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The map label for this gene is panE [C]

Identifier: 110833828

GI number: 110833828

Start: 1091734

End: 1092690

Strand: Direct

Name: panE [C]

Synonym: ABO_0967

Alternate gene names: 110833828

Gene position: 1091734-1092690 (Clockwise)

Preceding gene: 110833827

Following gene: 110833833

Centisome position: 34.99

GC content: 53.61

Gene sequence:

>957_bases
ATGATCCTCAAAAGCGCGGAGGCTAAGCCCCACATTGTGGTGATAGGCGCTGGTGCCATTGGTAGTTTTTATGGCGCGAT
CCTGAAACGGGCAGGGTGTGCGGTTAGTGTTGTGTTGCGTTCAGATTATGAGACAGTGAAAGCCTCTGGTTTCCGCTTTA
CTAGCCCGCTGGGTGACCTTTCGTGGACTCCAGATCATGTCTATCAGCCTGGTGAAACCCCGCTGCAAACGCCAGATTAT
GTGTTGTTGTGCGTCAAGGTGTTGCCGGGTGTGGACCGGGCAGAACTCGTTCGCTCTTGGTTAGGAAATCACACCGCACT
GGTGCTGATTGAGAACGGCCTGGATATTGAACGTGAGCTGGCCGATGCCTTCCCCGACAATCCATTGCTAAGTTGTTTGG
CATTCATTGCTGTGAGCCGCACCGGGCCGGGTACCGTTAATCACCAGGCCTATGGACAGCTGGTGATGGGGAATTTTCCA
AAGGGTTTTGATCAGCACTGCGAACAGTTGGCCAATTTGTTCCGCGAGGGCGGTATCGATGTCAACGGTACTGATGCGGT
GGTTGGCGAGCGTTGGCGCAAATGTGTCTGGAACACATCGTTCAATCCGTTGAGCGTGCTGGCCAACGGTGCTGATACGT
TGACCATGCTTGATGCTCCAGGTGGCGAAGCGTTGATCCGCCTTATGATGAAAGAGGTGATAGCGGTGGCTGAGGCTGAT
GGTTACCCCATGCCCCCCGACATCATCGAGAAGAATATATCGGGGACTCGCGCCATGGGCGCATATAAAAACTCTATGGC
GCTGGATTACTTGAATGATAGGCCTATCGAGCTGGAGGCCATTGTTGGCAATATAGTCGCTATCGCTGACCGTCTTGATG
TGCCGGTTCCGCATTTGCGCACGGTATTGGTGACATTGCGTATACGGCAGGGGGTAGACAGCGCTCACAGCGAATAA

Upstream 100 bases:

>100_bases
GCACTTTGTATTCATCGGCGATGGGTTTGTTTGTCATGCTCGGTTTGCCGGCGTTGTTTGGGCCCCAACAAGAACGCAGC
CTGTTAGGAGAATAGAGGCA

Downstream 100 bases:

>100_bases
CTTAAGAATTAGCAGCAACCTGTGATTACTGTCCGTTCTCAATGTCGGTGAGCTGTTCCTTGCTTAATATGGAAACGCTT
TCGGTAATGTCATCAAATAG

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MILKSAEAKPHIVVIGAGAIGSFYGAILKRAGCAVSVVLRSDYETVKASGFRFTSPLGDLSWTPDHVYQPGETPLQTPDY
VLLCVKVLPGVDRAELVRSWLGNHTALVLIENGLDIERELADAFPDNPLLSCLAFIAVSRTGPGTVNHQAYGQLVMGNFP
KGFDQHCEQLANLFREGGIDVNGTDAVVGERWRKCVWNTSFNPLSVLANGADTLTMLDAPGGEALIRLMMKEVIAVAEAD
GYPMPPDIIEKNISGTRAMGAYKNSMALDYLNDRPIELEAIVGNIVAIADRLDVPVPHLRTVLVTLRIRQGVDSAHSE

Sequences:

>Translated_318_residues
MILKSAEAKPHIVVIGAGAIGSFYGAILKRAGCAVSVVLRSDYETVKASGFRFTSPLGDLSWTPDHVYQPGETPLQTPDY
VLLCVKVLPGVDRAELVRSWLGNHTALVLIENGLDIERELADAFPDNPLLSCLAFIAVSRTGPGTVNHQAYGQLVMGNFP
KGFDQHCEQLANLFREGGIDVNGTDAVVGERWRKCVWNTSFNPLSVLANGADTLTMLDAPGGEALIRLMMKEVIAVAEAD
GYPMPPDIIEKNISGTRAMGAYKNSMALDYLNDRPIELEAIVGNIVAIADRLDVPVPHLRTVLVTLRIRQGVDSAHSE
>Mature_318_residues
MILKSAEAKPHIVVIGAGAIGSFYGAILKRAGCAVSVVLRSDYETVKASGFRFTSPLGDLSWTPDHVYQPGETPLQTPDY
VLLCVKVLPGVDRAELVRSWLGNHTALVLIENGLDIERELADAFPDNPLLSCLAFIAVSRTGPGTVNHQAYGQLVMGNFP
KGFDQHCEQLANLFREGGIDVNGTDAVVGERWRKCVWNTSFNPLSVLANGADTLTMLDAPGGEALIRLMMKEVIAVAEAD
GYPMPPDIIEKNISGTRAMGAYKNSMALDYLNDRPIELEAIVGNIVAIADRLDVPVPHLRTVLVTLRIRQGVDSAHSE

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320057, Length=324, Percent_Identity=28.7037037037037, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34374; Mature: 34374

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILKSAEAKPHIVVIGAGAIGSFYGAILKRAGCAVSVVLRSDYETVKASGFRFTSPLGDL
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCEEEECCCCCC
SWTPDHVYQPGETPLQTPDYVLLCVKVLPGVDRAELVRSWLGNHTALVLIENGLDIEREL
CCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHH
ADAFPDNPLLSCLAFIAVSRTGPGTVNHQAYGQLVMGNFPKGFDQHCEQLANLFREGGID
HHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCC
VNGTDAVVGERWRKCVWNTSFNPLSVLANGADTLTMLDAPGGEALIRLMMKEVIAVAEAD
CCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
GYPMPPDIIEKNISGTRAMGAYKNSMALDYLNDRPIELEAIVGNIVAIADRLDVPVPHLR
CCCCCHHHHHCCCCCCHHHHHHHCCCEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHH
TVLVTLRIRQGVDSAHSE
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MILKSAEAKPHIVVIGAGAIGSFYGAILKRAGCAVSVVLRSDYETVKASGFRFTSPLGDL
CCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCEEEECCCCCC
SWTPDHVYQPGETPLQTPDYVLLCVKVLPGVDRAELVRSWLGNHTALVLIENGLDIEREL
CCCHHHCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHH
ADAFPDNPLLSCLAFIAVSRTGPGTVNHQAYGQLVMGNFPKGFDQHCEQLANLFREGGID
HHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCC
VNGTDAVVGERWRKCVWNTSFNPLSVLANGADTLTMLDAPGGEALIRLMMKEVIAVAEAD
CCCCHHHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCC
GYPMPPDIIEKNISGTRAMGAYKNSMALDYLNDRPIELEAIVGNIVAIADRLDVPVPHLR
CCCCCHHHHHCCCCCCHHHHHHHCCCEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHH
TVLVTLRIRQGVDSAHSE
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]