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The map label for this gene is phr [H]

Identifier: 110680064

GI number: 110680064

Start: 2727412

End: 2728818

Strand: Direct

Name: phr [H]

Synonym: RD1_2859

Alternate gene names: 110680064

Gene position: 2727412-2728818 (Clockwise)

Preceding gene: 110680057

Following gene: 110680067

Centisome position: 65.99

GC content: 59.28

Gene sequence:

>1407_bases
TTGCTCCACGACCATGGGAACAAGGTTCATGTAGGTTTCAATCGGATCTTTCATGTGGAATGCCTGTCTGCTGCGTCGTT
GTCAGGACCATACCTGCGAACGGTTGACAGAACATTAGTGTTGGCGCGCAGGAGCCGCAAGGGGGGCTGCACAACTTTGG
GTTCCGCTGTTGACCTGCGTTCCCGCAAGCCTAAGTCGCGCCAGATGTCACAGCTATTTCCCCCCTCGCATCGTGCTGCG
CTTGAGCGGCTCACGGCTTTCGTTCCCAAAGCGGGGCGCGATTACGCGGCGCGCAGAAACTATGACCTTGGCCCGGGAAA
TCACACGCATGTGTCGACCCTATCACCCTACCTGCGCTGTCGGCTGATCACTGAAAGTGAAGTCGTCAATGCCGTCTTGC
ACCGCCACAGCCCGGCGGCTGCGGAAAAATTCGTGCAGGAGGTTTTCTGGCGTACCTATTGGAAAGGCTGGCTTGAACTG
CGCCCGGCGGTCTGGACGCAGTATCAGATGGCCCTCGATCAGGCGTGGAATGATGTCCAGACACAGGCAGGTCTGCGTGC
GCGCTGGGAAAACGCCTGTCGTGGCGAGACGGGGATCCACTGTTTCGATGCATGGGCGCGCGAGTTGGTCGAGACGGGAT
ACCTGCACAATCACGCCCGGATGTGGTTTGCATCCATCTGGATTTTCACGCTTGAATTGCCATGGGAACTGGGCGCGGAT
TTCTTTCTGCGGCATCTGCTCGACGGGGATCCGGCGTCAAACACATTGGGCTGGCGGTGGGTGGCTGGCATCCAGACCCA
AGGCAAAACCTATCTGGCCCGTACGAGCAATATATCGAAATTTACCGAAAATCGGTTTCACCCCAAGTGGCAACTGGCTG
GCGAAGCCATTCCGCGCCATGCCCCCCTGCCCCCGGAACCCCGCAGTTTACCGGCAGGGGATGCGTTTGATCCTGCACTG
CGCACCGGTTTCCTGCTGCATGAAGAAGACCTCAGCCCCGGCTTTTTCCTCAACATGGTTGACCCGCATGCCTGCGGTGT
CCTGCAGCCTCAAACCAAACTCGGCCCCCTGGAAAGCGCGCCCCACATCGCCGCTTTTCGCAGCGCGGCACTGGATGATG
TGACGACCCGCTGGAGCGAGCGTCTGGGCCCGCAGGCACCGTTGACTTCGCACAGCGATGTTGAGGCCTGGGCCAAGGCG
CAAAACCTTGAGCAGATCGTGACGCCCTATGCGCCGGTCGGACCCGTTGCCACACTGCTGGCGCAGGCGTCAAAATCCGA
TCACACACCGCCGATCATCCAACTGATGCGCCCCTATGACCGAATGACCTGGCCCCATGCAACCCGTGGGTTTTTTCCGT
TCAAAAAGAAACTGCCAACCTTCATCGCCGATATTCAGGCCGCGTGA

Upstream 100 bases:

>100_bases
TCAGCGACGACATGCCGTCATGCACAGGGCCGTTCAGAAAGATGATCCGCTCCTTCAGGAGGCGTGAGAAAATGTCATAT
GCACGCTCGCCCCTGCTGGT

Downstream 100 bases:

>100_bases
GTGCCAAAGAGGATGCACAGTCGCATTACACCAGGCGCGCCGTTTTCTCTCGGCATCATGCGGGCCTGAACAGCGCCGTG
GTCAATCACTTTTGCGGATT

Product: deoxyribodipyrimidine photo-lyase, putative

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MLHDHGNKVHVGFNRIFHVECLSAASLSGPYLRTVDRTLVLARRSRKGGCTTLGSAVDLRSRKPKSRQMSQLFPPSHRAA
LERLTAFVPKAGRDYAARRNYDLGPGNHTHVSTLSPYLRCRLITESEVVNAVLHRHSPAAAEKFVQEVFWRTYWKGWLEL
RPAVWTQYQMALDQAWNDVQTQAGLRARWENACRGETGIHCFDAWARELVETGYLHNHARMWFASIWIFTLELPWELGAD
FFLRHLLDGDPASNTLGWRWVAGIQTQGKTYLARTSNISKFTENRFHPKWQLAGEAIPRHAPLPPEPRSLPAGDAFDPAL
RTGFLLHEEDLSPGFFLNMVDPHACGVLQPQTKLGPLESAPHIAAFRSAALDDVTTRWSERLGPQAPLTSHSDVEAWAKA
QNLEQIVTPYAPVGPVATLLAQASKSDHTPPIIQLMRPYDRMTWPHATRGFFPFKKKLPTFIADIQAA

Sequences:

>Translated_468_residues
MLHDHGNKVHVGFNRIFHVECLSAASLSGPYLRTVDRTLVLARRSRKGGCTTLGSAVDLRSRKPKSRQMSQLFPPSHRAA
LERLTAFVPKAGRDYAARRNYDLGPGNHTHVSTLSPYLRCRLITESEVVNAVLHRHSPAAAEKFVQEVFWRTYWKGWLEL
RPAVWTQYQMALDQAWNDVQTQAGLRARWENACRGETGIHCFDAWARELVETGYLHNHARMWFASIWIFTLELPWELGAD
FFLRHLLDGDPASNTLGWRWVAGIQTQGKTYLARTSNISKFTENRFHPKWQLAGEAIPRHAPLPPEPRSLPAGDAFDPAL
RTGFLLHEEDLSPGFFLNMVDPHACGVLQPQTKLGPLESAPHIAAFRSAALDDVTTRWSERLGPQAPLTSHSDVEAWAKA
QNLEQIVTPYAPVGPVATLLAQASKSDHTPPIIQLMRPYDRMTWPHATRGFFPFKKKLPTFIADIQAA
>Mature_468_residues
MLHDHGNKVHVGFNRIFHVECLSAASLSGPYLRTVDRTLVLARRSRKGGCTTLGSAVDLRSRKPKSRQMSQLFPPSHRAA
LERLTAFVPKAGRDYAARRNYDLGPGNHTHVSTLSPYLRCRLITESEVVNAVLHRHSPAAAEKFVQEVFWRTYWKGWLEL
RPAVWTQYQMALDQAWNDVQTQAGLRARWENACRGETGIHCFDAWARELVETGYLHNHARMWFASIWIFTLELPWELGAD
FFLRHLLDGDPASNTLGWRWVAGIQTQGKTYLARTSNISKFTENRFHPKWQLAGEAIPRHAPLPPEPRSLPAGDAFDPAL
RTGFLLHEEDLSPGFFLNMVDPHACGVLQPQTKLGPLESAPHIAAFRSAALDDVTTRWSERLGPQAPLTSHSDVEAWAKA
QNLEQIVTPYAPVGPVATLLAQASKSDHTPPIIQLMRPYDRMTWPHATRGFFPFKKKLPTFIADIQAA

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Escherichia coli, GI1786926, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324962, Length=240, Percent_Identity=26.25, Blast_Score=80, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 52788; Mature: 52788

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHDHGNKVHVGFNRIFHVECLSAASLSGPYLRTVDRTLVLARRSRKGGCTTLGSAVDLR
CCCCCCCEEEECHHHEEEEHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHH
SRKPKSRQMSQLFPPSHRAALERLTAFVPKAGRDYAARRNYDLGPGNHTHVSTLSPYLRC
CCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCEE
RLITESEVVNAVLHRHSPAAAEKFVQEVFWRTYWKGWLELRPAVWTQYQMALDQAWNDVQ
EEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TQAGLRARWENACRGETGIHCFDAWARELVETGYLHNHARMWFASIWIFTLELPWELGAD
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHEEECCHHHCHH
FFLRHLLDGDPASNTLGWRWVAGIQTQGKTYLARTSNISKFTENRFHPKWQLAGEAIPRH
HHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHCCCCCCHHHCCCCCCCC
APLPPEPRSLPAGDAFDPALRTGFLLHEEDLSPGFFLNMVDPHACGVLQPQTKLGPLESA
CCCCCCCCCCCCCCCCCHHHHHCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
PHIAAFRSAALDDVTTRWSERLGPQAPLTSHSDVEAWAKAQNLEQIVTPYAPVGPVATLL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AQASKSDHTPPIIQLMRPYDRMTWPHATRGFFPFKKKLPTFIADIQAA
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLHDHGNKVHVGFNRIFHVECLSAASLSGPYLRTVDRTLVLARRSRKGGCTTLGSAVDLR
CCCCCCCEEEECHHHEEEEHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCHHHHH
SRKPKSRQMSQLFPPSHRAALERLTAFVPKAGRDYAARRNYDLGPGNHTHVSTLSPYLRC
CCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCCHHHCCCCCEE
RLITESEVVNAVLHRHSPAAAEKFVQEVFWRTYWKGWLELRPAVWTQYQMALDQAWNDVQ
EEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHH
TQAGLRARWENACRGETGIHCFDAWARELVETGYLHNHARMWFASIWIFTLELPWELGAD
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHEEECCHHHCHH
FFLRHLLDGDPASNTLGWRWVAGIQTQGKTYLARTSNISKFTENRFHPKWQLAGEAIPRH
HHHHHHHCCCCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHCCCCCCHHHCCCCCCCC
APLPPEPRSLPAGDAFDPALRTGFLLHEEDLSPGFFLNMVDPHACGVLQPQTKLGPLESA
CCCCCCCCCCCCCCCCCHHHHHCCEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCC
PHIAAFRSAALDDVTTRWSERLGPQAPLTSHSDVEAWAKAQNLEQIVTPYAPVGPVATLL
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AQASKSDHTPPIIQLMRPYDRMTWPHATRGFFPFKKKLPTFIADIQAA
HHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7678007 [H]