Click here to switch to the map view.

The map label for this gene is ilvB [H]

Identifier: 110679230

GI number: 110679230

Start: 1852126

End: 1853718

Strand: Direct

Name: ilvB [H]

Synonym: RD1_1943

Alternate gene names: 110679230

Gene position: 1852126-1853718 (Clockwise)

Preceding gene: 110679229

Following gene: 110679232

Centisome position: 44.81

GC content: 63.34

Gene sequence:

>1593_bases
ATGCAACGTCCCCTGGGAGCGCAGATTTCACATATGCTCAAGGATCGCGGTGTCGATGTCATCTTTGGCATTCCCGGCGT
CCACAATCAGGAAATGTATCGTGGCATCGAAGAGGCGGGCATCACTCACGTCCTGGCGCGTCACGAGCAGGGGGCGGGGT
TCATGGCCGATGGCTATGCGCGCGCGACGGGCAAACCGGGGGTGGCCTATGTGATCACCGGACCGGGCCTGTGCAATGCG
ATGACGCCCATGGGGCAGGCCTATTCGGATTCGGTTTCGATGCTGGTTTTGTCCTCCTGTCTGGATGAGGTGGCGGCACG
AAAAGGCCAGTTGCACCAGATGAAGGATCAGCGCGCCGCTGCGGAAACCGTCTGCGACTGGTCGGTGCAGGCGCAAACGG
CACAGGCCGCCTATCACCTGATTGACCGCGCCTTCACCGAGTTTCAGACCCGGCGCGCACGCCCCAAGCACATTCAGGTG
CCGATTGCCGCGCTTCAGGCGCCGGCACCGGATGCGCCAGCGCGCGTCGATCCGGCAACGATCTGCGCAGATGGGTTTCC
CCCCGCCGATGCCGGTCAGGTCGTTGCAGCGCTCAAATCCGCCAAACGCCCGATGATGATATTTGGCGGTGGCGCCGTGT
CTGCCGCCAGCGATTGTTACAAACTGGCCAGCCGTGCCGGGGCGGCGGCGTTTTGCACATATGCCGGGCGTGGTATCGTC
CCGTCGGATTATGCGCTTTACTTTGGTTCGACACTGGCGCGCCCGGATTCTGCGCGGGTTCTGGCGCAAGCTGATCTGCT
TTTGGTGATCGGGTCGGAGCTTGCAGAGGTTGATATCTGGCGCGACGGGCTCGGGCACACATGCCCCATGATCCGCGTGG
ACATCGACCCCTCCCATATGACCGGCGCGCGGCGCGACGGCGATGCGCAGATCCTGTGCCGGGCATCCACCTTTGCACAG
ACGCTCTGTGAGGCCCTCGAAGGGCATATTCCGCAAACCGAATGGCGCGCGCAGGACATCGCGGCAACACGCGCACAGTG
GCGCGCGGAAATAGCCGCGGAACGTCCGGGCATTGTGCCGGTCTGTGACGCGCTGCAAGCGGTCCTGCCGGACGGTACGA
TGATCTATTCCGACATGACGCAGTTTGCCTATGCGGCCAAGGAAGTCTGGGACATGGACCGCGCGGGCCACTGGCATCAC
CCGTTCGGCTTTGGCACCCTCGGCTATGCGACCCCCGCTGCGATCGGCGGGGCCATCGGGCGGGCGGGCAAGCCAACCCT
CGCCATCATTGGCGACTACGGGTTTCACTACACGATGCAGGAATTGGGCGTGGCGGTTGAACTTGGGCTGAGCCTGCCGA
TCCTGCTGTGGGACAATGGCAAGCTGAAAGAGATCGAGGACAGCATGGTGCGCGCTCAGATCGCGCCCAAGGCGGTCATC
GCCCGCAACCCGGATTTTTGCAAACTCGCCGAAGCCTTCGGTGCGCGTTCAGCGGCGCCGCAAACACTGGAGGCTTTGCA
GCACGCGGTGCGGGCGGCCTTTGAAGCAGATGGACCGACGCTGATCTATGTCACGCCGGACGTCGGAAAATAG

Upstream 100 bases:

>100_bases
GACACCGCCAAGTGGCTTTTGTCACTTGGCATGTTATTGGGTCGGCTCGAACTTCTGGCCGTCTATGCCATGCTCACCCT
TTCATTCTGGAGAGATTGAT

Downstream 100 bases:

>100_bases
CGTAAGGGGTTCATTCCCAACAGCTGACAAGCACGGTCATGCCAACCCCCAGGTCGGTAATGTCTTCGGGGTCAAGGCTG
GCGGTCTGATCACCCTTGCG

Product: acetohydroxy acid synthase large subunit, putative

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MQRPLGAQISHMLKDRGVDVIFGIPGVHNQEMYRGIEEAGITHVLARHEQGAGFMADGYARATGKPGVAYVITGPGLCNA
MTPMGQAYSDSVSMLVLSSCLDEVAARKGQLHQMKDQRAAAETVCDWSVQAQTAQAAYHLIDRAFTEFQTRRARPKHIQV
PIAALQAPAPDAPARVDPATICADGFPPADAGQVVAALKSAKRPMMIFGGGAVSAASDCYKLASRAGAAAFCTYAGRGIV
PSDYALYFGSTLARPDSARVLAQADLLLVIGSELAEVDIWRDGLGHTCPMIRVDIDPSHMTGARRDGDAQILCRASTFAQ
TLCEALEGHIPQTEWRAQDIAATRAQWRAEIAAERPGIVPVCDALQAVLPDGTMIYSDMTQFAYAAKEVWDMDRAGHWHH
PFGFGTLGYATPAAIGGAIGRAGKPTLAIIGDYGFHYTMQELGVAVELGLSLPILLWDNGKLKEIEDSMVRAQIAPKAVI
ARNPDFCKLAEAFGARSAAPQTLEALQHAVRAAFEADGPTLIYVTPDVGK

Sequences:

>Translated_530_residues
MQRPLGAQISHMLKDRGVDVIFGIPGVHNQEMYRGIEEAGITHVLARHEQGAGFMADGYARATGKPGVAYVITGPGLCNA
MTPMGQAYSDSVSMLVLSSCLDEVAARKGQLHQMKDQRAAAETVCDWSVQAQTAQAAYHLIDRAFTEFQTRRARPKHIQV
PIAALQAPAPDAPARVDPATICADGFPPADAGQVVAALKSAKRPMMIFGGGAVSAASDCYKLASRAGAAAFCTYAGRGIV
PSDYALYFGSTLARPDSARVLAQADLLLVIGSELAEVDIWRDGLGHTCPMIRVDIDPSHMTGARRDGDAQILCRASTFAQ
TLCEALEGHIPQTEWRAQDIAATRAQWRAEIAAERPGIVPVCDALQAVLPDGTMIYSDMTQFAYAAKEVWDMDRAGHWHH
PFGFGTLGYATPAAIGGAIGRAGKPTLAIIGDYGFHYTMQELGVAVELGLSLPILLWDNGKLKEIEDSMVRAQIAPKAVI
ARNPDFCKLAEAFGARSAAPQTLEALQHAVRAAFEADGPTLIYVTPDVGK
>Mature_530_residues
MQRPLGAQISHMLKDRGVDVIFGIPGVHNQEMYRGIEEAGITHVLARHEQGAGFMADGYARATGKPGVAYVITGPGLCNA
MTPMGQAYSDSVSMLVLSSCLDEVAARKGQLHQMKDQRAAAETVCDWSVQAQTAQAAYHLIDRAFTEFQTRRARPKHIQV
PIAALQAPAPDAPARVDPATICADGFPPADAGQVVAALKSAKRPMMIFGGGAVSAASDCYKLASRAGAAAFCTYAGRGIV
PSDYALYFGSTLARPDSARVLAQADLLLVIGSELAEVDIWRDGLGHTCPMIRVDIDPSHMTGARRDGDAQILCRASTFAQ
TLCEALEGHIPQTEWRAQDIAATRAQWRAEIAAERPGIVPVCDALQAVLPDGTMIYSDMTQFAYAAKEVWDMDRAGHWHH
PFGFGTLGYATPAAIGGAIGRAGKPTLAIIGDYGFHYTMQELGVAVELGLSLPILLWDNGKLKEIEDSMVRAQIAPKAVI
ARNPDFCKLAEAFGARSAAPQTLEALQHAVRAAFEADGPTLIYVTPDVGK

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=545, Percent_Identity=23.1192660550459, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=23.1182795698925, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI1790104, Length=545, Percent_Identity=25.8715596330275, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI87081685, Length=524, Percent_Identity=27.6717557251908, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1786717, Length=523, Percent_Identity=24.8565965583174, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788716, Length=545, Percent_Identity=22.9357798165138, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323755, Length=567, Percent_Identity=26.2786596119929, Blast_Score=142, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320816, Length=555, Percent_Identity=21.0810810810811, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19922626, Length=553, Percent_Identity=24.9547920433996, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 56578; Mature: 56578

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPLGAQISHMLKDRGVDVIFGIPGVHNQEMYRGIEEAGITHVLARHEQGAGFMADGYA
CCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCEE
RATGKPGVAYVITGPGLCNAMTPMGQAYSDSVSMLVLSSCLDEVAARKGQLHQMKDQRAA
CCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AETVCDWSVQAQTAQAAYHLIDRAFTEFQTRRARPKHIQVPIAALQAPAPDAPARVDPAT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCHH
ICADGFPPADAGQVVAALKSAKRPMMIFGGGAVSAASDCYKLASRAGAAAFCTYAGRGIV
EECCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEHHHCCCCCC
PSDYALYFGSTLARPDSARVLAQADLLLVIGSELAEVDIWRDGLGHTCPMIRVDIDPSHM
CCCHHHHHCCHHCCCCCCHHHHHCCEEEEECCHHHHHHHHHCCCCCCCCEEEEECCHHHC
TGARRDGDAQILCRASTFAQTLCEALEGHIPQTEWRAQDIAATRAQWRAEIAAERPGIVP
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
VCDALQAVLPDGTMIYSDMTQFAYAAKEVWDMDRAGHWHHPFGFGTLGYATPAAIGGAIG
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHC
RAGKPTLAIIGDYGFHYTMQELGVAVELGLSLPILLWDNGKLKEIEDSMVRAQIAPKAVI
CCCCCEEEEEECCCCCHHHHHCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
ARNPDFCKLAEAFGARSAAPQTLEALQHAVRAAFEADGPTLIYVTPDVGK
ECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure
MQRPLGAQISHMLKDRGVDVIFGIPGVHNQEMYRGIEEAGITHVLARHEQGAGFMADGYA
CCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEECCEE
RATGKPGVAYVITGPGLCNAMTPMGQAYSDSVSMLVLSSCLDEVAARKGQLHQMKDQRAA
CCCCCCCEEEEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AETVCDWSVQAQTAQAAYHLIDRAFTEFQTRRARPKHIQVPIAALQAPAPDAPARVDPAT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHCCCCCCCCCCCCCHH
ICADGFPPADAGQVVAALKSAKRPMMIFGGGAVSAASDCYKLASRAGAAAFCTYAGRGIV
EECCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEEHHHCCCCCC
PSDYALYFGSTLARPDSARVLAQADLLLVIGSELAEVDIWRDGLGHTCPMIRVDIDPSHM
CCCHHHHHCCHHCCCCCCHHHHHCCEEEEECCHHHHHHHHHCCCCCCCCEEEEECCHHHC
TGARRDGDAQILCRASTFAQTLCEALEGHIPQTEWRAQDIAATRAQWRAEIAAERPGIVP
CCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCH
VCDALQAVLPDGTMIYSDMTQFAYAAKEVWDMDRAGHWHHPFGFGTLGYATPAAIGGAIG
HHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHC
RAGKPTLAIIGDYGFHYTMQELGVAVELGLSLPILLWDNGKLKEIEDSMVRAQIAPKAVI
CCCCCEEEEEECCCCCHHHHHCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHCCCCEE
ARNPDFCKLAEAFGARSAAPQTLEALQHAVRAAFEADGPTLIYVTPDVGK
ECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]