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The map label for this gene is cysH [H]

Identifier: 110680166

GI number: 110680166

Start: 2844809

End: 2845570

Strand: Direct

Name: cysH [H]

Synonym: RD1_2967

Alternate gene names: 110680166

Gene position: 2844809-2845570 (Clockwise)

Preceding gene: 110680165

Following gene: 110680167

Centisome position: 68.83

GC content: 61.55

Gene sequence:

>762_bases
ATGCCGCTTGATGAGGCGCAGCCTGTGGACCAGAGCGGCAGGCGCACAGATGAGTTGCAGGCGCTGGTGCAGGAGCTGAA
CACGCGCCTGCGCCATCATGGGGCGGTGGATGTGCTGCAAGTCGCTCTGGCCGAAATCACCCCGCTGAGCCTCGTGTCCA
GCTTTGGGGCGGAATCGGTGGCCTTGCTGCATCTGGCCTCCATGGTGGATCGCAACATACCGGTGATCTTTGTGGATACC
GAAATGCTGTTCACGCAGACGCTGGTCTATCAACAGGAACTTGCGGAGCGTCTGGGCCTGCGCAACCTGCGGATCGTGCG
CAGCGGTGATATCGCGCACCGCGACCCAACTGGCACAATGCACCGGCACGACCCGGACGGATGCTGTGCCTTGCGCAAAA
CCGAACCGCTGCAAAAGGCGCTTGTCGGCAGCAATGGCTGGATCACCGGGCGCAAACGCTATCAATCCGGCCAACGCGCA
GCACTTGAACACTTCGAGATCGAAGCGCAGACCGGCCGCATCAAGGTGAACCCGCTCGCCTATTGGCAAGCCGGAGACGT
GGCCGACTACATCACTGAAAACCGCCTGCCCCGGCACCCGCTGGTCGCACAAGGCTACCCATCCATCGGCTGTGCGCCCT
GTACCTCGCCAGTGCAAAGCGGCGAAGACGCGCGCGCCGGACGCTGGCGCAACACTGAAAAAGACGAATGCGGCATCCAT
TTTGTGAACGGCAAAGTGGTCCGCCAAGGAGATATGAAATGA

Upstream 100 bases:

>100_bases
CTTGAATTGCGCGACGCACCCGAAGAAACGTTCCTCGAAACCTATCGCCGCATCGGTCTGGCCCCCTTCAAGGCGGCCCT
TTATCCGGAGGTGCAGGCCG

Downstream 100 bases:

>100_bases
CTGTCATCGTAACCGATACGGGCTTTGCCCCGGACGACTGGACCGAGGGTTTTGTGGCCCTCGGCGCTGCCAATGACGCC
GAAGCGCTGGATGTGCCCTC

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MPLDEAQPVDQSGRRTDELQALVQELNTRLRHHGAVDVLQVALAEITPLSLVSSFGAESVALLHLASMVDRNIPVIFVDT
EMLFTQTLVYQQELAERLGLRNLRIVRSGDIAHRDPTGTMHRHDPDGCCALRKTEPLQKALVGSNGWITGRKRYQSGQRA
ALEHFEIEAQTGRIKVNPLAYWQAGDVADYITENRLPRHPLVAQGYPSIGCAPCTSPVQSGEDARAGRWRNTEKDECGIH
FVNGKVVRQGDMK

Sequences:

>Translated_253_residues
MPLDEAQPVDQSGRRTDELQALVQELNTRLRHHGAVDVLQVALAEITPLSLVSSFGAESVALLHLASMVDRNIPVIFVDT
EMLFTQTLVYQQELAERLGLRNLRIVRSGDIAHRDPTGTMHRHDPDGCCALRKTEPLQKALVGSNGWITGRKRYQSGQRA
ALEHFEIEAQTGRIKVNPLAYWQAGDVADYITENRLPRHPLVAQGYPSIGCAPCTSPVQSGEDARAGRWRNTEKDECGIH
FVNGKVVRQGDMK
>Mature_252_residues
PLDEAQPVDQSGRRTDELQALVQELNTRLRHHGAVDVLQVALAEITPLSLVSSFGAESVALLHLASMVDRNIPVIFVDTE
MLFTQTLVYQQELAERLGLRNLRIVRSGDIAHRDPTGTMHRHDPDGCCALRKTEPLQKALVGSNGWITGRKRYQSGQRAA
LEHFEIEAQTGRIKVNPLAYWQAGDVADYITENRLPRHPLVAQGYPSIGCAPCTSPVQSGEDARAGRWRNTEKDECGIHF
VNGKVVRQGDMK

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=197, Percent_Identity=32.994923857868, Blast_Score=92, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6325425, Length=231, Percent_Identity=28.1385281385281, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 28107; Mature: 27976

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLDEAQPVDQSGRRTDELQALVQELNTRLRHHGAVDVLQVALAEITPLSLVSSFGAESV
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCHHH
ALLHLASMVDRNIPVIFVDTEMLFTQTLVYQQELAERLGLRNLRIVRSGDIAHRDPTGTM
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
HRHDPDGCCALRKTEPLQKALVGSNGWITGRKRYQSGQRAALEHFEIEAQTGRIKVNPLA
CCCCCCCCEECCCCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHEEEECCCEEEECEEE
YWQAGDVADYITENRLPRHPLVAQGYPSIGCAPCTSPVQSGEDARAGRWRNTEKDECGIH
EECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEE
FVNGKVVRQGDMK
EECCEEEECCCCC
>Mature Secondary Structure 
PLDEAQPVDQSGRRTDELQALVQELNTRLRHHGAVDVLQVALAEITPLSLVSSFGAESV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCHHH
ALLHLASMVDRNIPVIFVDTEMLFTQTLVYQQELAERLGLRNLRIVRSGDIAHRDPTGTM
HHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCC
HRHDPDGCCALRKTEPLQKALVGSNGWITGRKRYQSGQRAALEHFEIEAQTGRIKVNPLA
CCCCCCCCEECCCCCHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHEEEECCCEEEECEEE
YWQAGDVADYITENRLPRHPLVAQGYPSIGCAPCTSPVQSGEDARAGRWRNTEKDECGIH
EECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCEE
FVNGKVVRQGDMK
EECCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]