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The map label for this gene is cyaB [H]

Identifier: 110833746

GI number: 110833746

Start: 979919

End: 981463

Strand: Direct

Name: cyaB [H]

Synonym: ABO_0885

Alternate gene names: 110833746

Gene position: 979919-981463 (Clockwise)

Preceding gene: 110833741

Following gene: 110833748

Centisome position: 31.41

GC content: 52.56

Gene sequence:

>1545_bases
ATGACCTTCATCACAAAAAAGAAATCTCGCCGTCCTCAGCTGGGGCCTATGGAGCGCGCGCGCCGCCAGGCAAATTATAT
TCGCCTTTTGGCTTTTCTGGTGGCCGCCATGATCCTTATTGCGGGGCTAAACCTGAACCTGTTTCCTGCGCTATATATGC
TGGGGGTGGCGGGGCTGCTGATTTACCCCATGTCCGCCCAGGGCCTACTTTTTTTGTTCGACAAGCAGGATCGACCCACC
AAAATGGTTCATCAGCTGCTGATGCAAGCAGATGCTATGGTGATTGGCCTTGTGTGTGCTTTGCTACATTTCTCTCTGGT
GCCCGCCATGGTGCTGTTGATCATTGTTCATGCCAACGCGGTAAGTAGCGGAGGCCTCAAACCCTGGCTGATGAATATCC
TGATGACCGGCGTTGGCGCTCTGCTGATGGGCTGGGTTTTGGATTTCAAGGTGCTACCACCGCAACAGACACCGGTTTTG
CTGTCGGTTATCTCCATGCTCGGTTTGGGCATTTATGTCGGGGCGTCATCTGCATTTGCTCGCCTGCAGGCTCGCTATTT
GCAACAGGCACAGGAGCTGGTGCGCCATCAGCAGAAACAAGCGGTGGATATGTCTCGCAAGCTGGCCAAGTATTTACCGC
CCCAGGTGTGGGGTTCCATTTTTTCCGGCAAGCGCGATGCCAAGCTGGGAACCGAGCGTAAGCGGCTCACGGTATTTTTT
TCTGATATTAAAGGCTTTAGTGCCATTTCCGAAGAGCTGCCATTAGCGACTCTGACTAAGATGCTCAACACTTACCTGAG
CGAAATGACCCGCATTGCACTGCGCCACGGTGGCACTATCGACAAGTTCATCGGTGATGCAGTGATGGTGTTTTTCGGTG
ACCCGAAAAGCGCCGGTGCCCAGGAAGATGCCTACCGATGTGTATTAATGGCCATCGAGATGCAGGAGCAAATGAAATTA
TTACGCCAGCGCTGGGCTCACGAAGGTATTGAACACAAGCTGGAAATCCGTATTGGTATTAACACCGGGTATGCGACGGT
GGGCAACTTTGGCACCGATTCTCGTATGGACTACACCATTTTGGGCACTGATGTGAACCTGGCCAGTCGCCTAGAATCGG
CTTGCCGTCCAGGTGGCGTGCTGATTTCAGAGGCGACCCAAGAACTGGTGAAGGACCGAATTCAGTGCCGCAACATGGGT
GACATCCAAGTAAAAGGATTTAACCGGCCGATTTCGGTGTTTGAAGCTCTAGGAGCCAAAAGGGATAGCGGAGCAAAGAA
CCGTTATGTGTCGGCGCAAACGGCGGGTTTTGGTATGCATATCGACCTGGAGCGCATTCGTAACTTCGACAAGAACACTA
TCCTGCGCACCCTGGCCCATTGCGCCACAGATCTGAAACAGGACAAGCTAGTGGAAGTGGACTATGAGTCGGAAGGCTTC
AGCTTGCATGTGGAAAGCCACACCTTGAAAAAACGGGATCGTGAGAAAGTGATCGAAATGATGGGGCGTGCCGCCAAGAA
AGTGCAGACAGAAGTACGAGTGTAA

Upstream 100 bases:

>100_bases
GCTTCCAGGCAGCAAGGAATCCTCGACCTTTAGTCATCCCAGTCTTTTTTCTTATACGGTAAACCGCTAAGCTCCGCAGA
AATCGCGTGAAACCGATCAC

Downstream 100 bases:

>100_bases
TTCGCTACCCGCTCCCTGAGACGCTGCTTTAGGTGGGCAGGCGTCCACCTAAAGCAGCTGACCGAATGTTACTGACCAAG
AATGGCGTCAGCGGCTTTTT

Product: adenylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 2; Adenylyl cyclase 2; AC2 [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTFITKKKSRRPQLGPMERARRQANYIRLLAFLVAAMILIAGLNLNLFPALYMLGVAGLLIYPMSAQGLLFLFDKQDRPT
KMVHQLLMQADAMVIGLVCALLHFSLVPAMVLLIIVHANAVSSGGLKPWLMNILMTGVGALLMGWVLDFKVLPPQQTPVL
LSVISMLGLGIYVGASSAFARLQARYLQQAQELVRHQQKQAVDMSRKLAKYLPPQVWGSIFSGKRDAKLGTERKRLTVFF
SDIKGFSAISEELPLATLTKMLNTYLSEMTRIALRHGGTIDKFIGDAVMVFFGDPKSAGAQEDAYRCVLMAIEMQEQMKL
LRQRWAHEGIEHKLEIRIGINTGYATVGNFGTDSRMDYTILGTDVNLASRLESACRPGGVLISEATQELVKDRIQCRNMG
DIQVKGFNRPISVFEALGAKRDSGAKNRYVSAQTAGFGMHIDLERIRNFDKNTILRTLAHCATDLKQDKLVEVDYESEGF
SLHVESHTLKKRDREKVIEMMGRAAKKVQTEVRV

