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The map label for this gene is tdcB [H]

Identifier: 110681067

GI number: 110681067

Start: 3793526

End: 3794509

Strand: Direct

Name: tdcB [H]

Synonym: RD1_3931

Alternate gene names: 110681067

Gene position: 3793526-3794509 (Clockwise)

Preceding gene: 110681066

Following gene: 110681068

Centisome position: 91.78

GC content: 62.7

Gene sequence:

>984_bases
GTGAACATCGACGCAATCCGGGCCGCTGAACAAAGGTTGAAAGGCCATGTGCGGCGCACGCCCCTGCTGTGTTCACCCAA
CCTCGATGCGATCGCAGGGTGCCGCGTTTTCGTCAAGGCTGAGTGTTTGCAGCATACTGGCAGCTTTAAGTACCGCGGCG
CGCTGTCTGCGATTTCGGCCCTTGATGCTGATGCACGCAAGCGGGGCATCATCGCCTTTTCCAGCGGCAATCACGCGCAG
GGCATCGCCCTTGCCGCCCGCCAGTTTGACGCCCCTGCGGTGATCATCATGCCGCAGGATGCGCCAAGCACGAAAATTGA
AAATACGCGGACGCTCGGGGCGGAAATCGTCTTGTATGACCGGGTTGGGGGCGAAGATCGCGACGCCATTGGCGCTGAGT
TATCAGCAAAGCGCAATCTCACCCTGATCAAGCCGTTTGACAATGCGCAAGTCATCGCAGGTCAGGGCACCGCCGGGCTG
GAAATCGCAGCACAGGCGCAAGCGCGGGGCATCGACGACGCCGACGTGATCGTGTGCTGCGGCGGCGGTGGGTTCGCCTC
CGGCATCGCACTGGCGCTTGAGGCGGACGCACCGGGATTTCGCGTGCGCCCGGCTGAACCCGCCGGTTTCGATGACATGG
CGCGCTCCCTCAAAGCGGGCGCGCGGTTGCACAACGCGCAAACCTCCGGCAGCCTGTGTGACGCCATTATCACGCCCACG
CCGGGCGTTTTGACCTTCCCCATCTTGCAGCGTCTGGCAGGTCCGGGACTTGTGGTGAGCGATGAGGAGGCCCTGCACGC
CATGGCGCTGGCCTTTGCGCACCTCAAGGTCGTGGCCGAACCCGGCGGGGCGGTTGCGCTGGCATCGGCCCTGTTCCACA
CCTCTGAAATTGACGCAGACACGGTGATCGTTACCATCTCAGGCGGCAATGTGGATGCGGATGTTTTTCAAATGGCCTTG
AAGCGATGCGGGGATAGCGCGTGA

Upstream 100 bases:

>100_bases
CGGACATGATTTCAGCCACGGTGATCGGGCGGGGGCATGTGCCGTTTCTTGATGAACCGGAATCGGTGGCCGCACTGCAA
ACATGGGTTGAGGCGCTCAA

Downstream 100 bases:

>100_bases
TCTGGCAGTGTTTTTCAGCCCGGAATGTGAGGGAACGCGCATGAAAATGGCACAGCTTGGTGATATCGCGGTGCATTACC
GTGTGGATGGGCCTGAGGAT

Product: threonine dehydratase, putative

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MNIDAIRAAEQRLKGHVRRTPLLCSPNLDAIAGCRVFVKAECLQHTGSFKYRGALSAISALDADARKRGIIAFSSGNHAQ
GIALAARQFDAPAVIIMPQDAPSTKIENTRTLGAEIVLYDRVGGEDRDAIGAELSAKRNLTLIKPFDNAQVIAGQGTAGL
EIAAQAQARGIDDADVIVCCGGGGFASGIALALEADAPGFRVRPAEPAGFDDMARSLKAGARLHNAQTSGSLCDAIITPT
PGVLTFPILQRLAGPGLVVSDEEALHAMALAFAHLKVVAEPGGAVALASALFHTSEIDADTVIVTISGGNVDADVFQMAL
KRCGDSA

Sequences:

>Translated_327_residues
MNIDAIRAAEQRLKGHVRRTPLLCSPNLDAIAGCRVFVKAECLQHTGSFKYRGALSAISALDADARKRGIIAFSSGNHAQ
GIALAARQFDAPAVIIMPQDAPSTKIENTRTLGAEIVLYDRVGGEDRDAIGAELSAKRNLTLIKPFDNAQVIAGQGTAGL
EIAAQAQARGIDDADVIVCCGGGGFASGIALALEADAPGFRVRPAEPAGFDDMARSLKAGARLHNAQTSGSLCDAIITPT
PGVLTFPILQRLAGPGLVVSDEEALHAMALAFAHLKVVAEPGGAVALASALFHTSEIDADTVIVTISGGNVDADVFQMAL
KRCGDSA
>Mature_327_residues
MNIDAIRAAEQRLKGHVRRTPLLCSPNLDAIAGCRVFVKAECLQHTGSFKYRGALSAISALDADARKRGIIAFSSGNHAQ
GIALAARQFDAPAVIIMPQDAPSTKIENTRTLGAEIVLYDRVGGEDRDAIGAELSAKRNLTLIKPFDNAQVIAGQGTAGL
EIAAQAQARGIDDADVIVCCGGGGFASGIALALEADAPGFRVRPAEPAGFDDMARSLKAGARLHNAQTSGSLCDAIITPT
PGVLTFPILQRLAGPGLVVSDEEALHAMALAFAHLKVVAEPGGAVALASALFHTSEIDADTVIVTISGGNVDADVFQMAL
KRCGDSA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=33.2268370607029, Blast_Score=162, Evalue=4e-40,
Organism=Escherichia coli, GI1789505, Length=314, Percent_Identity=35.3503184713376, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790207, Length=309, Percent_Identity=30.42071197411, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17508781, Length=319, Percent_Identity=32.2884012539185, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI71991565, Length=329, Percent_Identity=33.1306990881459, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17537387, Length=319, Percent_Identity=31.0344827586207, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6322631, Length=308, Percent_Identity=39.6103896103896, Blast_Score=193, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6320930, Length=315, Percent_Identity=33.968253968254, Blast_Score=132, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6319788, Length=290, Percent_Identity=26.8965517241379, Blast_Score=72, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21355833, Length=322, Percent_Identity=30.4347826086957, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 33814; Mature: 33814

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDAIRAAEQRLKGHVRRTPLLCSPNLDAIAGCRVFVKAECLQHTGSFKYRGALSAISA
CCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCEEEHHHHHHCCCEEECHHHHHHHH
LDADARKRGIIAFSSGNHAQGIALAARQFDAPAVIIMPQDAPSTKIENTRTLGAEIVLYD
HCCCHHHCCEEEECCCCCCCHHEEEHHHCCCCEEEEEECCCCCCCCCCCEECCEEEEEEE
RVGGEDRDAIGAELSAKRNLTLIKPFDNAQVIAGQGTAGLEIAAQAQARGIDDADVIVCC
CCCCCCCHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCEEEEEHHHHCCCCCCCEEEEE
GGGGFASGIALALEADAPGFRVRPAEPAGFDDMARSLKAGARLHNAQTSGSLCDAIITPT
CCCCCCCCEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEECCC
PGVLTFPILQRLAGPGLVVSDEEALHAMALAFAHLKVVAEPGGAVALASALFHTSEIDAD
CCEEHHHHHHHHCCCCEEEECHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCCC
TVIVTISGGNVDADVFQMALKRCGDSA
EEEEEEECCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIDAIRAAEQRLKGHVRRTPLLCSPNLDAIAGCRVFVKAECLQHTGSFKYRGALSAISA
CCCHHHHHHHHHHHHHHHCCCEEECCCCCHHHHCCCEEEHHHHHHCCCEEECHHHHHHHH
LDADARKRGIIAFSSGNHAQGIALAARQFDAPAVIIMPQDAPSTKIENTRTLGAEIVLYD
HCCCHHHCCEEEECCCCCCCHHEEEHHHCCCCEEEEEECCCCCCCCCCCEECCEEEEEEE
RVGGEDRDAIGAELSAKRNLTLIKPFDNAQVIAGQGTAGLEIAAQAQARGIDDADVIVCC
CCCCCCCHHCCCCCCCCCCEEEEECCCCCEEEECCCCCCEEEEEHHHHCCCCCCCEEEEE
GGGGFASGIALALEADAPGFRVRPAEPAGFDDMARSLKAGARLHNAQTSGSLCDAIITPT
CCCCCCCCEEEEEECCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHEEECCC
PGVLTFPILQRLAGPGLVVSDEEALHAMALAFAHLKVVAEPGGAVALASALFHTSEIDAD
CCEEHHHHHHHHCCCCEEEECHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHHCCCCCCC
TVIVTISGGNVDADVFQMALKRCGDSA
EEEEEEECCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA