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The map label for this gene is gutB [H]

Identifier: 110680953

GI number: 110680953

Start: 3682923

End: 3683930

Strand: Direct

Name: gutB [H]

Synonym: RD1_3810

Alternate gene names: 110680953

Gene position: 3682923-3683930 (Clockwise)

Preceding gene: 110680952

Following gene: 110680954

Centisome position: 89.11

GC content: 64.68

Gene sequence:

>1008_bases
ATGAAGGCGTTAGTCTATACTGACATTGAGCAATTGACCTATCAGGACCGCCCCCTCCCAACCCCCGGCGCGGGCGAGCA
TCTGGTGCGCATCGAGGCGTCGGGGATTTGCGGGTCGGACATGCATGCTTTTCTCGGCCACGACGAACGCCGCCCTGCCC
CGCTGACATTGGGGCATGAGGCCGCCGGGGTTGTGGTCGGTGGGGCCATGGACGGGCGGCGTGTCACTCTGAATCCGTTG
GTCACCTGCCTGTCCTGCGATGCATGCACCTCGGGCCGCGAGAACCTTTGCAGCGATCGGCAGATCATCTCGATGCTGCC
GCGCGAAGGCGCGTTTGCCGAATATGTCTGCGCACCGGAGCGTAACCTTGTCACCGTACCGGATCACGTTGACCTCAAGA
AAGCCGCATTGACCGAACCCATTGCCTGTGGCTGGCACGCCGCGCGGCTCACCCGTGCCGTGGTGGGCGGCGATCTCAAG
GATGCCCGCTGCGCCGTCATCGGCGGCGGCGCCATTGGTGTTGGCGCGGCTTTGGCGCTTGCGGCACAGGGCGCTCGGGA
CATCACGGTGATTGAACCCAATGAGCTACGACGCGCGCGTCTTGCAGATGTCGCAGGCTTCGAGGTCTGCGCGCCGGATG
AACCCGCCGCCCCCGAAGCGGGCAGCGTGGATCTTGTGATCGACGGTGTGGGCTATGCGGCCACCCGCGCGGCGGCCTGC
GCGATGGTGCGTGCCGGCGGGGTGATCGGACACATCGGCCTCGGCAGTGGGGAGGGCGGTCTGGATGTGCGCCGCATGAC
GTTGCAGGAAATCACCTTTATTGGTACGTATACCTATACGGCGCAGGACTTCCGCGACACGGCCGAGGCCATTTTTGACG
GGCGGCTCGGCCCCCTTGACTGGATCGAGACACGCTCCCTGGCGCAGGGCCAATCTGCGTTTCACGACATTCGCAACGGT
CAGGTCGCATCGCCCAAGATCGTCCTGATCCCCGAACACGCCGATTAA

Upstream 100 bases:

>100_bases
AACCTGTGGACCTTGATGGACCACTGATGTTTTTCTGCGCGCCCGCGTCTGACTATGTGACTGGCCAGACACTATTTGTC
GACGGAGGTTTTACAGCAAA

Downstream 100 bases:

>100_bases
TCCGCAGCCCGCAACCGAAAAAGGACATAGCATGTACAAGAAGATCATCGTCTGCCTCGCTCTTGATCACGGCATAAGTG
AAACCGCGCTGGCCAAGGCG

Product: sorbitol dehydrogenase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKALVYTDIEQLTYQDRPLPTPGAGEHLVRIEASGICGSDMHAFLGHDERRPAPLTLGHEAAGVVVGGAMDGRRVTLNPL
VTCLSCDACTSGRENLCSDRQIISMLPREGAFAEYVCAPERNLVTVPDHVDLKKAALTEPIACGWHAARLTRAVVGGDLK
DARCAVIGGGAIGVGAALALAAQGARDITVIEPNELRRARLADVAGFEVCAPDEPAAPEAGSVDLVIDGVGYAATRAAAC
AMVRAGGVIGHIGLGSGEGGLDVRRMTLQEITFIGTYTYTAQDFRDTAEAIFDGRLGPLDWIETRSLAQGQSAFHDIRNG
QVASPKIVLIPEHAD

Sequences:

>Translated_335_residues
MKALVYTDIEQLTYQDRPLPTPGAGEHLVRIEASGICGSDMHAFLGHDERRPAPLTLGHEAAGVVVGGAMDGRRVTLNPL
VTCLSCDACTSGRENLCSDRQIISMLPREGAFAEYVCAPERNLVTVPDHVDLKKAALTEPIACGWHAARLTRAVVGGDLK
DARCAVIGGGAIGVGAALALAAQGARDITVIEPNELRRARLADVAGFEVCAPDEPAAPEAGSVDLVIDGVGYAATRAAAC
AMVRAGGVIGHIGLGSGEGGLDVRRMTLQEITFIGTYTYTAQDFRDTAEAIFDGRLGPLDWIETRSLAQGQSAFHDIRNG
QVASPKIVLIPEHAD
>Mature_335_residues
MKALVYTDIEQLTYQDRPLPTPGAGEHLVRIEASGICGSDMHAFLGHDERRPAPLTLGHEAAGVVVGGAMDGRRVTLNPL
VTCLSCDACTSGRENLCSDRQIISMLPREGAFAEYVCAPERNLVTVPDHVDLKKAALTEPIACGWHAARLTRAVVGGDLK
DARCAVIGGGAIGVGAALALAAQGARDITVIEPNELRRARLADVAGFEVCAPDEPAAPEAGSVDLVIDGVGYAATRAAAC
AMVRAGGVIGHIGLGSGEGGLDVRRMTLQEITFIGTYTYTAQDFRDTAEAIFDGRLGPLDWIETRSLAQGQSAFHDIRNG
QVASPKIVLIPEHAD

Specific function: Putative L-galactonate oxidoreductase that is required for growth on L-galactonate as the sole carbon source [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=287, Percent_Identity=27.8745644599303, Blast_Score=94, Evalue=1e-19,
Organism=Escherichia coli, GI226510992, Length=309, Percent_Identity=31.0679611650485, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1788073, Length=298, Percent_Identity=32.5503355704698, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787863, Length=180, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790045, Length=209, Percent_Identity=34.9282296650718, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788407, Length=331, Percent_Identity=27.190332326284, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790718, Length=288, Percent_Identity=27.4305555555556, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082125, Length=331, Percent_Identity=28.0966767371601, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788075, Length=338, Percent_Identity=24.5562130177515, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=25.9475218658892, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=32.5358851674641, Blast_Score=101, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI71988145, Length=335, Percent_Identity=24.7761194029851, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=28.4848484848485, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=154, Percent_Identity=35.0649350649351, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319257, Length=389, Percent_Identity=29.8200514138817, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322619, Length=359, Percent_Identity=26.1838440111421, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319955, Length=359, Percent_Identity=25.9052924791086, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323099, Length=327, Percent_Identity=27.217125382263, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=383, Percent_Identity=25.8485639686684, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=345, Percent_Identity=26.0869565217391, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323961, Length=348, Percent_Identity=26.1494252873563, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=193, Percent_Identity=33.160621761658, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319621, Length=210, Percent_Identity=31.9047619047619, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=130, Percent_Identity=33.8461538461538, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737897, Length=199, Percent_Identity=36.6834170854271, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17137530, Length=207, Percent_Identity=33.3333333333333, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17737895, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: NA

Molecular weight: Translated: 35183; Mature: 35183

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALVYTDIEQLTYQDRPLPTPGAGEHLVRIEASGICGSDMHAFLGHDERRPAPLTLGHE
CCEEEEECHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCEEECCC
AAGVVVGGAMDGRRVTLNPLVTCLSCDACTSGRENLCSDRQIISMLPREGAFAEYVCAPE
CCCEEEECCCCCCEEEHHHHHHHHCCCCCCCCHHHHCCCHHHHHHCCCCCCCEEEEECCC
RNLVTVPDHVDLKKAALTEPIACGWHAARLTRAVVGGDLKDARCAVIGGGAIGVGAALAL
CCEEECCCCCCHHHHHHCCCHHCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
AAQGARDITVIEPNELRRARLADVAGFEVCAPDEPAAPEAGSVDLVIDGVGYAATRAAAC
HHCCCCEEEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHH
AMVRAGGVIGHIGLGSGEGGLDVRRMTLQEITFIGTYTYTAQDFRDTAEAIFDGRLGPLD
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHEEEEEEEEEEHHHHHHHHHHHHCCCCCCCH
WIETRSLAQGQSAFHDIRNGQVASPKIVLIPEHAD
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MKALVYTDIEQLTYQDRPLPTPGAGEHLVRIEASGICGSDMHAFLGHDERRPAPLTLGHE
CCEEEEECHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCEEECCC
AAGVVVGGAMDGRRVTLNPLVTCLSCDACTSGRENLCSDRQIISMLPREGAFAEYVCAPE
CCCEEEECCCCCCEEEHHHHHHHHCCCCCCCCHHHHCCCHHHHHHCCCCCCCEEEEECCC
RNLVTVPDHVDLKKAALTEPIACGWHAARLTRAVVGGDLKDARCAVIGGGAIGVGAALAL
CCEEECCCCCCHHHHHHCCCHHCCHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHH
AAQGARDITVIEPNELRRARLADVAGFEVCAPDEPAAPEAGSVDLVIDGVGYAATRAAAC
HHCCCCEEEEECCHHHHHHHHHHHCCCEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHH
AMVRAGGVIGHIGLGSGEGGLDVRRMTLQEITFIGTYTYTAQDFRDTAEAIFDGRLGPLD
HHHHCCCEEEEEECCCCCCCCHHHHHHHHHEEEEEEEEEEHHHHHHHHHHHHCCCCCCCH
WIETRSLAQGQSAFHDIRNGQVASPKIVLIPEHAD
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]