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The map label for this gene is oxyR [H]

Identifier: 110679468

GI number: 110679468

Start: 2091815

End: 2092756

Strand: Reverse

Name: oxyR [H]

Synonym: RD1_2194

Alternate gene names: 110679468

Gene position: 2092756-2091815 (Counterclockwise)

Preceding gene: 110679470

Following gene: 110679467

Centisome position: 50.63

GC content: 61.68

Gene sequence:

>942_bases
ATGATTGGCCTCACCCTGAAACAGCTCAGATATTTCGACGCGCTCGCCCGCCACAAACACTTTGGGCGCGCCGCTGATTC
CTGCGCCATCACGCAGCCCGCCCTGTCCCTGCAGATCAAGGAACTCGAAGCATTGGTGGGCGCGCCGCTGGTTGAACGGG
CAACGCGCGAAATTCGCCTGACGTCCCTGGGGTCGGATTTCATCACCAGAACCCGCAAAATTCTGCTGAGTATTGATGAG
CTGGACGAACTCGCCCGCGCGGCGCAAGGCCCACTTGCCGGCCGACTCAGGCTCGGGGTCATTCCAACCGCCGCCCCCTA
TCTGTTACCGTCGATCATGACATCATTCGCGCAGAGGTTTGCGGATCTTGATGTCGAATTGCGCGAATCCGTGACGCAAG
CCCTGATTCAGGACCTGTTGGAGGCGCGATTGGATCTGGCGATTGTGGCCCTGCCGATTTCGGAACCCGCGTTGCGGGAG
TTTGCGCTCTTTGAAGAGGATTTCGTGCTGGTCCGCCCGCCGCAGGATGCAGGAAAACCCGTCCCAAGCCCGGAAATGCT
GCAGGAGATGCGCCTGTTGCTGCTTGAAGAGGGTCATTGTTTTCGCGATCAGGCCCTGTCCTTTTGCAAATCGGTCGAAG
CGCACCCCCGCCAGATGATGGAGGGCAGTTCGCTCTCGACGCTTGTGCAGATGGTCGGGGCGGGCATCGGCGTCACCTTG
ATCCCCGAAATGGCTCTGTCGCTGGAAACGCGGTCTGCGGATGTGGCGGTTGCGCGCTTTCCCAAACCCGGCCCGTCGCG
CACCATTGGCATGGTCTGGCGCAAAACCAACCCCCTGTCCGACCAGCTGATGCAGATTGGGGCCATCGTGCGCGGGGTTG
GGCAGAAGGCGCGTGATACGCACCCCCTGCCCCCGGCCAGCGGCGCAAAACGCATGCCCTGA

Upstream 100 bases:

>100_bases
TCTCTCCACAGTTGGTTGAGGGTTCAGTTTGGAACGGTTCTAACAACTGCACCGCAAAGACACTAATTGATTATTCTGAC
CATCGTGATAAGTTTTTCTT

Downstream 100 bases:

>100_bases
TGCACGACTGTGGCATGTGGCGGCACAGATTGGTAAATAATATCAGACCTCTAAGACGTCAAACACACGCCAGCGTATGC
GCATCGCCCAAATGACACAT

Product: oxidative stress transcription regulator, oxyR, putative

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MIGLTLKQLRYFDALARHKHFGRAADSCAITQPALSLQIKELEALVGAPLVERATREIRLTSLGSDFITRTRKILLSIDE
LDELARAAQGPLAGRLRLGVIPTAAPYLLPSIMTSFAQRFADLDVELRESVTQALIQDLLEARLDLAIVALPISEPALRE
FALFEEDFVLVRPPQDAGKPVPSPEMLQEMRLLLLEEGHCFRDQALSFCKSVEAHPRQMMEGSSLSTLVQMVGAGIGVTL
IPEMALSLETRSADVAVARFPKPGPSRTIGMVWRKTNPLSDQLMQIGAIVRGVGQKARDTHPLPPASGAKRMP

Sequences:

>Translated_313_residues
MIGLTLKQLRYFDALARHKHFGRAADSCAITQPALSLQIKELEALVGAPLVERATREIRLTSLGSDFITRTRKILLSIDE
LDELARAAQGPLAGRLRLGVIPTAAPYLLPSIMTSFAQRFADLDVELRESVTQALIQDLLEARLDLAIVALPISEPALRE
FALFEEDFVLVRPPQDAGKPVPSPEMLQEMRLLLLEEGHCFRDQALSFCKSVEAHPRQMMEGSSLSTLVQMVGAGIGVTL
IPEMALSLETRSADVAVARFPKPGPSRTIGMVWRKTNPLSDQLMQIGAIVRGVGQKARDTHPLPPASGAKRMP
>Mature_313_residues
MIGLTLKQLRYFDALARHKHFGRAADSCAITQPALSLQIKELEALVGAPLVERATREIRLTSLGSDFITRTRKILLSIDE
LDELARAAQGPLAGRLRLGVIPTAAPYLLPSIMTSFAQRFADLDVELRESVTQALIQDLLEARLDLAIVALPISEPALRE
FALFEEDFVLVRPPQDAGKPVPSPEMLQEMRLLLLEEGHCFRDQALSFCKSVEAHPRQMMEGSSLSTLVQMVGAGIGVTL
IPEMALSLETRSADVAVARFPKPGPSRTIGMVWRKTNPLSDQLMQIGAIVRGVGQKARDTHPLPPASGAKRMP

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=292, Percent_Identity=38.013698630137, Blast_Score=191, Evalue=5e-50,
Organism=Escherichia coli, GI157672245, Length=249, Percent_Identity=30.1204819277108, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787879, Length=254, Percent_Identity=31.8897637795276, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1788887, Length=291, Percent_Identity=27.4914089347079, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI2367136, Length=244, Percent_Identity=32.3770491803279, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788748, Length=311, Percent_Identity=28.9389067524116, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787806, Length=281, Percent_Identity=25.2669039145907, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI145693105, Length=300, Percent_Identity=25.6666666666667, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87081904, Length=292, Percent_Identity=27.3972602739726, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789173, Length=191, Percent_Identity=33.5078534031414, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790208, Length=252, Percent_Identity=27.3809523809524, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788297, Length=246, Percent_Identity=26.0162601626016, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1787601, Length=174, Percent_Identity=29.3103448275862, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082132, Length=236, Percent_Identity=25.4237288135593, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788481, Length=288, Percent_Identity=22.9166666666667, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI145693193, Length=122, Percent_Identity=30.327868852459, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34269; Mature: 34269

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGLTLKQLRYFDALARHKHFGRAADSCAITQPALSLQIKELEALVGAPLVERATREIRL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
TSLGSDFITRTRKILLSIDELDELARAAQGPLAGRLRLGVIPTAAPYLLPSIMTSFAQRF
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
ADLDVELRESVTQALIQDLLEARLDLAIVALPISEPALREFALFEEDFVLVRPPQDAGKP
HCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCEEEEECCHHCCCC
VPSPEMLQEMRLLLLEEGHCFRDQALSFCKSVEAHPRQMMEGSSLSTLVQMVGAGIGVTL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
IPEMALSLETRSADVAVARFPKPGPSRTIGMVWRKTNPLSDQLMQIGAIVRGVGQKARDT
HHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHCCC
HPLPPASGAKRMP
CCCCCCCCCCCCC
>Mature Secondary Structure
MIGLTLKQLRYFDALARHKHFGRAADSCAITQPALSLQIKELEALVGAPLVERATREIRL
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
TSLGSDFITRTRKILLSIDELDELARAAQGPLAGRLRLGVIPTAAPYLLPSIMTSFAQRF
HHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHH
ADLDVELRESVTQALIQDLLEARLDLAIVALPISEPALREFALFEEDFVLVRPPQDAGKP
HCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHCCCEEEEECCHHCCCC
VPSPEMLQEMRLLLLEEGHCFRDQALSFCKSVEAHPRQMMEGSSLSTLVQMVGAGIGVTL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
IPEMALSLETRSADVAVARFPKPGPSRTIGMVWRKTNPLSDQLMQIGAIVRGVGQKARDT
HHHHHHHHCCCCCCEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCHHHCCC
HPLPPASGAKRMP
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]