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The map label for this gene is lpxC

Identifier: 110833465

GI number: 110833465

Start: 662816

End: 663730

Strand: Direct

Name: lpxC

Synonym: ABO_0604

Alternate gene names: 110833465

Gene position: 662816-663730 (Clockwise)

Preceding gene: 110833464

Following gene: 110833467

Centisome position: 21.24

GC content: 54.32

Gene sequence:

>915_bases
ATGATCAGACAACGAACGCTAAAAAACGTGATCCGCGCCACTGGCGTAGGGCTTCACACCGGCGAAAAGGTCTACATGAC
CGTGCGCCCGGCACCGGTGGATACCGGTATCGTGTTCCGGCGAGTGGACCTGGACCCTGTTGTGGAGATCAAGGCTGCTG
CGGACGCGGTGGGCGAAACCACGCTCTCTTCCACGCTGGTTCAGGATGGCGTGAAAGTGGGTACGGTAGAGCACTTCTTG
TCCGCCATGGCGGGCCTCGGGATTGATAACGCCTTTGTGGAGTTGTCTGCCCCGGAGATGCCGATCATGGATGGTAGTGC
TGGTCCGTTCGTCTTCCTCCTGCAATCTGCTGGTATCAAGGAACAGGAAGCCGCCAAGAAGTTTATCCGCATCAAAAAAG
AAGTGACGGTGCGTGAAGACGACAAAACGGCAACATTCGTGCCTTTTGACGGCTTCAAGGTGACTTTTTCTATCGAGTTC
GATCACCCGGTGTTTGAAGAGCGCAACCAGCTGGCCAGTATCGACTTCTCCACGACCTCGTTCGTGAAAGAAGTGGCCCG
TGCCCGGACCTTTGGTTTTATGCGCGATATCGAGTTTCTGCGCAGTCAGAACTTGGCGTTGGGTGGCAGTGTCGATAATG
CCATTGTGGTGGACGAATACCGTATCCTCAACGAAGACGGTCTGCGTTATGACGACGAGTTCGTCAAACACAAGATGCTA
GATGCCATTGGCGACTTGTATCTGCTGGGCCACAGCCTGATTGGTGAGTTCATTGGCCATAAGTCTGGCCATGCACTTAA
CAATGCGCTGTTGCGGGAGATCCTCCGTCAGGAAGACTCCTACGAGGTGGTGACGTTCGAAGATGCCACCGATGCACCTG
TGTCTTATATGCGCCCTGTTTTGGCTGCAGAATAA

Upstream 100 bases:

>100_bases
GAGATGGGTGCAAAATAAGGGTGTTCCAGTATAATCGCGCCCTAATTTTGTGTTGAGGAAAGCGGTATCCTTAGGATACC
CGCAGCTGTGTGACAGACTG

Downstream 100 bases:

>100_bases
GTAGCGGTAAAGTAAAAAGTAAGTTGGAAAGCGAGTTGGCCGCTTCGGATCAGGATGACCCGGAAGTGATGCTGGCTCCG
ACCGAAGCAATTCGGTTGTA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MIRQRTLKNVIRATGVGLHTGEKVYMTVRPAPVDTGIVFRRVDLDPVVEIKAAADAVGETTLSSTLVQDGVKVGTVEHFL
SAMAGLGIDNAFVELSAPEMPIMDGSAGPFVFLLQSAGIKEQEAAKKFIRIKKEVTVREDDKTATFVPFDGFKVTFSIEF
DHPVFEERNQLASIDFSTTSFVKEVARARTFGFMRDIEFLRSQNLALGGSVDNAIVVDEYRILNEDGLRYDDEFVKHKML
DAIGDLYLLGHSLIGEFIGHKSGHALNNALLREILRQEDSYEVVTFEDATDAPVSYMRPVLAAE

Sequences:

>Translated_304_residues
MIRQRTLKNVIRATGVGLHTGEKVYMTVRPAPVDTGIVFRRVDLDPVVEIKAAADAVGETTLSSTLVQDGVKVGTVEHFL
SAMAGLGIDNAFVELSAPEMPIMDGSAGPFVFLLQSAGIKEQEAAKKFIRIKKEVTVREDDKTATFVPFDGFKVTFSIEF
DHPVFEERNQLASIDFSTTSFVKEVARARTFGFMRDIEFLRSQNLALGGSVDNAIVVDEYRILNEDGLRYDDEFVKHKML
DAIGDLYLLGHSLIGEFIGHKSGHALNNALLREILRQEDSYEVVTFEDATDAPVSYMRPVLAAE
>Mature_304_residues
MIRQRTLKNVIRATGVGLHTGEKVYMTVRPAPVDTGIVFRRVDLDPVVEIKAAADAVGETTLSSTLVQDGVKVGTVEHFL
SAMAGLGIDNAFVELSAPEMPIMDGSAGPFVFLLQSAGIKEQEAAKKFIRIKKEVTVREDDKTATFVPFDGFKVTFSIEF
DHPVFEERNQLASIDFSTTSFVKEVARARTFGFMRDIEFLRSQNLALGGSVDNAIVVDEYRILNEDGLRYDDEFVKHKML
DAIGDLYLLGHSLIGEFIGHKSGHALNNALLREILRQEDSYEVVTFEDATDAPVSYMRPVLAAE

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=300, Percent_Identity=56, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_ALCBS (Q0VRZ6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692324.1
- ProteinModelPortal:   Q0VRZ6
- SMR:   Q0VRZ6
- STRING:   Q0VRZ6
- GeneID:   4211462
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0604
- NMPDR:   fig|393595.12.peg.602
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   KAYKSGH
- PhylomeDB:   Q0VRZ6
- ProtClustDB:   PRK13186
- BioCyc:   ABOR393595:ABO_0604-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33651; Mature: 33651

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQRTLKNVIRATGVGLHTGEKVYMTVRPAPVDTGIVFRRVDLDPVVEIKAAADAVGET
CCCHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCEEEEEECCCCCEEHHHHHHHHHHH
TLSSTLVQDGVKVGTVEHFLSAMAGLGIDNAFVELSAPEMPIMDGSAGPFVFLLQSAGIK
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCC
EQEAAKKFIRIKKEVTVREDDKTATFVPFDGFKVTFSIEFDHPVFEERNQLASIDFSTTS
HHHHHHHHHHHHHHEEEEECCCEEEEEECCCEEEEEEEEECCCHHHHCCCEEEECCCHHH
FVKEVARARTFGFMRDIEFLRSQNLALGGSVDNAIVVDEYRILNEDGLRYDDEFVKHKML
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECEEEECCCCCCCCHHHHHHHHH
DAIGDLYLLGHSLIGEFIGHKSGHALNNALLREILRQEDSYEVVTFEDATDAPVSYMRPV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHH
LAAE
HCCC
>Mature Secondary Structure
MIRQRTLKNVIRATGVGLHTGEKVYMTVRPAPVDTGIVFRRVDLDPVVEIKAAADAVGET
CCCHHHHHHHHHHCCCCEECCCEEEEEEECCCCCCCEEEEEECCCCCEEHHHHHHHHHHH
TLSSTLVQDGVKVGTVEHFLSAMAGLGIDNAFVELSAPEMPIMDGSAGPFVFLLQSAGIK
HHHHHHHHCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCEEEEEECCCCC
EQEAAKKFIRIKKEVTVREDDKTATFVPFDGFKVTFSIEFDHPVFEERNQLASIDFSTTS
HHHHHHHHHHHHHHEEEEECCCEEEEEECCCEEEEEEEEECCCHHHHCCCEEEECCCHHH
FVKEVARARTFGFMRDIEFLRSQNLALGGSVDNAIVVDEYRILNEDGLRYDDEFVKHKML
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEEECEEEECCCCCCCCHHHHHHHHH
DAIGDLYLLGHSLIGEFIGHKSGHALNNALLREILRQEDSYEVVTFEDATDAPVSYMRPV
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHH
LAAE
HCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA