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The map label for this gene is lysR [H]

Identifier: 110681008

GI number: 110681008

Start: 3738224

End: 3739321

Strand: Direct

Name: lysR [H]

Synonym: RD1_3867

Alternate gene names: 110681008

Gene position: 3738224-3739321 (Clockwise)

Preceding gene: 110680998

Following gene: 110681009

Centisome position: 90.45

GC content: 57.38

Gene sequence:

>1098_bases
TTGCACTCCCGCCCGAACACCGTGATCGACGCCATCTCACGCTCCCCCAAACGCCCGGTTGCCCTTATCAATCGCGCCGC
GGGATGTATGCGCACGCTTTCGAAAAAGGATCTGCCCGTTGACGTTAGAAACAAGAAGAGATTAAATCAATTTAAAATCA
ATTATCAAAGTATTCGATTCACTTATGCAAAAAGCGACCTAGTGGGCACGATGAAGCTCCGGCACATGGAAGTGTTCAAC
GCCTTGATCGAGGCAGGTTCCGTGTCCCGCGCGGCTGAAAAGCTCAACCTGACGCAACCCGCCGTCAGCATCGCGCTCAG
TAACTTCGAGGCAGACCTCGGGTTTCGTCTGTTTCACCGCGAACGCGGGTTTTTCACGCCAACGACCGAAGCGATGCTGC
TGCATGAAGAGGTCATGAAGGGCTTGCAGGCGATTTCGCTGGTGGAACAGCGCGCGGCAGGCATTCTTTCAGGCCAGACC
GGTCACATCAGCATCGCGACGAATGGTGTGCTCGCGTTCAACTTTCTGCCGCAACTGCTGGCGTCGTTCCAACGAGATCA
CCCCAATATCAAGACGGATATCAAGGTCCATTCCTCGCGCCAGATCGCCACTTGGGTTGCCGGTCATCAGATCGATATCG
GCCTCATTGACCTGCCTGTGCCGGTGGCGGGGCTTCATGCGGAAATCTTCAACTTTGAATGTGTCTGCGCGGTTCACAAG
GACGACCCGCTTGCCGCGCAGGAGGTGATACACCCCACGTCCCTTGCCGGGCGCTCCGTTGTCAGCATTACCGGCGATCA
CCAGATTGACCGTCAGCTTGAAACGCTTCTGGCCGACAGCAACACCGTCATCACACGCAACGCCACCGCCTATTACTTTG
CAATTGCGCGCAACCTCGTGGCTGCCGGCGACTATGTCGCGATCCTTGACCCGATCAACGGCAAGGCGGATTTGCAGGAC
AATGTTGTGTGGCGTCCGTTCGTTCCGCGCATCGACAATGACCTCGCCGTGATCACCGCAAAGGGGCTGCCGCTCGGCCG
CGCGGTCCTGGAAATGCATACCCGCATCCGCTCAGCGCTCATGCAACGCGCCGCATGA

Upstream 100 bases:

>100_bases
CGTGTATCCCGAACCGATGATGGCAACATCGACAGTTTTCAGCGGTGTATCCGGCAAGACAGGCAGCGCTGGCAAGCCGT
CAAGCCAGAACGAACTGTCC

Downstream 100 bases:

>100_bases
CAGGCGCGCGCACACCCACTGCGCGCGCCGCTGGCCGGCTGGTCGCATTCATGCAGACCGCAGCCGCAGTGGTCCGCCGC
CATGACATCGAAATTGCCCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MHSRPNTVIDAISRSPKRPVALINRAAGCMRTLSKKDLPVDVRNKKRLNQFKINYQSIRFTYAKSDLVGTMKLRHMEVFN
ALIEAGSVSRAAEKLNLTQPAVSIALSNFEADLGFRLFHRERGFFTPTTEAMLLHEEVMKGLQAISLVEQRAAGILSGQT
GHISIATNGVLAFNFLPQLLASFQRDHPNIKTDIKVHSSRQIATWVAGHQIDIGLIDLPVPVAGLHAEIFNFECVCAVHK
DDPLAAQEVIHPTSLAGRSVVSITGDHQIDRQLETLLADSNTVITRNATAYYFAIARNLVAAGDYVAILDPINGKADLQD
NVVWRPFVPRIDNDLAVITAKGLPLGRAVLEMHTRIRSALMQRAA

Sequences:

>Translated_365_residues
MHSRPNTVIDAISRSPKRPVALINRAAGCMRTLSKKDLPVDVRNKKRLNQFKINYQSIRFTYAKSDLVGTMKLRHMEVFN
ALIEAGSVSRAAEKLNLTQPAVSIALSNFEADLGFRLFHRERGFFTPTTEAMLLHEEVMKGLQAISLVEQRAAGILSGQT
GHISIATNGVLAFNFLPQLLASFQRDHPNIKTDIKVHSSRQIATWVAGHQIDIGLIDLPVPVAGLHAEIFNFECVCAVHK
DDPLAAQEVIHPTSLAGRSVVSITGDHQIDRQLETLLADSNTVITRNATAYYFAIARNLVAAGDYVAILDPINGKADLQD
NVVWRPFVPRIDNDLAVITAKGLPLGRAVLEMHTRIRSALMQRAA
>Mature_365_residues
MHSRPNTVIDAISRSPKRPVALINRAAGCMRTLSKKDLPVDVRNKKRLNQFKINYQSIRFTYAKSDLVGTMKLRHMEVFN
ALIEAGSVSRAAEKLNLTQPAVSIALSNFEADLGFRLFHRERGFFTPTTEAMLLHEEVMKGLQAISLVEQRAAGILSGQT
GHISIATNGVLAFNFLPQLLASFQRDHPNIKTDIKVHSSRQIATWVAGHQIDIGLIDLPVPVAGLHAEIFNFECVCAVHK
DDPLAAQEVIHPTSLAGRSVVSITGDHQIDRQLETLLADSNTVITRNATAYYFAIARNLVAAGDYVAILDPINGKADLQD
NVVWRPFVPRIDNDLAVITAKGLPLGRAVLEMHTRIRSALMQRAA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=265, Percent_Identity=27.9245283018868, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1788481, Length=149, Percent_Identity=28.8590604026846, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1790262, Length=194, Percent_Identity=27.319587628866, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790399, Length=278, Percent_Identity=21.2230215827338, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI145693105, Length=272, Percent_Identity=23.8970588235294, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI157672245, Length=232, Percent_Identity=24.5689655172414, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI87081904, Length=257, Percent_Identity=26.4591439688716, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788887, Length=193, Percent_Identity=25.9067357512953, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 40230; Mature: 40230

Theoretical pI: Translated: 9.82; Mature: 9.82

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSRPNTVIDAISRSPKRPVALINRAAGCMRTLSKKDLPVDVRNKKRLNQFKINYQSIRF
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEEEEEEE
TYAKSDLVGTMKLRHMEVFNALIEAGSVSRAAEKLNLTQPAVSIALSNFEADLGFRLFHR
EEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEC
ERGFFTPTTEAMLLHEEVMKGLQAISLVEQRAAGILSGQTGHISIATNGVLAFNFLPQLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEHHHHHHHHH
ASFQRDHPNIKTDIKVHSSRQIATWVAGHQIDIGLIDLPVPVAGLHAEIFNFECVCAVHK
HHHHHCCCCCEEEEEEECCCEEEEEECCCEEEEEEEECCCCCCCCHHHHCCEEEEEEEEC
DDPLAAQEVIHPTSLAGRSVVSITGDHQIDRQLETLLADSNTVITRNATAYYFAIARNLV
CCCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
AAGDYVAILDPINGKADLQDNVVWRPFVPRIDNDLAVITAKGLPLGRAVLEMHTRIRSAL
HCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
MQRAA
HHHCC
>Mature Secondary Structure
MHSRPNTVIDAISRSPKRPVALINRAAGCMRTLSKKDLPVDVRNKKRLNQFKINYQSIRF
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHEEEEEEEEEE
TYAKSDLVGTMKLRHMEVFNALIEAGSVSRAAEKLNLTQPAVSIALSNFEADLGFRLFHR
EEECCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEC
ERGFFTPTTEAMLLHEEVMKGLQAISLVEQRAAGILSGQTGHISIATNGVLAFNFLPQLL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEHHHHHHHHH
ASFQRDHPNIKTDIKVHSSRQIATWVAGHQIDIGLIDLPVPVAGLHAEIFNFECVCAVHK
HHHHHCCCCCEEEEEEECCCEEEEEECCCEEEEEEEECCCCCCCCHHHHCCEEEEEEEEC
DDPLAAQEVIHPTSLAGRSVVSITGDHQIDRQLETLLADSNTVITRNATAYYFAIARNLV
CCCCHHHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHH
AAGDYVAILDPINGKADLQDNVVWRPFVPRIDNDLAVITAKGLPLGRAVLEMHTRIRSAL
HCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
MQRAA
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]