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The map label for this gene is clpA [C]

Identifier: 110680700

GI number: 110680700

Start: 3401344

End: 3403665

Strand: Direct

Name: clpA [C]

Synonym: RD1_3540

Alternate gene names: 110680700

Gene position: 3401344-3403665 (Clockwise)

Preceding gene: 110680699

Following gene: 110680702

Centisome position: 82.3

GC content: 56.63

Gene sequence:

>2322_bases
GTGCCTTCATTTTCAACGACACTGGAACAGGCAATTCATTCGGCATTGGCACTCGCAAACGCGCGTCGCCACGAATTTGC
CACGCTGGAACATTTGTTGCTGGCCCTGATTGACGAGCCTGACGCCTCCCGCGTGATGAAAGCGTGCAGCGTGGATACCG
ATGATCTCCGCAAGACACTTGTCGAATTTGTCGACGAGGATCTGAGCAACCTGGTAACCGACATAGACGGATCCGAAGCC
GTGCCGACCGCTGCTTTCCAGCGCGTCATCCAGCGCGCCGCGATCCATGTGCAATCCTCGGGCCGAACAGAAGTGACCGG
CGCGAATGTGCTGGTCGCCATTTTTGCCGAGCGCGAAAGCAATGCCGCATACTTCCTGCAGGAACAGGATATGACGCGCT
ATGATGCGGTGAACTTCATTGCGCATGGCGTAGCGAAAGACCCTGCATATGGTGAACCGCGCCCCGTGTCCGGCGCGCCC
GAAGCCGAAGAAGAAACACAAGGCGTGACCGACGGCGAAAAGAAAGAAAGCGCGCTTGAAAAATACTGCGTCGATTTGAA
CGCAAAGTCGCGCGAGGGCGATATTGATCCGCTCATTGGCCGCGACTCAGAGGTCGAGCGTTGTATCCAAGTGCTGTGTC
GGCGCCGCAAGAACAATCCTTTGCTGGTCGGCGACCCCGGGGTCGGGAAAACAGCAATCGCTGAAGGGCTGGCGCGCAAA
ATCGTTGCGGGCGAAACACCTGAGGTGCTTGCCAAGACGACCATTTATTCCCTCGACATGGGCGCGCTGCTGGCCGGCAC
GCGCTATCGCGGTGATTTCGAAGAGCGTCTGAAGGCCGTCGTGTCCGAGTTGGAAGATCATAAAGACGCGGTGCTTTTCA
TCGACGAAATTCATACCGTGATCGGTGCAGGGGCGACATCGGGTGGCGCGATGGATGCCTCCAATCTGCTCAAACCCGCC
TTGGCGGGCGGCAAACTGCGCACCATGGGGTCCACGACCTACAAGGAATTTCGCCAGCATTTCGAGAAGGACCGCGCGCT
GAGCCGCCGGTTCCAGAAGATCGACGTGAATGAGCCATCTGTCGAAGATGCAGTGAAAATCCTGCGGGGTCTGAAACCCT
ATTTCGAGGACCACCACGCGGTGAAATACACGGCCGATGCGATCAAGACGAGCGTCGAACTGGCCTCGCGTTACATCAAC
GACCGCAAGCTGCCCGACAGCGCCATTGACGTGATCGACGAAGCGGGCGCCGCTCAGCATTTGATCGTGGCCGCGAAACG
GCGCAAAACGATTGGCACCAAGGAGATCGAAAACGTCGTTGCTAAGATCGCGCGTATTCCGCCGAAGAACGTGTCCAAAG
ACGATGCAGAAGTCCTGAAGGACCTCGAAGGGTCGCTGAAACGCGTGGTGTTTGGTCAAAACGCAGCGATTGAAGCGCTT
TCATCCGCCATCAAACTGGCACGTGCCGGTTTGCGCGAACCGGAAAAGCCCATTGGCAACTATCTCTTTGCCGGGCCCAC
CGGTGTCGGCAAAACTGAAGTCGCCAAGCAACTGGCGGATACGCTGGGGGTTGAACTTCTACGCTTCGATATGTCCGAAT
ATATGGAGAAGCACGCGGTTTCGCGCCTGATCGGTGCCCCACCGGGATATGTCGGCTTCGATCAAGGCGGCATGTTGACC
GATGGCGTTGATCAGCATCCGCATTGCGTATTGCTTCTTGATGAAATGGAAAAAGCGCATCCGGATGTCTACAACATTCT
CCTGCAGGTCATGGATCACGGCAAACTGACAGACCACAATGGGAGAACCGTTGATTTCCGAAACGTCGTTCTGATCATGA
CCTCCAACGCGGGCGCCGCTGAACAGGCCAAGGAAGCGATTGGCTTTGGGCGTGATCGACGCGAAGGCGAAGATACCGCC
GCCATTGAACGCACATTCACGCCTGAATTCCGCAACAGGTTGGATGCGGTGATCAGCTTTGCGCCGCTACCCAAAGAGGT
GATCTTGCGCGTGGTCGAAAAGTTTGTGCTGCAACTCGAAGCGCAGTTGATGGACAGAAATGTTACAATCGAACTGACAA
AACCCGCCGCAGAGTGGCTCGCGGACAAAGGTTACGATGCGAAAATGGGCGCGCGCCCCTTGGGCCGTGTCATTCAAGAG
CACATCAAGAAACCGCTCGCCGAAGACTTGCTGTTCGGCAAGCTTGCCAAGGGCGGCGTTGTAAAAGTAGGTGTCAAGAA
TGGCGAGATCGATCTCAAAATCGAAGGACCGGACAAACCGCGTCTAGCCGGGGACAAACCACCTCTGCTGACTGCTGAGT
AG

Upstream 100 bases:

>100_bases
GCTAGGATCAACCAAACTCTAACTTAATGAGGCTATGGTTGGATGAAGGGCTGATATCCCTCGGCTCTGATACCGACCCC
GATCAGAAGGAGCACACAAC

Downstream 100 bases:

>100_bases
CCTTTTGGTATGGTGATACATTGAGCCTCTCTGTTGTAAAACAGGGAGGCTCGATTGCATTGAAAACCGCGACTGAAGCA
GAACAGCAGAGCTGGAGAAA

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 773; Mature: 772

Protein sequence:

>773_residues
MPSFSTTLEQAIHSALALANARRHEFATLEHLLLALIDEPDASRVMKACSVDTDDLRKTLVEFVDEDLSNLVTDIDGSEA
VPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERESNAAYFLQEQDMTRYDAVNFIAHGVAKDPAYGEPRPVSGAP
EAEEETQGVTDGEKKESALEKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPLLVGDPGVGKTAIAEGLARK
IVAGETPEVLAKTTIYSLDMGALLAGTRYRGDFEERLKAVVSELEDHKDAVLFIDEIHTVIGAGATSGGAMDASNLLKPA
LAGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPSVEDAVKILRGLKPYFEDHHAVKYTADAIKTSVELASRYIN
DRKLPDSAIDVIDEAGAAQHLIVAAKRRKTIGTKEIENVVAKIARIPPKNVSKDDAEVLKDLEGSLKRVVFGQNAAIEAL
SSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAVSRLIGAPPGYVGFDQGGMLT
DGVDQHPHCVLLLDEMEKAHPDVYNILLQVMDHGKLTDHNGRTVDFRNVVLIMTSNAGAAEQAKEAIGFGRDRREGEDTA
AIERTFTPEFRNRLDAVISFAPLPKEVILRVVEKFVLQLEAQLMDRNVTIELTKPAAEWLADKGYDAKMGARPLGRVIQE
HIKKPLAEDLLFGKLAKGGVVKVGVKNGEIDLKIEGPDKPRLAGDKPPLLTAE

Sequences:

>Translated_773_residues
MPSFSTTLEQAIHSALALANARRHEFATLEHLLLALIDEPDASRVMKACSVDTDDLRKTLVEFVDEDLSNLVTDIDGSEA
VPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERESNAAYFLQEQDMTRYDAVNFIAHGVAKDPAYGEPRPVSGAP
EAEEETQGVTDGEKKESALEKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPLLVGDPGVGKTAIAEGLARK
IVAGETPEVLAKTTIYSLDMGALLAGTRYRGDFEERLKAVVSELEDHKDAVLFIDEIHTVIGAGATSGGAMDASNLLKPA
LAGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPSVEDAVKILRGLKPYFEDHHAVKYTADAIKTSVELASRYIN
DRKLPDSAIDVIDEAGAAQHLIVAAKRRKTIGTKEIENVVAKIARIPPKNVSKDDAEVLKDLEGSLKRVVFGQNAAIEAL
SSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAVSRLIGAPPGYVGFDQGGMLT
DGVDQHPHCVLLLDEMEKAHPDVYNILLQVMDHGKLTDHNGRTVDFRNVVLIMTSNAGAAEQAKEAIGFGRDRREGEDTA
AIERTFTPEFRNRLDAVISFAPLPKEVILRVVEKFVLQLEAQLMDRNVTIELTKPAAEWLADKGYDAKMGARPLGRVIQE
HIKKPLAEDLLFGKLAKGGVVKVGVKNGEIDLKIEGPDKPRLAGDKPPLLTAE
>Mature_772_residues
PSFSTTLEQAIHSALALANARRHEFATLEHLLLALIDEPDASRVMKACSVDTDDLRKTLVEFVDEDLSNLVTDIDGSEAV
PTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERESNAAYFLQEQDMTRYDAVNFIAHGVAKDPAYGEPRPVSGAPE
AEEETQGVTDGEKKESALEKYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPLLVGDPGVGKTAIAEGLARKI
VAGETPEVLAKTTIYSLDMGALLAGTRYRGDFEERLKAVVSELEDHKDAVLFIDEIHTVIGAGATSGGAMDASNLLKPAL
AGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPSVEDAVKILRGLKPYFEDHHAVKYTADAIKTSVELASRYIND
RKLPDSAIDVIDEAGAAQHLIVAAKRRKTIGTKEIENVVAKIARIPPKNVSKDDAEVLKDLEGSLKRVVFGQNAAIEALS
SAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAVSRLIGAPPGYVGFDQGGMLTD
GVDQHPHCVLLLDEMEKAHPDVYNILLQVMDHGKLTDHNGRTVDFRNVVLIMTSNAGAAEQAKEAIGFGRDRREGEDTAA
IERTFTPEFRNRLDAVISFAPLPKEVILRVVEKFVLQLEAQLMDRNVTIELTKPAAEWLADKGYDAKMGARPLGRVIQEH
IKKPLAEDLLFGKLAKGGVVKVGVKNGEIDLKIEGPDKPRLAGDKPPLLTAE

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=336, Percent_Identity=33.0357142857143, Blast_Score=172, Evalue=1e-42,
Organism=Escherichia coli, GI1787109, Length=738, Percent_Identity=59.4850948509485, Blast_Score=902, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=255, Percent_Identity=55.6862745098039, Blast_Score=290, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6320464, Length=331, Percent_Identity=45.0151057401813, Blast_Score=276, Evalue=7e-75,
Organism=Saccharomyces cerevisiae, GI6323002, Length=240, Percent_Identity=50, Blast_Score=250, Evalue=7e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84473; Mature: 84342

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFSTTLEQAIHSALALANARRHEFATLEHLLLALIDEPDASRVMKACSVDTDDLRKTL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
VEFVDEDLSNLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERES
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEECCC
NAAYFLQEQDMTRYDAVNFIAHGVAKDPAYGEPRPVSGAPEAEEETQGVTDGEKKESALE
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHH
KYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPLLVGDPGVGKTAIAEGLARK
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
IVAGETPEVLAKTTIYSLDMGALLAGTRYRGDFEERLKAVVSELEDHKDAVLFIDEIHTV
HHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHH
IGAGATSGGAMDASNLLKPALAGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPS
HHCCCCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VEDAVKILRGLKPYFEDHHAVKYTADAIKTSVELASRYINDRKLPDSAIDVIDEAGAAQH
HHHHHHHHHHCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
LIVAAKRRKTIGTKEIENVVAKIARIPPKNVSKDDAEVLKDLEGSLKRVVFGQNAAIEAL
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
SSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAV
HHHHHHHHHHCCCCCCHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRLIGAPPGYVGFDQGGMLTDGVDQHPHCVLLLDEMEKAHPDVYNILLQVMDHGKLTDHN
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCC
GRTVDFRNVVLIMTSNAGAAEQAKEAIGFGRDRREGEDTAAIERTFTPEFRNRLDAVISF
CCEEEECCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHC
APLPKEVILRVVEKFVLQLEAQLMDRNVTIELTKPAAEWLADKGYDAKMGARPLGRVIQE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHH
HIKKPLAEDLLFGKLAKGGVVKVGVKNGEIDLKIEGPDKPRLAGDKPPLLTAE
HHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PSFSTTLEQAIHSALALANARRHEFATLEHLLLALIDEPDASRVMKACSVDTDDLRKTL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHH
VEFVDEDLSNLVTDIDGSEAVPTAAFQRVIQRAAIHVQSSGRTEVTGANVLVAIFAERES
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCCCEEEEEEEECCC
NAAYFLQEQDMTRYDAVNFIAHGVAKDPAYGEPRPVSGAPEAEEETQGVTDGEKKESALE
CCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHH
KYCVDLNAKSREGDIDPLIGRDSEVERCIQVLCRRRKNNPLLVGDPGVGKTAIAEGLARK
HHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHH
IVAGETPEVLAKTTIYSLDMGALLAGTRYRGDFEERLKAVVSELEDHKDAVLFIDEIHTV
HHCCCCHHHHHHHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHH
IGAGATSGGAMDASNLLKPALAGGKLRTMGSTTYKEFRQHFEKDRALSRRFQKIDVNEPS
HHCCCCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VEDAVKILRGLKPYFEDHHAVKYTADAIKTSVELASRYINDRKLPDSAIDVIDEAGAAQH
HHHHHHHHHHCCHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHH
LIVAAKRRKTIGTKEIENVVAKIARIPPKNVSKDDAEVLKDLEGSLKRVVFGQNAAIEAL
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHH
SSAIKLARAGLREPEKPIGNYLFAGPTGVGKTEVAKQLADTLGVELLRFDMSEYMEKHAV
HHHHHHHHHHCCCCCCHHCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRLIGAPPGYVGFDQGGMLTDGVDQHPHCVLLLDEMEKAHPDVYNILLQVMDHGKLTDHN
HHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHCCHHHHHHHHHHHCCCCCCCC
GRTVDFRNVVLIMTSNAGAAEQAKEAIGFGRDRREGEDTAAIERTFTPEFRNRLDAVISF
CCEEEECCEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHC
APLPKEVILRVVEKFVLQLEAQLMDRNVTIELTKPAAEWLADKGYDAKMGARPLGRVIQE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHCCCCCCCCCCCHHHHHHHH
HIKKPLAEDLLFGKLAKGGVVKVGVKNGEIDLKIEGPDKPRLAGDKPPLLTAE
HHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]