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The map label for this gene is purC

Identifier: 110833640

GI number: 110833640

Start: 872213

End: 872929

Strand: Direct

Name: purC

Synonym: ABO_0779

Alternate gene names: 110833640

Gene position: 872213-872929 (Clockwise)

Preceding gene: 110833639

Following gene: 110833641

Centisome position: 27.95

GC content: 51.46

Gene sequence:

>717_bases
ATGGAAAAACGCGACGAGTTGTATGCCGGCAAAGCCAAGTCCGTGTACACCACCGATGACGAAGACATGCTGATTATGCT
GTTTCGTGACGATACCTCCGCCTTTGATGGTAAGAAAAAAGAGGCATTGGCTCGCAAGGGGGCAGTGAATAATCAGTTCA
ACGCAGCCATTATGGAAAAGCTGAAAGCGGCGGGCATCCCCTGCCATTTTGAGAAAACCCTATCGGCCACTGAATCCCTG
GTGAAGAAGCTAGATATGATTCCGGTGGAATGCGTGGTGCGTAATATTGCTGCGGGCTCCATATGCCGCCGCTTGGGTGT
GGAAGAGGGCCTGGAGTTGACGCCGCCAACGTTTGAGTTCTTCTTAAAGGACGATGACTTGGGGGACCCCATGGTCAATG
ATTTCCATATTCGTAGCTTTGGTTGGGCCAGCGACGATCAGGTGGCACAGATGAAAACCCTCACCTTTGCGGTGAACGAC
GTGCTCAAACAGCTGTTTCTGGACGGGGGCATGCTGCTGGTGGATTACAAGCTGGAGTTTGGCATGTTTAAAGGTGAGGT
ATTACTGGGGGATGAATTTAGCCCGGATGGCTGCCGCTTGTGGGACAAGGATAGCCGCGAAAAATTGGATAAAGACCGTT
TCCGTCAGGGGTTGGGCGGAGTGGTTGAAGCCTATGAAGAAGTGGGTAAGCGTCTGGGAATGACCTTCGAATATTAA

Upstream 100 bases:

>100_bases
TGGTAACCCGCGGGCGTGAACGAATTAGCGTTGCTAGTCAGACGGAAGGGTTTGACTGGCTACAAGTACATTAATGCTGA
CCTGAGTAATAGGCCTTTCC

Downstream 100 bases:

>100_bases
AATCGTTAACCATTACCCATCAAGCTGCAGCCAGTGATTTGATGGGTAATACTGCCAATTAAAAATAAGTAGAAAAGGTG
GGAGTATGAAATCTGTGATG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MEKRDELYAGKAKSVYTTDDEDMLIMLFRDDTSAFDGKKKEALARKGAVNNQFNAAIMEKLKAAGIPCHFEKTLSATESL
VKKLDMIPVECVVRNIAAGSICRRLGVEEGLELTPPTFEFFLKDDDLGDPMVNDFHIRSFGWASDDQVAQMKTLTFAVND
VLKQLFLDGGMLLVDYKLEFGMFKGEVLLGDEFSPDGCRLWDKDSREKLDKDRFRQGLGGVVEAYEEVGKRLGMTFEY

Sequences:

>Translated_238_residues
MEKRDELYAGKAKSVYTTDDEDMLIMLFRDDTSAFDGKKKEALARKGAVNNQFNAAIMEKLKAAGIPCHFEKTLSATESL
VKKLDMIPVECVVRNIAAGSICRRLGVEEGLELTPPTFEFFLKDDDLGDPMVNDFHIRSFGWASDDQVAQMKTLTFAVND
VLKQLFLDGGMLLVDYKLEFGMFKGEVLLGDEFSPDGCRLWDKDSREKLDKDRFRQGLGGVVEAYEEVGKRLGMTFEY
>Mature_238_residues
MEKRDELYAGKAKSVYTTDDEDMLIMLFRDDTSAFDGKKKEALARKGAVNNQFNAAIMEKLKAAGIPCHFEKTLSATESL
VKKLDMIPVECVVRNIAAGSICRRLGVEEGLELTPPTFEFFLKDDDLGDPMVNDFHIRSFGWASDDQVAQMKTLTFAVND
VLKQLFLDGGMLLVDYKLEFGMFKGEVLLGDEFSPDGCRLWDKDSREKLDKDRFRQGLGGVVEAYEEVGKRLGMTFEY

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=245, Percent_Identity=31.8367346938775, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI5453539, Length=245, Percent_Identity=31.8367346938775, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI119220559, Length=252, Percent_Identity=30.5555555555556, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788820, Length=237, Percent_Identity=62.0253164556962, Blast_Score=315, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17531275, Length=244, Percent_Identity=33.1967213114754, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18860083, Length=217, Percent_Identity=33.6405529953917, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583917, Length=218, Percent_Identity=31.1926605504587, Blast_Score=91, Evalue=8e-19,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_ALCBS (Q0VRH1)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692499.1
- ProteinModelPortal:   Q0VRH1
- SMR:   Q0VRH1
- STRING:   Q0VRH1
- GeneID:   4211142
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0779
- NMPDR:   fig|393595.12.peg.783
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q0VRH1
- ProtClustDB:   CLSK2779257
- BioCyc:   ABOR393595:ABO_0779-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26843; Mature: 26843

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRDELYAGKAKSVYTTDDEDMLIMLFRDDTSAFDGKKKEALARKGAVNNQFNAAIMEK
CCCCHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
LKAAGIPCHFEKTLSATESLVKKLDMIPVECVVRNIAAGSICRRLGVEEGLELTPPTFEF
HHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCCCEEE
FLKDDDLGDPMVNDFHIRSFGWASDDQVAQMKTLTFAVNDVLKQLFLDGGMLLVDYKLEF
EECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GMFKGEVLLGDEFSPDGCRLWDKDSREKLDKDRFRQGLGGVVEAYEEVGKRLGMTFEY
CCEECEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MEKRDELYAGKAKSVYTTDDEDMLIMLFRDDTSAFDGKKKEALARKGAVNNQFNAAIMEK
CCCCHHHHCCCCCCEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHH
LKAAGIPCHFEKTLSATESLVKKLDMIPVECVVRNIAAGSICRRLGVEEGLELTPPTFEF
HHHCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHCCCCCCCCCEEE
FLKDDDLGDPMVNDFHIRSFGWASDDQVAQMKTLTFAVNDVLKQLFLDGGMLLVDYKLEF
EECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEC
GMFKGEVLLGDEFSPDGCRLWDKDSREKLDKDRFRQGLGGVVEAYEEVGKRLGMTFEY
CCEECEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA