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The map label for this gene is cysG [H]

Identifier: 110680163

GI number: 110680163

Start: 2841430

End: 2842857

Strand: Direct

Name: cysG [H]

Synonym: RD1_2964

Alternate gene names: 110680163

Gene position: 2841430-2842857 (Clockwise)

Preceding gene: 110680161

Following gene: 110680164

Centisome position: 68.75

GC content: 63.94

Gene sequence:

>1428_bases
ATGGATCATTTCCCTGTTTTCCTGCGTGTGCACGGGCGCCGCATTGTGGTGTCAGGCGGCGGAGAGGCCGCGTTGGCAAA
ACTGCGCCTGCTGCTCAAGACCACCGGGCATATCAACGTCTTTGCCCAAAACCCAGCGCCCGAAATTCAGAAATGGGCGG
CAGAGGGCAAGCTGACGCTGTTCAACCGGGCCATGGCACCGGGTGATGCGCTCTGTGCCGCCTTGTTTTACGCCGCGGAT
GAGGATGACGCCGAGGACGCCCGCACCTCAGCAATTGCGCGGGCCGATGGCGCGCTGGTGAACATCGTGGACAATCTGCA
GGACAGTCAATTCATCACCCCCGCCATTGTGGACCGCGACCCGGTCACCGTTGCAATCGGGACAGAAGGCGCGGCCCCGG
TTCTGGCCCGTTCGATCAAGGCTGATCTGGAAAGCCGCCTTCCGGTTGCGCTGGGGCCACTGGCAAGGATCGGCAAAACC
TTTCGCAAGGCCGCCGATGCGCTGCCCTTTGGCCGCGCACGGCGCGACTTCTGGCGCGCGTTTTACTTTGAAACCGGTCC
CAAAGCGATCAAACAGGGCGAAGCCGCCGTGCGCCAAGGGCTGGACGGCCTGCTTGACGATCACCTGAACCGCAAGGCGC
GCCCGGGTCACGTGCATTTCATCGGGGCGGGTCCGGGCGATCCGGATCTGCTGACGCTGAAGGCGCGGCGCGCCCTCGAT
GAGGCGGATGTGGTGATCCATGACCGCCTGATCAGCCAGCCCATACTTGAACTGGCCCGCCGGGAAGCCATCATGATCGA
CGCTGGCAAGGAAGGCTTCGGCCCCTCCACCCCGCAAGAGGACATCAACGCGCTGCTGGTGCAACACGCGCGCAGCGGGG
CGCAGGTCGTCCGGCTCAAATCCGGCGATGCCACCGTCTTCGGGCGGTTGGACGAAGAGATCGACGCAGTTGACGCGCAT
CAGATCAGTTGGGAGATCGTGCCCGGAATCACCGCTGCCTCGGCAGCCGTGGCCGCCATCGGCCAGAGCCTCACCAAGCG
GGGGCGCAATTCCTCGGTGCGCTTACTGACCGGACATAACATCGCCGGCTTTGCCGATCATGACTGGGCTGCACTTGCCC
GTCCGGGCGAAGTCGCCGCGATCTACATGGGCAAGAAATCCGCGCGTTTCATGCAAGGGCGGCTGATCATGCATGGTGCG
GATCGGCACACCCCCGTGACCCTTGTCGAAAACGCCTCCCGCCCAGAACAGAGGATCATCGAAACAACGCTCGATGCGCT
TCCCGCAGCGCTGTCGGCGGCAGAAATGTCCGGCCCTGCCCTGACATTTTACGGATTACCCAAACGCAAAGCAGCACGCG
CCGCTGCGGACCTCGCGCCCGCGCTCAACACGGCCACGCGCCCCACACATGCACAGGAGGCTTTCTGA

Upstream 100 bases:

>100_bases
CTCCCTGCATAAATAGAACATTTGTTCTTATCAAGCGGCGCATATGGTAAAAATTCAGAATTATATTCTATATTGTCCTC
AAGAAGTTTGAGGTACCCCC

Downstream 100 bases:

>100_bases
TGCCCAAAGCATTCACGCCCAAAGTCGTCACCGCAAACCATTTGCTCAAAGGTGACGTCATTTATCAGACCGCCACTGGA
TGGACCCGCGATCTGGCCGA

Product: siroheme synthase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MDHFPVFLRVHGRRIVVSGGGEAALAKLRLLLKTTGHINVFAQNPAPEIQKWAAEGKLTLFNRAMAPGDALCAALFYAAD
EDDAEDARTSAIARADGALVNIVDNLQDSQFITPAIVDRDPVTVAIGTEGAAPVLARSIKADLESRLPVALGPLARIGKT
FRKAADALPFGRARRDFWRAFYFETGPKAIKQGEAAVRQGLDGLLDDHLNRKARPGHVHFIGAGPGDPDLLTLKARRALD
EADVVIHDRLISQPILELARREAIMIDAGKEGFGPSTPQEDINALLVQHARSGAQVVRLKSGDATVFGRLDEEIDAVDAH
QISWEIVPGITAASAAVAAIGQSLTKRGRNSSVRLLTGHNIAGFADHDWAALARPGEVAAIYMGKKSARFMQGRLIMHGA
DRHTPVTLVENASRPEQRIIETTLDALPAALSAAEMSGPALTFYGLPKRKAARAAADLAPALNTATRPTHAQEAF

Sequences:

>Translated_475_residues
MDHFPVFLRVHGRRIVVSGGGEAALAKLRLLLKTTGHINVFAQNPAPEIQKWAAEGKLTLFNRAMAPGDALCAALFYAAD
EDDAEDARTSAIARADGALVNIVDNLQDSQFITPAIVDRDPVTVAIGTEGAAPVLARSIKADLESRLPVALGPLARIGKT
FRKAADALPFGRARRDFWRAFYFETGPKAIKQGEAAVRQGLDGLLDDHLNRKARPGHVHFIGAGPGDPDLLTLKARRALD
EADVVIHDRLISQPILELARREAIMIDAGKEGFGPSTPQEDINALLVQHARSGAQVVRLKSGDATVFGRLDEEIDAVDAH
QISWEIVPGITAASAAVAAIGQSLTKRGRNSSVRLLTGHNIAGFADHDWAALARPGEVAAIYMGKKSARFMQGRLIMHGA
DRHTPVTLVENASRPEQRIIETTLDALPAALSAAEMSGPALTFYGLPKRKAARAAADLAPALNTATRPTHAQEAF
>Mature_475_residues
MDHFPVFLRVHGRRIVVSGGGEAALAKLRLLLKTTGHINVFAQNPAPEIQKWAAEGKLTLFNRAMAPGDALCAALFYAAD
EDDAEDARTSAIARADGALVNIVDNLQDSQFITPAIVDRDPVTVAIGTEGAAPVLARSIKADLESRLPVALGPLARIGKT
FRKAADALPFGRARRDFWRAFYFETGPKAIKQGEAAVRQGLDGLLDDHLNRKARPGHVHFIGAGPGDPDLLTLKARRALD
EADVVIHDRLISQPILELARREAIMIDAGKEGFGPSTPQEDINALLVQHARSGAQVVRLKSGDATVFGRLDEEIDAVDAH
QISWEIVPGITAASAAVAAIGQSLTKRGRNSSVRLLTGHNIAGFADHDWAALARPGEVAAIYMGKKSARFMQGRLIMHGA
DRHTPVTLVENASRPEQRIIETTLDALPAALSAAEMSGPALTFYGLPKRKAARAAADLAPALNTATRPTHAQEAF

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=448, Percent_Identity=37.2767857142857, Blast_Score=271, Evalue=5e-74,
Organism=Saccharomyces cerevisiae, GI6322922, Length=270, Percent_Identity=25.5555555555556, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 50815; Mature: 50815

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHFPVFLRVHGRRIVVSGGGEAALAKLRLLLKTTGHINVFAQNPAPEIQKWAAEGKLTL
CCCCEEEEEEECEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCEEE
FNRAMAPGDALCAALFYAADEDDAEDARTSAIARADGALVNIVDNLQDSQFITPAIVDRD
ECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCCEEECCC
PVTVAIGTEGAAPVLARSIKADLESRLPVALGPLARIGKTFRKAADALPFGRARRDFWRA
CEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FYFETGPKAIKQGEAAVRQGLDGLLDDHLNRKARPGHVHFIGAGPGDPDLLTLKARRALD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEHHHHCCC
EADVVIHDRLISQPILELARREAIMIDAGKEGFGPSTPQEDINALLVQHARSGAQVVRLK
CCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEE
SGDATVFGRLDEEIDAVDAHQISWEIVPGITAASAAVAAIGQSLTKRGRNSSVRLLTGHN
CCCEEEEECCCHHHCCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
IAGFADHDWAALARPGEVAAIYMGKKSARFMQGRLIMHGADRHTPVTLVENASRPEQRII
CCCCCCCCHHHHCCCCCEEEEEECCCCHHHHHCEEEEECCCCCCCEEEEECCCCHHHHHH
ETTLDALPAALSAAEMSGPALTFYGLPKRKAARAAADLAPALNTATRPTHAQEAF
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MDHFPVFLRVHGRRIVVSGGGEAALAKLRLLLKTTGHINVFAQNPAPEIQKWAAEGKLTL
CCCCEEEEEEECEEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCEEE
FNRAMAPGDALCAALFYAADEDDAEDARTSAIARADGALVNIVDNLQDSQFITPAIVDRD
ECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEHHCCCCCCCCCCEEECCC
PVTVAIGTEGAAPVLARSIKADLESRLPVALGPLARIGKTFRKAADALPFGRARRDFWRA
CEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
FYFETGPKAIKQGEAAVRQGLDGLLDDHLNRKARPGHVHFIGAGPGDPDLLTLKARRALD
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEHHHHCCC
EADVVIHDRLISQPILELARREAIMIDAGKEGFGPSTPQEDINALLVQHARSGAQVVRLK
CCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEE
SGDATVFGRLDEEIDAVDAHQISWEIVPGITAASAAVAAIGQSLTKRGRNSSVRLLTGHN
CCCEEEEECCCHHHCCCCHHEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
IAGFADHDWAALARPGEVAAIYMGKKSARFMQGRLIMHGADRHTPVTLVENASRPEQRII
CCCCCCCCHHHHCCCCCEEEEEECCCCHHHHHCEEEEECCCCCCCEEEEECCCCHHHHHH
ETTLDALPAALSAAEMSGPALTFYGLPKRKAARAAADLAPALNTATRPTHAQEAF
HHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA