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The map label for this gene is obgE

Identifier: 110833315

GI number: 110833315

Start: 493209

End: 494384

Strand: Direct

Name: obgE

Synonym: ABO_0454

Alternate gene names: 110833315

Gene position: 493209-494384 (Clockwise)

Preceding gene: 110833314

Following gene: 110833316

Centisome position: 15.81

GC content: 57.23

Gene sequence:

>1176_bases
ATGCAATTTGTCGATGAAGCCACTATTGATGTCCATGCCGGAAAAGGCGGCGACGGCTGTTTGAGTTTTCGTCGCGAAAA
GTACGTGGAGTTTGGTGGGCCTGATGGCGGTGATGGCGGCGCCGGTGGGCATGTATTCGTGCAGGCTGACACCAATATCA
ACACCCTGGTGGATTACCGCTACGATCGTATCTTCAAGGCGCGCAACGGTGAGCCGGGAAAGGGTCGGCAAATGACCGGT
AAGTCCGCTGAAGACATTATTCTGTATGTGCCGGTAGGAACCACCGTAGTGGACTTGGATACGGATGAGGTGCTGGCGGA
TCTAACCGATACGGATAAGCCGGTGATGGTGGCCCAGGCGGGTCGCGGTGGCTTGGGCAATATTCACTTCAAGAGCAGCG
TGAACCAGGCGCCGCGGAAAACCACCAAAGGCAAGCCGGGCGAATCCCGACGTTTGCGGCTGGAGTTGAAGGTGTTGGCG
GATGTGGGGCTGTTGGGTATGCCCAATGCGGGCAAGAGCACCTTGATTCGCGCCATTTCTGCGGCCAAGCCAAAAGTGGC
GGATTACCCGTTTACAACGTTGATTCCCAATCTTGGTGTGGTGAAAGCCGATCGCTATCGCAGTTTTGTAGTGGCGGATA
TCCCGGGTCTGATTGAGGGGGCGGCTGAGGGAGCCGGCTTGGGGATTCGCTTTCTTAAGCATTTGGCCCGTACCCGCTTG
CTGCTCCATGTGGTGGATTTGGCGCCAATGGATGGCTCTAGCCCCGCCAATCATATTGATGCCATTGCCGATGAGCTGGA
TCGCTTTTCCCCGGCTCTTGCGGAGCAGGAGCGGTGGCTGGTGTTTAACAAAATTGACTTGCTGGCCGATGATGAGGCTC
AAGCTCAAGTAGATGCTATTGTCGATGAGTTGGGCTGGCAGGGGCCGGTGTTCAAGGTGTCTGCTGCGGCGGGCGTCGGC
TGTGAAGATTTGGTTTACGCTTTAATGAATGCCATTGAGGACCGTCGCCTGCTGGAGCGAGAAGATCCTGCCTATGCTGC
CGCCCAGCAGGACCTGCGAGCCCGCCTGGAAGAGGAGGCGCGGGAGCGGGTTCAGGAGCTCAAGGCTGAGGCGCGGCAGG
CTCGCCAAAATGACGACGATGATGATCATGATGTGGAGGTTGTCTACGAGCCCTAG

Upstream 100 bases:

>100_bases
GAGGCTCGCGCCCGCGGGGCTTTTTTGTACGTGTTTTTCGTGTTCCAACTCATGCCCTTTACCGTAAAATGGCATCTATC
CCCTTGAGAGTCTGTTTCCC

Downstream 100 bases:

>100_bases
TGGACTTGTTCTGGTGCGCGTGAATGAATCAATGTCGGATGTTTGTCTCAGGTAATAAGGAGTGAGCGTGGCGGATCGCC
AGCGTTGGGTAATCAAGATA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MQFVDEATIDVHAGKGGDGCLSFRREKYVEFGGPDGGDGGAGGHVFVQADTNINTLVDYRYDRIFKARNGEPGKGRQMTG
KSAEDIILYVPVGTTVVDLDTDEVLADLTDTDKPVMVAQAGRGGLGNIHFKSSVNQAPRKTTKGKPGESRRLRLELKVLA
DVGLLGMPNAGKSTLIRAISAAKPKVADYPFTTLIPNLGVVKADRYRSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRL
LLHVVDLAPMDGSSPANHIDAIADELDRFSPALAEQERWLVFNKIDLLADDEAQAQVDAIVDELGWQGPVFKVSAAAGVG
CEDLVYALMNAIEDRRLLEREDPAYAAAQQDLRARLEEEARERVQELKAEARQARQNDDDDDHDVEVVYEP

Sequences:

