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The map label for this gene is tktA [H]

Identifier: 110680181

GI number: 110680181

Start: 2857039

End: 2859084

Strand: Direct

Name: tktA [H]

Synonym: RD1_2982

Alternate gene names: 110680181

Gene position: 2857039-2859084 (Clockwise)

Preceding gene: 110680178

Following gene: 110680183

Centisome position: 69.13

GC content: 62.76

Gene sequence:

>2046_bases
GTGGATCTCAAAGCACGCGCCGCTGCGCACCCGGACCACTGGTCCAAAGCCAATGCAATTCGCGCACTGGCCCTGGACGC
CGTCGCCGCTGCGAATTCGGGCCACTCGGGCATGCCCATCGGGATGGCGGATGCAGCCACGGTTCTGTTCGAAAAACACC
TGAATTTCGATCCTACCGCCCCGAACTGGCCCGATCGTGACAGGTTCATCCTGTCGGCTGGCCATGGTTCCATGCTGCTT
TACGCGCTGCTGCACCTGACGGGCTACGAAGACATGACGCTGGAGCAGATCAAGAATTTCCGCCAGTGGGGCGCGATCAC
GGCCGGCCATCCGGAATATGGCCATGCCACCGGCATCGAGACGACAACCGGGCCCTTGGGACAGGGCATCTCCAACGCCG
TGGGCTTTGCCATGGCCGAAGAGATCCAGCGCGCGCACTATGGCAAGAAGGTCGTGGATCACTATACCTATGTCATCGCG
GGGGACGGCTGCCTGATGGAAGGTGTGAGCCAGGAGGCGATCACCCTTGCCGGGCGCCATCAACTGTCCAAGCTGGTTGT
GCTCTGGGACAACAACAACATCACCATCGACGGCCCCGTCAGCCTGTCGGACCGCACGGATCAGGTCGGACGTTTCGTTT
CTGCCGGCTGGGATGTGATCGAAATTGACGGCCATGACCCCGTGGAAATCGACGCCGCCCTCACGCGCGCCAAGAAGAAC
CAGAAACCGACGATGATTGCCTGCAAGACGCATATCGCGCTGGGGCACGCAGCGCAGGATACCTCGAAAGGGCACGGCGC
GCTGACCAATGCAGAGCAGAACACCGCCGCCAAGGCCGCATGGGGCTGGACAACCGGCCCGTTTGAAGTGCCCGATGCCG
TTCTGCAAAGCTGGCACGCCATCGGTGCGCGGGGCAAAGCCGCGCGCGAGGCGTGGGAAGCCCGCTTTGACAGCCTGCCC
CGCGGCAAGCGCGAGACGTTCAACCGCGCCTATGCGCTGGAGGTGCCCAAAAAGCTGAGCGCGACCGTCAAGGCGTTTAA
AAAGCAGATGTCAGAGGGCGCGCCCAAACTGGCCACCCGCGCAAGCTCCGAGAAAGTCTTGGAAGTCATCAATCCGATCA
TGCCCGAAACCGTTGGTGGATCGGCTGACCTGACCGGGTCCAACAACACCAAGACCAGCGATCTCGGCGTCTTTGACACC
GATAATCGCGGCGGGCGCTACGTTTACTGGGGCATTCGCGAACACGGTATGGCGGCGGCCATGAACGGCATGGCCCTGCA
TGGCGGTTTGCGGCCCTATGGCGGTACGTTCATGTGTTTCACGGATTACGCACGCCCCGCCATGCGTCTGGCCGCGCTGA
TGAAAATCCCGACGGTCTTTGTGATGACCCACGACAGCATCGGTCTGGGCGAGGACGGCCCCACCCACCAACCGGTGGAG
CATCTGGCGATCAGCCGGGCGACCCCCAACACCTATGTCTTCCGGCCCGCCGATACGATTGAAACCGCAGAAAGCTGGGA
GCTGGCCCTGTCGAGCAAAACCACGCCTTCGGTGCTCTCGCTGACACGGCAGGGCCTGCCGACAGTCCGCACCGAGCACA
AGACCCGCAATATGGTCGCGCAAGGCGCTTATGTGCTGGCAGATGCGGTTGGCAAACGACAGGCGATCCTGATGGCGACG
GGTTCGGAAGTATCACTGGCCATGGCAGCGCGCGATATTCTGCACGCCGAAGGGATCGGCACGCGGGTCGTGTCCATGCC
CTGCTGGGAGCTCTTTGAAGAGCAGGACGAGGCCCTGCGCAAACGTGTCCTGCCCGGCGGCCCGGTCCGCGTGGCAATTG
AAGCAGGCATCCGCATGGGCTGGGACCGCTGGCTCTTTGGCGAACGGGGCAAGCGCGAGAAATCAGGCTTCATCGGCATG
CATGACTTCGGGGCCTCCGCGCCTGCGGATGTTCTGTTCAAGGAACTGGGCATCACCGCCGAGGCCGCAGCGCAGAAAGT
GCGCGATCTTCTGGCGGGCAAATGGAAACCCGATACGCGCGTCTAG

Upstream 100 bases:

>100_bases
GCCCTTGATCTTTACGGGCGGACTGATATGCAACGCCCAACACTGACTGGAATAAAAACGTCCCGCATCGCGGGGTTACA
GCCGACAAAGGAAGCTCCTC

Downstream 100 bases:

>100_bases
AGCCTCTGACGAAATATCTGAAACATCACGTAACGCGTTGAAACCCTTGATTTCAGGCAGCGTTGCGTGACTAAGGTTTA
TCGCATGCCGCTTCAGCCGG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 681; Mature: 681

Protein sequence:

>681_residues
MDLKARAAAHPDHWSKANAIRALALDAVAAANSGHSGMPIGMADAATVLFEKHLNFDPTAPNWPDRDRFILSAGHGSMLL
YALLHLTGYEDMTLEQIKNFRQWGAITAGHPEYGHATGIETTTGPLGQGISNAVGFAMAEEIQRAHYGKKVVDHYTYVIA
GDGCLMEGVSQEAITLAGRHQLSKLVVLWDNNNITIDGPVSLSDRTDQVGRFVSAGWDVIEIDGHDPVEIDAALTRAKKN
QKPTMIACKTHIALGHAAQDTSKGHGALTNAEQNTAAKAAWGWTTGPFEVPDAVLQSWHAIGARGKAAREAWEARFDSLP
RGKRETFNRAYALEVPKKLSATVKAFKKQMSEGAPKLATRASSEKVLEVINPIMPETVGGSADLTGSNNTKTSDLGVFDT
DNRGGRYVYWGIREHGMAAAMNGMALHGGLRPYGGTFMCFTDYARPAMRLAALMKIPTVFVMTHDSIGLGEDGPTHQPVE
HLAISRATPNTYVFRPADTIETAESWELALSSKTTPSVLSLTRQGLPTVRTEHKTRNMVAQGAYVLADAVGKRQAILMAT
GSEVSLAMAARDILHAEGIGTRVVSMPCWELFEEQDEALRKRVLPGGPVRVAIEAGIRMGWDRWLFGERGKREKSGFIGM
HDFGASAPADVLFKELGITAEAAAQKVRDLLAGKWKPDTRV

Sequences:

>Translated_681_residues
MDLKARAAAHPDHWSKANAIRALALDAVAAANSGHSGMPIGMADAATVLFEKHLNFDPTAPNWPDRDRFILSAGHGSMLL
YALLHLTGYEDMTLEQIKNFRQWGAITAGHPEYGHATGIETTTGPLGQGISNAVGFAMAEEIQRAHYGKKVVDHYTYVIA
GDGCLMEGVSQEAITLAGRHQLSKLVVLWDNNNITIDGPVSLSDRTDQVGRFVSAGWDVIEIDGHDPVEIDAALTRAKKN
QKPTMIACKTHIALGHAAQDTSKGHGALTNAEQNTAAKAAWGWTTGPFEVPDAVLQSWHAIGARGKAAREAWEARFDSLP
RGKRETFNRAYALEVPKKLSATVKAFKKQMSEGAPKLATRASSEKVLEVINPIMPETVGGSADLTGSNNTKTSDLGVFDT
DNRGGRYVYWGIREHGMAAAMNGMALHGGLRPYGGTFMCFTDYARPAMRLAALMKIPTVFVMTHDSIGLGEDGPTHQPVE
HLAISRATPNTYVFRPADTIETAESWELALSSKTTPSVLSLTRQGLPTVRTEHKTRNMVAQGAYVLADAVGKRQAILMAT
GSEVSLAMAARDILHAEGIGTRVVSMPCWELFEEQDEALRKRVLPGGPVRVAIEAGIRMGWDRWLFGERGKREKSGFIGM
HDFGASAPADVLFKELGITAEAAAQKVRDLLAGKWKPDTRV
>Mature_681_residues
MDLKARAAAHPDHWSKANAIRALALDAVAAANSGHSGMPIGMADAATVLFEKHLNFDPTAPNWPDRDRFILSAGHGSMLL
YALLHLTGYEDMTLEQIKNFRQWGAITAGHPEYGHATGIETTTGPLGQGISNAVGFAMAEEIQRAHYGKKVVDHYTYVIA
GDGCLMEGVSQEAITLAGRHQLSKLVVLWDNNNITIDGPVSLSDRTDQVGRFVSAGWDVIEIDGHDPVEIDAALTRAKKN
QKPTMIACKTHIALGHAAQDTSKGHGALTNAEQNTAAKAAWGWTTGPFEVPDAVLQSWHAIGARGKAAREAWEARFDSLP
RGKRETFNRAYALEVPKKLSATVKAFKKQMSEGAPKLATRASSEKVLEVINPIMPETVGGSADLTGSNNTKTSDLGVFDT
DNRGGRYVYWGIREHGMAAAMNGMALHGGLRPYGGTFMCFTDYARPAMRLAALMKIPTVFVMTHDSIGLGEDGPTHQPVE
HLAISRATPNTYVFRPADTIETAESWELALSSKTTPSVLSLTRQGLPTVRTEHKTRNMVAQGAYVLADAVGKRQAILMAT
GSEVSLAMAARDILHAEGIGTRVVSMPCWELFEEQDEALRKRVLPGGPVRVAIEAGIRMGWDRWLFGERGKREKSGFIGM
HDFGASAPADVLFKELGITAEAAAQKVRDLLAGKWKPDTRV

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=674, Percent_Identity=25.6676557863501, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI4507521, Length=674, Percent_Identity=25.6676557863501, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI133778974, Length=574, Percent_Identity=25.9581881533101, Blast_Score=129, Evalue=1e-29,
Organism=Escherichia coli, GI48994911, Length=666, Percent_Identity=46.2462462462462, Blast_Score=567, Evalue=1e-163,
Organism=Escherichia coli, GI1788808, Length=668, Percent_Identity=45.3592814371257, Blast_Score=547, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI17539652, Length=579, Percent_Identity=26.0794473229706, Blast_Score=146, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6325331, Length=672, Percent_Identity=41.6666666666667, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6319593, Length=675, Percent_Identity=40.8888888888889, Blast_Score=452, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551847, Length=251, Percent_Identity=33.0677290836653, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550715, Length=251, Percent_Identity=33.0677290836653, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666278, Length=236, Percent_Identity=31.7796610169492, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24645119, Length=208, Percent_Identity=34.6153846153846, Blast_Score=96, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73683; Mature: 73683

Theoretical pI: Translated: 7.45; Mature: 7.45

Prosite motif: PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKARAAAHPDHWSKANAIRALALDAVAAANSGHSGMPIGMADAATVLFEKHLNFDPTA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
PNWPDRDRFILSAGHGSMLLYALLHLTGYEDMTLEQIKNFRQWGAITAGHPEYGHATGIE
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCC
TTTGPLGQGISNAVGFAMAEEIQRAHYGKKVVDHYTYVIAGDGCLMEGVSQEAITLAGRH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHCCCCHHHHHHHHHH
QLSKLVVLWDNNNITIDGPVSLSDRTDQVGRFVSAGWDVIEIDGHDPVEIDAALTRAKKN
CCEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCC
QKPTMIACKTHIALGHAAQDTSKGHGALTNAEQNTAAKAAWGWTTGPFEVPDAVLQSWHA
CCCCEEEEEEHEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHH
IGARGKAAREAWEARFDSLPRGKRETFNRAYALEVPKKLSATVKAFKKQMSEGAPKLATR
HCCCCHHHHHHHHHHHHCCCCCHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHH
ASSEKVLEVINPIMPETVGGSADLTGSNNTKTSDLGVFDTDNRGGRYVYWGIREHGMAAA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEHHHCCHHHH
MNGMALHGGLRPYGGTFMCFTDYARPAMRLAALMKIPTVFVMTHDSIGLGEDGPTHQPVE
HCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHH
HLAISRATPNTYVFRPADTIETAESWELALSSKTTPSVLSLTRQGLPTVRTEHKTRNMVA
HHHHCCCCCCCEEECCCCHHHCCCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
QGAYVLADAVGKRQAILMATGSEVSLAMAARDILHAEGIGTRVVSMPCWELFEEQDEALR
CCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
KRVLPGGPVRVAIEAGIRMGWDRWLFGERGKREKSGFIGMHDFGASAPADVLFKELGITA
HHCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCH
EAAAQKVRDLLAGKWKPDTRV
HHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MDLKARAAAHPDHWSKANAIRALALDAVAAANSGHSGMPIGMADAATVLFEKHLNFDPTA
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCC
PNWPDRDRFILSAGHGSMLLYALLHLTGYEDMTLEQIKNFRQWGAITAGHPEYGHATGIE
CCCCCCCCEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCEECCCCCCCCCCCCC
TTTGPLGQGISNAVGFAMAEEIQRAHYGKKVVDHYTYVIAGDGCLMEGVSQEAITLAGRH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCHHHCCCCHHHHHHHHHH
QLSKLVVLWDNNNITIDGPVSLSDRTDQVGRFVSAGWDVIEIDGHDPVEIDAALTRAKKN
CCEEEEEEECCCEEEEECCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHCC
QKPTMIACKTHIALGHAAQDTSKGHGALTNAEQNTAAKAAWGWTTGPFEVPDAVLQSWHA
CCCCEEEEEEHEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHH
IGARGKAAREAWEARFDSLPRGKRETFNRAYALEVPKKLSATVKAFKKQMSEGAPKLATR
HCCCCHHHHHHHHHHHHCCCCCHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCCCHHHHH
ASSEKVLEVINPIMPETVGGSADLTGSNNTKTSDLGVFDTDNRGGRYVYWGIREHGMAAA
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEEEEHHHCCHHHH
MNGMALHGGLRPYGGTFMCFTDYARPAMRLAALMKIPTVFVMTHDSIGLGEDGPTHQPVE
HCCEEEECCCCCCCCEEEEEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHH
HLAISRATPNTYVFRPADTIETAESWELALSSKTTPSVLSLTRQGLPTVRTEHKTRNMVA
HHHHCCCCCCCEEECCCCHHHCCCCCEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
QGAYVLADAVGKRQAILMATGSEVSLAMAARDILHAEGIGTRVVSMPCWELFEEQDEALR
CCHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHH
KRVLPGGPVRVAIEAGIRMGWDRWLFGERGKREKSGFIGMHDFGASAPADVLFKELGITA
HHCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCH
EAAAQKVRDLLAGKWKPDTRV
HHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8635754; 9256491 [H]