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The map label for this gene is hemN [H]

Identifier: 110678592

GI number: 110678592

Start: 1229472

End: 1230827

Strand: Reverse

Name: hemN [H]

Synonym: RD1_1267

Alternate gene names: 110678592

Gene position: 1230827-1229472 (Counterclockwise)

Preceding gene: 110678594

Following gene: 110678586

Centisome position: 29.78

GC content: 57.67

Gene sequence:

>1356_bases
ATGACACTGACATCCAAACTCGCCAAATTGGGTCTATTTGACGCAAGAGTTCCGCGTTACACCAGCTATCCGACGGCTCC
GCAGTTTTCTGCCGACACCACGGACGCTGACGCGCGCGCCTGGATCGCTGCGATACCGCCGGGAAGCCGCATTTCATTGT
ATTTGCACATACCGTTTTGCCGACGGTTGTGTTGGTTTTGCGCCTGCCGCACTCAGGGCATATCAAATAATGGCCCAGTG
GCGGCCTATCTGTCTACACTAAAAGCAGAATTAAGTATGTTGGCGGCCATTTTACCGCCCGACATCAGCCTCAGCCGTGT
CCATTGGGGCGGCGGCACGCCCACCCTGTTTGAAGCGGGCATGATCGAAGAGCTGGCCGGGGCAATCAACGATCTGGCCC
CCATGGCCCCAAATGGTGAGTTTTCGGTCGAAGTCGACCCCAATGAAATAGACCAGTCCCGGGTGGATGCGCTGGCAGCG
GCCGGTATGACCCGCGCCTCGATTGGCGTGCAGGATTTCGATGTCGAGATACAGACAACCATCGGCCGGCTGCAGAGTTT
CGACGTGACACGCTTTGCGGCGGATATGTTGCGGGCCTCGGGGGTGCATTCGCTGAACACGGATATCCTGTTTGGACTGC
CACATCAGACGACGGAAAAAATTGCCGCCAGTGTGCAGAAGCTTCTTACGTTGTCGCCTGATCGTGTCGCGCTTTACGGC
TACGCGCATGTGCCATGGATGGCGCGGCGCCAATCGCTGATTCCGTCCGATGCGCTGCCAGCACCCGAAGAGCGGCTGAA
ACTCTTTGAAACAGCCCGGCAACTGTTTGAATGGGACGGGTATCGCCAGATCGGGATTGATCACTTCGCCGTGCCACACG
ACACGCTGGCCGTGGCCGCGCGGACCGGCAAACTGCGCCGCAATTTTCAGGGGTATACGGATGAACCGGCTGAAGTGCTG
ATCGGTCTGGGCGCATCGGCAATTTCGCGCTTCCCGCAGGGCTATGCTCAAAACAACCCCTCGACATCCGGCTATACCAA
ATCCATTCGCGAAGGCGCGTTTTCCACATCGCGCGGGCATTGCTTTTCAGAGGATGACCGACTGCGCGGGCGTCTGATCG
AAGCGATCATGTGCGATTTCGAAGTCGACATCGATGATATGATCTCCCGCTTTCCGAAGCGTGAAGCGCACATTCGGGCC
CTGCTGGCGCGGGCCGCAGCCCATTTTGGCGATATCGTTCAACTTAAAAAAGACAGGTTCCAGGTTTTGCCCGATGGGCA
CGCGCTGGCACGGATCATAGCGCGCCATTTTGATGCCTATGAAATGTCCAGCGCGGGACATGTGTCGGCAATCTGA

Upstream 100 bases:

>100_bases
CGCATTCCTTGACGTTAGGCACAACGACGTCTTGCATCAAATTTCTCCGCACTTGATCCACATCAAAGTCTCCGCTTCCG
ACAAACCATATCCAGTCTCC

Downstream 100 bases:

>100_bases
GGATGAGAGCCTCTGACGAAGTGCCTGAACCTTCAAATATCACGTAACGCGTTGCGACCCTTGATTTCAGGCCGTGTCAC
GCGCCGCAGGTTTTTCGCAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MTLTSKLAKLGLFDARVPRYTSYPTAPQFSADTTDADARAWIAAIPPGSRISLYLHIPFCRRLCWFCACRTQGISNNGPV
AAYLSTLKAELSMLAAILPPDISLSRVHWGGGTPTLFEAGMIEELAGAINDLAPMAPNGEFSVEVDPNEIDQSRVDALAA
AGMTRASIGVQDFDVEIQTTIGRLQSFDVTRFAADMLRASGVHSLNTDILFGLPHQTTEKIAASVQKLLTLSPDRVALYG
YAHVPWMARRQSLIPSDALPAPEERLKLFETARQLFEWDGYRQIGIDHFAVPHDTLAVAARTGKLRRNFQGYTDEPAEVL
IGLGASAISRFPQGYAQNNPSTSGYTKSIREGAFSTSRGHCFSEDDRLRGRLIEAIMCDFEVDIDDMISRFPKREAHIRA
LLARAAAHFGDIVQLKKDRFQVLPDGHALARIIARHFDAYEMSSAGHVSAI

Sequences:

>Translated_451_residues
MTLTSKLAKLGLFDARVPRYTSYPTAPQFSADTTDADARAWIAAIPPGSRISLYLHIPFCRRLCWFCACRTQGISNNGPV
AAYLSTLKAELSMLAAILPPDISLSRVHWGGGTPTLFEAGMIEELAGAINDLAPMAPNGEFSVEVDPNEIDQSRVDALAA
AGMTRASIGVQDFDVEIQTTIGRLQSFDVTRFAADMLRASGVHSLNTDILFGLPHQTTEKIAASVQKLLTLSPDRVALYG
YAHVPWMARRQSLIPSDALPAPEERLKLFETARQLFEWDGYRQIGIDHFAVPHDTLAVAARTGKLRRNFQGYTDEPAEVL
IGLGASAISRFPQGYAQNNPSTSGYTKSIREGAFSTSRGHCFSEDDRLRGRLIEAIMCDFEVDIDDMISRFPKREAHIRA
LLARAAAHFGDIVQLKKDRFQVLPDGHALARIIARHFDAYEMSSAGHVSAI
>Mature_450_residues
TLTSKLAKLGLFDARVPRYTSYPTAPQFSADTTDADARAWIAAIPPGSRISLYLHIPFCRRLCWFCACRTQGISNNGPVA
AYLSTLKAELSMLAAILPPDISLSRVHWGGGTPTLFEAGMIEELAGAINDLAPMAPNGEFSVEVDPNEIDQSRVDALAAA
GMTRASIGVQDFDVEIQTTIGRLQSFDVTRFAADMLRASGVHSLNTDILFGLPHQTTEKIAASVQKLLTLSPDRVALYGY
AHVPWMARRQSLIPSDALPAPEERLKLFETARQLFEWDGYRQIGIDHFAVPHDTLAVAARTGKLRRNFQGYTDEPAEVLI
GLGASAISRFPQGYAQNNPSTSGYTKSIREGAFSTSRGHCFSEDDRLRGRLIEAIMCDFEVDIDDMISRFPKREAHIRAL
LARAAAHFGDIVQLKKDRFQVLPDGHALARIIARHFDAYEMSSAGHVSAI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=312, Percent_Identity=27.5641025641026, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI87082341, Length=440, Percent_Identity=35.6818181818182, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1789325, Length=295, Percent_Identity=26.1016949152542, Blast_Score=108, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 49520; Mature: 49389

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTSKLAKLGLFDARVPRYTSYPTAPQFSADTTDADARAWIAAIPPGSRISLYLHIPFC
CCHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECHHH
RRLCWFCACRTQGISNNGPVAAYLSTLKAELSMLAAILPPDISLSRVHWGGGTPTLFEAG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
MIEELAGAINDLAPMAPNGEFSVEVDPNEIDQSRVDALAAAGMTRASIGVQDFDVEIQTT
HHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEHHHH
IGRLQSFDVTRFAADMLRASGVHSLNTDILFGLPHQTTEKIAASVQKLLTLSPDRVALYG
HHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEE
YAHVPWMARRQSLIPSDALPAPEERLKLFETARQLFEWDGYRQIGIDHFAVPHDTLAVAA
EECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHH
RTGKLRRNFQGYTDEPAEVLIGLGASAISRFPQGYAQNNPSTSGYTKSIREGAFSTSRGH
HHHHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCC
CFSEDDRLRGRLIEAIMCDFEVDIDDMISRFPKREAHIRALLARAAAHFGDIVQLKKDRF
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLPDGHALARIIARHFDAYEMSSAGHVSAI
HCCCCHHHHHHHHHHHCCHHHCCCCCCCCCC
>Mature Secondary Structure 
TLTSKLAKLGLFDARVPRYTSYPTAPQFSADTTDADARAWIAAIPPGSRISLYLHIPFC
CHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECHHH
RRLCWFCACRTQGISNNGPVAAYLSTLKAELSMLAAILPPDISLSRVHWGGGTPTLFEAG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHH
MIEELAGAINDLAPMAPNGEFSVEVDPNEIDQSRVDALAAAGMTRASIGVQDFDVEIQTT
HHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHCCCCCCCEEHHHH
IGRLQSFDVTRFAADMLRASGVHSLNTDILFGLPHQTTEKIAASVQKLLTLSPDRVALYG
HHHHHHCHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCCCEEEEE
YAHVPWMARRQSLIPSDALPAPEERLKLFETARQLFEWDGYRQIGIDHFAVPHDTLAVAA
EECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHH
RTGKLRRNFQGYTDEPAEVLIGLGASAISRFPQGYAQNNPSTSGYTKSIREGAFSTSRGH
HHHHHHHCCCCCCCCHHHHHHCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCC
CFSEDDRLRGRLIEAIMCDFEVDIDDMISRFPKREAHIRALLARAAAHFGDIVQLKKDRF
CCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
QVLPDGHALARIIARHFDAYEMSSAGHVSAI
HCCCCHHHHHHHHHHHCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8809776 [H]