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The map label for this gene is bclA [H]

Identifier: 110679955

GI number: 110679955

Start: 2612755

End: 2614287

Strand: Direct

Name: bclA [H]

Synonym: RD1_2743

Alternate gene names: 110679955

Gene position: 2612755-2614287 (Clockwise)

Preceding gene: 110679953

Following gene: 110679956

Centisome position: 63.22

GC content: 62.88

Gene sequence:

>1533_bases
ATGGTATCTCTCTATGACGCAGGCCCTTTCCCGCCGTGCCCGACCCCGTTCAACCTGACGCGTCATGTGCTGGCCGCAGG
TCGTGCGCATCCGCAAAAACAGGCCTTGCTGATTGTATCCGCCGATCATACCGAAACATGGTCGTTCGGCGCATTGGAGG
CGGCAGTGCGCGGCACGGCCACGGGATTCCTGCGCCAGGGGCTGACACCCGGTGATGTGATCGTCATGCGCCTTGGCAAT
ACCATCGACTTTCCCATCACCTATCTGGCCGCTTTGGCCGCCGGGCTGGTGCCTGTACCGACCTCGGCCGCCCTGACGCA
GAGCGAGGCGGCATTTGTCATCAAAACCGTCTCCCCCAAGGCGGTGGTGGCGGCACCGGATATCCCCTGCCCGGATTTCG
CGGTGACGATTGACCTTGAAACACTGCAATCCTTCCGCAGCCTGCCCGCCGCGCCCTATCATCTGGGCGACCCGGAGCGC
CTCGGGTACATCATTTTCACCTCCGGCACATCGGGCAAGCCGCGTGCGGTGGCGCATGCGCATCGGGCCATCTGGGCGCG
GCAGATGATGTTTGACGGATGGTACGGTTTGCGACCCGATGACCGTTTGCTGCATGCGGGGGCTTTCAACTGGACCTATA
CGCTGGGCACAGGGCTGATGGACCCGTGGACGCTTGGCGCCACTGCGGTGATACCGGTGGCAGGCACCAGACCGCAGGAA
TTGCCCGCGTTACTGGCCCGGCATGACGCCAGCATCTTTGCCGCAGCACCGGGGGTATATCGCCAGATGCTGGATCGCGC
GACACCCGTTCCCCTGCCCGCCCTGCGCCATGGGTTGAGCGCGGGTGAAAAGCTGCCCCCGGCCCTGGCCGAGCGGTGGG
TGCATGCGACCGGTCGCCCCGTTTTTGAAGCCTATGGCATGTCCGAATGCTCCACCTTCATTTCGCAATGCCCGGCAGAT
CAAAACGTCGCGGGCACCTTGGGCAAGCCCCAAAAGGGTCGCCGCATTGCCCTGTTAAAAAACGGTGAACCGGTTGCTCT
GGGCGATGAAGGCACGATTGCCGTCGCGCGCAGTGATCCGGGGCTGATGCTGGGGTATCTGAATGCGCCGCAGGAAACCG
CCGAACGCATGCGCGGGGCGTGGTTTCTGACCGGCGATCAGGGGGTGATGAACGCACAGGGGCACATCACCTACATGGGC
CGCGATGACGACATGATGAACGCAGGCGGCTATCGCGTGTCCCCCATAGAGGTGGAACGCGTGCTGGCCGACTACCCCGG
CATCACGGCCGTGGCGGTCACAGAGGTTCGCATCAAAACGGATACCACCGTGATCGGTGCGTTTTACACAGGCGCAAACG
CACTGGACGCAGACAAACTGCGCGCCTATGTGTCGCAAACCCTCGCGCGCTACAAACAGCCGCGCGTGTTCGAACACCTG
CCGGACCTGCCCATGGGCGCAAATGGCAAAATCCTGCGCCGTGTTCTGCGCCAACGCTTTGAGAGGCACCATGACCGAAA
AGACCAAGATTGA

Upstream 100 bases:

>100_bases
ATGGTGATCAGTTTGTTTGGCTTGCTCCGGCTCATGTATGCACTTGTATGCGCAAGCCCGCAGGCTTGCAACGCCGCTGC
CCGCCCGGTAGCACCGCGAT

Downstream 100 bases:

>100_bases
CATCATATCAGACCCGATCTGCCCGTGGTGCTATATCGGCAAGACGAATCTGGACCGCGCATTGGCGGAAAATCCGGATC
ACCCTTTCCTGATTGAATGG

Product: hypothetical protein

Products: NA

Alternate protein names: Benzoyl-CoA synthetase [H]

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MVSLYDAGPFPPCPTPFNLTRHVLAAGRAHPQKQALLIVSADHTETWSFGALEAAVRGTATGFLRQGLTPGDVIVMRLGN
TIDFPITYLAALAAGLVPVPTSAALTQSEAAFVIKTVSPKAVVAAPDIPCPDFAVTIDLETLQSFRSLPAAPYHLGDPER
LGYIIFTSGTSGKPRAVAHAHRAIWARQMMFDGWYGLRPDDRLLHAGAFNWTYTLGTGLMDPWTLGATAVIPVAGTRPQE
LPALLARHDASIFAAAPGVYRQMLDRATPVPLPALRHGLSAGEKLPPALAERWVHATGRPVFEAYGMSECSTFISQCPAD
QNVAGTLGKPQKGRRIALLKNGEPVALGDEGTIAVARSDPGLMLGYLNAPQETAERMRGAWFLTGDQGVMNAQGHITYMG
RDDDMMNAGGYRVSPIEVERVLADYPGITAVAVTEVRIKTDTTVIGAFYTGANALDADKLRAYVSQTLARYKQPRVFEHL
PDLPMGANGKILRRVLRQRFERHHDRKDQD

Sequences:

>Translated_510_residues
MVSLYDAGPFPPCPTPFNLTRHVLAAGRAHPQKQALLIVSADHTETWSFGALEAAVRGTATGFLRQGLTPGDVIVMRLGN
TIDFPITYLAALAAGLVPVPTSAALTQSEAAFVIKTVSPKAVVAAPDIPCPDFAVTIDLETLQSFRSLPAAPYHLGDPER
LGYIIFTSGTSGKPRAVAHAHRAIWARQMMFDGWYGLRPDDRLLHAGAFNWTYTLGTGLMDPWTLGATAVIPVAGTRPQE
LPALLARHDASIFAAAPGVYRQMLDRATPVPLPALRHGLSAGEKLPPALAERWVHATGRPVFEAYGMSECSTFISQCPAD
QNVAGTLGKPQKGRRIALLKNGEPVALGDEGTIAVARSDPGLMLGYLNAPQETAERMRGAWFLTGDQGVMNAQGHITYMG
RDDDMMNAGGYRVSPIEVERVLADYPGITAVAVTEVRIKTDTTVIGAFYTGANALDADKLRAYVSQTLARYKQPRVFEHL
PDLPMGANGKILRRVLRQRFERHHDRKDQD
>Mature_510_residues
MVSLYDAGPFPPCPTPFNLTRHVLAAGRAHPQKQALLIVSADHTETWSFGALEAAVRGTATGFLRQGLTPGDVIVMRLGN
TIDFPITYLAALAAGLVPVPTSAALTQSEAAFVIKTVSPKAVVAAPDIPCPDFAVTIDLETLQSFRSLPAAPYHLGDPER
LGYIIFTSGTSGKPRAVAHAHRAIWARQMMFDGWYGLRPDDRLLHAGAFNWTYTLGTGLMDPWTLGATAVIPVAGTRPQE
LPALLARHDASIFAAAPGVYRQMLDRATPVPLPALRHGLSAGEKLPPALAERWVHATGRPVFEAYGMSECSTFISQCPAD
QNVAGTLGKPQKGRRIALLKNGEPVALGDEGTIAVARSDPGLMLGYLNAPQETAERMRGAWFLTGDQGVMNAQGHITYMG
RDDDMMNAGGYRVSPIEVERVLADYPGITAVAVTEVRIKTDTTVIGAFYTGANALDADKLRAYVSQTLARYKQPRVFEHL
PDLPMGANGKILRRVLRQRFERHHDRKDQD

Specific function: Catalyzes the ligation of benzoate and CoA to form benzoyl-CoA at the expense of ATP. The enzyme also ligates 2- aminobenzoate and CoA. The enzyme shows activity toward a number of benzoate derivates [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=530, Percent_Identity=26.7924528301887, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI58082049, Length=527, Percent_Identity=25.8064516129032, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI157311624, Length=527, Percent_Identity=25.8064516129032, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI157311622, Length=527, Percent_Identity=25.8064516129032, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI122937307, Length=531, Percent_Identity=26.1770244821092, Blast_Score=172, Evalue=7e-43,
Organism=Homo sapiens, GI115511026, Length=532, Percent_Identity=26.8796992481203, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI38505220, Length=536, Percent_Identity=25.3731343283582, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI156151445, Length=536, Percent_Identity=23.6940298507463, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI42544134, Length=350, Percent_Identity=25.1428571428571, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI187761345, Length=378, Percent_Identity=26.7195767195767, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI187761343, Length=378, Percent_Identity=26.7195767195767, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI195947378, Length=413, Percent_Identity=25.4237288135593, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI8923896, Length=381, Percent_Identity=23.0971128608924, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1788107, Length=525, Percent_Identity=26.0952380952381, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI145693145, Length=515, Percent_Identity=24.8543689320388, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI221142682, Length=509, Percent_Identity=22.5933202357564, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1789201, Length=347, Percent_Identity=25.9365994236311, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786810, Length=501, Percent_Identity=22.5548902195609, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786801, Length=492, Percent_Identity=25.4065040650407, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788595, Length=470, Percent_Identity=26.5957446808511, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790505, Length=360, Percent_Identity=25.8333333333333, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17558820, Length=468, Percent_Identity=23.9316239316239, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=500, Percent_Identity=23, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17559526, Length=361, Percent_Identity=25.207756232687, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17557194, Length=561, Percent_Identity=23.3511586452763, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994703, Length=536, Percent_Identity=23.3208955223881, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994694, Length=536, Percent_Identity=23.3208955223881, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71994690, Length=536, Percent_Identity=23.3208955223881, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71985884, Length=364, Percent_Identity=25.5494505494505, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17556356, Length=219, Percent_Identity=27.3972602739726, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560308, Length=345, Percent_Identity=22.3188405797101, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=483, Percent_Identity=23.6024844720497, Blast_Score=133, Evalue=7e-32,
Organism=Drosophila melanogaster, GI24581924, Length=522, Percent_Identity=24.1379310344828, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18859661, Length=545, Percent_Identity=24.2201834862385, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI20130357, Length=353, Percent_Identity=24.0793201133144, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667959, Length=385, Percent_Identity=26.4935064935065, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI62472339, Length=385, Percent_Identity=26.4935064935065, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922652, Length=484, Percent_Identity=23.3471074380165, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24667955, Length=389, Percent_Identity=26.7352185089974, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24648257, Length=411, Percent_Identity=24.5742092457421, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24648260, Length=350, Percent_Identity=24.8571428571429, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356947, Length=353, Percent_Identity=24.0793201133144, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011957 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.25 [H]

Molecular weight: Translated: 55157; Mature: 55157

Theoretical pI: Translated: 8.32; Mature: 8.32

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSLYDAGPFPPCPTPFNLTRHVLAAGRAHPQKQALLIVSADHTETWSFGALEAAVRGTA
CEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
TGFLRQGLTPGDVIVMRLGNTIDFPITYLAALAAGLVPVPTSAALTQSEAAFVIKTVSPK
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECCCC
AVVAAPDIPCPDFAVTIDLETLQSFRSLPAAPYHLGDPERLGYIIFTSGTSGKPRAVAHA
EEEECCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCHHHEEEEEEECCCCCCCHHHHHH
HRAIWARQMMFDGWYGLRPDDRLLHAGAFNWTYTLGTGLMDPWTLGATAVIPVAGTRPQE
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHH
LPALLARHDASIFAAAPGVYRQMLDRATPVPLPALRHGLSAGEKLPPALAERWVHATGRP
HHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCH
VFEAYGMSECSTFISQCPADQNVAGTLGKPQKGRRIALLKNGEPVALGDEGTIAVARSDP
HHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCEEEEECCC
GLMLGYLNAPQETAERMRGAWFLTGDQGVMNAQGHITYMGRDDDMMNAGGYRVSPIEVER
CEEEEECCCCHHHHHHHCCCEEEECCCCEEECCCEEEEECCCCCCCCCCCEEECHHHHHH
VLADYPGITAVAVTEVRIKTDTTVIGAFYTGANALDADKLRAYVSQTLARYKQPRVFEHL
HHHCCCCCEEEEEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHC
PDLPMGANGKILRRVLRQRFERHHDRKDQD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MVSLYDAGPFPPCPTPFNLTRHVLAAGRAHPQKQALLIVSADHTETWSFGALEAAVRGTA
CEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHH
TGFLRQGLTPGDVIVMRLGNTIDFPITYLAALAAGLVPVPTSAALTQSEAAFVIKTVSPK
HHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHCCCCCEEEEEECCCC
AVVAAPDIPCPDFAVTIDLETLQSFRSLPAAPYHLGDPERLGYIIFTSGTSGKPRAVAHA
EEEECCCCCCCCEEEEEEHHHHHHHHCCCCCCCCCCCHHHEEEEEEECCCCCCCHHHHHH
HRAIWARQMMFDGWYGLRPDDRLLHAGAFNWTYTLGTGLMDPWTLGATAVIPVAGTRPQE
HHHHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCCCCEEEEECCCCCHHH
LPALLARHDASIFAAAPGVYRQMLDRATPVPLPALRHGLSAGEKLPPALAERWVHATGRP
HHHHHHHCCCCEEEECCHHHHHHHHHCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCH
VFEAYGMSECSTFISQCPADQNVAGTLGKPQKGRRIALLKNGEPVALGDEGTIAVARSDP
HHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCCCCEEEEECCC
GLMLGYLNAPQETAERMRGAWFLTGDQGVMNAQGHITYMGRDDDMMNAGGYRVSPIEVER
CEEEEECCCCHHHHHHHCCCEEEECCCCEEECCCEEEEECCCCCCCCCCCEEECHHHHHH
VLADYPGITAVAVTEVRIKTDTTVIGAFYTGANALDADKLRAYVSQTLARYKQPRVFEHL
HHHCCCCCEEEEEEEEEEEECCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCHHHHC
PDLPMGANGKILRRVLRQRFERHHDRKDQD
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12897012 [H]