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The map label for this gene is cpdB [H]

Identifier: 110678583

GI number: 110678583

Start: 1218382

End: 1220253

Strand: Reverse

Name: cpdB [H]

Synonym: RD1_1258

Alternate gene names: 110678583

Gene position: 1220253-1218382 (Counterclockwise)

Preceding gene: 110678586

Following gene: 110678582

Centisome position: 29.52

GC content: 59.29

Gene sequence:

>1872_bases
ATGCCGATCCGGAGAAAGAAAATAACAGACGCACGGTCCAGAGAATTTCGCCTGCGCATTCTGGCAACCAGTGATCTGCA
CATGCAGATGACCTGTTTCGACTATGTCAATGACCGCCCCAATACCGGTGGCAGTCTGGCAAAGCTGGCGACGCTGATCA
AAAAGGCGCGCCGGGAAGCAGATGAAGCCGGGGCTGCGTGCCTGCTGTTAGACAATGGCGACACATTTCAGGGCACGCCC
ATGGCGGACCTGCTGGCGCGCGACGAAATCCATGGCCCGCACCCCATGGTTCAGGCGATGAATGCGCTGCACTATGACGC
GGGCGGGCTGGGCAATCACGATTTTGACTACGGCAGCGCGCATCTCGACAAGGTGCTGTTTGAGCAAAACATGCCGGTCG
TCTGTTCAAACCTGATCTCGTCAGAACTGAACACCGTCAAAACACAAGTGATCCTCGAACGCAGCTTGACCGACCAATAT
GGCAAGCCCGAAACCCTTCGAATGGGAATCCTGTCCAGCCTGCCCGACAAAACTGCGCTGTGGAACCAACATCAACTGAA
AGACCGCGTCGCATTTACCCCCCCGATACCCGCCTTGCGCGACGCGGCGGCGGCGTTGCGCGCGCAGGGCGTCGATCTGA
TCATCGTACTGGCGCATATGGGCTTTTCCCTGTTCGACGAGGGGCCCGCAGCGCAGAATCTAGTGAGCGAAGTTGCCCAG
CTTGCCGACGTGGACATCGTCGTGGCAGGGCACACGCACCTGCGTTTTCCCGGTCCTGATCACGCGGGTCTGAAACATGT
AAATACCGTCACGGGACGTGTCCACGGCAAACCCGTGGTGCAACCCGGTCCGACCGGCAATGACCTCGGTGTCATTGATC
TGACGCTTCGCAAGGCAGATGCAGCAAGCCTCTGTACCATGGCCGACGCGCAGATTGCGCTCTGGGCGACGGGTCCGAAT
ACCGCCGAAGACACCGACATCATTGCCTGCACGCAAGACATGCATGACCAGACCCGGCGCCACCTTGGCCAACAGGTCAC
CCATATCGAAAAACCCATGCACAGCTATTTTGCGCTATGCCAGCCCAGTCCGATACCAGCCCTGCTTGCAGCGTCAAAAC
ACAAGGCCATCCGCAAGATCATTGCAGGCACAAAATATGCTGACCTGCCCCTTCTGGCCGCTGCATCCGCCCCCTCAACG
GGTGGGTTTGACGGGCCGGAGAACTTTCTGTTCCTCTCAGAGGGCAAAGTTGAAAGGCGCCATATCTCGGGCATGAACCC
CTATGCCAACCACGTCTGGGCGGTCAAAACCACCGGAGCACAGATTCGTGACTGGCTCGAACGCTCTGCCCTGATTTTCA
ACACGCTGATGCCCGACGCACCGGACCAGATGCTGATCAACACCCACATCCCGAGCTTCCGGTGCGATTTTATCTACGGG
TTACGCTACGAGATCGACCCTTCCCGCCCTGCACGTTTTGATGCCGCCGGGCAGGCCGTTCCCGGCGCGCGTGGCAGGAT
CGGGGATATAACGTGGAACGATGCGCCCTTGCAGGACGCTCAGGAGTTTCTTGTCGCAACAACCGACCATCGCGCCAGCG
GGGGCGGGCTGTTCAAGGTGTTTTCGCGGGATGAGATCGTCGTGCAGGGCCATGCGCCGCTGCAGGCCGCCGTGATGGAT
TACCTCAGCGATCCGGACTTTGATGCCTTGCAGGCCACGCAGCCATGGTCGTTTCCCAAGGATATCTGCCGCAGCGCGAT
TCTACTGACGGCGCCGGAGGCCGAAAGCCATCTCCACGAGATCGCCCATCTCAAACCACAGGTGTGCGGCCAGACCGATG
ACGGTTTCCTGCGCATCCGTATCACGCTTTGA

Upstream 100 bases:

>100_bases
ACATAAAGAGTTCAAGAGCTTGGGCAATAAACTCGCCACCAAGCCTTGCCAACCCCAGCATGATCTGTTGGAAGTTGATA
CACCCATCAGTTGTCTTGCC

Downstream 100 bases:

>100_bases
GCGCAAACGCGGTCTTGCGCAACGCAACCCTCTTGCCTATATGGAAAGTGAGAGGTTGGTGCGGGCGAGCGCCTCGCCAA
CCCGGTCAGATCCGGAAGGA

Product: 2`,3`-cyclic-nucleotide 2`-phosphodiesterase

Products: NA

Alternate protein names: 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase; 5'-nucleotidase [H]

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MPIRRKKITDARSREFRLRILATSDLHMQMTCFDYVNDRPNTGGSLAKLATLIKKARREADEAGAACLLLDNGDTFQGTP
MADLLARDEIHGPHPMVQAMNALHYDAGGLGNHDFDYGSAHLDKVLFEQNMPVVCSNLISSELNTVKTQVILERSLTDQY
GKPETLRMGILSSLPDKTALWNQHQLKDRVAFTPPIPALRDAAAALRAQGVDLIIVLAHMGFSLFDEGPAAQNLVSEVAQ
LADVDIVVAGHTHLRFPGPDHAGLKHVNTVTGRVHGKPVVQPGPTGNDLGVIDLTLRKADAASLCTMADAQIALWATGPN
TAEDTDIIACTQDMHDQTRRHLGQQVTHIEKPMHSYFALCQPSPIPALLAASKHKAIRKIIAGTKYADLPLLAAASAPST
GGFDGPENFLFLSEGKVERRHISGMNPYANHVWAVKTTGAQIRDWLERSALIFNTLMPDAPDQMLINTHIPSFRCDFIYG
LRYEIDPSRPARFDAAGQAVPGARGRIGDITWNDAPLQDAQEFLVATTDHRASGGGLFKVFSRDEIVVQGHAPLQAAVMD
YLSDPDFDALQATQPWSFPKDICRSAILLTAPEAESHLHEIAHLKPQVCGQTDDGFLRIRITL

Sequences:

>Translated_623_residues
MPIRRKKITDARSREFRLRILATSDLHMQMTCFDYVNDRPNTGGSLAKLATLIKKARREADEAGAACLLLDNGDTFQGTP
MADLLARDEIHGPHPMVQAMNALHYDAGGLGNHDFDYGSAHLDKVLFEQNMPVVCSNLISSELNTVKTQVILERSLTDQY
GKPETLRMGILSSLPDKTALWNQHQLKDRVAFTPPIPALRDAAAALRAQGVDLIIVLAHMGFSLFDEGPAAQNLVSEVAQ
LADVDIVVAGHTHLRFPGPDHAGLKHVNTVTGRVHGKPVVQPGPTGNDLGVIDLTLRKADAASLCTMADAQIALWATGPN
TAEDTDIIACTQDMHDQTRRHLGQQVTHIEKPMHSYFALCQPSPIPALLAASKHKAIRKIIAGTKYADLPLLAAASAPST
GGFDGPENFLFLSEGKVERRHISGMNPYANHVWAVKTTGAQIRDWLERSALIFNTLMPDAPDQMLINTHIPSFRCDFIYG
LRYEIDPSRPARFDAAGQAVPGARGRIGDITWNDAPLQDAQEFLVATTDHRASGGGLFKVFSRDEIVVQGHAPLQAAVMD
YLSDPDFDALQATQPWSFPKDICRSAILLTAPEAESHLHEIAHLKPQVCGQTDDGFLRIRITL
>Mature_622_residues
PIRRKKITDARSREFRLRILATSDLHMQMTCFDYVNDRPNTGGSLAKLATLIKKARREADEAGAACLLLDNGDTFQGTPM
ADLLARDEIHGPHPMVQAMNALHYDAGGLGNHDFDYGSAHLDKVLFEQNMPVVCSNLISSELNTVKTQVILERSLTDQYG
KPETLRMGILSSLPDKTALWNQHQLKDRVAFTPPIPALRDAAAALRAQGVDLIIVLAHMGFSLFDEGPAAQNLVSEVAQL
ADVDIVVAGHTHLRFPGPDHAGLKHVNTVTGRVHGKPVVQPGPTGNDLGVIDLTLRKADAASLCTMADAQIALWATGPNT
AEDTDIIACTQDMHDQTRRHLGQQVTHIEKPMHSYFALCQPSPIPALLAASKHKAIRKIIAGTKYADLPLLAAASAPSTG
GFDGPENFLFLSEGKVERRHISGMNPYANHVWAVKTTGAQIRDWLERSALIFNTLMPDAPDQMLINTHIPSFRCDFIYGL
RYEIDPSRPARFDAAGQAVPGARGRIGDITWNDAPLQDAQEFLVATTDHRASGGGLFKVFSRDEIVVQGHAPLQAAVMDY
LSDPDFDALQATQPWSFPKDICRSAILLTAPEAESHLHEIAHLKPQVCGQTDDGFLRIRITL

Specific function: Catalyzes the release of inorganic phosphate from 2',3'- cyclic nucleotides through consecutive 2',3'-phosphodiesterase and 3'- (or 2') nucleotidase activities. Also possesses a 5'- nucleotidase activity. Does not catalyze the release of inorganic phospha

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 5'-nucleotidase family [H]

Homologues:

Organism=Escherichia coli, GI1790658, Length=530, Percent_Identity=31.6981132075472, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI19922446, Length=421, Percent_Identity=26.1282660332542, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24654424, Length=421, Percent_Identity=26.1282660332542, Blast_Score=93, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922444, Length=249, Percent_Identity=28.5140562248996, Blast_Score=86, Evalue=9e-17,
Organism=Drosophila melanogaster, GI28573524, Length=349, Percent_Identity=24.0687679083095, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR019931
- InterPro:   IPR004843
- InterPro:   IPR001899 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00149 Metallophos [H]

EC number: =3.1.3.6; =3.1.4.16; =3.1.3.5 [H]

Molecular weight: Translated: 68080; Mature: 67949

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRRKKITDARSREFRLRILATSDLHMQMTCFDYVNDRPNTGGSLAKLATLIKKARREA
CCCCCCCCCCCCCCEEEEEEEEECCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHH
DEAGAACLLLDNGDTFQGTPMADLLARDEIHGPHPMVQAMNALHYDAGGLGNHDFDYGSA
HHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHH
HLDKVLFEQNMPVVCSNLISSELNTVKTQVILERSLTDQYGKPETLRMGILSSLPDKTAL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
WNQHQLKDRVAFTPPIPALRDAAAALRAQGVDLIIVLAHMGFSLFDEGPAAQNLVSEVAQ
CCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHCCCCHHHHHHHHHHH
LADVDIVVAGHTHLRFPGPDHAGLKHVNTVTGRVHGKPVVQPGPTGNDLGVIDLTLRKAD
HCCCEEEEECCEEEECCCCCCCCCHHHHHHCCEECCCCCCCCCCCCCCCEEEEEEEECCC
AASLCTMADAQIALWATGPNTAEDTDIIACTQDMHDQTRRHLGQQVTHIEKPMHSYFALC
HHHHHEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPSPIPALLAASKHKAIRKIIAGTKYADLPLLAAASAPSTGGFDGPENFLFLSEGKVERR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCHHH
HISGMNPYANHVWAVKTTGAQIRDWLERSALIFNTLMPDAPDQMLINTHIPSFRCDFIYG
HCCCCCCHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEE
LRYEIDPSRPARFDAAGQAVPGARGRIGDITWNDAPLQDAQEFLVATTDHRASGGGLFKV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCEEEE
FSRDEIVVQGHAPLQAAVMDYLSDPDFDALQATQPWSFPKDICRSAILLTAPEAESHLHE
ECCCEEEEECCCCHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHCCEEEEECCCHHHHHHH
IAHLKPQVCGQTDDGFLRIRITL
HHHCCHHHCCCCCCCEEEEEEEC
>Mature Secondary Structure 
PIRRKKITDARSREFRLRILATSDLHMQMTCFDYVNDRPNTGGSLAKLATLIKKARREA
CCCCCCCCCCCCCEEEEEEEEECCCEEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHHH
DEAGAACLLLDNGDTFQGTPMADLLARDEIHGPHPMVQAMNALHYDAGGLGNHDFDYGSA
HHCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHH
HLDKVLFEQNMPVVCSNLISSELNTVKTQVILERSLTDQYGKPETLRMGILSSLPDKTAL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHH
WNQHQLKDRVAFTPPIPALRDAAAALRAQGVDLIIVLAHMGFSLFDEGPAAQNLVSEVAQ
CCHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEEEEHHCCHHHHCCCCHHHHHHHHHHH
LADVDIVVAGHTHLRFPGPDHAGLKHVNTVTGRVHGKPVVQPGPTGNDLGVIDLTLRKAD
HCCCEEEEECCEEEECCCCCCCCCHHHHHHCCEECCCCCCCCCCCCCCCEEEEEEEECCC
AASLCTMADAQIALWATGPNTAEDTDIIACTQDMHDQTRRHLGQQVTHIEKPMHSYFALC
HHHHHEECCCEEEEEECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QPSPIPALLAASKHKAIRKIIAGTKYADLPLLAAASAPSTGGFDGPENFLFLSEGKVERR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCEEEECCCCCHHH
HISGMNPYANHVWAVKTTGAQIRDWLERSALIFNTLMPDAPDQMLINTHIPSFRCDFIYG
HCCCCCCHHCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEEE
LRYEIDPSRPARFDAAGQAVPGARGRIGDITWNDAPLQDAQEFLVATTDHRASGGGLFKV
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCCCCCCCCEEEE
FSRDEIVVQGHAPLQAAVMDYLSDPDFDALQATQPWSFPKDICRSAILLTAPEAESHLHE
ECCCEEEEECCCCHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHCCEEEEECCCHHHHHHH
IAHLKPQVCGQTDDGFLRIRITL
HHHCCHHHCCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969503; 9384377 [H]