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The map label for this gene is yeiA [H]

Identifier: 110680292

GI number: 110680292

Start: 2979988

End: 2981292

Strand: Reverse

Name: yeiA [H]

Synonym: RD1_3103

Alternate gene names: 110680292

Gene position: 2981292-2979988 (Counterclockwise)

Preceding gene: 110680293

Following gene: 110680290

Centisome position: 72.13

GC content: 59.77

Gene sequence:

>1305_bases
ATGGCTGATCTGACGTCGGAATTTCTGGGCATTACCTCACCAAATCCGTTTTGGCTGGCCTCTGCGCCGCCAACTGACAA
GGAATACAACGTGCGCCGCGCCTTTGAGGCGGGGTGGGGCGGTGTCGTGTGGAAGACACTCGGAGCAGAAGGGCCACCGG
TGGTGAACGTCAACGGCCCGCGCTACGGTGTGATCCATGGTGCGGACCGGCGGGTGCTGGGCATGAACAACATCGAGTTG
ATCACCGACCGCTCGCTTGAGATCAACCTCGAAGAGATCACCCGCGTGAAAAAGGACTATCCTGATCGCGCCATGATCGT
CTCCATCATGGTGCCTTGCGAGGAGCAGGCGTGGAAAGACATCTTGCCAAGGGTCGAAGCGACCGGCGCGGATGGCATCG
AGCTGAACTTCGGCTGCCCGCATGGCATGTCAGAGCGCGGCATGGGGGCCGCCGTCGGTCAGGTGCCCGAATACATCGAA
ATGGTCACGCGCTGGTGCAAGCAGTATTACAGCAAACCCGTGATCGTGAAACTCACGCCCAATATCACCGATATCCGCAA
ACCCGCAGCTGCCGCCAAACGCGGTGGGGCGGATGCGGTGTCGCTGATCAACACGATCAATTCCATCGTGTCGGTTGATC
TCGATACGATGAGCCCATATCCGTCGATTGACGGCAAGGGCACCCACGGCGGCTATTGCGGGCCGGCGGTCAAACCCATC
GCGCTCAGCATGGTGTCCGAGATCGCGCGGGACCCCGAAACGCACGGCTTACCGATTTCCGGCATCGGGGGGGTCACCAC
ATGGCGCGATGCGGCCGAATACATCACCATGGGCTGTGGCAATGTGCAGGTCTGCACGGCGGCCATGACCTATGGGTTCA
AGGTGGTGCAGGAAATGATTTCCGGCCTGTCGCAATGGATGGATGAAAAGGGGCATACGAACATTCGCGACTTCATGGGC
GCAGCGATACCGAACACAACCGATTGGCAGTATCTCAACCTCAACTATGTCGCCAAGGCGCAGATCAATCAGGCTGATTG
CATCAGTTGCGGGCGGTGCTATGCGGCCTGCGAGGATACATCCCACCAGGCCATCGCCATGTCCGAAGACAGGGTGTTCA
GCGTCATCGACGAGGAATGCGTCGCCTGCAACCTCTGCGTTGAGGTTTGCCCGGTGGAAAACTGCATCACCATGGTCCCG
ATGGAGCAGGGCAAGGTCGATCCGCGCACCGGCAAGGTGGTTGAAAAGGACTATGCCAACTGGACCACGCACCCCAACAA
CCCCGGCGCGGTTGCCGCCGAGTAA

Upstream 100 bases:

>100_bases
GCGATTGCGCCCTTGGCGGCGATGATCTGACCGTGACAGCCGTGGCCGAAGGGCGCGACGCGGCAATGGATATTCATGCA
GCACTGAACGGGAGCGTATA

Downstream 100 bases:

>100_bases
TCCACGACAACCGTTTCTCCCCGGCTGCCGGAGTACTCATCCTGAGTGCTTCGGCAGTTAGGTTTGAGGGGTCAGCATCC
GCCGCAGCATGTCTTCGAGG

Product: dihydropyrimidine dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MADLTSEFLGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGPRYGVIHGADRRVLGMNNIEL
ITDRSLEINLEEITRVKKDYPDRAMIVSIMVPCEEQAWKDILPRVEATGADGIELNFGCPHGMSERGMGAAVGQVPEYIE
MVTRWCKQYYSKPVIVKLTPNITDIRKPAAAAKRGGADAVSLINTINSIVSVDLDTMSPYPSIDGKGTHGGYCGPAVKPI
ALSMVSEIARDPETHGLPISGIGGVTTWRDAAEYITMGCGNVQVCTAAMTYGFKVVQEMISGLSQWMDEKGHTNIRDFMG
AAIPNTTDWQYLNLNYVAKAQINQADCISCGRCYAACEDTSHQAIAMSEDRVFSVIDEECVACNLCVEVCPVENCITMVP
MEQGKVDPRTGKVVEKDYANWTTHPNNPGAVAAE

Sequences:

>Translated_434_residues
MADLTSEFLGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGPRYGVIHGADRRVLGMNNIEL
ITDRSLEINLEEITRVKKDYPDRAMIVSIMVPCEEQAWKDILPRVEATGADGIELNFGCPHGMSERGMGAAVGQVPEYIE
MVTRWCKQYYSKPVIVKLTPNITDIRKPAAAAKRGGADAVSLINTINSIVSVDLDTMSPYPSIDGKGTHGGYCGPAVKPI
ALSMVSEIARDPETHGLPISGIGGVTTWRDAAEYITMGCGNVQVCTAAMTYGFKVVQEMISGLSQWMDEKGHTNIRDFMG
AAIPNTTDWQYLNLNYVAKAQINQADCISCGRCYAACEDTSHQAIAMSEDRVFSVIDEECVACNLCVEVCPVENCITMVP
MEQGKVDPRTGKVVEKDYANWTTHPNNPGAVAAE
>Mature_433_residues
ADLTSEFLGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGPRYGVIHGADRRVLGMNNIELI
TDRSLEINLEEITRVKKDYPDRAMIVSIMVPCEEQAWKDILPRVEATGADGIELNFGCPHGMSERGMGAAVGQVPEYIEM
VTRWCKQYYSKPVIVKLTPNITDIRKPAAAAKRGGADAVSLINTINSIVSVDLDTMSPYPSIDGKGTHGGYCGPAVKPIA
LSMVSEIARDPETHGLPISGIGGVTTWRDAAEYITMGCGNVQVCTAAMTYGFKVVQEMISGLSQWMDEKGHTNIRDFMGA
AIPNTTDWQYLNLNYVAKAQINQADCISCGRCYAACEDTSHQAIAMSEDRVFSVIDEECVACNLCVEVCPVENCITMVPM
EQGKVDPRTGKVVEKDYANWTTHPNNPGAVAAE

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=341, Percent_Identity=36.6568914956012, Blast_Score=219, Evalue=5e-57,
Organism=Escherichia coli, GI87082059, Length=411, Percent_Identity=41.1192214111922, Blast_Score=320, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI71984108, Length=333, Percent_Identity=37.2372372372372, Blast_Score=217, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6322633, Length=328, Percent_Identity=26.8292682926829, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24640763, Length=321, Percent_Identity=40.4984423676012, Blast_Score=237, Evalue=9e-63,
Organism=Drosophila melanogaster, GI18858217, Length=321, Percent_Identity=40.4984423676012, Blast_Score=237, Evalue=9e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 47163; Mature: 47032

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00198 4FE4S_FERREDOXIN ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
3.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLTSEFLGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGP
CCCCCHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGVIHGADRRVLGMNNIELITDRSLEINLEEITRVKKDYPDRAMIVSIMVPCEEQAWKD
EEEEEECCCCEEECCCCEEEEECCCEEECHHHHHHHHHCCCCCEEEEEEECCCCHHHHHH
ILPRVEATGADGIELNFGCPHGMSERGMGAAVGQVPEYIEMVTRWCKQYYSKPVIVKLTP
HHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NITDIRKPAAAAKRGGADAVSLINTINSIVSVDLDTMSPYPSIDGKGTHGGYCGPAVKPI
CHHHHHCCHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCHHHH
ALSMVSEIARDPETHGLPISGIGGVTTWRDAAEYITMGCGNVQVCTAAMTYGFKVVQEMI
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SGLSQWMDEKGHTNIRDFMGAAIPNTTDWQYLNLNYVAKAQINQADCISCGRCYAACEDT
HHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHCHHHHHCCCC
SHQAIAMSEDRVFSVIDEECVACNLCVEVCPVENCITMVPMEQGKVDPRTGKVVEKDYAN
CCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCCCCHHHHCCC
WTTHPNNPGAVAAE
CCCCCCCCCCCCCC
>Mature Secondary Structure 
ADLTSEFLGITSPNPFWLASAPPTDKEYNVRRAFEAGWGGVVWKTLGAEGPPVVNVNGP
CCCCHHHHCCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCHHHHHCCCCCCCEEEECCC
RYGVIHGADRRVLGMNNIELITDRSLEINLEEITRVKKDYPDRAMIVSIMVPCEEQAWKD
EEEEEECCCCEEECCCCEEEEECCCEEECHHHHHHHHHCCCCCEEEEEEECCCCHHHHHH
ILPRVEATGADGIELNFGCPHGMSERGMGAAVGQVPEYIEMVTRWCKQYYSKPVIVKLTP
HHCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
NITDIRKPAAAAKRGGADAVSLINTINSIVSVDLDTMSPYPSIDGKGTHGGYCGPAVKPI
CHHHHHCCHHHHHCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCHHHH
ALSMVSEIARDPETHGLPISGIGGVTTWRDAAEYITMGCGNVQVCTAAMTYGFKVVQEMI
HHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SGLSQWMDEKGHTNIRDFMGAAIPNTTDWQYLNLNYVAKAQINQADCISCGRCYAACEDT
HHHHHHHHCCCCCCHHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHCHHHHHCCCC
SHQAIAMSEDRVFSVIDEECVACNLCVEVCPVENCITMVPMEQGKVDPRTGKVVEKDYAN
CCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHCCCCCCCCCCCHHHHCCC
WTTHPNNPGAVAAE
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]