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The map label for this gene is apqZ [H]

Identifier: 110680240

GI number: 110680240

Start: 2915924

End: 2916613

Strand: Reverse

Name: apqZ [H]

Synonym: RD1_3048

Alternate gene names: 110680240

Gene position: 2916613-2915924 (Counterclockwise)

Preceding gene: 110680241

Following gene: 110680238

Centisome position: 70.57

GC content: 58.26

Gene sequence:

>690_bases
ATGACAAAGAAACTGATGGCCGAATTTTTCGGCACGTTTTGGCTGGTGTTCGGTGGTTGCGGCAGTGCCGTTCTGGCCGC
CGGTGTGGCTGATGTGGGTATTGGCTGGCTCGGGGTGAGCCTCGCATTTGGCCTGACGGTGATGACGATGGCCTATACGG
TGGGTCATATTTCGGGCGGTCATTTCAATCCGGCGGTGTCGCTCGGTCTGCTGATCGGGGGACGATTTGATGGCAAGGAT
CTCTTGCCTTATTGGGCAGCCCAGGTGGCCGGTGCTGCCCTCGCAGCCGCGGTCTTGTTCATGATCGTATCTGGCGGCGC
CAGGTTTGAAGGGGTTGGTGGCTTTGCCTCAAACGGGTATGCCGAGGCCTCGCCGCAGGGGTATTCACTGATCTCTGTTT
TGGTTGTCGAGATTGTGCTGACCGCATTTTTCCTGATTATCATCCTCGGTTCCACGTCTTCAGGTGCACCGGCTGGCTTT
GCGCCCATTGCCATTGGTCTGGGATTGACCTTGATCCACCTGATTTCGATCCCGGTCTCCAATACATCGGTCAACCCGGC
CCGCTCAACAGGTGTTGCGCTGTTTGCCGAAGGTCCCGCCGTGACGCAGCTTTGGCTGTTTTGGGTGGCTCCCTTGATCG
GCGCAGCGATCGGCGCGGCGATCTGGAAGCTCATGACCACCGACGATTGA

Upstream 100 bases:

>100_bases
CAGAAATGACGCCGGTTTTTTCAATTTTACCGTCGTGATTTGAAATTCATTCAGTTTAAGGTTGAACGCACCAATCATTT
GATTTGAACAGAGGTGCGCA

Downstream 100 bases:

>100_bases
CACCCGCGCAGAGGATCACGGCCTCCGCCGATCGCAGGGGAGGCCGTGCAACAGTCAGGCGGATGACGCCAGTTCGTTCG
CCATTTCGTGGTTCCGGTCC

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: Aquaporin X [H]

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTKKLMAEFFGTFWLVFGGCGSAVLAAGVADVGIGWLGVSLAFGLTVMTMAYTVGHISGGHFNPAVSLGLLIGGRFDGKD
LLPYWAAQVAGAALAAAVLFMIVSGGARFEGVGGFASNGYAEASPQGYSLISVLVVEIVLTAFFLIIILGSTSSGAPAGF
APIAIGLGLTLIHLISIPVSNTSVNPARSTGVALFAEGPAVTQLWLFWVAPLIGAAIGAAIWKLMTTDD

Sequences:

>Translated_229_residues
MTKKLMAEFFGTFWLVFGGCGSAVLAAGVADVGIGWLGVSLAFGLTVMTMAYTVGHISGGHFNPAVSLGLLIGGRFDGKD
LLPYWAAQVAGAALAAAVLFMIVSGGARFEGVGGFASNGYAEASPQGYSLISVLVVEIVLTAFFLIIILGSTSSGAPAGF
APIAIGLGLTLIHLISIPVSNTSVNPARSTGVALFAEGPAVTQLWLFWVAPLIGAAIGAAIWKLMTTDD
>Mature_228_residues
TKKLMAEFFGTFWLVFGGCGSAVLAAGVADVGIGWLGVSLAFGLTVMTMAYTVGHISGGHFNPAVSLGLLIGGRFDGKDL
LPYWAAQVAGAALAAAVLFMIVSGGARFEGVGGFASNGYAEASPQGYSLISVLVVEIVLTAFFLIIILGSTSSGAPAGFA
PIAIGLGLTLIHLISIPVSNTSVNPARSTGVALFAEGPAVTQLWLFWVAPLIGAAIGAAIWKLMTTDD

Specific function: Transport of water across the membrane. Possibly involved in the adaptation to variation in intravacuolar pH or osmolarity [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI37694062, Length=229, Percent_Identity=35.8078602620087, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4502183, Length=225, Percent_Identity=36.8888888888889, Blast_Score=104, Evalue=5e-23,
Organism=Homo sapiens, GI6912506, Length=226, Percent_Identity=34.070796460177, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI4502179, Length=231, Percent_Identity=32.034632034632, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4755125, Length=239, Percent_Identity=30.1255230125523, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4502181, Length=239, Percent_Identity=30.1255230125523, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI45446752, Length=207, Percent_Identity=36.231884057971, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI157266307, Length=247, Percent_Identity=35.2226720647773, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI86792455, Length=234, Percent_Identity=31.6239316239316, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI22538420, Length=249, Percent_Identity=28.9156626506024, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI4826645, Length=252, Percent_Identity=28.968253968254, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1787101, Length=209, Percent_Identity=67.4641148325359, Blast_Score=265, Evalue=2e-72,
Organism=Escherichia coli, GI1790362, Length=210, Percent_Identity=32.8571428571429, Blast_Score=78, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71993722, Length=244, Percent_Identity=29.9180327868852, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71994009, Length=236, Percent_Identity=30.0847457627119, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=242, Percent_Identity=30.9917355371901, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17558372, Length=246, Percent_Identity=28.0487804878049, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24652747, Length=230, Percent_Identity=32.6086956521739, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551084, Length=230, Percent_Identity=32.6086956521739, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24652751, Length=222, Percent_Identity=30.1801801801802, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19922038, Length=222, Percent_Identity=30.1801801801802, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 23283; Mature: 23151

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKLMAEFFGTFWLVFGGCGSAVLAAGVADVGIGWLGVSLAFGLTVMTMAYTVGHISGG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HFNPAVSLGLLIGGRFDGKDLLPYWAAQVAGAALAAAVLFMIVSGGARFEGVGGFASNGY
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AEASPQGYSLISVLVVEIVLTAFFLIIILGSTSSGAPAGFAPIAIGLGLTLIHLISIPVS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVALFAEGPAVTQLWLFWVAPLIGAAIGAAIWKLMTTDD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKKLMAEFFGTFWLVFGGCGSAVLAAGVADVGIGWLGVSLAFGLTVMTMAYTVGHISGG
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
HFNPAVSLGLLIGGRFDGKDLLPYWAAQVAGAALAAAVLFMIVSGGARFEGVGGFASNGY
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
AEASPQGYSLISVLVVEIVLTAFFLIIILGSTSSGAPAGFAPIAIGLGLTLIHLISIPVS
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
NTSVNPARSTGVALFAEGPAVTQLWLFWVAPLIGAAIGAAIWKLMTTDD
CCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11101683 [H]