Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 110679865

GI number: 110679865

Start: 2518663

End: 2519298

Strand: Direct

Name: gmk

Synonym: RD1_2638

Alternate gene names: 110679865

Gene position: 2518663-2519298 (Clockwise)

Preceding gene: 110679864

Following gene: 110679866

Centisome position: 60.94

GC content: 60.06

Gene sequence:

>636_bases
ATGCGCCGCGGACTTCTGATTATCCTCAGCTCACCCTCGGGCGCTGGCAAATCCACCTTGGCGCGGCGGTTGCGGGACTG
GGACACGGACATCGAATTCTCAGTGTCCGCCACGACCCGTGCCGCGCGTCCGGGCGAGGTTGACGGGCGTGAGTACCATT
TCGTGGATGAGGCTGCCTTCAAATCGCAGGTGAGCAATGGGGGTATGCTGGAGCATGCGCATGTTTTCGGCAACTTCTAT
GGCTCGCCAAGCGGCCCTGTTCAGGAGGCCATCAACGCCGGTCGCGATGTGTTGTTCGACATCGACTGGCAAGGGGCGCA
GCAAATCACCAATTCGGCCCTCAGCGCGCATACGCTGTCCATTTTCCTGTTGCCGCCCTCGATCCGCGAGTTGCGCAACC
GTCTGGAGAAACGCGCACAGGATGATGCCGCAACCATCGCGCGCCGCATGGACAAGAGTTGGGATGAGATCAGTCATTGG
GGCAGCTACGATTATGTGCTGGTGAATGACGATCTGGACACCACCGAGGCGCATCTGAAAACCATCGTAACGGCCACGCG
CCTGCGGCGCAGCCAACAGCCGGGACTGACCGAACACGTGCGCCACCTGCAATCCGAATTCGAAAGGTTATCATGA

Upstream 100 bases:

>100_bases
GGCGCAAAACACCGAATTGACACGCTGCGGTCTTGCACTGAAGGCAGTGATCGATCAGATGCGGGAGCAAGTACAGAATG
TGGAGTAACCGATGAAACCC

Downstream 100 bases:

>100_bases
CGTTATACGCTTTAGGTGAGGATATACCTCAACTGCATGAGGACACATGGGTCGCACCGGGTGCGAACCTGATTGGCAAG
GTTGTACTGGAAGCGGGGGC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRRGLLIILSSPSGAGKSTLARRLRDWDTDIEFSVSATTRAARPGEVDGREYHFVDEAAFKSQVSNGGMLEHAHVFGNFY
GSPSGPVQEAINAGRDVLFDIDWQGAQQITNSALSAHTLSIFLLPPSIRELRNRLEKRAQDDAATIARRMDKSWDEISHW
GSYDYVLVNDDLDTTEAHLKTIVTATRLRRSQQPGLTEHVRHLQSEFERLS

Sequences:

>Translated_211_residues
MRRGLLIILSSPSGAGKSTLARRLRDWDTDIEFSVSATTRAARPGEVDGREYHFVDEAAFKSQVSNGGMLEHAHVFGNFY
GSPSGPVQEAINAGRDVLFDIDWQGAQQITNSALSAHTLSIFLLPPSIRELRNRLEKRAQDDAATIARRMDKSWDEISHW
GSYDYVLVNDDLDTTEAHLKTIVTATRLRRSQQPGLTEHVRHLQSEFERLS
>Mature_211_residues
MRRGLLIILSSPSGAGKSTLARRLRDWDTDIEFSVSATTRAARPGEVDGREYHFVDEAAFKSQVSNGGMLEHAHVFGNFY
GSPSGPVQEAINAGRDVLFDIDWQGAQQITNSALSAHTLSIFLLPPSIRELRNRLEKRAQDDAATIARRMDKSWDEISHW
GSYDYVLVNDDLDTTEAHLKTIVTATRLRRSQQPGLTEHVRHLQSEFERLS

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=193, Percent_Identity=34.7150259067358, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI4504221, Length=193, Percent_Identity=34.7150259067358, Blast_Score=116, Evalue=1e-26,
Organism=Homo sapiens, GI226874831, Length=193, Percent_Identity=34.7150259067358, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI38570142, Length=181, Percent_Identity=32.5966850828729, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI14780902, Length=194, Percent_Identity=25.7731958762887, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI21361598, Length=200, Percent_Identity=25.5, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI52630447, Length=196, Percent_Identity=27.5510204081633, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI111154074, Length=176, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=195, Percent_Identity=49.7435897435897, Blast_Score=186, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=36.046511627907, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=36.046511627907, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320662, Length=185, Percent_Identity=38.3783783783784, Blast_Score=133, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=31.7948717948718, Blast_Score=110, Evalue=5e-25,
Organism=Drosophila melanogaster, GI116007136, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554481, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI85724806, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640542, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45554489, Length=195, Percent_Identity=25.6410256410256, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI161077626, Length=195, Percent_Identity=25.6410256410256, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_ROSDO (Q166A7)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682872.1
- ProteinModelPortal:   Q166A7
- STRING:   Q166A7
- GeneID:   4195963
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2638
- NMPDR:   fig|375451.6.peg.2451
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q166A7
- ProtClustDB:   PRK00300
- BioCyc:   RDEN375451:RD1_2638-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23690; Mature: 23690

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRGLLIILSSPSGAGKSTLARRLRDWDTDIEFSVSATTRAARPGEVDGREYHFVDEAAF
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHH
KSQVSNGGMLEHAHVFGNFYGSPSGPVQEAINAGRDVLFDIDWQGAQQITNSALSAHTLS
HHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHEEEE
IFLLPPSIRELRNRLEKRAQDDAATIARRMDKSWDEISHWGSYDYVLVNDDLDTTEAHLK
EEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCHHHHHHH
TIVTATRLRRSQQPGLTEHVRHLQSEFERLS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRRGLLIILSSPSGAGKSTLARRLRDWDTDIEFSVSATTRAARPGEVDGREYHFVDEAAF
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEHHHHHH
KSQVSNGGMLEHAHVFGNFYGSPSGPVQEAINAGRDVLFDIDWQGAQQITNSALSAHTLS
HHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHEEEE
IFLLPPSIRELRNRLEKRAQDDAATIARRMDKSWDEISHWGSYDYVLVNDDLDTTEAHLK
EEEECCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHCCCCCEEEECCCCCHHHHHHH
TIVTATRLRRSQQPGLTEHVRHLQSEFERLS
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA