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The map label for this gene is npdA [H]

Identifier: 110678986

GI number: 110678986

Start: 1618798

End: 1619490

Strand: Reverse

Name: npdA [H]

Synonym: RD1_1683

Alternate gene names: 110678986

Gene position: 1619490-1618798 (Counterclockwise)

Preceding gene: 110678992

Following gene: 110678981

Centisome position: 39.18

GC content: 62.48

Gene sequence:

>693_bases
ATGAAGAAAATCGTGATACTGACCGGGGCCGGCATTTCAGCGGAAAGCGGGCTTGGCACCTTTCGCGCCGAAGGCGGTCT
CTGGGCGGAGCACCGGATCGAAGATGTGGCCACGCCAGAAGGCTTTGCGCGCGATCCCAGGCTCGTGGTCGATTTTTACA
ATGCCCGCCGGGCACAGGCGGCAGAGGCTGCACCGAATGCCGCTCATCTGGCGCTGGCGAAACTGGAGGAGGCCTTCGAC
GGGGAGGTCGTGCTGGTGACGCAGAATGTCGATGATCTGCACGAAAAAGCCGGGATGAAACGGGTGATGCATATGCATGG
TGCCCTGAACGGGGCCTTGTGCGGTGCCTGTGATCATCGCTGGCCTGCCCCGATGGTCATGGCGCCCGGTGACACCTGCC
CAGGCTGCGAAGCCCCCGCAGCACGCCCGGACATCGTCTGGTTCGGCGAAATGCCCTATGACATGGAAGAAATCTATGAC
CACCTCGCGCAGGCGGACCTTTTTGCGGGCATCGGCACGTCGGGGAATGTCTATCCTGCAGCCGGTTTCGTGGCCGAAGC
GCGCCGCTCCGGGGCGCGCACGCTTGAATTCAACCTTGAGCCTTCAGCGGTCGGCAGCCAGTTCGATAACATCCGCATCG
GCCCTGCGACCCAGACAGTGCCTGCATGGGTCGCAGAAATCCTTGGGAGCTGA

Upstream 100 bases:

>100_bases
AAAATCACCGCCTTCGCAAGCCCGCAGCGCAGCGTTTCGCACAGGCTTTGACATGAACCGGCAGACTGGGCACAACGGGG
CCAGCAATGGGAAAACCGAT

Downstream 100 bases:

>100_bases
ACGCAGTTTCGGTTAGTTGGTTTTGCCGTGGTTCATGTGGCCATGGTTCATATGCCCATGCTTCGGCTTGCGCTCATTAT
CGACGGGGATCATGACGGTC

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MKKIVILTGAGISAESGLGTFRAEGGLWAEHRIEDVATPEGFARDPRLVVDFYNARRAQAAEAAPNAAHLALAKLEEAFD
GEVVLVTQNVDDLHEKAGMKRVMHMHGALNGALCGACDHRWPAPMVMAPGDTCPGCEAPAARPDIVWFGEMPYDMEEIYD
HLAQADLFAGIGTSGNVYPAAGFVAEARRSGARTLEFNLEPSAVGSQFDNIRIGPATQTVPAWVAEILGS

Sequences:

>Translated_230_residues
MKKIVILTGAGISAESGLGTFRAEGGLWAEHRIEDVATPEGFARDPRLVVDFYNARRAQAAEAAPNAAHLALAKLEEAFD
GEVVLVTQNVDDLHEKAGMKRVMHMHGALNGALCGACDHRWPAPMVMAPGDTCPGCEAPAARPDIVWFGEMPYDMEEIYD
HLAQADLFAGIGTSGNVYPAAGFVAEARRSGARTLEFNLEPSAVGSQFDNIRIGPATQTVPAWVAEILGS
>Mature_230_residues
MKKIVILTGAGISAESGLGTFRAEGGLWAEHRIEDVATPEGFARDPRLVVDFYNARRAQAAEAAPNAAHLALAKLEEAFD
GEVVLVTQNVDDLHEKAGMKRVMHMHGALNGALCGACDHRWPAPMVMAPGDTCPGCEAPAARPDIVWFGEMPYDMEEIYD
HLAQADLFAGIGTSGNVYPAAGFVAEARRSGARTLEFNLEPSAVGSQFDNIRIGPATQTVPAWVAEILGS

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=236, Percent_Identity=39.4067796610169, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI6912664, Length=252, Percent_Identity=37.3015873015873, Blast_Score=154, Evalue=6e-38,
Organism=Homo sapiens, GI13787215, Length=237, Percent_Identity=37.5527426160338, Blast_Score=150, Evalue=7e-37,
Organism=Homo sapiens, GI6912662, Length=241, Percent_Identity=29.045643153527, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7657575, Length=209, Percent_Identity=31.5789473684211, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI6912660, Length=208, Percent_Identity=30.2884615384615, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI63054862, Length=203, Percent_Identity=30.5418719211823, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI300797577, Length=228, Percent_Identity=29.3859649122807, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI308199517, Length=229, Percent_Identity=57.2052401746725, Blast_Score=256, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI17541892, Length=200, Percent_Identity=31, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71990482, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71990487, Length=251, Percent_Identity=27.4900398406374, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17567771, Length=130, Percent_Identity=33.8461538461538, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17137536, Length=224, Percent_Identity=30.8035714285714, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI28571445, Length=122, Percent_Identity=40.1639344262295, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 24514; Mature: 24514

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIVILTGAGISAESGLGTFRAEGGLWAEHRIEDVATPEGFARDPRLVVDFYNARRAQA
CCEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHH
AEAAPNAAHLALAKLEEAFDGEVVLVTQNVDDLHEKAGMKRVMHMHGALNGALCGACDHR
HHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCC
WPAPMVMAPGDTCPGCEAPAARPDIVWFGEMPYDMEEIYDHLAQADLFAGIGTSGNVYPA
CCCCEEECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
AGFVAEARRSGARTLEFNLEPSAVGSQFDNIRIGPATQTVPAWVAEILGS
HHHHHHHHHCCCEEEEEECCHHHHCCCCCCEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKKIVILTGAGISAESGLGTFRAEGGLWAEHRIEDVATPEGFARDPRLVVDFYNARRAQA
CCEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHH
AEAAPNAAHLALAKLEEAFDGEVVLVTQNVDDLHEKAGMKRVMHMHGALNGALCGACDHR
HHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCEECCCCCC
WPAPMVMAPGDTCPGCEAPAARPDIVWFGEMPYDMEEIYDHLAQADLFAGIGTSGNVYPA
CCCCEEECCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
AGFVAEARRSGARTLEFNLEPSAVGSQFDNIRIGPATQTVPAWVAEILGS
HHHHHHHHHCCCEEEEEECCHHHHCCCCCCEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA