Click here to switch to the map view.

The map label for this gene is argG

Identifier: 110833586

GI number: 110833586

Start: 815507

End: 816730

Strand: Direct

Name: argG

Synonym: ABO_0725

Alternate gene names: 110833586

Gene position: 815507-816730 (Clockwise)

Preceding gene: 110833584

Following gene: 110833587

Centisome position: 26.14

GC content: 54.25

Gene sequence:

>1224_bases
ATGTCCAAGATCAACAAGGTGGTACTGGCTTATTCCGGTGGCCTGGATACCTCGGTTATCGTCAAATGGCTGCAAGATAC
CTATGACTGTGAAGTGGTGACGTTCACCGCGGATATCGGTCAGGGTGAGGAAGTGGAGCCAGCCCGGGCCAAGGCAGAAG
CCATGGGCGTGAAAGAGATCTACATTGAAGACCTGCGCGAAGAGTTCGTCCGTGATTATGTCTTCCCTATGTTCCGCGCC
AATGCCATCTACGAAGGTGAATATCTGCTGGGTACGTCTATTGCGCGCCCATTGATCGCTAAGCGCCTGGTGGAAATCGC
CGAAGAAACGGGCGCCGATGCTATTTCTCATGGCGCCACCGGCAAAGGTAACGACCAGGTGCGTTTCGAGCTGGGCGCCT
ACGCCTTAGCCCCCGGCATCCAGGTAATTGCTCCCTGGCGCGAGTGGGACTTGAACTCCCGCGAAAAGCTGATGGCGTAT
TGTGAAGAGCGCAATATTCCGGTGGATTTCTCCAACAAGAAGAAAAAATCCCCGTACTCCATGGATGCCAACCTGCTGCA
CATCTCCTATGAAGGCGGCAACCTTGAAGACCCGTGGTGGGAAGCGGAAGAAGACATGTGGCGTTGGAGCGTTAGCCCGG
AAGCAGCGCCGGATCAGGCGACTTACATTACTCTGGGCTTCGAAAAAGGCGATATCGTTTCTATCGATGGTGAAACCCTG
AGCCCGGCCGATGTGCTGACCAAGCTGAACAAGCTGGGTGGAGATAACGGCATTGGCCGCCTGGATATCGTGGAAAACCG
CTATGTGGGCATGAAGTCCCGTGGCTGCTACGAAACACCCGGTGGCACTATTATGTTGCCGGCTCACCGTGCCATCGAGT
CTCTGACACTGGATCGTGAATCTGCACACTTGAAAGATTCGGTAATGCCCAAGTACGCGGAGCTGCTGTACAACGGTTAC
TGGTGGAGCCCGGAACGTCTGGCTCTGCAGAAGCTGATTGATGCCACCCAGGAACACGTGAACGGTGAAGTACGCCTGAA
GCTCTATAAAGGCAGCGTGACTGTGGTGGGTCGTCGTTCCGACAATGACAGCTTGTTCGACGCCTCCATTGCTACTTTTG
AAGACGATGCCGGTGCTTATGATCAGAAGGACGCGGAAGGCTTTATTAAGCTAAATGCTCTGCGCTTACGTATTGCGGCT
AAAACCGGCCGTAAGCTTAGCTAA

Upstream 100 bases:

>100_bases
CAAGGGGGCAGGCGGGTACAATACGCCCCCTCTATATGCCTCACGATTCATCGGGCGCTGGCTCATGCGCTGCCGGCGAC
CCATTTGCGGAGTCTTTTCA

Downstream 100 bases:

>100_bases
GAAACGCGGCACGTTGCATGTGCACGGAAACCGCCGCGAACCCTGGGTTCGCGGCGGTTTTTTTTGGCTGTTTTTCAGCC
CCATAGGTCACATGGACATC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MSKINKVVLAYSGGLDTSVIVKWLQDTYDCEVVTFTADIGQGEEVEPARAKAEAMGVKEIYIEDLREEFVRDYVFPMFRA
NAIYEGEYLLGTSIARPLIAKRLVEIAEETGADAISHGATGKGNDQVRFELGAYALAPGIQVIAPWREWDLNSREKLMAY
CEERNIPVDFSNKKKKSPYSMDANLLHISYEGGNLEDPWWEAEEDMWRWSVSPEAAPDQATYITLGFEKGDIVSIDGETL
SPADVLTKLNKLGGDNGIGRLDIVENRYVGMKSRGCYETPGGTIMLPAHRAIESLTLDRESAHLKDSVMPKYAELLYNGY
WWSPERLALQKLIDATQEHVNGEVRLKLYKGSVTVVGRRSDNDSLFDASIATFEDDAGAYDQKDAEGFIKLNALRLRIAA
KTGRKLS

Sequences:

>Translated_407_residues
MSKINKVVLAYSGGLDTSVIVKWLQDTYDCEVVTFTADIGQGEEVEPARAKAEAMGVKEIYIEDLREEFVRDYVFPMFRA
NAIYEGEYLLGTSIARPLIAKRLVEIAEETGADAISHGATGKGNDQVRFELGAYALAPGIQVIAPWREWDLNSREKLMAY
CEERNIPVDFSNKKKKSPYSMDANLLHISYEGGNLEDPWWEAEEDMWRWSVSPEAAPDQATYITLGFEKGDIVSIDGETL
SPADVLTKLNKLGGDNGIGRLDIVENRYVGMKSRGCYETPGGTIMLPAHRAIESLTLDRESAHLKDSVMPKYAELLYNGY
WWSPERLALQKLIDATQEHVNGEVRLKLYKGSVTVVGRRSDNDSLFDASIATFEDDAGAYDQKDAEGFIKLNALRLRIAA
KTGRKLS
>Mature_406_residues
SKINKVVLAYSGGLDTSVIVKWLQDTYDCEVVTFTADIGQGEEVEPARAKAEAMGVKEIYIEDLREEFVRDYVFPMFRAN
AIYEGEYLLGTSIARPLIAKRLVEIAEETGADAISHGATGKGNDQVRFELGAYALAPGIQVIAPWREWDLNSREKLMAYC
EERNIPVDFSNKKKKSPYSMDANLLHISYEGGNLEDPWWEAEEDMWRWSVSPEAAPDQATYITLGFEKGDIVSIDGETLS
PADVLTKLNKLGGDNGIGRLDIVENRYVGMKSRGCYETPGGTIMLPAHRAIESLTLDRESAHLKDSVMPKYAELLYNGYW
WSPERLALQKLIDATQEHVNGEVRLKLYKGSVTVVGRRSDNDSLFDASIATFEDDAGAYDQKDAEGFIKLNALRLRIAAK
TGRKLS

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI53759107, Length=407, Percent_Identity=46.4373464373464, Blast_Score=347, Evalue=1e-95,
Organism=Homo sapiens, GI16950633, Length=407, Percent_Identity=46.4373464373464, Blast_Score=347, Evalue=1e-95,
Organism=Escherichia coli, GI1789563, Length=378, Percent_Identity=27.2486772486773, Blast_Score=111, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6324514, Length=411, Percent_Identity=44.5255474452555, Blast_Score=343, Evalue=3e-95,
Organism=Drosophila melanogaster, GI21358151, Length=403, Percent_Identity=44.4168734491315, Blast_Score=342, Evalue=3e-94,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ASSY_ALCBS (Q0VRM5)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692445.1
- ProteinModelPortal:   Q0VRM5
- SMR:   Q0VRM5
- STRING:   Q0VRM5
- GeneID:   4213481
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0725
- NMPDR:   fig|393595.12.peg.728
- eggNOG:   COG0137
- HOGENOM:   HBG335267
- OMA:   PLIAKRQ
- PhylomeDB:   Q0VRM5
- BioCyc:   ABOR393595:ABO_0725-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00005
- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR11587
- TIGRFAMs:   TIGR00032

Pfam domain/function: PF00764 Arginosuc_synth

EC number: =6.3.4.5

Molecular weight: Translated: 45443; Mature: 45312

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1; PS00565 ARGININOSUCCIN_SYN_2

Important sites: BINDING 37-37 BINDING 88-88 BINDING 93-93 BINDING 118-118 BINDING 120-120 BINDING 124-124 BINDING 124-124 BINDING 125-125 BINDING 128-128 BINDING 180-180 BINDING 189-189 BINDING 265-265 BINDING 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKINKVVLAYSGGLDTSVIVKWLQDTYDCEVVTFTADIGQGEEVEPARAKAEAMGVKEI
CCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCHHHH
YIEDLREEFVRDYVFPMFRANAIYEGEYLLGTSIARPLIAKRLVEIAEETGADAISHGAT
HHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
GKGNDQVRFELGAYALAPGIQVIAPWREWDLNSREKLMAYCEERNIPVDFSNKKKKSPYS
CCCCCEEEEEECCEEECCCCEEEECHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
MDANLLHISYEGGNLEDPWWEAEEDMWRWSVSPEAAPDQATYITLGFEKGDIVSIDGETL
CCCEEEEEEECCCCCCCCCCCCCCHHEEEECCCCCCCCCEEEEEEEECCCCEEEECCCCC
SPADVLTKLNKLGGDNGIGRLDIVENRYVGMKSRGCYETPGGTIMLPAHRAIESLTLDRE
CHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECCCCEEEECCHHHHHHHHCCCH
SAHLKDSVMPKYAELLYNGYWWSPERLALQKLIDATQEHVNGEVRLKLYKGSVTVVGRRS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEEECC
DNDSLFDASIATFEDDAGAYDQKDAEGFIKLNALRLRIAAKTGRKLS
CCCCEEECEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCC
>Mature Secondary Structure 
SKINKVVLAYSGGLDTSVIVKWLQDTYDCEVVTFTADIGQGEEVEPARAKAEAMGVKEI
CCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHCCHHHH
YIEDLREEFVRDYVFPMFRANAIYEGEYLLGTSIARPLIAKRLVEIAEETGADAISHGAT
HHHHHHHHHHHHHHHHHHHCCEEECCCEEECHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
GKGNDQVRFELGAYALAPGIQVIAPWREWDLNSREKLMAYCEERNIPVDFSNKKKKSPYS
CCCCCEEEEEECCEEECCCCEEEECHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
MDANLLHISYEGGNLEDPWWEAEEDMWRWSVSPEAAPDQATYITLGFEKGDIVSIDGETL
CCCEEEEEEECCCCCCCCCCCCCCHHEEEECCCCCCCCCEEEEEEEECCCCEEEECCCCC
SPADVLTKLNKLGGDNGIGRLDIVENRYVGMKSRGCYETPGGTIMLPAHRAIESLTLDRE
CHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEECCCCEEEECCHHHHHHHHCCCH
SAHLKDSVMPKYAELLYNGYWWSPERLALQKLIDATQEHVNGEVRLKLYKGSVTVVGRRS
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEEECCEEEEEECC
DNDSLFDASIATFEDDAGAYDQKDAEGFIKLNALRLRIAAKTGRKLS
CCCCEEECEEEEECCCCCCCCCCCCCCEEEEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA