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The map label for this gene is hisD [H]

Identifier: 110680951

GI number: 110680951

Start: 3680861

End: 3682168

Strand: Direct

Name: hisD [H]

Synonym: RD1_3808

Alternate gene names: 110680951

Gene position: 3680861-3682168 (Clockwise)

Preceding gene: 110680948

Following gene: 110680952

Centisome position: 89.06

GC content: 59.48

Gene sequence:

>1308_bases
ATGGCTCGTGAATATCTGAAAAAAGCTGAAAAGACCGCGATGACAGATGCGGGGGACGTGCGCGAAATCGTTCAAAATAT
TCTGAGCGATATCGAGGCGGGTGGGGATGCCGCAGCGATGCGTTATGCGGAGCAGTTCGATAAATACGCCGGCAATGTCA
TCCTGACCGACGACGAAATTGAAGCCGCCAGCGCCAAGGTCAGCCAGAAACTGAAAGATGATATTGCCTTTGCGCATGAT
AATGTGCGCCGCTTTGCCGAAGTGCAGAAATCCACGATGAAGGATGTGGAGCTTGAGATCGTCCCCGGTTTGATCGCCGG
GCAAAAGGCGATCCCCGTGCGCGCGGCCGGATGCTATGTTCCCGGTGGACGCTATAGTCACATCGCCAGCGCCATCATGA
CCGTCACCACGGCAAAGGTGGCGGGCTGCCAGCACATCACCGCATGTTCGCCGCCGCGCCCCGATGTCGGGATCAACCCC
GCCATCGTCTATGCCGCCAACCTCTGCGGTGCCGACAAAATCCTGTCCATGGGCGGGGTTCAGGGGGTCGCCGCCATGAC
CTTTGGCCTCTTTGGTCTGCCAAAAGCCGACATTCTGGTCGGGCCGGGCAACCAATTTGTCGCCGAAGCCAAGCGCATCC
TGTTTGGTCGCGTGGGCATTGATATGATCGCCGGGCCAACCGACAGTCTGGTCTTGGCTGATGCCACGGCGGATCCATTC
ATGGTCGCAACAGACCTAGTCAGCCAGGCAGAGCATGGGTATAATTCGCCGGTCTGGCTGGTGACGGACAGCCGCGTGTT
GGCGGAAAAGGTCATGGAGCTGGTGCCGGGCATGATTGACGATCTGCCAGAACTGAACCGCGACAACGCCTTTGCCGCGT
GGCGCGACTATGCAGAGGTCATCGTCTGTGCCAACCGCGAGGAAATGGCCGCCTGCTCGGATGACTACGCCCCCGAACAC
CTGACCGTACAGGCCGAAGACCTGCCGTGGTGGCTCGACCGGTTGCAGTGCTACGGCTCGCTCTTCCTTGGGGAAGAGAC
AACCGTTTCATTTGGCGACAAAGCCTCGGGCACCAATCACGTTCTGCCAACATCGCGATCCGCAAAATACACGGGCGGTC
TGTCGGTCCACAAATACATGAAAATCGTCACGTGGCAGCGCTCCACCCGGGACGGCGCACGACCGGTGGCCGAAGCCACG
GCGCGGATTTCACGTCTGGAGGGGATGGAAGGGCACGCGCGCGCCGCGGATGCGCGCCTGCACAAGTATTTTCCGAACGA
GAACTTTGACCTCTCAGCGGTGGATTAA

Upstream 100 bases:

>100_bases
CGTCATGCAAGCGCTTACACATCTGCATACCAAGGGATTCTATTGGTGGGCAACCCCAGTATTCATCCAACTGACACATG
TGACACGCTGGAGGCGCGAA

Downstream 100 bases:

>100_bases
GTCAGGTGGCGGCGCTCTTTGATGTCAGCGGCAGGGTGGTTTGCGTGACCGGCGCAAGCAGCGGCCTCGGTCGACAGGCC
GCCACGATGCTGGCACAGGC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MAREYLKKAEKTAMTDAGDVREIVQNILSDIEAGGDAAAMRYAEQFDKYAGNVILTDDEIEAASAKVSQKLKDDIAFAHD
NVRRFAEVQKSTMKDVELEIVPGLIAGQKAIPVRAAGCYVPGGRYSHIASAIMTVTTAKVAGCQHITACSPPRPDVGINP
AIVYAANLCGADKILSMGGVQGVAAMTFGLFGLPKADILVGPGNQFVAEAKRILFGRVGIDMIAGPTDSLVLADATADPF
MVATDLVSQAEHGYNSPVWLVTDSRVLAEKVMELVPGMIDDLPELNRDNAFAAWRDYAEVIVCANREEMAACSDDYAPEH
LTVQAEDLPWWLDRLQCYGSLFLGEETTVSFGDKASGTNHVLPTSRSAKYTGGLSVHKYMKIVTWQRSTRDGARPVAEAT
ARISRLEGMEGHARAADARLHKYFPNENFDLSAVD

