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The map label for this gene is nikC [H]

Identifier: 110679153

GI number: 110679153

Start: 1783229

End: 1784023

Strand: Direct

Name: nikC [H]

Synonym: RD1_1863

Alternate gene names: 110679153

Gene position: 1783229-1784023 (Clockwise)

Preceding gene: 110679152

Following gene: 110679154

Centisome position: 43.15

GC content: 62.14

Gene sequence:

>795_bases
ATGCGTAGTGTGTTCGTGCTTGTCGCTCTTCTGGTGAGCCTTGCGTTGTTTGGCCCGGTGCTCGCGCCGCACGATCCCGC
TGCGATCAATATCCCCAACCGCCTCAGCCCGCCAAGCGCTGACTGGCTGCTCGGGACTGATGCAATGGGGCGCGACATCC
TGTCGAGGCTCTTGCACGGGGCACGCTGGTCGCTCGGTCTGGCCTTTCTGATATCCGTCATGGGCCTGTGCATCGGCACG
CTGGTAGGTCTGCTTGCCGCGCAGGGCGGCAGGATCGTCGATTGGGTGGTGATGCGCACCACGGATTCATTCCTCGCCTT
TCCCGAATTGATCGCTGCGGTTGTCATTGCAGGCGTGCTTGGCGCCGGGACTGGCAGTCTGATCTTTGCCCTGACCGTGA
CGGGGTGGATTCGCTATGCACGGGTTGCGCGTGGCATTGGTCTGTCCCTGCAAACGCGCGGCTATGTGGTTCAGGCGCGG
CTCGCCCGGGTATCGCCGGTCTATATCGCCCGGTGGCACTACCTGCCATCGCTGTTACCATCGCTTACGGTGGTCTGGAC
CGGCATGTTCGCTCGTGCGATCCTGGGCATATCGGCTCTTGGCTTTCTGGGCTTTGGTGTACAGCCACCTACGCCGGAGT
GGGGTACGATGTTGCTGGATGCGCGTATCCACATGCGCTCGACCCCACTGCAGATGATCTGGCCGGGGCTTGCGGTCGTT
TTCTGCGTCCTTGCGATCAACCTTGCCGGGGACGTGTTGCGCGACGCCTTGACCGAAGGGGATCACAGGAAATGA

Upstream 100 bases:

>100_bases
GTGCAGGCCGTGGTGATCGTCACGGCGGTGATCTTTGTGATCATCAACCTCGTGATTGATCTGCTATATCGTGCCCTCGA
CCCCCGGATCGGAGAGCGCA

Downstream 100 bases:

>100_bases
CAGGCACGGATAAACCCGGTCTCGCCATCGGCTTGCGCATCCTGTCGGGTGTTCTCTTTGCCGGCATGCTGGTCTGCGTC
AAAGCTGTGAGCGCGGATGT

Product: nickel transport system permease protein nikC

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MRSVFVLVALLVSLALFGPVLAPHDPAAINIPNRLSPPSADWLLGTDAMGRDILSRLLHGARWSLGLAFLISVMGLCIGT
LVGLLAAQGGRIVDWVVMRTTDSFLAFPELIAAVVIAGVLGAGTGSLIFALTVTGWIRYARVARGIGLSLQTRGYVVQAR
LARVSPVYIARWHYLPSLLPSLTVVWTGMFARAILGISALGFLGFGVQPPTPEWGTMLLDARIHMRSTPLQMIWPGLAVV
FCVLAINLAGDVLRDALTEGDHRK

Sequences:

>Translated_264_residues
MRSVFVLVALLVSLALFGPVLAPHDPAAINIPNRLSPPSADWLLGTDAMGRDILSRLLHGARWSLGLAFLISVMGLCIGT
LVGLLAAQGGRIVDWVVMRTTDSFLAFPELIAAVVIAGVLGAGTGSLIFALTVTGWIRYARVARGIGLSLQTRGYVVQAR
LARVSPVYIARWHYLPSLLPSLTVVWTGMFARAILGISALGFLGFGVQPPTPEWGTMLLDARIHMRSTPLQMIWPGLAVV
FCVLAINLAGDVLRDALTEGDHRK
>Mature_264_residues
MRSVFVLVALLVSLALFGPVLAPHDPAAINIPNRLSPPSADWLLGTDAMGRDILSRLLHGARWSLGLAFLISVMGLCIGT
LVGLLAAQGGRIVDWVVMRTTDSFLAFPELIAAVVIAGVLGAGTGSLIFALTVTGWIRYARVARGIGLSLQTRGYVVQAR
LARVSPVYIARWHYLPSLLPSLTVVWTGMFARAILGISALGFLGFGVQPPTPEWGTMLLDARIHMRSTPLQMIWPGLAVV
FCVLAINLAGDVLRDALTEGDHRK

Specific function: Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789889, Length=245, Percent_Identity=41.2244897959184, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1787054, Length=253, Percent_Identity=38.3399209486166, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1787760, Length=252, Percent_Identity=34.5238095238095, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789964, Length=250, Percent_Identity=41.6, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1787549, Length=256, Percent_Identity=33.203125, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1787498, Length=261, Percent_Identity=31.4176245210728, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788505, Length=222, Percent_Identity=27.4774774774775, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR014157 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 28296; Mature: 28296

Theoretical pI: Translated: 10.73; Mature: 10.73

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSVFVLVALLVSLALFGPVLAPHDPAAINIPNRLSPPSADWLLGTDAMGRDILSRLLHG
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHH
ARWSLGLAFLISVMGLCIGTLVGLLAAQGGRIVDWVVMRTTDSFLAFPELIAAVVIAGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHH
GAGTGSLIFALTVTGWIRYARVARGIGLSLQTRGYVVQARLARVSPVYIARWHYLPSLLP
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHH
SLTVVWTGMFARAILGISALGFLGFGVQPPTPEWGTMLLDARIHMRSTPLQMIWPGLAVV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEHHHHHHCCCCHHHHHHHHHHH
FCVLAINLAGDVLRDALTEGDHRK
HHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRSVFVLVALLVSLALFGPVLAPHDPAAINIPNRLSPPSADWLLGTDAMGRDILSRLLHG
CHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCEEECCHHHHHHHHHHHHHH
ARWSLGLAFLISVMGLCIGTLVGLLAAQGGRIVDWVVMRTTDSFLAFPELIAAVVIAGVL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHH
GAGTGSLIFALTVTGWIRYARVARGIGLSLQTRGYVVQARLARVSPVYIARWHYLPSLLP
CCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHH
SLTVVWTGMFARAILGISALGFLGFGVQPPTPEWGTMLLDARIHMRSTPLQMIWPGLAVV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEHHHHHHCCCCHHHHHHHHHHH
FCVLAINLAGDVLRDALTEGDHRK
HHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]