>Translated_391_residues
MQFVDEATIDVHAGKGGDGCLSFRREKYVEFGGPDGGDGGAGGHVFVQADTNINTLVDYRYDRIFKARNGEPGKGRQMTG
KSAEDIILYVPVGTTVVDLDTDEVLADLTDTDKPVMVAQAGRGGLGNIHFKSSVNQAPRKTTKGKPGESRRLRLELKVLA
DVGLLGMPNAGKSTLIRAISAAKPKVADYPFTTLIPNLGVVKADRYRSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRL
LLHVVDLAPMDGSSPANHIDAIADELDRFSPALAEQERWLVFNKIDLLADDEAQAQVDAIVDELGWQGPVFKVSAAAGVG
CEDLVYALMNAIEDRRLLEREDPAYAAAQQDLRARLEEEARERVQELKAEARQARQNDDDDDHDVEVVYEP
>Mature_391_residues
MQFVDEATIDVHAGKGGDGCLSFRREKYVEFGGPDGGDGGAGGHVFVQADTNINTLVDYRYDRIFKARNGEPGKGRQMTG
KSAEDIILYVPVGTTVVDLDTDEVLADLTDTDKPVMVAQAGRGGLGNIHFKSSVNQAPRKTTKGKPGESRRLRLELKVLA
DVGLLGMPNAGKSTLIRAISAAKPKVADYPFTTLIPNLGVVKADRYRSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRL
LLHVVDLAPMDGSSPANHIDAIADELDRFSPALAEQERWLVFNKIDLLADDEAQAQVDAIVDELGWQGPVFKVSAAAGVG
CEDLVYALMNAIEDRRLLEREDPAYAAAQQDLRARLEEEARERVQELKAEARQARQNDDDDDHDVEVVYEP

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=328, Percent_Identity=42.6829268292683, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI111955139, Length=319, Percent_Identity=33.8557993730408, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI111955063, Length=196, Percent_Identity=34.1836734693878, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1789574, Length=367, Percent_Identity=54.4959128065395, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=35.15625, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=328, Percent_Identity=39.9390243902439, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17552324, Length=353, Percent_Identity=28.8951841359773, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17509631, Length=153, Percent_Identity=32.6797385620915, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321962, Length=179, Percent_Identity=39.1061452513966, Blast_Score=119, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6319281, Length=111, Percent_Identity=36.036036036036, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129375, Length=326, Percent_Identity=39.5705521472393, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24585318, Length=309, Percent_Identity=34.9514563106796, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_ALCBS (Q0VSE6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692174.1
- ProteinModelPortal:   Q0VSE6
- SMR:   Q0VSE6
- STRING:   Q0VSE6
- GeneID:   4213117
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_0454
- NMPDR:   fig|393595.12.peg.453
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   YIQADEN
- PhylomeDB:   Q0VSE6
- ProtClustDB:   PRK12298
- BioCyc:   ABOR393595:ABO_0454-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 42485; Mature: 42485

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFVDEATIDVHAGKGGDGCLSFRREKYVEFGGPDGGDGGAGGHVFVQADTNINTLVDYR
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHH
YDRIFKARNGEPGKGRQMTGKSAEDIILYVPVGTTVVDLDTDEVLADLTDTDKPVMVAQA
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHCCCCCCCEEEEEC
GRGGLGNIHFKSSVNQAPRKTTKGKPGESRRLRLELKVLADVGLLGMPNAGKSTLIRAIS
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPNLGVVKADRYRSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRL
HCCCCCCCCCHHHHCCCCCEEECCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPMDGSSPANHIDAIADELDRFSPALAEQERWLVFNKIDLLADDEAQAQVDAI
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCCEEEEEEEEEEECCHHHHHHHHH
VDELGWQGPVFKVSAAAGVGCEDLVYALMNAIEDRRLLEREDPAYAAAQQDLRARLEEEA
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RERVQELKAEARQARQNDDDDDHDVEVVYEP
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECC
>Mature Secondary Structure
MQFVDEATIDVHAGKGGDGCLSFRREKYVEFGGPDGGDGGAGGHVFVQADTNINTLVDYR
CCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCHHHHHH
YDRIFKARNGEPGKGRQMTGKSAEDIILYVPVGTTVVDLDTDEVLADLTDTDKPVMVAQA
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHHHHCCCCCCCEEEEEC
GRGGLGNIHFKSSVNQAPRKTTKGKPGESRRLRLELKVLADVGLLGMPNAGKSTLIRAIS
CCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPNLGVVKADRYRSFVVADIPGLIEGAAEGAGLGIRFLKHLARTRL
HCCCCCCCCCHHHHCCCCCEEECCCCCEEEEECCCHHHHHCCCCCCHHHHHHHHHHHHHH
LLHVVDLAPMDGSSPANHIDAIADELDRFSPALAEQERWLVFNKIDLLADDEAQAQVDAI
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHCCCCEEEEEEEEEEECCHHHHHHHHH
VDELGWQGPVFKVSAAAGVGCEDLVYALMNAIEDRRLLEREDPAYAAAQQDLRARLEEEA
HHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RERVQELKAEARQARQNDDDDDHDVEVVYEP
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA