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The map label for this gene is lpxA [H]

Identifier: 110834016

GI number: 110834016

Start: 1312537

End: 1313304

Strand: Direct

Name: lpxA [H]

Synonym: ABO_1155

Alternate gene names: 110834016

Gene position: 1312537-1313304 (Clockwise)

Preceding gene: 110834015

Following gene: 110834017

Centisome position: 42.07

GC content: 52.73

Gene sequence:

>768_bases
ATGATTCATCCGACCGCCCTTATTGATCCGGCCGCGGAGCTTGCAGATGATGTGCGGGTGGGCCCGTATTCCGTGATTGG
CCCCAATGTGGAAATTGGAGCGGGCACCGTGGTGGCCTCTCATGTGGTCATCAACGGCCCCACAACTATTGGTCGTAACA
ACCATATTTTTCAGTTCGCGTCCGTGGGCGAAGACTGCCAAGATAAAAAATATAAGGGAGAGCCAACCCGGCTGGAAATC
GGAGACGATAACGTTATTCGTGAATCGGTCACCATTCACCGGGGTACCATTCAGGATAACTCTCTGACTAAAATCGGTGA
CCGTAATCTCTTAATGGCTTATGTGCACGTGGCCCATGATTGTATCATTGGCGATGACTGTATCTTTGCCAATAATGCGT
CTGTAGCGGGCCACGCCCATGTCGGCAATGGTGTGATTCTGGGCGGCATGACAGGGGTGCACCAGTTCTGCAAGATTGGT
TCTTACGCGATGACGTCGGGCTGTTCTCTCGTGCTCAAAGATATTCCTGCCTATGTGATGGTATCTGGTAATCCTGCCGG
CGCCCGCAGCATGAACTTTGAGGGTATGCGTCGTCGTGGTTGGTCTAAAGATGTGGTTAGCAGCTTGCGCAAGGCTTACA
AGCTGGTCTACCGCCAGGGGCTGACATTGGAGCAGGCGTTGCTGGAATTAGAGTCCATGGAGCCGTCGGATGCGCTACAG
ATTTTTATCGATTCTCTAAAGTCTTCCGAGCGCGGCATCACGCGCTGA

Upstream 100 bases:

>100_bases
ATGCTCGTGGCTGAACAGAAAGTCTAGTCCATACCGTACGCCAGCGCGGAGCTGGCGTATACTTGCTTGCCTTCACCACC
AAAATAAAAGTGACTAGTCC

Downstream 100 bases:

>100_bases
TATGACACAGCGTAAGGATGCTCCGCTTGTCGCGCTGATTGCCGGGGAAGCTTCCGGGGATATTTTAGGGGCAGGCCTCA
TGCAGGCCCTTGAAAATCGT

Product: acyl-(acyl-carrier-protein)--UDP-N- acetylglucosamine O-acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MIHPTALIDPAAELADDVRVGPYSVIGPNVEIGAGTVVASHVVINGPTTIGRNNHIFQFASVGEDCQDKKYKGEPTRLEI
GDDNVIRESVTIHRGTIQDNSLTKIGDRNLLMAYVHVAHDCIIGDDCIFANNASVAGHAHVGNGVILGGMTGVHQFCKIG
SYAMTSGCSLVLKDIPAYVMVSGNPAGARSMNFEGMRRRGWSKDVVSSLRKAYKLVYRQGLTLEQALLELESMEPSDALQ
IFIDSLKSSERGITR

Sequences:

>Translated_255_residues
MIHPTALIDPAAELADDVRVGPYSVIGPNVEIGAGTVVASHVVINGPTTIGRNNHIFQFASVGEDCQDKKYKGEPTRLEI
GDDNVIRESVTIHRGTIQDNSLTKIGDRNLLMAYVHVAHDCIIGDDCIFANNASVAGHAHVGNGVILGGMTGVHQFCKIG
SYAMTSGCSLVLKDIPAYVMVSGNPAGARSMNFEGMRRRGWSKDVVSSLRKAYKLVYRQGLTLEQALLELESMEPSDALQ
IFIDSLKSSERGITR
>Mature_255_residues
MIHPTALIDPAAELADDVRVGPYSVIGPNVEIGAGTVVASHVVINGPTTIGRNNHIFQFASVGEDCQDKKYKGEPTRLEI
GDDNVIRESVTIHRGTIQDNSLTKIGDRNLLMAYVHVAHDCIIGDDCIFANNASVAGHAHVGNGVILGGMTGVHQFCKIG
SYAMTSGCSLVLKDIPAYVMVSGNPAGARSMNFEGMRRRGWSKDVVSSLRKAYKLVYRQGLTLEQALLELESMEPSDALQ
IFIDSLKSSERGITR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=256, Percent_Identity=52.34375, Blast_Score=289, Evalue=1e-79,
Organism=Escherichia coli, GI1786376, Length=215, Percent_Identity=28.8372093023256, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 27495; Mature: 27495

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHPTALIDPAAELADDVRVGPYSVIGPNVEIGAGTVVASHVVINGPTTIGRNNHIFQFA
CCCCCCCCCCHHHHHHHCCCCCEEEECCCEEECCCEEEEEEEEECCCCCCCCCCCEEEEC
SVGEDCQDKKYKGEPTRLEIGDDNVIRESVTIHRGTIQDNSLTKIGDRNLLMAYVHVAHD
CCCCCHHCCCCCCCCCEEEECCCCHHHHEEEEEECCCCCCCEEECCCCHHHHHHHHHHHH
CIIGDDCIFANNASVAGHAHVGNGVILGGMTGVHQFCKIGSYAMTSGCSLVLKDIPAYVM
HEECCCEEEECCCCCCCEEECCCCEEECCHHHHHHHHHCCCHHHHCCCCEEEECCCEEEE
VSGNPAGARSMNFEGMRRRGWSKDVVSSLRKAYKLVYRQGLTLEQALLELESMEPSDALQ
EECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
IFIDSLKSSERGITR
HHHHHHHCCCCCCCC
>Mature Secondary Structure
MIHPTALIDPAAELADDVRVGPYSVIGPNVEIGAGTVVASHVVINGPTTIGRNNHIFQFA
CCCCCCCCCCHHHHHHHCCCCCEEEECCCEEECCCEEEEEEEEECCCCCCCCCCCEEEEC
SVGEDCQDKKYKGEPTRLEIGDDNVIRESVTIHRGTIQDNSLTKIGDRNLLMAYVHVAHD
CCCCCHHCCCCCCCCCEEEECCCCHHHHEEEEEECCCCCCCEEECCCCHHHHHHHHHHHH
CIIGDDCIFANNASVAGHAHVGNGVILGGMTGVHQFCKIGSYAMTSGCSLVLKDIPAYVM
HEECCCEEEECCCCCCCEEECCCCEEECCHHHHHHHHHCCCHHHHCCCCEEEECCCEEEE
VSGNPAGARSMNFEGMRRRGWSKDVVSSLRKAYKLVYRQGLTLEQALLELESMEPSDALQ
EECCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHH
IFIDSLKSSERGITR
HHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA