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The map label for this gene is hemC [H]

Identifier: 110678608

GI number: 110678608

Start: 1245809

End: 1246753

Strand: Reverse

Name: hemC [H]

Synonym: RD1_1283

Alternate gene names: 110678608

Gene position: 1246753-1245809 (Counterclockwise)

Preceding gene: 110678614

Following gene: 110678603

Centisome position: 30.17

GC content: 60.95

Gene sequence:

>945_bases
ATGACAGTAATGCTTCCTTCCCCCGACTCGCCCCTCAAGATCGGCACCCGCGGCTCGCCTCTGGCGATGGCGCAGGCCTT
TGAAACCCGTGCGCGCCTGATGCAAGCCTTTGATTTGCCTGAGAATGCCTTCACCATCGTCGTGATCAAAGTCACCGGTG
ACATGATTCAGGATCGCGCGCTGAAAGACATCGGTGGCAAGGGTCTTTTCACCCGTGAAATTGAAGAAGATCTGCTGTCA
GAAAAAATTGACATCGCGGTGCATTCCATGAAGGACATGCCGACGCTGCAACCGGACGGGCTGATCCTTGATACCTACCT
GCCGCGCGAGGATGTGCGCGATGCGTTCATCTCGCCGACGCTGAAAGGTATCGCCGATCTGGCGCAGGGCGCGGTGGTCG
GCACTTCCAGCCTGCGGCGCAAGGCACAGCTGCTCAACCGCCGCCCGGACCTGAATGTGGTCGAATTTCGCGGCAATGTG
CAGACGCGGCTGAAAAAGCTGGCGGATGGCGTGGCCGAATGCACCTTCCTTGCCTGCGCCGGGTTGAGCCGTCTGAAAAT
GGATGAGGTGCCTGCGACGCCGATTGAAACCGACCACATGCTGCCAGCGGTAGCGCAGGGTGCCATCGGGATCGAACGCC
GGATCGCGGACACAAACACGGCAGAGTTGCTGAGCGCGATCCATGATGGCCCTACCGGTCAGCGGCTCGCGGCCGAACGC
AATTTCCTGCTGACGCTGGATGGTTCCTGCGAGACACCGATTGCGGGGCTGGCAGAGCTTTCGGGCGATCATCTGCGGCT
GCGCGGTGAAGTGCTTCGCCCGGATGGGTCCGAAGCGCTCAACGGTGAACGCTCAGGTCCGATATCGGATGGCGCGGCCA
TGGGGCGCGATCTTGCCGAAAAACTGCTCAAGCGCGCCGGACCCAGCTTTTTCGACTGGCACTAG

Upstream 100 bases:

>100_bases
CGTCCTCTTGGTAACTCAAAACGTTGGTCTTCGTCTCAGGCGGTATTGTCAAGTCACAGACGGGTTGTCAGGGTAAATTG
ACGCGCTTAAAGATGTGATT

Downstream 100 bases:

>100_bases
ATCGTCTCACGAAACACCCGAAACATCACTTAGCGCTTTGAGATCTTTCATTTCAGGCAGCGTTACGTGGTTAGGATTTT
TGGAATGACGCTTTAGCCCA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MTVMLPSPDSPLKIGTRGSPLAMAQAFETRARLMQAFDLPENAFTIVVIKVTGDMIQDRALKDIGGKGLFTREIEEDLLS
EKIDIAVHSMKDMPTLQPDGLILDTYLPREDVRDAFISPTLKGIADLAQGAVVGTSSLRRKAQLLNRRPDLNVVEFRGNV
QTRLKKLADGVAECTFLACAGLSRLKMDEVPATPIETDHMLPAVAQGAIGIERRIADTNTAELLSAIHDGPTGQRLAAER
NFLLTLDGSCETPIAGLAELSGDHLRLRGEVLRPDGSEALNGERSGPISDGAAMGRDLAEKLLKRAGPSFFDWH

Sequences:

>Translated_314_residues
MTVMLPSPDSPLKIGTRGSPLAMAQAFETRARLMQAFDLPENAFTIVVIKVTGDMIQDRALKDIGGKGLFTREIEEDLLS
EKIDIAVHSMKDMPTLQPDGLILDTYLPREDVRDAFISPTLKGIADLAQGAVVGTSSLRRKAQLLNRRPDLNVVEFRGNV
QTRLKKLADGVAECTFLACAGLSRLKMDEVPATPIETDHMLPAVAQGAIGIERRIADTNTAELLSAIHDGPTGQRLAAER
NFLLTLDGSCETPIAGLAELSGDHLRLRGEVLRPDGSEALNGERSGPISDGAAMGRDLAEKLLKRAGPSFFDWH
>Mature_313_residues
TVMLPSPDSPLKIGTRGSPLAMAQAFETRARLMQAFDLPENAFTIVVIKVTGDMIQDRALKDIGGKGLFTREIEEDLLSE
KIDIAVHSMKDMPTLQPDGLILDTYLPREDVRDAFISPTLKGIADLAQGAVVGTSSLRRKAQLLNRRPDLNVVEFRGNVQ
TRLKKLADGVAECTFLACAGLSRLKMDEVPATPIETDHMLPAVAQGAIGIERRIADTNTAELLSAIHDGPTGQRLAAERN
FLLTLDGSCETPIAGLAELSGDHLRLRGEVLRPDGSEALNGERSGPISDGAAMGRDLAEKLLKRAGPSFFDWH

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=274, Percent_Identity=37.956204379562, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI20149500, Length=274, Percent_Identity=37.956204379562, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI48994974, Length=296, Percent_Identity=45.945945945946, Blast_Score=231, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=35.7594936708861, Blast_Score=170, Evalue=3e-43,
Organism=Drosophila melanogaster, GI20130425, Length=260, Percent_Identity=39.2307692307692, Blast_Score=162, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33971; Mature: 33840

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVMLPSPDSPLKIGTRGSPLAMAQAFETRARLMQAFDLPENAFTIVVIKVTGDMIQDRA
CEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHH
LKDIGGKGLFTREIEEDLLSEKIDIAVHSMKDMPTLQPDGLILDTYLPREDVRDAFISPT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHH
LKGIADLAQGAVVGTSSLRRKAQLLNRRPDLNVVEFRGNVQTRLKKLADGVAECTFLACA
HHHHHHHHCCCEECHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GLSRLKMDEVPATPIETDHMLPAVAQGAIGIERRIADTNTAELLSAIHDGPTGQRLAAER
CHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCC
NFLLTLDGSCETPIAGLAELSGDHLRLRGEVLRPDGSEALNGERSGPISDGAAMGRDLAE
CEEEEECCCCCCCHHHHHHCCCCEEEEECEEECCCCCHHCCCCCCCCCCCHHHHHHHHHH
KLLKRAGPSFFDWH
HHHHHCCCCCCCCC
>Mature Secondary Structure 
TVMLPSPDSPLKIGTRGSPLAMAQAFETRARLMQAFDLPENAFTIVVIKVTGDMIQDRA
EEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHH
LKDIGGKGLFTREIEEDLLSEKIDIAVHSMKDMPTLQPDGLILDTYLPREDVRDAFISPT
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHH
LKGIADLAQGAVVGTSSLRRKAQLLNRRPDLNVVEFRGNVQTRLKKLADGVAECTFLACA
HHHHHHHHCCCEECHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GLSRLKMDEVPATPIETDHMLPAVAQGAIGIERRIADTNTAELLSAIHDGPTGQRLAAER
CHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHCCC
NFLLTLDGSCETPIAGLAELSGDHLRLRGEVLRPDGSEALNGERSGPISDGAAMGRDLAE
CEEEEECCCCCCCHHHHHHCCCCEEEEECEEECCCCCHHCCCCCCCCCCCHHHHHHHHHH
KLLKRAGPSFFDWH
HHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA