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The map label for this gene is lktA [H]

Identifier: 110679731

GI number: 110679731

Start: 2377621

End: 2379657

Strand: Direct

Name: lktA [H]

Synonym: RD1_2492

Alternate gene names: 110679731

Gene position: 2377621-2379657 (Clockwise)

Preceding gene: 110679726

Following gene: 110679733

Centisome position: 57.53

GC content: 63.92

Gene sequence:

>2037_bases
ATGTCCGCCGGTGCAGGCGATGACCGGGCCTTTGGCGGGACAGGCGATGACACGATCTTTGGCGAAGACGGCACGGACGT
TCTGGGCGGCGGTGCCGGCAACGACATGCTCGACGGTGGTGCTGGCAACGACATCATCAACGGGGGCGCGGGCAATGACG
TTGTCAGCGGCGGCACGGGCGACGACAGTGTCACTGCAGGCACCGGCAATGACGACGTGGACGGTGGCGACGGGACGGAT
AACCTGCGTGGCAATGATGGCCGTGACGAGATCAACGGCGGCGCGGGTGCGGACCGCATCGCGGGTGGCGCTGACAATGA
CAGGCTGACCGGCGGCTCCGGAAACGACCTCATCTTTGGTGGTGACGGCGATGATGTGATCACCGGCGGTGGTGATGATG
ACCGCCTCGTGGGCGGACACGGCGCAGACATGTTCCATTTCGGCACTGCGGACGGGCGGGATGTGATTACCGACTTTGAA
GCCGGTGTCGACAGCATCCGTCTGGCGGATGCGTCGCACTACAGTCTCAGCTACAATACGTTCACGGGCGACACGACGCT
GGCCTATGGCGCAACCACGGTTGTCCTGCGCGACACGGTGCTGACGCGGGCGGATATCTCGGTGCAGCCGCTCTCGGTTG
TTGCGCTGACGGGCCTCGATGCGGGCGACAACGCGGGTATCTCGGTCTCCACCGCCGGGGATATCAACGGCGACGGCACA
TCAGAGGTTGTCATCGGCGCCTTCAGCGCAGACCGCGATGCGCTGCTCTCACCCGGTGAGGCCTATGTGCTCGACGGCGC
CATGTTAGGGGCGTTGGAGCCAACCAACGGTTTTGCAGCGCTCGACCTTGGTGACCTTTCGGGTGGCGCTGGGGTGCTCC
TGCAAGGCGCGCTCAACGCTGAATTCGCGGGGTGGAGCGTGGCCGACGCAGGCGACGTCGATGGAGATGGCCGTGCGGAT
GTCATTGTGGGCGCGTTTGGTGCCAATATCTTTGCAGGTCGCGCTTTTGTGGTCTTCGGCGACGCGATCGAAGATGCACG
CGCGAGTGAAACCGCCATCGACCTCGGAGCGCTGACACCGGATCAGGGCGTGACGCTCACCGGTTCTGCGATCCTTGATT
ATGCCGGGCATCAGGTCGCAGCCCTCGGCGATCTGGACGGGGATGGTTTGGATGATATCATTATCGGTGCAGGCCAAGCT
GACGGGCGCAGGGGCGAAACCCATGTCGTATTTGGGTCGGCCATTGTCGCAGGGACGGGCGAAGACGGCGACGGTGAAAT
CGCGCTTGGCGATCTGTCCGGCGGCGATGGTGTCACCATCACCGGCGCAAAGGCGCAGGACCTGCTGGGCTTTGCGGTGT
CCGGTGCGGGCGATGTGGACGCGGACGGCTTGCTTGACGTGATCGCAGGGGGATGGACCGGCTCGCCGGACGGCTCTGGC
GCACAAAACGGGGTTGGTGCCGTGATCTTTGGCTCGGCAATCCTCGCCGCGCGCGGTTCCGGTGGCGAAATCGATGCAGG
CACAATGACCAACAGAGAGGGCCTCGTGATCTACGGCCCGGAGGCAGGGGATGCGCTTGGCCGGGGCCTTGCGGATGCGG
GCGATATTGATGGTGACGGCTTTGGCGATGTGCTCTTTGGGGCGTATCTGTCTGATGCGGATGGCATTCCCTTCGGCGGG
GAGGCGTATCTGCTGTCAGGTGCCGCACTGACGGCTGAAACACTGCCGGGCCTTGATGTGTCGGTTGATGTCTCTGATCT
GTCCGGCGGGCGTGGGGTGCGCTTTGTCGGTGCGGATGAACGGGACCTGACCGGGTTCTCGGTTTCAACGGCAGGTGATG
TCGATGGCGGCGGTGCGCCGGATGTGCTTGTCGGTGCCTATGGGTTGGGCGAAAGTGGCGGTGCCTATCTCGTCTTTGGC
GAGGCCTTGGCGGCGGATTTCACCGCTGAGGGCGATGGCTTCTTCCACTTTGCCGATATGACGCCCGACGAAGGCGTCAA
AATCCTTGGCCTCGGCGAGGACAACACCGCAGGATAG

Upstream 100 bases:

>100_bases
TTTGCTGCACATTTTGCTGCACAATCCGCAGCACGCCGCGATCCCGCATTCAACAAAATCAATCACTTAACCAATTGATA
AGCAATAACTTTCGGACTTC

Downstream 100 bases:

>100_bases
AGCGTCGCAGATGTCGGGGATCTCGATGGCGACGGGCGCGATGATATACTGCTCTCTTCATGGCGCGGCGATCTGGGCGG
TGCCGATGCTGGCGAGGCTT

Product: type I secretion target repeat-containing protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MSAGAGDDRAFGGTGDDTIFGEDGTDVLGGGAGNDMLDGGAGNDIINGGAGNDVVSGGTGDDSVTAGTGNDDVDGGDGTD
NLRGNDGRDEINGGAGADRIAGGADNDRLTGGSGNDLIFGGDGDDVITGGGDDDRLVGGHGADMFHFGTADGRDVITDFE
AGVDSIRLADASHYSLSYNTFTGDTTLAYGATTVVLRDTVLTRADISVQPLSVVALTGLDAGDNAGISVSTAGDINGDGT
SEVVIGAFSADRDALLSPGEAYVLDGAMLGALEPTNGFAALDLGDLSGGAGVLLQGALNAEFAGWSVADAGDVDGDGRAD
VIVGAFGANIFAGRAFVVFGDAIEDARASETAIDLGALTPDQGVTLTGSAILDYAGHQVAALGDLDGDGLDDIIIGAGQA
DGRRGETHVVFGSAIVAGTGEDGDGEIALGDLSGGDGVTITGAKAQDLLGFAVSGAGDVDADGLLDVIAGGWTGSPDGSG
AQNGVGAVIFGSAILAARGSGGEIDAGTMTNREGLVIYGPEAGDALGRGLADAGDIDGDGFGDVLFGAYLSDADGIPFGG
EAYLLSGAALTAETLPGLDVSVDVSDLSGGRGVRFVGADERDLTGFSVSTAGDVDGGGAPDVLVGAYGLGESGGAYLVFG
EALAADFTAEGDGFFHFADMTPDEGVKILGLGEDNTAG

Sequences:

>Translated_678_residues
MSAGAGDDRAFGGTGDDTIFGEDGTDVLGGGAGNDMLDGGAGNDIINGGAGNDVVSGGTGDDSVTAGTGNDDVDGGDGTD
NLRGNDGRDEINGGAGADRIAGGADNDRLTGGSGNDLIFGGDGDDVITGGGDDDRLVGGHGADMFHFGTADGRDVITDFE
AGVDSIRLADASHYSLSYNTFTGDTTLAYGATTVVLRDTVLTRADISVQPLSVVALTGLDAGDNAGISVSTAGDINGDGT
SEVVIGAFSADRDALLSPGEAYVLDGAMLGALEPTNGFAALDLGDLSGGAGVLLQGALNAEFAGWSVADAGDVDGDGRAD
VIVGAFGANIFAGRAFVVFGDAIEDARASETAIDLGALTPDQGVTLTGSAILDYAGHQVAALGDLDGDGLDDIIIGAGQA
DGRRGETHVVFGSAIVAGTGEDGDGEIALGDLSGGDGVTITGAKAQDLLGFAVSGAGDVDADGLLDVIAGGWTGSPDGSG
AQNGVGAVIFGSAILAARGSGGEIDAGTMTNREGLVIYGPEAGDALGRGLADAGDIDGDGFGDVLFGAYLSDADGIPFGG
EAYLLSGAALTAETLPGLDVSVDVSDLSGGRGVRFVGADERDLTGFSVSTAGDVDGGGAPDVLVGAYGLGESGGAYLVFG
EALAADFTAEGDGFFHFADMTPDEGVKILGLGEDNTAG
>Mature_677_residues
SAGAGDDRAFGGTGDDTIFGEDGTDVLGGGAGNDMLDGGAGNDIINGGAGNDVVSGGTGDDSVTAGTGNDDVDGGDGTDN
LRGNDGRDEINGGAGADRIAGGADNDRLTGGSGNDLIFGGDGDDVITGGGDDDRLVGGHGADMFHFGTADGRDVITDFEA
GVDSIRLADASHYSLSYNTFTGDTTLAYGATTVVLRDTVLTRADISVQPLSVVALTGLDAGDNAGISVSTAGDINGDGTS
EVVIGAFSADRDALLSPGEAYVLDGAMLGALEPTNGFAALDLGDLSGGAGVLLQGALNAEFAGWSVADAGDVDGDGRADV
IVGAFGANIFAGRAFVVFGDAIEDARASETAIDLGALTPDQGVTLTGSAILDYAGHQVAALGDLDGDGLDDIIIGAGQAD
GRRGETHVVFGSAIVAGTGEDGDGEIALGDLSGGDGVTITGAKAQDLLGFAVSGAGDVDADGLLDVIAGGWTGSPDGSGA
QNGVGAVIFGSAILAARGSGGEIDAGTMTNREGLVIYGPEAGDALGRGLADAGDIDGDGFGDVLFGAYLSDADGIPFGGE
AYLLSGAALTAETLPGLDVSVDVSDLSGGRGVRFVGADERDLTGFSVSTAGDVDGGGAPDVLVGAYGLGESGGAYLVFGE
ALAADFTAEGDGFFHFADMTPDEGVKILGLGEDNTAG

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 66027; Mature: 65896

Theoretical pI: Translated: 3.48; Mature: 3.48

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGAGDDRAFGGTGDDTIFGEDGTDVLGGGAGNDMLDGGAGNDIINGGAGNDVVSGGTG
CCCCCCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DDSVTAGTGNDDVDGGDGTDNLRGNDGRDEINGGAGADRIAGGADNDRLTGGSGNDLIFG
CCCEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHCCCCCCCCEECCCCCCEEEEC
GDGDDVITGGGDDDRLVGGHGADMFHFGTADGRDVITDFEAGVDSIRLADASHYSLSYNT
CCCCCEEECCCCCCCEECCCCCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEE
FTGDTTLAYGATTVVLRDTVLTRADISVQPLSVVALTGLDAGDNAGISVSTAGDINGDGT
ECCCCEEECCEEEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCC
SEVVIGAFSADRDALLSPGEAYVLDGAMLGALEPTNGFAALDLGDLSGGAGVLLQGALNA
CEEEEEEECCCCHHHCCCCCEEEECCEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCC
EFAGWSVADAGDVDGDGRADVIVGAFGANIFAGRAFVVFGDAIEDARASETAIDLGALTP
CCCCCEECCCCCCCCCCCCEEEEEECCCCEECCEEEEEECCCHHCCCCCCCEEEECCCCC
DQGVTLTGSAILDYAGHQVAALGDLDGDGLDDIIIGAGQADGRRGETHVVFGSAIVAGTG
CCCEEEECCHHHHCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEEECC
EDGDGEIALGDLSGGDGVTITGAKAQDLLGFAVSGAGDVDADGLLDVIAGGWTGSPDGSG
CCCCCCEEEEECCCCCCEEEECCCHHHEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCC
AQNGVGAVIFGSAILAARGSGGEIDAGTMTNREGLVIYGPEAGDALGRGLADAGDIDGDG
CCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCCCCCCC
FGDVLFGAYLSDADGIPFGGEAYLLSGAALTAETLPGLDVSVDVSDLSGGRGVRFVGADE
CHHHHHHHHHCCCCCCCCCCCEEEEECCEEEHHHCCCCEEEEEHHHCCCCCEEEEECCCC
RDLTGFSVSTAGDVDGGGAPDVLVGAYGLGESGGAYLVFGEALAADFTAEGDGFFHFADM
CCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCEECCEEECCCCEEEEECC
TPDEGVKILGLGEDNTAG
CCCCCEEEEEECCCCCCC
>Mature Secondary Structure 
SAGAGDDRAFGGTGDDTIFGEDGTDVLGGGAGNDMLDGGAGNDIINGGAGNDVVSGGTG
CCCCCCCCCCCCCCCCCEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DDSVTAGTGNDDVDGGDGTDNLRGNDGRDEINGGAGADRIAGGADNDRLTGGSGNDLIFG
CCCEEECCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCHHCCCCCCCCEECCCCCCEEEEC
GDGDDVITGGGDDDRLVGGHGADMFHFGTADGRDVITDFEAGVDSIRLADASHYSLSYNT
CCCCCEEECCCCCCCEECCCCCCEEEECCCCCCHHHHHHHCCCCEEEEECCCCEEEEEEE
FTGDTTLAYGATTVVLRDTVLTRADISVQPLSVVALTGLDAGDNAGISVSTAGDINGDGT
ECCCCEEECCEEEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCC
SEVVIGAFSADRDALLSPGEAYVLDGAMLGALEPTNGFAALDLGDLSGGAGVLLQGALNA
CEEEEEEECCCCHHHCCCCCEEEECCEEEECCCCCCCEEEEEECCCCCCCCEEEEECCCC
EFAGWSVADAGDVDGDGRADVIVGAFGANIFAGRAFVVFGDAIEDARASETAIDLGALTP
CCCCCEECCCCCCCCCCCCEEEEEECCCCEECCEEEEEECCCHHCCCCCCCEEEECCCCC
DQGVTLTGSAILDYAGHQVAALGDLDGDGLDDIIIGAGQADGRRGETHVVFGSAIVAGTG
CCCEEEECCHHHHCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCEEEEEEEEEEEECC
EDGDGEIALGDLSGGDGVTITGAKAQDLLGFAVSGAGDVDADGLLDVIAGGWTGSPDGSG
CCCCCCEEEEECCCCCCEEEECCCHHHEEEEEECCCCCCCCCCHHHHHCCCCCCCCCCCC
AQNGVGAVIFGSAILAARGSGGEIDAGTMTNREGLVIYGPEAGDALGRGLADAGDIDGDG
CCCCCEEEEECCEEEEECCCCCCCCCCCCCCCCCEEEECCCCCHHHHCCCCCCCCCCCCC
FGDVLFGAYLSDADGIPFGGEAYLLSGAALTAETLPGLDVSVDVSDLSGGRGVRFVGADE
CHHHHHHHHHCCCCCCCCCCCEEEEECCEEEHHHCCCCEEEEEHHHCCCCCEEEEECCCC
RDLTGFSVSTAGDVDGGGAPDVLVGAYGLGESGGAYLVFGEALAADFTAEGDGFFHFADM
CCCCCEEEECCCCCCCCCCCCEEEEEECCCCCCCEEEEECCCEECCEEECCCCEEEEECC
TPDEGVKILGLGEDNTAG
CCCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]