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The map label for this gene is acsA [H]

Identifier: 110679587

GI number: 110679587

Start: 2229120

End: 2231090

Strand: Reverse

Name: acsA [H]

Synonym: RD1_2332

Alternate gene names: 110679587

Gene position: 2231090-2229120 (Counterclockwise)

Preceding gene: 110679591

Following gene: 110679586

Centisome position: 53.98

GC content: 61.04

Gene sequence:

>1971_bases
ATGTCCGACACGAAAAACACCCCGAAATCCTATCCGCCATCCGCTGACATGGTGGCAAATGCCCACGTCACCTTATCGCA
ATACGCGTCTCTTTATTCGGAGTCTGTTTCGGATTCTGAGGGGTTTTGGCGGCGTGAGGGGGGGCGGGTTGACTGGATCA
AGCCGTTCACCAAGGTCAGGGATGTGAACTTCGATCTCGGCTCTGTGTCGATCAACTGGTACGGCGATGGGACGTTGAAT
GTGGCGGCCAATTGCGTCGATCGCCATCTGGCCACGCGCGCCGATCAGACCGCGATCATCTGGGAGCCGGATGACCCCAA
GGATGCCGCCAAACATATCACCTACAAGCAATTGCATGTTTCGGTCTGCAAGATGGCCAATGTGCTGGAAAGCCTTGGCG
TGCGGCGCGGCGACCGGGTGGTGATCTACCTGCCGATGATCCCCGAGGCGGCCTATGCGATGCTGGCCTGTGCGCGCATC
GGCGCGATCCACTCCATCGTCTTTGCCGGGTTCTCGCCCGATGCACTTGCCGCGCGGATCAATGGCAGTGACGCCAAAGT
CGTCATCACCGCCGATCACGCCCCGCGCGGCGGGCGCGCCACAGCGCTCAAGGCCAATACGGATGCGGCCCTGCTGCACT
GCAAGGACAGCGTGAAGTGCCTCGTCGTCAAGCGCACAGGCGGGCAGACCACCTGGATCGACGGGCGCGATTTTGACTGC
GGCGAGATGATGCTGGAGGCCTCCGATGTCTCCCACCCCGCCGAGATGAACGCCGAAGACCCGCTGTTCATCCTCTATAC
CTCCGGCTCCACCGGGCAGCCCAAGGGCGTCGTGCACACCTCGGGCGGCTATCTCACCTATGCCGCGATGACCCATGAGA
TCGTGTTTGATTACCACGATGGCGATGTGTTCTGGTGCACCGCCGATGTGGGCTGGGTGACGGGCCACAGCTATATCGTC
TACGGGCCGCTGGCCAATGGCGCGACCACCATCATGTTCGAGGGCGTGCCGACCTACCCCGATGCCAGCCGCTTCTGGCA
GGTCTGCGAAAAGCACAAAGTCAACCAGTTCTACACCGCCCCCACCGCCATCCGCGCGCTGATGGGACAGGGCAAGGAGT
TCGTCGAAAAATGCGATCTGAGTGATCTCAAGGTGCTGGGCACCGTGGGCGAGCCGATCAACCCCGAGGCCTGGAACTGG
TACAATGACGTGGTGGGCAAGGGCAAATGCCCCATCGTCGACACCTGGTGGCAGACCGAAACAGGCGGGCATCTGATGAC
CCCTCTGCCCGGCGCGCATACCATGAAACCGGGCTCGGCGATGAAGCCTTTCTTTGGCATCAAGCCGATGGTGCTGGAGC
CTGCGTCAGGCGAGGTGCTGGAGGGCAACGACGTCGAGGGCGTGCTGGTCATCGCCGACAGCTGGCCCGGCCAGATGCGC
ACCATCTGGGGCGATCACGAACGCTTCGAAAAGACCTACTTCTCTGATTACAAAGGCTATTACTTCACCGGAGATGGCTG
CAAGCGCGACGCGGACGGCGATTACTGGATCACGGGACGGGTCGATGACGTGATCAACGTCTCGGGCCACCGCATGGGCA
CCGCAGAGGTCGAAAGCGCGCTGGTCGCCCACGCCAAAGTCGCCGAAGCCGCCGTTGTCGGATACCCGCATGACATCAAG
GGACAGGGCATCTACTGCTACGTCACGCTGATGAACGGCGAAGAGCCCAGCGATGAGCTCTATCAGGAATTGCGCAAATG
GGTCCGCGCAGAAATCGGCCCCATCGCATCCCCAGACCTCATCCAATGGGCCCCCGGCCTGCCCAAAACACGCTCCGGCA
AAATCATGCGCCGCATCCTGCGCAAAATCGCCGAAGACGACTTCGCAACCCTCGGAGACACCTCAACACTCGCAGACCCA
ACCGTCGTAGATGACCTCATCAAAAACAGAATGAACAAACAGGACGCTTGA

Upstream 100 bases:

>100_bases
CTTCAAACTACACCCAGCACGCAAAGGGCTGGCAGCCAAGTCATCGGCCATACACAAGATGCCGCCCCATACGCACACGA
TCAAAGAGGGAGGAGCCACA

Downstream 100 bases:

>100_bases
TAATATGGATGGGTCGTGCCTCGCGCGATGTCACGACCCCGAATTGCTGCGCGGCAGGCCGTGGATACTGTCTGGCGCGC
AGGATCCTCTTGCCCTGACA

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 656; Mature: 655

Protein sequence:

>656_residues
MSDTKNTPKSYPPSADMVANAHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGDGTLN
VAANCVDRHLATRADQTAIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARI
GAIHSIVFAGFSPDALAARINGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDC
GEMMLEASDVSHPAEMNAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGHSYIV
YGPLANGATTIMFEGVPTYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNW
YNDVVGKGKCPIVDTWWQTETGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMR
TIWGDHERFEKTYFSDYKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYPHDIK
GQGIYCYVTLMNGEEPSDELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADP
TVVDDLIKNRMNKQDA

Sequences:

>Translated_656_residues
MSDTKNTPKSYPPSADMVANAHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGDGTLN
VAANCVDRHLATRADQTAIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARI
GAIHSIVFAGFSPDALAARINGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDC
GEMMLEASDVSHPAEMNAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGHSYIV
YGPLANGATTIMFEGVPTYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNW
YNDVVGKGKCPIVDTWWQTETGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMR
TIWGDHERFEKTYFSDYKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYPHDIK
GQGIYCYVTLMNGEEPSDELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADP
TVVDDLIKNRMNKQDA
>Mature_655_residues
SDTKNTPKSYPPSADMVANAHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVRDVNFDLGSVSINWYGDGTLNV
AANCVDRHLATRADQTAIIWEPDDPKDAAKHITYKQLHVSVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARIG
AIHSIVFAGFSPDALAARINGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDCG
EMMLEASDVSHPAEMNAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHDGDVFWCTADVGWVTGHSYIVY
GPLANGATTIMFEGVPTYPDASRFWQVCEKHKVNQFYTAPTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNWY
NDVVGKGKCPIVDTWWQTETGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMRT
IWGDHERFEKTYFSDYKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESALVAHAKVAEAAVVGYPHDIKG
QGIYCYVTLMNGEEPSDELYQELRKWVRAEIGPIASPDLIQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADPT
VVDDLIKNRMNKQDA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=674, Percent_Identity=52.9673590504451, Blast_Score=696, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=687, Percent_Identity=52.1106259097525, Blast_Score=694, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=632, Percent_Identity=48.8924050632911, Blast_Score=630, Evalue=1e-180,
Organism=Homo sapiens, GI13375727, Length=643, Percent_Identity=37.6360808709176, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI38505220, Length=512, Percent_Identity=29.1015625, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI42544132, Length=515, Percent_Identity=29.126213592233, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI115511026, Length=504, Percent_Identity=28.3730158730159, Blast_Score=173, Evalue=6e-43,
Organism=Homo sapiens, GI122937307, Length=512, Percent_Identity=26.953125, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI31982927, Length=647, Percent_Identity=22.7202472952087, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI58082049, Length=517, Percent_Identity=25.9187620889749, Blast_Score=150, Evalue=5e-36,
Organism=Homo sapiens, GI157311624, Length=517, Percent_Identity=25.3384912959381, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI157311622, Length=517, Percent_Identity=25.3384912959381, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI42544134, Length=331, Percent_Identity=26.5861027190332, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI187761345, Length=404, Percent_Identity=26.2376237623762, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI187761343, Length=404, Percent_Identity=26.2376237623762, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI156151445, Length=591, Percent_Identity=22.8426395939086, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1790505, Length=638, Percent_Identity=61.7554858934169, Blast_Score=827, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=37.4603174603175, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI145693145, Length=514, Percent_Identity=24.9027237354086, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71983001, Length=658, Percent_Identity=50.7598784194529, Blast_Score=621, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI71982997, Length=658, Percent_Identity=50.7598784194529, Blast_Score=620, Evalue=1e-178,
Organism=Caenorhabditis elegans, GI17569507, Length=596, Percent_Identity=22.4832214765101, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17559526, Length=556, Percent_Identity=23.7410071942446, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17557194, Length=567, Percent_Identity=22.9276895943563, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17558820, Length=552, Percent_Identity=22.463768115942, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17538037, Length=155, Percent_Identity=29.6774193548387, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=47.900466562986, Blast_Score=605, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6319264, Length=637, Percent_Identity=47.8806907378336, Blast_Score=590, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6319699, Length=383, Percent_Identity=24.5430809399478, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667955, Length=661, Percent_Identity=53.7065052950076, Blast_Score=689, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=564, Percent_Identity=57.9787234042553, Blast_Score=644, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=522, Percent_Identity=58.8122605363985, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI21355225, Length=657, Percent_Identity=33.0289193302892, Blast_Score=345, Evalue=4e-95,
Organism=Drosophila melanogaster, GI21355181, Length=536, Percent_Identity=23.8805970149254, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI18859661, Length=184, Percent_Identity=30.9782608695652, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72047; Mature: 71916

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTKNTPKSYPPSADMVANAHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVR
CCCCCCCCCCCCCCCCEEEECEEEHHHHHHHHHHCCCCCCCCEECCCCEEEEECHHHHHE
DVNFDLGSVSINWYGDGTLNVAANCVDRHLATRADQTAIIWEPDDPKDAAKHITYKQLHV
ECCCEECEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCHHHHHH
SVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDALAARI
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
NGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDC
CCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCEEEEEEEECCCCEEEECCCCCCH
GEMMLEASDVSHPAEMNAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHD
HHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEEEC
GDVFWCTADVGWVTGHSYIVYGPLANGATTIMFEGVPTYPDASRFWQVCEKHKVNQFYTA
CCEEEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECC
PTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNWYNDVVGKGKCPIVDTWWQTE
HHHHHHHHHCCHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCC
TGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMR
CCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEEECCCCCCEE
TIWGDHERFEKTYFSDYKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESA
EECCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHH
LVAHAKVAEAAVVGYPHDIKGQGIYCYVTLMNGEEPSDELYQELRKWVRAEIGPIASPDL
HHHHHHHHHHEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCH
IQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADPTVVDDLIKNRMNKQDA
HHCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SDTKNTPKSYPPSADMVANAHVTLSQYASLYSESVSDSEGFWRREGGRVDWIKPFTKVR
CCCCCCCCCCCCCCCEEEECEEEHHHHHHHHHHCCCCCCCCEECCCCEEEEECHHHHHE
DVNFDLGSVSINWYGDGTLNVAANCVDRHLATRADQTAIIWEPDDPKDAAKHITYKQLHV
ECCCEECEEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCHHHHHH
SVCKMANVLESLGVRRGDRVVIYLPMIPEAAYAMLACARIGAIHSIVFAGFSPDALAARI
HHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
NGSDAKVVITADHAPRGGRATALKANTDAALLHCKDSVKCLVVKRTGGQTTWIDGRDFDC
CCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEECCCEEEEEEEECCCCEEEECCCCCCH
GEMMLEASDVSHPAEMNAEDPLFILYTSGSTGQPKGVVHTSGGYLTYAAMTHEIVFDYHD
HHHHEECCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEEEC
GDVFWCTADVGWVTGHSYIVYGPLANGATTIMFEGVPTYPDASRFWQVCEKHKVNQFYTA
CCEEEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECC
PTAIRALMGQGKEFVEKCDLSDLKVLGTVGEPINPEAWNWYNDVVGKGKCPIVDTWWQTE
HHHHHHHHHCCHHHHHHCCCCCEEEEECCCCCCCCCCCCHHHHHCCCCCCCEEECCCCCC
TGGHLMTPLPGAHTMKPGSAMKPFFGIKPMVLEPASGEVLEGNDVEGVLVIADSWPGQMR
CCCEEECCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCEECCCCCCEEEEEECCCCCCEE
TIWGDHERFEKTYFSDYKGYYFTGDGCKRDADGDYWITGRVDDVINVSGHRMGTAEVESA
EECCCHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEECCCCEEECCCCCCCHHHHHHH
LVAHAKVAEAAVVGYPHDIKGQGIYCYVTLMNGEEPSDELYQELRKWVRAEIGPIASPDL
HHHHHHHHHHEEECCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCH
IQWAPGLPKTRSGKIMRRILRKIAEDDFATLGDTSTLADPTVVDDLIKNRMNKQDA
HHCCCCCCCCCCCHHHHHHHHHHHCCCCHHCCCCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9256491 [H]