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The map label for this gene is guaD [H]

Identifier: 110679291

GI number: 110679291

Start: 1915518

End: 1916825

Strand: Reverse

Name: guaD [H]

Synonym: RD1_2008

Alternate gene names: 110679291

Gene position: 1916825-1915518 (Counterclockwise)

Preceding gene: 110679297

Following gene: 110679286

Centisome position: 46.38

GC content: 61.77

Gene sequence:

>1308_bases
ATGAGCGAATATGATCTGATCCTTGGGCAGACGTTCCAAGTCACCGCCAACCCGATGACGACGCCCTGGCAGCAGGCCGT
GACGGTCGCCAGCGATGGCGCTGTTTTGCTGCGAGACGGTCGCATCGAACAGGTCGGTCATGCCAGTGATCTGCGCCAGC
AACACCCGCAGGCCCGGATCACGGACTATGGGGATAAGCTGGTCTGCCCGGGCTTTGTCGACGCGCATGTCCACTACCCG
CAGACCGCCATCATCGCCAGTTGGGGCAAACAGCTGATCGACTGGCTGAACACCTATACCTTTCCCGAAGAAACCCGCCT
GTGCGATCCCGCCTACGCACGGGCCATCGCGGATCGCTACCTCGACCTCGCGCTGGCACATGGCACCACGACGGTCTGCT
CTTATGCCACGTCCCACCCGGCCAGCGTGGATGCCTTTTTCGACGCGGCAGAACGGCGCGGGCTGCGCGTTATCGCGGGC
AAAACCTGCATGGACCGCAATGCGCCGGAGGCGCTTTGTGATACCGTTCAACACGCCCATGACGAAAGCAAATCGCTGCT
GGAAAAATGGCATGGCCGGGGTCGTGCGCATTATGCGATCACGCCGCGCTTTTCGCCCACTTCGACGCCGGAACAACTGG
AAGCCCTCGGTGCGCTTTGGGCACAGCATCCGAGCTGCCTCATGCAGACGCATCTGAGTGAGCAGGTGCCGGAAATCAAA
TGGGTGCGCGAACTTTTCCCGACGGCGCGCGACTATCTCGATACCTATGAGATGCATGGGTTGATCGGGGAGCGCGCGGT
TTTTGGCCATGCCATCCACCTTGAACCGCGCGAAATCGACCGCATCGCAGAGACCGGCGCGGCGCTGGTGCATTGTCCGA
CCTCGAACACCTTTATCGGGTCCGGGTTGATGGATGTGGCGGGCCTCGCGGCGCGTTCCGTCCCTGTCGGATTGGCAACA
GACACGGGCGGCGGGTCGTCGTTTTCGATGTTGCGCACGATGGCCGCCGCTTACGAGGTGGCCCAACTGCGCGGCACCGC
GTTGCACCCGGCGCAACTGCTTTATCTTGCGACTGCCGGGTCGGCGCGTGCGTTGCATTTGCATGACACAATCGGCACCC
TTTCACCGGGGTATGAAGCCGACCTGACGATCCTTGATCTGGCCTCCACCCCAGCGATTTCCCAACGCGCCGCCGAAGCG
GAAACCATCTGGGAAGCGATTTTTCCAACCATCATGATGGGCGATGACCGGGCCATTGCAGATGTCTGGATCGCCGGAAA
ACGGCGGATCACAGACCAGAGCGTCTGA

Upstream 100 bases:

>100_bases
CTCCTGCTGCAGGGCAGACAATAGGCGCGCGCCAATGTGGTTACAATGGCGCGCGCGGATGATCGTTGCTGTTGCCGGGG
CAAGCGCCTAAGAGTTGCCT

Downstream 100 bases:

>100_bases
CGAAGTATGTGGTTCCGGCTTTTCGCATGACGCCTTAGCCGCCCGGCCCGTCACATCCCGTCGCGCAGGGCCTCCACCAG
ACTGTTCTGGCGGGCAATCA

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MSEYDLILGQTFQVTANPMTTPWQQAVTVASDGAVLLRDGRIEQVGHASDLRQQHPQARITDYGDKLVCPGFVDAHVHYP
QTAIIASWGKQLIDWLNTYTFPEETRLCDPAYARAIADRYLDLALAHGTTTVCSYATSHPASVDAFFDAAERRGLRVIAG
KTCMDRNAPEALCDTVQHAHDESKSLLEKWHGRGRAHYAITPRFSPTSTPEQLEALGALWAQHPSCLMQTHLSEQVPEIK
WVRELFPTARDYLDTYEMHGLIGERAVFGHAIHLEPREIDRIAETGAALVHCPTSNTFIGSGLMDVAGLAARSVPVGLAT
DTGGGSSFSMLRTMAAAYEVAQLRGTALHPAQLLYLATAGSARALHLHDTIGTLSPGYEADLTILDLASTPAISQRAAEA
ETIWEAIFPTIMMGDDRAIADVWIAGKRRITDQSV

Sequences:

>Translated_435_residues
MSEYDLILGQTFQVTANPMTTPWQQAVTVASDGAVLLRDGRIEQVGHASDLRQQHPQARITDYGDKLVCPGFVDAHVHYP
QTAIIASWGKQLIDWLNTYTFPEETRLCDPAYARAIADRYLDLALAHGTTTVCSYATSHPASVDAFFDAAERRGLRVIAG
KTCMDRNAPEALCDTVQHAHDESKSLLEKWHGRGRAHYAITPRFSPTSTPEQLEALGALWAQHPSCLMQTHLSEQVPEIK
WVRELFPTARDYLDTYEMHGLIGERAVFGHAIHLEPREIDRIAETGAALVHCPTSNTFIGSGLMDVAGLAARSVPVGLAT
DTGGGSSFSMLRTMAAAYEVAQLRGTALHPAQLLYLATAGSARALHLHDTIGTLSPGYEADLTILDLASTPAISQRAAEA
ETIWEAIFPTIMMGDDRAIADVWIAGKRRITDQSV
>Mature_434_residues
SEYDLILGQTFQVTANPMTTPWQQAVTVASDGAVLLRDGRIEQVGHASDLRQQHPQARITDYGDKLVCPGFVDAHVHYPQ
TAIIASWGKQLIDWLNTYTFPEETRLCDPAYARAIADRYLDLALAHGTTTVCSYATSHPASVDAFFDAAERRGLRVIAGK
TCMDRNAPEALCDTVQHAHDESKSLLEKWHGRGRAHYAITPRFSPTSTPEQLEALGALWAQHPSCLMQTHLSEQVPEIKW
VRELFPTARDYLDTYEMHGLIGERAVFGHAIHLEPREIDRIAETGAALVHCPTSNTFIGSGLMDVAGLAARSVPVGLATD
TGGGSSFSMLRTMAAAYEVAQLRGTALHPAQLLYLATAGSARALHLHDTIGTLSPGYEADLTILDLASTPAISQRAAEAE
TIWEAIFPTIMMGDDRAIADVWIAGKRRITDQSV

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=380, Percent_Identity=30, Blast_Score=188, Evalue=7e-48,
Organism=Escherichia coli, GI1789249, Length=403, Percent_Identity=42.6799007444169, Blast_Score=374, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6319963, Length=393, Percent_Identity=31.5521628498728, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24643849, Length=405, Percent_Identity=33.5802469135802, Blast_Score=214, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 47494; Mature: 47363

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEYDLILGQTFQVTANPMTTPWQQAVTVASDGAVLLRDGRIEQVGHASDLRQQHPQARI
CCCCCEEECCEEEEECCCCCCCHHHHEEEECCCEEEEECCCHHHCCCHHHHHHHCCCCCC
TDYGDKLVCPGFVDAHVHYPQTAIIASWGKQLIDWLNTYTFPEETRLCDPAYARAIADRY
CCCCCCEECCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHH
LDLALAHGTTTVCSYATSHPASVDAFFDAAERRGLRVIAGKTCMDRNAPEALCDTVQHAH
HHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHH
DESKSLLEKWHGRGRAHYAITPRFSPTSTPEQLEALGALWAQHPSCLMQTHLSEQVPEIK
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHH
WVRELFPTARDYLDTYEMHGLIGERAVFGHAIHLEPREIDRIAETGAALVHCPTSNTFIG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHCEEEECCHHHHHHHHHCCCEEEECCCCCCCCC
SGLMDVAGLAARSVPVGLATDTGGGSSFSMLRTMAAAYEVAQLRGTALHPAQLLYLATAG
CCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECC
SARALHLHDTIGTLSPGYEADLTILDLASTPAISQRAAEAETIWEAIFPTIMMGDDRAIA
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEE
DVWIAGKRRITDQSV
HEEECCCCCCCCCCC
>Mature Secondary Structure 
SEYDLILGQTFQVTANPMTTPWQQAVTVASDGAVLLRDGRIEQVGHASDLRQQHPQARI
CCCCEEECCEEEEECCCCCCCHHHHEEEECCCEEEEECCCHHHCCCHHHHHHHCCCCCC
TDYGDKLVCPGFVDAHVHYPQTAIIASWGKQLIDWLNTYTFPEETRLCDPAYARAIADRY
CCCCCCEECCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHHH
LDLALAHGTTTVCSYATSHPASVDAFFDAAERRGLRVIAGKTCMDRNAPEALCDTVQHAH
HHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCHHHHHHHHHHHH
DESKSLLEKWHGRGRAHYAITPRFSPTSTPEQLEALGALWAQHPSCLMQTHLSEQVPEIK
HHHHHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHH
WVRELFPTARDYLDTYEMHGLIGERAVFGHAIHLEPREIDRIAETGAALVHCPTSNTFIG
HHHHHHHHHHHHHHHHHHHHHHHCHHHHCEEEECCHHHHHHHHHCCCEEEECCCCCCCCC
SGLMDVAGLAARSVPVGLATDTGGGSSFSMLRTMAAAYEVAQLRGTALHPAQLLYLATAG
CCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEEECC
SARALHLHDTIGTLSPGYEADLTILDLASTPAISQRAAEAETIWEAIFPTIMMGDDRAIA
CCEEEEEECCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEE
DVWIAGKRRITDQSV
HEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]