Sequences:

>Translated_514_residues
MTFITKKKSRRPQLGPMERARRQANYIRLLAFLVAAMILIAGLNLNLFPALYMLGVAGLLIYPMSAQGLLFLFDKQDRPT
KMVHQLLMQADAMVIGLVCALLHFSLVPAMVLLIIVHANAVSSGGLKPWLMNILMTGVGALLMGWVLDFKVLPPQQTPVL
LSVISMLGLGIYVGASSAFARLQARYLQQAQELVRHQQKQAVDMSRKLAKYLPPQVWGSIFSGKRDAKLGTERKRLTVFF
SDIKGFSAISEELPLATLTKMLNTYLSEMTRIALRHGGTIDKFIGDAVMVFFGDPKSAGAQEDAYRCVLMAIEMQEQMKL
LRQRWAHEGIEHKLEIRIGINTGYATVGNFGTDSRMDYTILGTDVNLASRLESACRPGGVLISEATQELVKDRIQCRNMG
DIQVKGFNRPISVFEALGAKRDSGAKNRYVSAQTAGFGMHIDLERIRNFDKNTILRTLAHCATDLKQDKLVEVDYESEGF
SLHVESHTLKKRDREKVIEMMGRAAKKVQTEVRV
>Mature_513_residues
TFITKKKSRRPQLGPMERARRQANYIRLLAFLVAAMILIAGLNLNLFPALYMLGVAGLLIYPMSAQGLLFLFDKQDRPTK
MVHQLLMQADAMVIGLVCALLHFSLVPAMVLLIIVHANAVSSGGLKPWLMNILMTGVGALLMGWVLDFKVLPPQQTPVLL
SVISMLGLGIYVGASSAFARLQARYLQQAQELVRHQQKQAVDMSRKLAKYLPPQVWGSIFSGKRDAKLGTERKRLTVFFS
DIKGFSAISEELPLATLTKMLNTYLSEMTRIALRHGGTIDKFIGDAVMVFFGDPKSAGAQEDAYRCVLMAIEMQEQMKLL
RQRWAHEGIEHKLEIRIGINTGYATVGNFGTDSRMDYTILGTDVNLASRLESACRPGGVLISEATQELVKDRIQCRNMGD
IQVKGFNRPISVFEALGAKRDSGAKNRYVSAQTAGFGMHIDLERIRNFDKNTILRTLAHCATDLKQDKLVEVDYESEGFS
LHVESHTLKKRDREKVIEMMGRAAKKVQTEVRV

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Homo sapiens, GI4557257, Length=172, Percent_Identity=30.2325581395349, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI148536830, Length=159, Percent_Identity=27.6729559748428, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193206632, Length=192, Percent_Identity=32.8125, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534657, Length=256, Percent_Identity=27.34375, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17557192, Length=251, Percent_Identity=27.4900398406374, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17534659, Length=214, Percent_Identity=29.4392523364486, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193207841, Length=252, Percent_Identity=25.3968253968254, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193206054, Length=259, Percent_Identity=26.6409266409266, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71989822, Length=241, Percent_Identity=26.5560165975104, Blast_Score=66, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71989805, Length=241, Percent_Identity=26.5560165975104, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221330470, Length=228, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221330468, Length=228, Percent_Identity=28.9473684210526, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI62484477, Length=271, Percent_Identity=28.4132841328413, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI62484298, Length=271, Percent_Identity=28.4132841328413, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116008008, Length=271, Percent_Identity=28.4132841328413, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585694, Length=294, Percent_Identity=24.1496598639456, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24647268, Length=214, Percent_Identity=30.3738317757009, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR011006
- InterPro:   IPR001789 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00072 Response_reg [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 57376; Mature: 57245

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TFITKKKSRRPQLGPMERARRQANYIRLLAFLVAAMILIAGLNLNLFPALYMLGVAGLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
IYPMSAQGLLFLFDKQDRPTKMVHQLLMQADAMVIGLVCALLHFSLVPAMVLLIIVHANA
HCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VSSGGLKPWLMNILMTGVGALLMGWVLDFKVLPPQQTPVLLSVISMLGLGIYVGASSAFA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCEECCCCCCHHHHHHHHHHHHHHHCCCHHHHH
RLQARYLQQAQELVRHQQKQAVDMSRKLAKYLPPQVWGSIFSGKRDAKLGTERKRLTVFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCHHHEEEEH
SDIKGFSAISEELPLATLTKMLNTYLSEMTRIALRHGGTIDKFIGDAVMVFFGDPKSAGA
HHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCEEEEEECCCCCCCC
QEDAYRCVLMAIEMQEQMKLLRQRWAHEGIEHKLEIRIGINTGYATVGNFGTDSRMDYTI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCEECCCCCCCCCCEEEE
LGTDVNLASRLESACRPGGVLISEATQELVKDRIQCRNMGDIQVKGFNRPISVFEALGAK
EECCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHCCC
RDSGAKNRYVSAQTAGFGMHIDLERIRNFDKNTILRTLAHCATDLKQDKLVEVDYESEGF
CCCCCCCCEEEEECCCCCEEEEHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCC
SLHVESHTLKKRDREKVIEMMGRAAKKVQTEVRV
EEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]