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The map label for this gene is ttgR [H]

Identifier: 110833827

GI number: 110833827

Start: 1090860

End: 1091507

Strand: Direct

Name: ttgR [H]

Synonym: ABO_0966

Alternate gene names: 110833827

Gene position: 1090860-1091507 (Clockwise)

Preceding gene: 110833821

Following gene: 110833828

Centisome position: 34.96

GC content: 53.86

Gene sequence:

>648_bases
ATGGTTCGGCGCACCAAGGCAGAAGCGATGGAAACCCGTACCCATATCTTGGATGCGGCGGAACAAGTTTTTCATCGCAA
GGGCGTGTTGTCTGCCTCATTACATGATATTGCCTGTGAGGCGGGAGTGACGCGCGGAGCGATTTATTGGCACTTCAAAA
ATAAGCATGATGTCTTTGTGGCCATGGCGGACCGTCGGCGCTTGCCATTTGAGGCCTTAGCCCAGCGGGCAGAGGCGGAT
GATGAGGCGGATCCAATGGGACGCCTGCGTGAGTTTATGGTGTATTTGTTACAGCAAGTGGCTCAGGATCCGTCCCAGCG
CCGGGTTTTCGAGATCATTTTTCAGAAGTGCGAGTTCAGTGATGAGAATCGGGATCTGCTATTGCGCCAGCGCGATGCGT
GCAGGGATGCGTCTGACGGACTGGAAACGACTTTCAGGAATGCTATTGCCAAAGGGCAGCTTCCTGCAGGGTTAAACATT
GGGCGTGCGGTGACATTGCTGCATAGCCTGCTCAATGGCGTGATCATGTATTGGTTGTTGGATCCGTCAGTTTTTGATCT
GGCGGATGCCGCGCCGGATTATGTGGATACTTTCCTGTTCAGCCTGCAGCGTTCCCCCAGCCTTGTGGTTGGTGAAGGTT
CTGTGTGA

Upstream 100 bases:

>100_bases
TGAAAAATGAATCAGGTTCAGTATATACATTCAGTAATGTATGTATAGATCTTTTGGCTAACTTGAACAAAATACTGTCA
ATTCCATTTGGGAGTCTCCA

Downstream 100 bases:

>100_bases
GAACGGCTCGCGCTTATTTTTCATGAACAAACCTCGTTTGAACTTTCGATAACCTGGGCGTATGAAACATACTCGGTGGC
GTGCTGTTGTTGCCGCGGGC

Product: transcriptional regulator TtgR

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MVRRTKAEAMETRTHILDAAEQVFHRKGVLSASLHDIACEAGVTRGAIYWHFKNKHDVFVAMADRRRLPFEALAQRAEAD
DEADPMGRLREFMVYLLQQVAQDPSQRRVFEIIFQKCEFSDENRDLLLRQRDACRDASDGLETTFRNAIAKGQLPAGLNI
GRAVTLLHSLLNGVIMYWLLDPSVFDLADAAPDYVDTFLFSLQRSPSLVVGEGSV

Sequences:

>Translated_215_residues
MVRRTKAEAMETRTHILDAAEQVFHRKGVLSASLHDIACEAGVTRGAIYWHFKNKHDVFVAMADRRRLPFEALAQRAEAD
DEADPMGRLREFMVYLLQQVAQDPSQRRVFEIIFQKCEFSDENRDLLLRQRDACRDASDGLETTFRNAIAKGQLPAGLNI
GRAVTLLHSLLNGVIMYWLLDPSVFDLADAAPDYVDTFLFSLQRSPSLVVGEGSV
>Mature_215_residues
MVRRTKAEAMETRTHILDAAEQVFHRKGVLSASLHDIACEAGVTRGAIYWHFKNKHDVFVAMADRRRLPFEALAQRAEAD
DEADPMGRLREFMVYLLQQVAQDPSQRRVFEIIFQKCEFSDENRDLLLRQRDACRDASDGLETTFRNAIAKGQLPAGLNI
GRAVTLLHSLLNGVIMYWLLDPSVFDLADAAPDYVDTFLFSLQRSPSLVVGEGSV

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=208, Percent_Identity=39.9038461538462, Blast_Score=155, Evalue=1e-39,
Organism=Escherichia coli, GI1789664, Length=200, Percent_Identity=33, Blast_Score=117, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 24282; Mature: 24282

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKAEAMETRTHILDAAEQVFHRKGVLSASLHDIACEAGVTRGAIYWHFKNKHDVFV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
AMADRRRLPFEALAQRAEADDEADPMGRLREFMVYLLQQVAQDPSQRRVFEIIFQKCEFS
EECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
DENRDLLLRQRDACRDASDGLETTFRNAIAKGQLPAGLNIGRAVTLLHSLLNGVIMYWLL
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DPSVFDLADAAPDYVDTFLFSLQRSPSLVVGEGSV
CCHHHHHHHCCHHHHHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure
MVRRTKAEAMETRTHILDAAEQVFHRKGVLSASLHDIACEAGVTRGAIYWHFKNKHDVFV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
AMADRRRLPFEALAQRAEADDEADPMGRLREFMVYLLQQVAQDPSQRRVFEIIFQKCEFS
EECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
DENRDLLLRQRDACRDASDGLETTFRNAIAKGQLPAGLNIGRAVTLLHSLLNGVIMYWLL
CCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DPSVFDLADAAPDYVDTFLFSLQRSPSLVVGEGSV
CCHHHHHHHCCHHHHHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]