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The map label for this gene is pyrH

Identifier: 110679816

GI number: 110679816

Start: 2469832

End: 2470560

Strand: Direct

Name: pyrH

Synonym: RD1_2585

Alternate gene names: 110679816

Gene position: 2469832-2470560 (Clockwise)

Preceding gene: 110679814

Following gene: 110679817

Centisome position: 59.76

GC content: 60.22

Gene sequence:

>729_bases
ATGACAACGCCCGAACCTCAGGCCGCCTTTAAGCGCGTTATGCTTAAAATCTCGGGGGAAGCGTTGATGGGGGATCAGGG
ATTTGGGCTGCACCCGCCGACAGTGGAGCGGGTCGCGCGCGAGGTGCAGTCGGTCCACGCGCTTGGTGTCGAGATCTGCA
TGGTGATCGGCGGTGGCAATATCTTTCGCGGCCTGCAGGGCTCTGCGCAGGGGATGGAGCGGACAACCGCCGATTACATG
GGCATGTTGGCCACGGTGATGAACGCGCTGGCGATGCAATCGGCGCTGGAGGGCCTTGGTATTCACACGCGGGTGATTTC
GGCGATCACGATGAACGAGGTGGCAGAACCCTACATCCGCCGCCGCGCCGTGCGCCATCTTGAGAAAAAGCGCGTGTGCA
TTTTTGCCGCCGGCACCGGGAACCCCTATTTCACCACGGACACCGCCGCCACCTTGCGCGCAAACGAAATGTCCTGCGAG
GCGATTTTCAAGGGTACCAAGGTGGATGGGGTCTATGACAAGGACCCCGCAAAATTCGCGGATGCCAAACGCTATGACAC
TGTCACCTATGATGATGTGCTGGCAAAACGGCTGGGGGTGATGGATGCCTCTGCCATTGCGCTGGCGCGGGATAACAACT
TGCCCATCATCGTGTTTTCGCTGGATGAACCGGGCGGGTTTCGCGGCATTCTGGCCGGTGAGGGCACCTATACGCGGGTT
CAGGACTAG

Upstream 100 bases:

>100_bases
CGTCCATTTTTTACGCGCCCTTGAAAGTTCGGTGCATTGCAGTTCCCGCGGTTTTGGGACATTTTGCGCGCAAAGACAAA
TCACCGATCAGGAGCCGCCC

Downstream 100 bases:

>100_bases
CGGCGCCTTCGGACACGGCGGCGCTGTACACTCCGCACCCGAGCAGATTATAACTCCCCAAATGTACGAAAGGGCAGTGA
GCAATGTCAGAAGACTTCAT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 242; Mature: 241

Protein sequence:

>242_residues
MTTPEPQAAFKRVMLKISGEALMGDQGFGLHPPTVERVAREVQSVHALGVEICMVIGGGNIFRGLQGSAQGMERTTADYM
GMLATVMNALAMQSALEGLGIHTRVISAITMNEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMSCE
AIFKGTKVDGVYDKDPAKFADAKRYDTVTYDDVLAKRLGVMDASAIALARDNNLPIIVFSLDEPGGFRGILAGEGTYTRV
QD

Sequences:

>Translated_242_residues
MTTPEPQAAFKRVMLKISGEALMGDQGFGLHPPTVERVAREVQSVHALGVEICMVIGGGNIFRGLQGSAQGMERTTADYM
GMLATVMNALAMQSALEGLGIHTRVISAITMNEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMSCE
AIFKGTKVDGVYDKDPAKFADAKRYDTVTYDDVLAKRLGVMDASAIALARDNNLPIIVFSLDEPGGFRGILAGEGTYTRV
QD
>Mature_241_residues
TTPEPQAAFKRVMLKISGEALMGDQGFGLHPPTVERVAREVQSVHALGVEICMVIGGGNIFRGLQGSAQGMERTTADYMG
MLATVMNALAMQSALEGLGIHTRVISAITMNEVAEPYIRRRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMSCEA
IFKGTKVDGVYDKDPAKFADAKRYDTVTYDDVLAKRLGVMDASAIALARDNNLPIIVFSLDEPGGFRGILAGEGTYTRVQ
D

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=233, Percent_Identity=47.2103004291845, Blast_Score=226, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_ROSDO (Q166F6)

Other databases:

- EMBL:   CP000362
- RefSeq:   YP_682823.1
- ProteinModelPortal:   Q166F6
- SMR:   Q166F6
- STRING:   Q166F6
- GeneID:   4195025
- GenomeReviews:   CP000362_GR
- KEGG:   rde:RD1_2585
- NMPDR:   fig|375451.6.peg.2402
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q166F6
- ProtClustDB:   PRK00358
- BioCyc:   RDEN375451:RD1_2585-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26182; Mature: 26050

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: BINDING 58-58 BINDING 59-59 BINDING 63-63 BINDING 78-78 BINDING 166-166 BINDING 172-172 BINDING 175-175

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPEPQAAFKRVMLKISGEALMGDQGFGLHPPTVERVAREVQSVHALGVEICMVIGGGN
CCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCH
IFRGLQGSAQGMERTTADYMGMLATVMNALAMQSALEGLGIHTRVISAITMNEVAEPYIR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMSCEAIFKGTKVDGVYDKDPAKFA
HHHHHHHHHCCEEEEEECCCCCEEECCCHHEEECCCCCHHHHHCCCCCCCCCCCCCHHHH
DAKRYDTVTYDDVLAKRLGVMDASAIALARDNNLPIIVFSLDEPGGFRGILAGEGTYTRV
CCHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCEEEEEECCCCEEEC
QD
CC
>Mature Secondary Structure 
TTPEPQAAFKRVMLKISGEALMGDQGFGLHPPTVERVAREVQSVHALGVEICMVIGGGN
CCCCHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEECCH
IFRGLQGSAQGMERTTADYMGMLATVMNALAMQSALEGLGIHTRVISAITMNEVAEPYIR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RRAVRHLEKKRVCIFAAGTGNPYFTTDTAATLRANEMSCEAIFKGTKVDGVYDKDPAKFA
HHHHHHHHHCCEEEEEECCCCCEEECCCHHEEECCCCCHHHHHCCCCCCCCCCCCCHHHH
DAKRYDTVTYDDVLAKRLGVMDASAIALARDNNLPIIVFSLDEPGGFRGILAGEGTYTRV
CCHHCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCEEEEEECCCCEEEC
QD
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA