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The map label for this gene is metR [H]

Identifier: 110833723

GI number: 110833723

Start: 961716

End: 962639

Strand: Direct

Name: metR [H]

Synonym: ABO_0862

Alternate gene names: 110833723

Gene position: 961716-962639 (Clockwise)

Preceding gene: 110833721

Following gene: 110833731

Centisome position: 30.82

GC content: 58.66

Gene sequence:

>924_bases
ATGCTTGAACTCAGACATCTCGCTACGTTGCGTGCCATTGAGGAGGCTGGATCACTGGTGGAGGCGGCAGAGCGGCTGCA
CGTTACCCAGTCGGCCTTGTCTCATCAGTTGAAAGATCTTGAACATCGATTGGGTGTGGCGCTGTTGGTGAGGCGAACCC
GGCCGGTGCGTTTTACCACGGCCGGGTTGCGAGTGCTGGCGCTAGCACGCGATGTGCTCCCCCGGGTGCAGCAAACAGAA
AGGGAACTGAAACGCTTGGCCGCCGGCCAGACTGGGCGGCTACATATCGCCATCGAGTGCCATTCCTGTTTTCAGTGGCT
AATGCCGGCCCTGGATGCGTTTCGGGAACACTGGCCTGAAGTGGAGTTGGATTTATCGGCGGCGTTCAGTTTTGCACCGT
TGCCTGCGCTGGCGCGGGGAGACCTGGATATGGTGGTGAGTTCCGATCCGGTGGAAAACGATGCCGTGCTGTATGTGCCA
TTGTTCCGCTACGAGCTGGTGCTGGCGGTGTCACGACAATCGCCGCTGGCGGGGAAAAAGTGGATCCTCCCCGACGACAT
CACCGACCAAACGCTGATTACCTACCCGGTGGATCGTGAGCGACTGGATGTGTTCAGCGCCTTTTTGGGCCCGGCGGGTA
AAGAACCCGCAGCCATACGCACGGCTGAGCTGACCCCCATGACAGCGCAATTAGTGGCCGCAGGTCGCGGTGTAGCCGCG
TTACCAAACTGGGCACTAACGGAATATACCGAACACGATTTATTGAAAACCGTACGGCTTGGTGAAAAGGGGGTGTGGCG
AACGCTTTATGCGGCAGTGCGTGTGGAGGACGAACAGACCCCCTATGTGCAGGAGTTTCTCGGCACCGCCCGGGACCTGT
GTTTCAAGACGCTAAGTGGTGTGCGGGCAGTAAAGGGCAGTTAA

Upstream 100 bases:

>100_bases
AAGTATGAATTTTTCTCAACAATAGAATTTGCTTGCTCCAGGCGTCTCATCGCCTGCAAGCCAGTTTTCACCTCTACAAT
TAGCTCAAGGAAAGGCATTC

Downstream 100 bases:

>100_bases
TGTTTATAAAAAATAACGGTAGGGCTGGTTCTATGGGGGGCACGCTTGCGGGTGGCTAGCCTCGCTAGCGGCGCGATTTT
TGTTCGTCTGTTTCGGTTGC

Product: transcriptional activator MetR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MLELRHLATLRAIEEAGSLVEAAERLHVTQSALSHQLKDLEHRLGVALLVRRTRPVRFTTAGLRVLALARDVLPRVQQTE
RELKRLAAGQTGRLHIAIECHSCFQWLMPALDAFREHWPEVELDLSAAFSFAPLPALARGDLDMVVSSDPVENDAVLYVP
LFRYELVLAVSRQSPLAGKKWILPDDITDQTLITYPVDRERLDVFSAFLGPAGKEPAAIRTAELTPMTAQLVAAGRGVAA
LPNWALTEYTEHDLLKTVRLGEKGVWRTLYAAVRVEDEQTPYVQEFLGTARDLCFKTLSGVRAVKGS

Sequences:

>Translated_307_residues
MLELRHLATLRAIEEAGSLVEAAERLHVTQSALSHQLKDLEHRLGVALLVRRTRPVRFTTAGLRVLALARDVLPRVQQTE
RELKRLAAGQTGRLHIAIECHSCFQWLMPALDAFREHWPEVELDLSAAFSFAPLPALARGDLDMVVSSDPVENDAVLYVP
LFRYELVLAVSRQSPLAGKKWILPDDITDQTLITYPVDRERLDVFSAFLGPAGKEPAAIRTAELTPMTAQLVAAGRGVAA
LPNWALTEYTEHDLLKTVRLGEKGVWRTLYAAVRVEDEQTPYVQEFLGTARDLCFKTLSGVRAVKGS
>Mature_307_residues
MLELRHLATLRAIEEAGSLVEAAERLHVTQSALSHQLKDLEHRLGVALLVRRTRPVRFTTAGLRVLALARDVLPRVQQTE
RELKRLAAGQTGRLHIAIECHSCFQWLMPALDAFREHWPEVELDLSAAFSFAPLPALARGDLDMVVSSDPVENDAVLYVP
LFRYELVLAVSRQSPLAGKKWILPDDITDQTLITYPVDRERLDVFSAFLGPAGKEPAAIRTAELTPMTAQLVAAGRGVAA
LPNWALTEYTEHDLLKTVRLGEKGVWRTLYAAVRVEDEQTPYVQEFLGTARDLCFKTLSGVRAVKGS

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=305, Percent_Identity=44.9180327868852, Blast_Score=265, Evalue=2e-72,
Organism=Escherichia coli, GI157672245, Length=293, Percent_Identity=28.3276450511945, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790399, Length=247, Percent_Identity=30.3643724696356, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=28.9795918367347, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI145693105, Length=287, Percent_Identity=25.0871080139373, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787879, Length=296, Percent_Identity=25.3378378378378, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787806, Length=271, Percent_Identity=23.9852398523985, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1786401, Length=254, Percent_Identity=26.3779527559055, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787530, Length=264, Percent_Identity=25.3787878787879, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1789506, Length=191, Percent_Identity=25.6544502617801, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082024, Length=173, Percent_Identity=30.635838150289, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788296, Length=306, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790208, Length=262, Percent_Identity=27.4809160305344, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI145693193, Length=183, Percent_Identity=28.9617486338798, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=28.0632411067194, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788748, Length=252, Percent_Identity=25.3968253968254, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1786713, Length=99, Percent_Identity=38.3838383838384, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789173, Length=124, Percent_Identity=31.4516129032258, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI87082132, Length=289, Percent_Identity=25.2595155709343, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1787949, Length=99, Percent_Identity=35.3535353535354, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34147; Mature: 34147

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS00024 HEMOPEXIN ; PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELRHLATLRAIEEAGSLVEAAERLHVTQSALSHQLKDLEHRLGVALLVRRTRPVRFTT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEH
AGLRVLALARDVLPRVQQTERELKRLAAGQTGRLHIAIECHSCFQWLMPALDAFREHWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC
VELDLSAAFSFAPLPALARGDLDMVVSSDPVENDAVLYVPLFRYELVLAVSRQSPLAGKK
EEEEHHHHHCCCCCCHHHCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCC
WILPDDITDQTLITYPVDRERLDVFSAFLGPAGKEPAAIRTAELTPMTAQLVAAGRGVAA
CCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCCCC
LPNWALTEYTEHDLLKTVRLGEKGVWRTLYAAVRVEDEQTPYVQEFLGTARDLCFKTLSG
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHH
VRAVKGS
HHHCCCC
>Mature Secondary Structure
MLELRHLATLRAIEEAGSLVEAAERLHVTQSALSHQLKDLEHRLGVALLVRRTRPVRFTT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEH
AGLRVLALARDVLPRVQQTERELKRLAAGQTGRLHIAIECHSCFQWLMPALDAFREHWPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCC
VELDLSAAFSFAPLPALARGDLDMVVSSDPVENDAVLYVPLFRYELVLAVSRQSPLAGKK
EEEEHHHHHCCCCCCHHHCCCEEEEEECCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCC
WILPDDITDQTLITYPVDRERLDVFSAFLGPAGKEPAAIRTAELTPMTAQLVAAGRGVAA
CCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHCCCCCCC
LPNWALTEYTEHDLLKTVRLGEKGVWRTLYAAVRVEDEQTPYVQEFLGTARDLCFKTLSG
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHH
VRAVKGS
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]