAGPVALAPLDDLLDADIITLHVPLTQSGEHATGHLLDASRLSRLGPGQMLINTCRGPVIDNLALSQQLASGT
GPMTVLDVWETEPQVPATLYQQVVMGSPHIAGYSLEGKLKGTSMLYDAVCQWSGQGIASGTAMADAPPLNPAVNSEADLL
ALLQVAYRLEDDHRRLGESLHDTDPSAAFDRLRKHYPVRHELHYWQYDGSVDDTWRAIISRLFEPD
>Mature_385_residues
ALNFFIGSLTPRTMMHIIADANMPGLEPFEAFATVERVDGRSLTREQLGDADVLLVRSVTRVDRALLAGSQVKFVGSATI
GTDHVDLAYLSEAGIQFAHAPGCNARAVAEYVLQAVLLLCARQGREVQGARVAVVGLGNVGRRVADWLSALGMEVRGCDP
LLDAQGYAGPVALAPLDDLLDADIITLHVPLTQSGEHATGHLLDASRLSRLGPGQMLINTCRGPVIDNLALSQQLASGTG
PMTVLDVWETEPQVPATLYQQVVMGSPHIAGYSLEGKLKGTSMLYDAVCQWSGQGIASGTAMADAPPLNPAVNSEADLLA
LLQVAYRLEDDHRRLGESLHDTDPSAAFDRLRKHYPVRHELHYWQYDGSVDDTWRAIISRLFEPD

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=288, Percent_Identity=28.4722222222222, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI61743967, Length=310, Percent_Identity=25.4838709677419, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI4557497, Length=310, Percent_Identity=25.4838709677419, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI145580578, Length=310, Percent_Identity=24.5161290322581, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI4557499, Length=310, Percent_Identity=24.5161290322581, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1788660, Length=350, Percent_Identity=42.2857142857143, Blast_Score=228, Evalue=4e-61,
Organism=Escherichia coli, GI1789279, Length=260, Percent_Identity=28.8461538461538, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787645, Length=199, Percent_Identity=28.1407035175879, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=264, Percent_Identity=31.4393939393939, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322116, Length=228, Percent_Identity=29.8245614035088, Blast_Score=90, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=228, Percent_Identity=29.8245614035088, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=283, Percent_Identity=26.8551236749117, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19921140, Length=262, Percent_Identity=27.4809160305344, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646446, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646448, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646452, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646450, Length=217, Percent_Identity=27.1889400921659, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI62472511, Length=300, Percent_Identity=24, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.290 [H]

Molecular weight: Translated: 41620; Mature: 41489

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNFFIGSLTPRTMMHIIADANMPGLEPFEAFATVERVDGRSLTREQLGDADVLLVRSV
CEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHH
TRVDRALLAGSQVKFVGSATIGTDHVDLAYLSEAGIQFAHAPGCNARAVAEYVLQAVLLL
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
CARQGREVQGARVAVVGLGNVGRRVADWLSALGMEVRGCDPLLDAQGYAGPVALAPLDDL
HHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHH
LDADIITLHVPLTQSGEHATGHLLDASRLSRLGPGQMLINTCRGPVIDNLALSQQLASGT
HCCCEEEEEEECCCCCCCCCCCEECHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
GPMTVLDVWETEPQVPATLYQQVVMGSPHIAGYSLEGKLKGTSMLYDAVCQWSGQGIASG
CCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCC
TAMADAPPLNPAVNSEADLLALLQVAYRLEDDHRRLGESLHDTDPSAAFDRLRKHYPVRH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
ELHYWQYDGSVDDTWRAIISRLFEPD
CEEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALNFFIGSLTPRTMMHIIADANMPGLEPFEAFATVERVDGRSLTREQLGDADVLLVRSV
EEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHH
TRVDRALLAGSQVKFVGSATIGTDHVDLAYLSEAGIQFAHAPGCNARAVAEYVLQAVLLL
HHHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHH
CARQGREVQGARVAVVGLGNVGRRVADWLSALGMEVRGCDPLLDAQGYAGPVALAPLDDL
HHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHH
LDADIITLHVPLTQSGEHATGHLLDASRLSRLGPGQMLINTCRGPVIDNLALSQQLASGT
HCCCEEEEEEECCCCCCCCCCCEECHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCC
GPMTVLDVWETEPQVPATLYQQVVMGSPHIAGYSLEGKLKGTSMLYDAVCQWSGQGIASG
CCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCC
TAMADAPPLNPAVNSEADLLALLQVAYRLEDDHRRLGESLHDTDPSAAFDRLRKHYPVRH
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
ELHYWQYDGSVDDTWRAIISRLFEPD
CEEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA