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The map label for this gene is hom [H]

Identifier: 110679774

GI number: 110679774

Start: 2427807

End: 2429093

Strand: Reverse

Name: hom [H]

Synonym: RD1_2538

Alternate gene names: 110679774

Gene position: 2429093-2427807 (Counterclockwise)

Preceding gene: 110679775

Following gene: 110679773

Centisome position: 58.77

GC content: 63.09

Gene sequence:

>1287_bases
ATGTCTCAGCCTCTTCGTCTCGGTATCGCAGGTCTTGGTACGGTTGGCATTGGCGTGGTGTGCATTCTGAGGGAACATGC
CGCCTTGCTGGAGGCGCGCACCGGTCGCCGCCTTGAAATCACCGCCGTTTCGGCGCGCGACCACACCAAGGACCGCGGCA
TATCGCTGGCGTCTTATGCGTGGGAAGCAGACCCGGTTGCCCTTGCGCAGCGCGGTGACATCGATGTTTTTGTCGAACTG
ATCGGTGGCGATGAAGGACCGGCAAAAGACGCTGTCGAAGCCGCGCTGTCAAAAGGCAAGGATGTCGTCACAGCCAACAA
GGCGCTGCTGGCGATCCACGGTCAGGCGCTGGCCGAACAGGCCGAAGCGGATGGGCGCGCGCTGCGCTACGAGGCCGCCG
TTGCGGGCGGTATCCCGGTGATCAAAGCACTGACCGAAGGGTTGGCGGGCAATGCCGTCACCCGCGTCATGGGCGTGATG
AACGGGTCGTGCAACTACATCCTGACGCGGATGGAAACCGCCGGTCTCAGCTACGATGAAGTCTTTGCCGAGGCCGACGG
GCTTGGCTATCTCGAAGCGGACCCACAACTGGACGTGGGCGGGATCGATGCCGCGCACAAACTGGCCATCCTGTCCTCTC
TCGCCTTTGGCACCAAGGTCGATTTTGCCGGAATCACGCTGGAAGGCATCGACCGGGTCAGCATTGATGACATCCGGGCC
GCTGCTGATATGGGCTACAAGATCAAACTGCTGGGCGTTGCGCAACAGACCGCGCGCGGCCTTGAACAGCGCATGCAGCC
CTGCCTTGTCCCTGCCACGTCACCTTTGGGTCAACTCGACGGCGGCACCAATATGGTCGTCCTTGAGGGCGATGCGGTCG
GGCAGATCGTGCTGCGCGGACCCGGTGCGGGTGAAGGCCCCACGGCAAGTGCCGTGCTGAGCGATATCTGCGATCTGGCG
CGCGGGTTCTCGGGGCCGGTCTTTGGTCTGCCCGCAACAACGCTTGAAACCTCGCAACCTGCCACGGCGGCCCTGCCCGC
CTCCTACTATCTGCGCATGTCACTGCATGACAAACCCGGCGCGCTTGCCAAGATCGCGACGGTTCTGGGCGAGGCTGGCG
TCTCGATTGACCGGATGCGCCAATATGGCCATGCAGATACCGCGGCGCCGGTCTTGATTGTCACGCACAAAACAACGCCC
GCCGCCATATCCGACGCCCTGGCGGCGATGCAAACCACGGCTGTCTTGTCCGGCGATCCCGTCGCCCTGCGTATCGAAGA
CGTCTGA

Upstream 100 bases:

>100_bases
AATAACGCCCGTCTCCGGTCGCTTGCGCGTTGCACGCTTCAATCTGACAGGATAAACGCCGCGCAGACACCACATCCAAA
TGCGCAAAGGAATCACCCCG

Downstream 100 bases:

>100_bases
CACGGACAGCATCATTGTTCTTATCCTCCGGGGCGGCTACAACGCGCCCCGACGCTCATTCTTCTGGACCAAAAGGAATT
TGTAATGCCTGCCACCGCCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSQPLRLGIAGLGTVGIGVVCILREHAALLEARTGRRLEITAVSARDHTKDRGISLASYAWEADPVALAQRGDIDVFVEL
IGGDEGPAKDAVEAALSKGKDVVTANKALLAIHGQALAEQAEADGRALRYEAAVAGGIPVIKALTEGLAGNAVTRVMGVM
NGSCNYILTRMETAGLSYDEVFAEADGLGYLEADPQLDVGGIDAAHKLAILSSLAFGTKVDFAGITLEGIDRVSIDDIRA
AADMGYKIKLLGVAQQTARGLEQRMQPCLVPATSPLGQLDGGTNMVVLEGDAVGQIVLRGPGAGEGPTASAVLSDICDLA
RGFSGPVFGLPATTLETSQPATAALPASYYLRMSLHDKPGALAKIATVLGEAGVSIDRMRQYGHADTAAPVLIVTHKTTP
AAISDALAAMQTTAVLSGDPVALRIEDV

Sequences:

>Translated_428_residues
MSQPLRLGIAGLGTVGIGVVCILREHAALLEARTGRRLEITAVSARDHTKDRGISLASYAWEADPVALAQRGDIDVFVEL
IGGDEGPAKDAVEAALSKGKDVVTANKALLAIHGQALAEQAEADGRALRYEAAVAGGIPVIKALTEGLAGNAVTRVMGVM
NGSCNYILTRMETAGLSYDEVFAEADGLGYLEADPQLDVGGIDAAHKLAILSSLAFGTKVDFAGITLEGIDRVSIDDIRA
AADMGYKIKLLGVAQQTARGLEQRMQPCLVPATSPLGQLDGGTNMVVLEGDAVGQIVLRGPGAGEGPTASAVLSDICDLA
RGFSGPVFGLPATTLETSQPATAALPASYYLRMSLHDKPGALAKIATVLGEAGVSIDRMRQYGHADTAAPVLIVTHKTTP
AAISDALAAMQTTAVLSGDPVALRIEDV
>Mature_427_residues
SQPLRLGIAGLGTVGIGVVCILREHAALLEARTGRRLEITAVSARDHTKDRGISLASYAWEADPVALAQRGDIDVFVELI
GGDEGPAKDAVEAALSKGKDVVTANKALLAIHGQALAEQAEADGRALRYEAAVAGGIPVIKALTEGLAGNAVTRVMGVMN
GSCNYILTRMETAGLSYDEVFAEADGLGYLEADPQLDVGGIDAAHKLAILSSLAFGTKVDFAGITLEGIDRVSIDDIRAA
ADMGYKIKLLGVAQQTARGLEQRMQPCLVPATSPLGQLDGGTNMVVLEGDAVGQIVLRGPGAGEGPTASAVLSDICDLAR
GFSGPVFGLPATTLETSQPATAALPASYYLRMSLHDKPGALAKIATVLGEAGVSIDRMRQYGHADTAAPVLIVTHKTTPA
AISDALAAMQTTAVLSGDPVALRIEDV

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=28.9156626506024, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790376, Length=251, Percent_Identity=25.4980079681275, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44094; Mature: 43963

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPLRLGIAGLGTVGIGVVCILREHAALLEARTGRRLEITAVSARDHTKDRGISLASYA
CCCCCEECEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCCEEEHCC
WEADPVALAQRGDIDVFVELIGGDEGPAKDAVEAALSKGKDVVTANKALLAIHGQALAEQ
CCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCEEEEECCHHHHHH
AEADGRALRYEAAVAGGIPVIKALTEGLAGNAVTRVMGVMNGSCNYILTRMETAGLSYDE
HCCCCCEEEEEHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEHHHCCCCHHH
VFAEADGLGYLEADPQLDVGGIDAAHKLAILSSLAFGTKVDFAGITLEGIDRVSIDDIRA
HHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEECCCCCCCHHHHHH
AADMGYKIKLLGVAQQTARGLEQRMQPCLVPATSPLGQLDGGTNMVVLEGDAVGQIVLRG
HHCCCEEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEC
PGAGEGPTASAVLSDICDLARGFSGPVFGLPATTLETSQPATAALPASYYLRMSLHDKPG
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
ALAKIATVLGEAGVSIDRMRQYGHADTAAPVLIVTHKTTPAAISDALAAMQTTAVLSGDP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEECCCC
VALRIEDV
EEEEEECC
>Mature Secondary Structure 
SQPLRLGIAGLGTVGIGVVCILREHAALLEARTGRRLEITAVSARDHTKDRGISLASYA
CCCCEECEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHCCCEEEHCC
WEADPVALAQRGDIDVFVELIGGDEGPAKDAVEAALSKGKDVVTANKALLAIHGQALAEQ
CCCCCEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCEEEEECCHHHHHH
AEADGRALRYEAAVAGGIPVIKALTEGLAGNAVTRVMGVMNGSCNYILTRMETAGLSYDE
HCCCCCEEEEEHHHHCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEHHHCCCCHHH
VFAEADGLGYLEADPQLDVGGIDAAHKLAILSSLAFGTKVDFAGITLEGIDRVSIDDIRA
HHHHCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEECCCCCCCHHHHHH
AADMGYKIKLLGVAQQTARGLEQRMQPCLVPATSPLGQLDGGTNMVVLEGDAVGQIVLRG
HHCCCEEEEEEECHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEC
PGAGEGPTASAVLSDICDLARGFSGPVFGLPATTLETSQPATAALPASYYLRMSLHDKPG
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCC
ALAKIATVLGEAGVSIDRMRQYGHADTAAPVLIVTHKTTPAAISDALAAMQTTAVLSGDP
HHHHHHHHHHHCCCCHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHEEECCCC
VALRIEDV
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]