Sequences:

>Translated_435_residues
MAREYLKKAEKTAMTDAGDVREIVQNILSDIEAGGDAAAMRYAEQFDKYAGNVILTDDEIEAASAKVSQKLKDDIAFAHD
NVRRFAEVQKSTMKDVELEIVPGLIAGQKAIPVRAAGCYVPGGRYSHIASAIMTVTTAKVAGCQHITACSPPRPDVGINP
AIVYAANLCGADKILSMGGVQGVAAMTFGLFGLPKADILVGPGNQFVAEAKRILFGRVGIDMIAGPTDSLVLADATADPF
MVATDLVSQAEHGYNSPVWLVTDSRVLAEKVMELVPGMIDDLPELNRDNAFAAWRDYAEVIVCANREEMAACSDDYAPEH
LTVQAEDLPWWLDRLQCYGSLFLGEETTVSFGDKASGTNHVLPTSRSAKYTGGLSVHKYMKIVTWQRSTRDGARPVAEAT
ARISRLEGMEGHARAADARLHKYFPNENFDLSAVD
>Mature_434_residues
AREYLKKAEKTAMTDAGDVREIVQNILSDIEAGGDAAAMRYAEQFDKYAGNVILTDDEIEAASAKVSQKLKDDIAFAHDN
VRRFAEVQKSTMKDVELEIVPGLIAGQKAIPVRAAGCYVPGGRYSHIASAIMTVTTAKVAGCQHITACSPPRPDVGINPA
IVYAANLCGADKILSMGGVQGVAAMTFGLFGLPKADILVGPGNQFVAEAKRILFGRVGIDMIAGPTDSLVLADATADPFM
VATDLVSQAEHGYNSPVWLVTDSRVLAEKVMELVPGMIDDLPELNRDNAFAAWRDYAEVIVCANREEMAACSDDYAPEHL
TVQAEDLPWWLDRLQCYGSLFLGEETTVSFGDKASGTNHVLPTSRSAKYTGGLSVHKYMKIVTWQRSTRDGARPVAEATA
RISRLEGMEGHARAADARLHKYFPNENFDLSAVD

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=415, Percent_Identity=35.6626506024096, Blast_Score=250, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6319819, Length=423, Percent_Identity=33.5697399527187, Blast_Score=235, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46992; Mature: 46861

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAREYLKKAEKTAMTDAGDVREIVQNILSDIEAGGDAAAMRYAEQFDKYAGNVILTDDEI
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCH
EAASAKVSQKLKDDIAFAHDNVRRFAEVQKSTMKDVELEIVPGLIAGQKAIPVRAAGCYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHCCCCCCCEEECCEEC
PGGRYSHIASAIMTVTTAKVAGCQHITACSPPRPDVGINPAIVYAANLCGADKILSMGGV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEEHHCCHHHHHHHCCC
QGVAAMTFGLFGLPKADILVGPGNQFVAEAKRILFGRVGIDMIAGPTDSLVLADATADPF
CHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCCH
MVATDLVSQAEHGYNSPVWLVTDSRVLAEKVMELVPGMIDDLPELNRDNAFAAWRDYAEV
HHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHE
IVCANREEMAACSDDYAPEHLTVQAEDLPWWLDRLQCYGSLFLGEETTVSFGDKASGTNH
EEECCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHEECCCCEEECCCCCCCCCC
VLPTSRSAKYTGGLSVHKYMKIVTWQRSTRDGARPVAEATARISRLEGMEGHARAADARL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
HKYFPNENFDLSAVD
HHHCCCCCCCEEECC
>Mature Secondary Structure 
AREYLKKAEKTAMTDAGDVREIVQNILSDIEAGGDAAAMRYAEQFDKYAGNVILTDDEI
CHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEECCCH
EAASAKVSQKLKDDIAFAHDNVRRFAEVQKSTMKDVELEIVPGLIAGQKAIPVRAAGCYV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHCCCCCCCEEECCEEC
PGGRYSHIASAIMTVTTAKVAGCQHITACSPPRPDVGINPAIVYAANLCGADKILSMGGV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEEHHCCHHHHHHHCCC
QGVAAMTFGLFGLPKADILVGPGNQFVAEAKRILFGRVGIDMIAGPTDSLVLADATADPF
CHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCEECCCCCCEEEEECCCCCH
MVATDLVSQAEHGYNSPVWLVTDSRVLAEKVMELVPGMIDDLPELNRDNAFAAWRDYAEV
HHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCHHHHHHHHCCCCCCHHHHHHHHHE
IVCANREEMAACSDDYAPEHLTVQAEDLPWWLDRLQCYGSLFLGEETTVSFGDKASGTNH
EEECCCHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHEECCCCEEECCCCCCCCCC
VLPTSRSAKYTGGLSVHKYMKIVTWQRSTRDGARPVAEATARISRLEGMEGHARAADARL
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHH
HKYFPNENFDLSAVD
HHHCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA