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The map label for this gene is fabH [H]

Identifier: 110680655

GI number: 110680655

Start: 3360770

End: 3361894

Strand: Direct

Name: fabH [H]

Synonym: RD1_3492

Alternate gene names: 110680655

Gene position: 3360770-3361894 (Clockwise)

Preceding gene: 110680654

Following gene: 110680657

Centisome position: 81.31

GC content: 56.36

Gene sequence:

>1125_bases
ATGCACAGACCAGCCATAACCGGAACCGGCGTTTTCACGCCTGAGAATGTCATCACCAACGCGGAATTGGTGGCGGCCTT
CAACGCCTATGTGGATATTTACAATGCGGAAAATGCAGCCGGGATTGCGGCGGGCGAGGTAGAGGCCAAGGCGTATTCGT
CCGAAGAGTTCATCGTCAAAGCCTCCGGCATTCAACAGCGTTATGTCATTGATAAGGAAGGGGTCCTTGACCCAAAGGTC
ATGCACCCGCTGCTGCGACAACGGGGCGATGAAGAACCTTCGCTGATGGCCGAGATGGGCGTGGATGCGGCACGAAAGGC
GCTCTCGCAAGCCGGTAGTGAGGCGGGCGACGTGGATCTGATACTCTGCGCCGCCTCCAATATGGAACGCGCATACCCCG
CAATTGCCGTGGAAATCCAGAACCTTCTTGGCGCGGGCGGCTTTGCCTTTGACATGAATGTGGCCTGTTCGTCGGCGACC
TTTGGGATTCAGACAGCCGCTGATATGATCAGATCCGGCAGCATCCGACGCGCATTGGTCATCAACCCTGAAATCTGTTC
GGCCCATCTGGAATGGCGGGACCGCGATTGTCATTTCATCTTTGGCGATGTGGCCACGGCCACGCTGATCGAACGGACAG
AAGATGCAAAAAACGGATATTTTGAAATAGTATCAACGCGCTGCGCGACGGAATTCTCGAACAACATTCGCAACAACAAC
GGCTATCTGCGCCGGTCCCGCCCGGCGGGTATGGTGGACCGGCGCGACATGCAATTCATGCAAAACGGGCGCAAGGTCTT
CAAGGAAGTGCTGCCCATGGTGTCTGAGCACATCAGCGCGCATCTGACGTCCGAAAGCGTAAGCGCGGCGCAGCTCAAGC
GGCTGTGGTTGCATCAGGCCAACAAGACCATGAATGACTTTATCGGGCGCAAAGTGCTCGGCCGCACCCCGAAACCAGCA
GAACAGCCGAATATTCTGCAAGACTACGCCAATACCTCATCAGCGGGTTCCATCATCGCCTTTTCAAAATACTCCGAAGA
CTTACAGGCGGGTGACCTCGGGCTGATCTGTTCTTTCGGGGCCGGATACTCCGTCGGGTCCGTCCTGCTCAAGCGTCACA
AGTAA

Upstream 100 bases:

>100_bases
AGGCCAGCCCCTGCCGCTCGAACGCTGCGTCAAGATGTGTCTGCATGCTTGACCCAAGGCCCTATATCCGGTCTCACTTG
GGCATGTGTCGGAGGACCCC

Downstream 100 bases:

>100_bases
CGCGGTATTCGTCCGCCTTCACGCCCCGCCGTGATCGTTTTCCAGATGCAATTTCATGTCGATCAGCACCTGCTGCAGCA
GCGTGGTTTCTTTCAACAGC

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MHRPAITGTGVFTPENVITNAELVAAFNAYVDIYNAENAAGIAAGEVEAKAYSSEEFIVKASGIQQRYVIDKEGVLDPKV
MHPLLRQRGDEEPSLMAEMGVDAARKALSQAGSEAGDVDLILCAASNMERAYPAIAVEIQNLLGAGGFAFDMNVACSSAT
FGIQTAADMIRSGSIRRALVINPEICSAHLEWRDRDCHFIFGDVATATLIERTEDAKNGYFEIVSTRCATEFSNNIRNNN
GYLRRSRPAGMVDRRDMQFMQNGRKVFKEVLPMVSEHISAHLTSESVSAAQLKRLWLHQANKTMNDFIGRKVLGRTPKPA
EQPNILQDYANTSSAGSIIAFSKYSEDLQAGDLGLICSFGAGYSVGSVLLKRHK

Sequences:

