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The map label for this gene is edd [H]

Identifier: 110680084

GI number: 110680084

Start: 2755689

End: 2757494

Strand: Reverse

Name: edd [H]

Synonym: RD1_2879

Alternate gene names: 110680084

Gene position: 2757494-2755689 (Counterclockwise)

Preceding gene: 110680085

Following gene: 110680083

Centisome position: 66.72

GC content: 61.57

Gene sequence:

>1806_bases
ATGCCCCTGAACGAGACGATTGATCGCGTCACCCGGCGCATTATCGAACGCAGCAAAGGCCCCCGTGGAGAGTATCTGGA
CCGTATGAACGCCGCACGGGTCAAGGGCCCGGCGCGCGCACATCTGAGCTGTAGCGGTCAGGCGCATGCCTATGCGGGCG
CGGGACAGGATCAGGCCAAGCTGGCCCATGAAACGGCGGGCAATCTGGGGATCGTCACCACCTATAATGACATGCTTTCC
GCGCATCAGCCTTTCGAGCGTTTTCCCGATCTGATCCGCGAAGCCGCGCGCGAGGCAGGCGGGACCGCACAGGTGGCAGG
CGGTGTTCCGGCCATGTGTGACGGCGTGACACAGGGCGAGCCGGGCATGGAACTCAGCCTGTTTTCGCGCGATGTTATTG
CCATGGCGACCTCTGTCGCGATGAGCCACAACACCTTTGATGCGGCGGTCTATCTGGGTGTCTGTGACAAAATCGTGCCC
GGTCTTGTGATCGCGGCGCAGACCTTCGGTCACGTGCCCACCGTGTTCCTGCCAGCGGGTCCCATGACCTCGGGTCTGTC
CAATGACGAAAAAAGCACCGTGCGTCAGAAATTTGCTGCCGGGGAAGTGGGCCGCGCGGAATTAATGAAAGCCGAGATGG
GCGCCTATCACGGGCCGGGCACCTGCACATTCTACGGCACGGCCAATACCAACCAGATGCTGATGGAATTCATGGGGCTG
CATTTGCCGGGCACCAGCTTTGTGACACCGAATACAGGCCTGCGCGATGCGCTGACCAAAGCGGGTGCACAGCGTGCGCT
GGCTCTGTCTGATCTGGGCGACAGCTACACGCCGGTCTGCGATATCCTGACGGAAAAGGCCTTCGTCAATGGTATCGTCG
GGTTGAATGCAACCGGCGGTTCGACCAATCTGCTGATCCACCTGGTGGCGATGGCCCGGGCCGGTGGGATCATTCTGGAC
TGGCAGGATTTTTCGGATATTTCGGATGTGACGCCGCTGCTGGCACGGGTGTATCCCAACGGTCTGGCGGATGTGAACCA
TTTCCATGCGGCGGGGGGGCTCGGCTACATGATCCGCGAACTACTCGGGGCCGGATTGCTGCACGGCGATACAAAAACCG
TCGCGGGCGGCGGGCTGGAGCTTTACACGCAGGAGCCAAAGCTGATCGAGGGCGAGGTCGTCTGGGAACAGGGAACCACC
GAAAGCCTGAACATGAAGATCGTGCGCCCTGCAGCGGACCCGTTTCAGGCGACAGGAGGTCTCAAACGGCTGTCCGGCTC
CTTGGGCAATGCGGTGATCAAGGCGTCGGCGGTCAAACCGGAACACCAGATTGTCGAGGCACCGGTGCGCGTCTTCCATG
ATCAGGAGACGGTCAAGAATGCCTGCCGGGCGGGTGAAATCACGCAGGATACCGTGATTGTCGTGCGCTTTCAGGGACCC
AAGGCCAATGGCATGCCCGAATTGCACAGCCTGACGCCCGCCTTGAAAAACCTGCAGGCCAAAGGGCTGAACGTGGCTCT
TGTTACGGATGGGCGGATGTCCGGTGCCTCGGGCTCCGTGCCTGCGGCGATCCACGTCAGCCCCGAGGCGCTGGATGGCG
GCGCGATTGCGAAGCTGCGCGACGGGGATATTGTGCGCGTGGATGCGATTGCCGGAGTGCTTGAAATCCTGACGGATGGC
GTGTTGGATCGGGCGGTTGCACAGGCTGATCTGTCGGCGAATGAATTCGGTCTCGGGCGCGAGTTGTTTGCCAATTTCCG
CCGCCAGGTGGGATCGGCAGATACCGGTGCCTGCGCGCTGTTCTAG

Upstream 100 bases:

>100_bases
TGCCAATCGCATGATCGATACTGGACGCAAACTGGCGACACTGGCCAAAAGCTGACCTGAGCCGGTCCGTTTGAACGTCA
CAGCCATTGGAGAAAGCGAC

Downstream 100 bases:

>100_bases
GAAAGGAAAACACAGATGACCCCTCAAGACGCAAGCAGACGCGCCCGCGACATCTGCGGCATGGCACCAATTGTCCCGGT
ATTGGTCGTGGAAGATGCCA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MPLNETIDRVTRRIIERSKGPRGEYLDRMNAARVKGPARAHLSCSGQAHAYAGAGQDQAKLAHETAGNLGIVTTYNDMLS
AHQPFERFPDLIREAAREAGGTAQVAGGVPAMCDGVTQGEPGMELSLFSRDVIAMATSVAMSHNTFDAAVYLGVCDKIVP
GLVIAAQTFGHVPTVFLPAGPMTSGLSNDEKSTVRQKFAAGEVGRAELMKAEMGAYHGPGTCTFYGTANTNQMLMEFMGL
HLPGTSFVTPNTGLRDALTKAGAQRALALSDLGDSYTPVCDILTEKAFVNGIVGLNATGGSTNLLIHLVAMARAGGIILD
WQDFSDISDVTPLLARVYPNGLADVNHFHAAGGLGYMIRELLGAGLLHGDTKTVAGGGLELYTQEPKLIEGEVVWEQGTT
ESLNMKIVRPAADPFQATGGLKRLSGSLGNAVIKASAVKPEHQIVEAPVRVFHDQETVKNACRAGEITQDTVIVVRFQGP
KANGMPELHSLTPALKNLQAKGLNVALVTDGRMSGASGSVPAAIHVSPEALDGGAIAKLRDGDIVRVDAIAGVLEILTDG
VLDRAVAQADLSANEFGLGRELFANFRRQVGSADTGACALF

Sequences:

>Translated_601_residues
MPLNETIDRVTRRIIERSKGPRGEYLDRMNAARVKGPARAHLSCSGQAHAYAGAGQDQAKLAHETAGNLGIVTTYNDMLS
AHQPFERFPDLIREAAREAGGTAQVAGGVPAMCDGVTQGEPGMELSLFSRDVIAMATSVAMSHNTFDAAVYLGVCDKIVP
GLVIAAQTFGHVPTVFLPAGPMTSGLSNDEKSTVRQKFAAGEVGRAELMKAEMGAYHGPGTCTFYGTANTNQMLMEFMGL
HLPGTSFVTPNTGLRDALTKAGAQRALALSDLGDSYTPVCDILTEKAFVNGIVGLNATGGSTNLLIHLVAMARAGGIILD
WQDFSDISDVTPLLARVYPNGLADVNHFHAAGGLGYMIRELLGAGLLHGDTKTVAGGGLELYTQEPKLIEGEVVWEQGTT
ESLNMKIVRPAADPFQATGGLKRLSGSLGNAVIKASAVKPEHQIVEAPVRVFHDQETVKNACRAGEITQDTVIVVRFQGP
KANGMPELHSLTPALKNLQAKGLNVALVTDGRMSGASGSVPAAIHVSPEALDGGAIAKLRDGDIVRVDAIAGVLEILTDG
VLDRAVAQADLSANEFGLGRELFANFRRQVGSADTGACALF
>Mature_600_residues
PLNETIDRVTRRIIERSKGPRGEYLDRMNAARVKGPARAHLSCSGQAHAYAGAGQDQAKLAHETAGNLGIVTTYNDMLSA
HQPFERFPDLIREAAREAGGTAQVAGGVPAMCDGVTQGEPGMELSLFSRDVIAMATSVAMSHNTFDAAVYLGVCDKIVPG
LVIAAQTFGHVPTVFLPAGPMTSGLSNDEKSTVRQKFAAGEVGRAELMKAEMGAYHGPGTCTFYGTANTNQMLMEFMGLH
LPGTSFVTPNTGLRDALTKAGAQRALALSDLGDSYTPVCDILTEKAFVNGIVGLNATGGSTNLLIHLVAMARAGGIILDW
QDFSDISDVTPLLARVYPNGLADVNHFHAAGGLGYMIRELLGAGLLHGDTKTVAGGGLELYTQEPKLIEGEVVWEQGTTE
SLNMKIVRPAADPFQATGGLKRLSGSLGNAVIKASAVKPEHQIVEAPVRVFHDQETVKNACRAGEITQDTVIVVRFQGPK
ANGMPELHSLTPALKNLQAKGLNVALVTDGRMSGASGSVPAAIHVSPEALDGGAIAKLRDGDIVRVDAIAGVLEILTDGV
LDRAVAQADLSANEFGLGRELFANFRRQVGSADTGACALF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=55.3897180762852, Blast_Score=672, Evalue=0.0,
Organism=Escherichia coli, GI1786464, Length=460, Percent_Identity=34.3478260869565, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI48994964, Length=519, Percent_Identity=27.9383429672447, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI2367371, Length=459, Percent_Identity=33.1154684095861, Blast_Score=164, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6322476, Length=507, Percent_Identity=32.741617357002, Blast_Score=192, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 63114; Mature: 62982

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLNETIDRVTRRIIERSKGPRGEYLDRMNAARVKGPARAHLSCSGQAHAYAGAGQDQAK
CCCHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCCCCEEEEECCCCCEECCCCCHHHH
LAHETAGNLGIVTTYNDMLSAHQPFERFPDLIREAAREAGGTAQVAGGVPAMCDGVTQGE
HHHHCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCC
PGMELSLFSRDVIAMATSVAMSHNTFDAAVYLGVCDKIVPGLVIAAQTFGHVPTVFLPAG
CCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
PMTSGLSNDEKSTVRQKFAAGEVGRAELMKAEMGAYHGPGTCTFYGTANTNQMLMEFMGL
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCC
HLPGTSFVTPNTGLRDALTKAGAQRALALSDLGDSYTPVCDILTEKAFVNGIVGLNATGG
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEECCCCC
STNLLIHLVAMARAGGIILDWQDFSDISDVTPLLARVYPNGLADVNHFHAAGGLGYMIRE
CHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHH
LLGAGLLHGDTKTVAGGGLELYTQEPKLIEGEVVWEQGTTESLNMKIVRPAADPFQATGG
HHCCCEECCCCCEECCCCEEEEECCCCEEECEEEECCCCCCCCCEEEECCCCCCHHHCCC
LKRLSGSLGNAVIKASAVKPEHQIVEAPVRVFHDQETVKNACRAGEITQDTVIVVRFQGP
HHHHHCHHCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCC
KANGMPELHSLTPALKNLQAKGLNVALVTDGRMSGASGSVPAAIHVSPEALDGGAIAKLR
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEC
DGDIVRVDAIAGVLEILTDGVLDRAVAQADLSANEFGLGRELFANFRRQVGSADTGACAL
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEC
F
C
>Mature Secondary Structure 
PLNETIDRVTRRIIERSKGPRGEYLDRMNAARVKGPARAHLSCSGQAHAYAGAGQDQAK
CCHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHCCCCCCEEEEECCCCCEECCCCCHHHH
LAHETAGNLGIVTTYNDMLSAHQPFERFPDLIREAAREAGGTAQVAGGVPAMCDGVTQGE
HHHHCCCCEEEEEECHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCCC
PGMELSLFSRDVIAMATSVAMSHNTFDAAVYLGVCDKIVPGLVIAAQTFGHVPTVFLPAG
CCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
PMTSGLSNDEKSTVRQKFAAGEVGRAELMKAEMGAYHGPGTCTFYGTANTNQMLMEFMGL
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHCC
HLPGTSFVTPNTGLRDALTKAGAQRALALSDLGDSYTPVCDILTEKAFVNGIVGLNATGG
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCEEEECCCCC
STNLLIHLVAMARAGGIILDWQDFSDISDVTPLLARVYPNGLADVNHFHAAGGLGYMIRE
CHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHH
LLGAGLLHGDTKTVAGGGLELYTQEPKLIEGEVVWEQGTTESLNMKIVRPAADPFQATGG
HHCCCEECCCCCEECCCCEEEEECCCCEEECEEEECCCCCCCCCEEEECCCCCCHHHCCC
LKRLSGSLGNAVIKASAVKPEHQIVEAPVRVFHDQETVKNACRAGEITQDTVIVVRFQGP
HHHHHCHHCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEEECCC
KANGMPELHSLTPALKNLQAKGLNVALVTDGRMSGASGSVPAAIHVSPEALDGGAIAKLR
CCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEC
DGDIVRVDAIAGVLEILTDGVLDRAVAQADLSANEFGLGRELFANFRRQVGSADTGACAL
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEC
F
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]