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The map label for this gene is cysM [C]

Identifier: 110680826

GI number: 110680826

Start: 3537846

End: 3538889

Strand: Direct

Name: cysM [C]

Synonym: RD1_3674

Alternate gene names: 110680826

Gene position: 3537846-3538889 (Clockwise)

Preceding gene: 110680825

Following gene: 110680829

Centisome position: 85.6

GC content: 57.47

Gene sequence:

>1044_bases
ATGGACAATTGGGTCGCCCACGCCATTCGACAGATCAACGCCGATGCGCATCGCTCGGCTGATACCCATCTGTTCAAGCT
CCCCTTGCCGCGCCTCACCGGTGTGGACATCTATCTGAAGGACGAGAGCACGCATCCCACAGGCAGCCTCAAACATCGCC
TCGCGCGGTCGCTTTTTTTATACGCTTTGTGCAATGGCAAGATCAAAGCGGACACACCCATCGTCGAAGCCTCCTCTGGC
AGCACCGCCGTTTCGGAGGCCTATTTCGCGCGGATGATCGGCGTTCCCTTTATCGCCGTTCTCCCCAAAAGCACCGCCCG
CAGCAAAATCCGGCAAATCGAGTTTTATGGCGGCAAGGTTCACTTCGTGGATGCCGCACCGCAGATGCATGACGCCTCGG
TTGCGCTCGCCGCCTCAATCGGTGGCTATTTCATGGATCAGTTCACCTATGCCGAGCGTGCCACCGACTGGCGGGGCAAT
AACAACATTGCCGAAAGCGTGTTCACCCAGATGGAACAGGAACCCCATCCCATCCCCGCGCATCTGGTAATGAGTGCGGG
CACCGGCGGCACGTCTGCCACCCTGGGCCGTTACATTCGCTATAAGGGCTATGATACGGAACTCACGGTCGTGGATCCGG
AAAACTCCGTGTTTTATCAAAGCTACATGACAGGGGATCGCAGTCTGCTGTCGGATAAATCCAGCCGTATCGAAGGGATC
GGGCGGCCGAAGGTCGAACTCTCCTTTCAGCCCGGCGTCATTGATCACATGATCGCGGTGCCGGATGCTGCGAGCGTGGC
AACCATGCTGTGGCTCGAAGAGTTGATCGGGCGCAAGACGGGGCCCTCCTCCGGAACGAACCTTTGGGGGGCACTGAAGC
GCGCACAGGACATGATCAAAGCCGGACGCGATGGGTCAATCGTCACATTGCTATGCGACAGCGGGGATCGCTATCTCGAC
ACCTATTACAATCCGGATTGGGTCAGCCACTGTATCGGGGCCTATCAGGATTATTCCGACCACCTGAACAAACATTTCAA
GTGA

Upstream 100 bases:

>100_bases
TCATTTTCTGATGCGGTTGATTTCTTCCACGGGCGCGCTTTTGCTTTTGCTCAAATCCATTTAAAGGGGCCAAGGACTGC
CGCGCAAAAGGAGAGTTTTA

Downstream 100 bases:

>100_bases
TCAGGCACGCTCAGGCAACTTCGCCAAGGATGTGATCCAGCACCTCTATGATCATCGCGGCATCCTCAGCTTCGATGGTC
AGCGGGGGGCGAATTTTGAG

Product: pyridoxal-phosphate dependent enzyme

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDNWVAHAIRQINADAHRSADTHLFKLPLPRLTGVDIYLKDESTHPTGSLKHRLARSLFLYALCNGKIKADTPIVEASSG
STAVSEAYFARMIGVPFIAVLPKSTARSKIRQIEFYGGKVHFVDAAPQMHDASVALAASIGGYFMDQFTYAERATDWRGN
NNIAESVFTQMEQEPHPIPAHLVMSAGTGGTSATLGRYIRYKGYDTELTVVDPENSVFYQSYMTGDRSLLSDKSSRIEGI
GRPKVELSFQPGVIDHMIAVPDAASVATMLWLEELIGRKTGPSSGTNLWGALKRAQDMIKAGRDGSIVTLLCDSGDRYLD
TYYNPDWVSHCIGAYQDYSDHLNKHFK

Sequences:

>Translated_347_residues
MDNWVAHAIRQINADAHRSADTHLFKLPLPRLTGVDIYLKDESTHPTGSLKHRLARSLFLYALCNGKIKADTPIVEASSG
STAVSEAYFARMIGVPFIAVLPKSTARSKIRQIEFYGGKVHFVDAAPQMHDASVALAASIGGYFMDQFTYAERATDWRGN
NNIAESVFTQMEQEPHPIPAHLVMSAGTGGTSATLGRYIRYKGYDTELTVVDPENSVFYQSYMTGDRSLLSDKSSRIEGI
GRPKVELSFQPGVIDHMIAVPDAASVATMLWLEELIGRKTGPSSGTNLWGALKRAQDMIKAGRDGSIVTLLCDSGDRYLD
TYYNPDWVSHCIGAYQDYSDHLNKHFK
>Mature_347_residues
MDNWVAHAIRQINADAHRSADTHLFKLPLPRLTGVDIYLKDESTHPTGSLKHRLARSLFLYALCNGKIKADTPIVEASSG
STAVSEAYFARMIGVPFIAVLPKSTARSKIRQIEFYGGKVHFVDAAPQMHDASVALAASIGGYFMDQFTYAERATDWRGN
NNIAESVFTQMEQEPHPIPAHLVMSAGTGGTSATLGRYIRYKGYDTELTVVDPENSVFYQSYMTGDRSLLSDKSSRIEGI
GRPKVELSFQPGVIDHMIAVPDAASVATMLWLEELIGRKTGPSSGTNLWGALKRAQDMIKAGRDGSIVTLLCDSGDRYLD
TYYNPDWVSHCIGAYQDYSDHLNKHFK

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=304, Percent_Identity=24.6710526315789, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI295821200, Length=304, Percent_Identity=24.6710526315789, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI4557415, Length=304, Percent_Identity=24.6710526315789, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=27.7591973244147, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788754, Length=308, Percent_Identity=23.7012987012987, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71996324, Length=350, Percent_Identity=34.2857142857143, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17539800, Length=363, Percent_Identity=31.9559228650138, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17539640, Length=354, Percent_Identity=29.6610169491525, Blast_Score=143, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=25.1515151515152, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 38315; Mature: 38315

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNWVAHAIRQINADAHRSADTHLFKLPLPRLTGVDIYLKDESTHPTGSLKHRLARSLFL
CCHHHHHHHHHHCCHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
YALCNGKIKADTPIVEASSGSTAVSEAYFARMIGVPFIAVLPKSTARSKIRQIEFYGGKV
HHHHCCEEECCCCEEECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHEEEEECCEE
HFVDAAPQMHDASVALAASIGGYFMDQFTYAERATDWRGNNNIAESVFTQMEQEPHPIPA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCC
HLVMSAGTGGTSATLGRYIRYKGYDTELTVVDPENSVFYQSYMTGDRSLLSDKSSRIEGI
EEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEEEHHHCCCHHHHHCCHHHHCCC
GRPKVELSFQPGVIDHMIAVPDAASVATMLWLEELIGRKTGPSSGTNLWGALKRAQDMIK
CCCCEEEEECCCHHHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGRDGSIVTLLCDSGDRYLDTYYNPDWVSHCIGAYQDYSDHLNKHFK
CCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDNWVAHAIRQINADAHRSADTHLFKLPLPRLTGVDIYLKDESTHPTGSLKHRLARSLFL
CCHHHHHHHHHHCCHHCCCCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
YALCNGKIKADTPIVEASSGSTAVSEAYFARMIGVPFIAVLPKSTARSKIRQIEFYGGKV
HHHHCCEEECCCCEEECCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHEEEEECCEE
HFVDAAPQMHDASVALAASIGGYFMDQFTYAERATDWRGNNNIAESVFTQMEQEPHPIPA
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCC
HLVMSAGTGGTSATLGRYIRYKGYDTELTVVDPENSVFYQSYMTGDRSLLSDKSSRIEGI
EEEEECCCCCCHHHHHHHHEECCCCCEEEEECCCCCEEEEHHHCCCHHHHHCCHHHHCCC
GRPKVELSFQPGVIDHMIAVPDAASVATMLWLEELIGRKTGPSSGTNLWGALKRAQDMIK
CCCCEEEEECCCHHHHHEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
AGRDGSIVTLLCDSGDRYLDTYYNPDWVSHCIGAYQDYSDHLNKHFK
CCCCCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]