>Translated_374_residues
MHRPAITGTGVFTPENVITNAELVAAFNAYVDIYNAENAAGIAAGEVEAKAYSSEEFIVKASGIQQRYVIDKEGVLDPKV
MHPLLRQRGDEEPSLMAEMGVDAARKALSQAGSEAGDVDLILCAASNMERAYPAIAVEIQNLLGAGGFAFDMNVACSSAT
FGIQTAADMIRSGSIRRALVINPEICSAHLEWRDRDCHFIFGDVATATLIERTEDAKNGYFEIVSTRCATEFSNNIRNNN
GYLRRSRPAGMVDRRDMQFMQNGRKVFKEVLPMVSEHISAHLTSESVSAAQLKRLWLHQANKTMNDFIGRKVLGRTPKPA
EQPNILQDYANTSSAGSIIAFSKYSEDLQAGDLGLICSFGAGYSVGSVLLKRHK
>Mature_374_residues
MHRPAITGTGVFTPENVITNAELVAAFNAYVDIYNAENAAGIAAGEVEAKAYSSEEFIVKASGIQQRYVIDKEGVLDPKV
MHPLLRQRGDEEPSLMAEMGVDAARKALSQAGSEAGDVDLILCAASNMERAYPAIAVEIQNLLGAGGFAFDMNVACSSAT
FGIQTAADMIRSGSIRRALVINPEICSAHLEWRDRDCHFIFGDVATATLIERTEDAKNGYFEIVSTRCATEFSNNIRNNN
GYLRRSRPAGMVDRRDMQFMQNGRKVFKEVLPMVSEHISAHLTSESVSAAQLKRLWLHQANKTMNDFIGRKVLGRTPKPA
EQPNILQDYANTSSAGSIIAFSKYSEDLQAGDLGLICSFGAGYSVGSVLLKRHK

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family [H]

Homologues:

Organism=Escherichia coli, GI1787333, Length=372, Percent_Identity=26.0752688172043, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C [H]

EC number: =2.3.1.180 [H]

Molecular weight: Translated: 40763; Mature: 40763

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRPAITGTGVFTPENVITNAELVAAFNAYVDIYNAENAAGIAAGEVEAKAYSSEEFIVK
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHHEEEECCCCCCCEECCCCHHHHCCCCCEEEE
ASGIQQRYVIDKEGVLDPKVMHPLLRQRGDEEPSLMAEMGVDAARKALSQAGSEAGDVDL
ECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHCCCCCCCEEE
ILCAASNMERAYPAIAVEIQNLLGAGGFAFDMNVACSSATFGIQTAADMIRSGSIRRALV
EEEECCCCCHHCHHHHEEHHHHHCCCCEEEEECEEECCCCCCHHHHHHHHHCCCCCEEEE
INPEICSAHLEWRDRDCHFIFGDVATATLIERTEDAKNGYFEIVSTRCATEFSNNIRNNN
ECHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCC
GYLRRSRPAGMVDRRDMQFMQNGRKVFKEVLPMVSEHISAHLTSESVSAAQLKRLWLHQA
CCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NKTMNDFIGRKVLGRTPKPAEQPNILQDYANTSSAGSIIAFSKYSEDLQAGDLGLICSFG
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCHHCCCCEEEEEECC
AGYSVGSVLLKRHK
CCCHHHHHHHHCCC
>Mature Secondary Structure
MHRPAITGTGVFTPENVITNAELVAAFNAYVDIYNAENAAGIAAGEVEAKAYSSEEFIVK
CCCCCCCCCCCCCCHHHHCCHHHHHHHHHHEEEECCCCCCCEECCCCHHHHCCCCCEEEE
ASGIQQRYVIDKEGVLDPKVMHPLLRQRGDEEPSLMAEMGVDAARKALSQAGSEAGDVDL
ECCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHCCCCCCCEEE
ILCAASNMERAYPAIAVEIQNLLGAGGFAFDMNVACSSATFGIQTAADMIRSGSIRRALV
EEEECCCCCHHCHHHHEEHHHHHCCCCEEEEECEEECCCCCCHHHHHHHHHCCCCCEEEE
INPEICSAHLEWRDRDCHFIFGDVATATLIERTEDAKNGYFEIVSTRCATEFSNNIRNNN
ECHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCC
GYLRRSRPAGMVDRRDMQFMQNGRKVFKEVLPMVSEHISAHLTSESVSAAQLKRLWLHQA
CCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NKTMNDFIGRKVLGRTPKPAEQPNILQDYANTSSAGSIIAFSKYSEDLQAGDLGLICSFG
CCHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCHHCCCCEEEEEECC
AGYSVGSVLLKRHK
CCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]