Click here to switch to the map view.

The map label for this gene is glyA [H]

Identifier: 110678495

GI number: 110678495

Start: 1125851

End: 1127140

Strand: Direct

Name: glyA [H]

Synonym: RD1_1165

Alternate gene names: 110678495

Gene position: 1125851-1127140 (Clockwise)

Preceding gene: 110678494

Following gene: 110678496

Centisome position: 27.24

GC content: 57.13

Gene sequence:

>1290_bases
ATGAACGCGCTTGACCGAAACACTTCTACCTTCTTTACGTCCAGCCTTGCACAAACGGACCCTGAAATCGCATCGGCAGT
AGCCTTGGAACTGAAACGCCAACGTGACGAAATCGAACTGATCGCGTCGGAAAACATCGTGAGCCAAGCCGTGATTGAAG
CCCAGGGTTCGGTCATGACCAACAAATATGCCGAAGGGTATCCGGGGCGTCGGTATTATGGCGGGTGCCAACATGTGGAT
GTGGCTGAAAACCTGGCGATTGAGCGCGCTTGCAAACTGTTCGGATGTGACTTCGCCAACGTGCAGCCGAATTCCGGCAG
CCAGGCCAACCAGGGCGTGTTTCAGGCGGTGTTGAAACCCGGTGACACGATCCTCGGCATGAGCCTTGATGCGGGCGGTC
ATTTGACCCACGGGGCTGCCCCAAACCAATCCGGAAAATGGTTCAACGCGGTTCAATATGGCGTGAGAAAAGACACGCTG
GACGTGGATTATGATCAGCTTGAGGCATTGGCGTTGGAACATAAGCCACAGATGATCATTGCCGGGGGATCGGCCATCCC
CCGCACACTGGATTTCGCGCGCTTCCGTGCGATCGCAGACAAGGTTGGTGCCTATCTTCTTGCGGATATCGCCCACTACG
CCGGGCTGATCGCGACCGGGCATTACCCATCGCCATTCCCGCATGTGCATGTCGCAACCACGACAACGCATAAAACCCTG
CGTGGACCGCGCGGTGGTATGATCCTGACGAACGACGAGGCGCTGGCGAAAAAGTTCAACTCCGCTATCTTCCCCGGCAT
TCAGGGCGGGCCCCTGATGCATGTGATCGCCGCCAAAGCCGTCGCTTTTGGTGAAGCGCTGGAACCTGATTTTGAACGCT
ATCAGGCGCAGGTCATCAAGAACGCGCAGGCCATGGCGGATGAGTTGATCAAAGGCGGCCTCGACATCGTGACAGGGGGC
ACCGATACCCATCTAATGCTGGTTGATCTGCGGCCCAAAGGGGTCAAGGGCAACGTGGCGGAAAAAGCTTTGGGCCGCGC
GCATATCACCTGTAACAAGAACGGCATTCCGTTTGACACTGAAAAACCGATGATCACGAGCGGTCTGCGGTTGGGATCGC
CCGCAGGAACAACGCGTGGGTTCACTGAAACTGAGTTCCGGCAGATCGCGGGCTGGATTGTCGAAGTGGTGGATGGCATC
GCGCGCCATGGTCCCGAGGAAAACGGCGAAGTGGAAGCGGGTGTTCGTGCCAAAGTGCAGGCGCTCTGTGACGCCTTTCC
GATCTACTAA

Upstream 100 bases:

>100_bases
GCGTGCTGGACAATCTTGCCGACTTCTTTGACGGGCGCACACCACGCGACCGCGTCGCATAATCATTCGACATTTCACAA
CAAACAGATTGGAGGCGGCG

Downstream 100 bases:

>100_bases
ACCTACATTCTAACGCCGGGCGCGCAGGGTTATTCGCCCTGCGCGTTTTTCTGTCGCGCCATCGTATCGCGCGTTGTTTC
CAAAGCGCAGTGGCGACACT

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNALDRNTSTFFTSSLAQTDPEIASAVALELKRQRDEIELIASENIVSQAVIEAQGSVMTNKYAEGYPGRRYYGGCQHVD
VAENLAIERACKLFGCDFANVQPNSGSQANQGVFQAVLKPGDTILGMSLDAGGHLTHGAAPNQSGKWFNAVQYGVRKDTL
DVDYDQLEALALEHKPQMIIAGGSAIPRTLDFARFRAIADKVGAYLLADIAHYAGLIATGHYPSPFPHVHVATTTTHKTL
RGPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALEPDFERYQAQVIKNAQAMADELIKGGLDIVTGG
TDTHLMLVDLRPKGVKGNVAEKALGRAHITCNKNGIPFDTEKPMITSGLRLGSPAGTTRGFTETEFRQIAGWIVEVVDGI
ARHGPEENGEVEAGVRAKVQALCDAFPIY

Sequences:

>Translated_429_residues
MNALDRNTSTFFTSSLAQTDPEIASAVALELKRQRDEIELIASENIVSQAVIEAQGSVMTNKYAEGYPGRRYYGGCQHVD
VAENLAIERACKLFGCDFANVQPNSGSQANQGVFQAVLKPGDTILGMSLDAGGHLTHGAAPNQSGKWFNAVQYGVRKDTL
DVDYDQLEALALEHKPQMIIAGGSAIPRTLDFARFRAIADKVGAYLLADIAHYAGLIATGHYPSPFPHVHVATTTTHKTL
RGPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALEPDFERYQAQVIKNAQAMADELIKGGLDIVTGG
TDTHLMLVDLRPKGVKGNVAEKALGRAHITCNKNGIPFDTEKPMITSGLRLGSPAGTTRGFTETEFRQIAGWIVEVVDGI
ARHGPEENGEVEAGVRAKVQALCDAFPIY
>Mature_429_residues
MNALDRNTSTFFTSSLAQTDPEIASAVALELKRQRDEIELIASENIVSQAVIEAQGSVMTNKYAEGYPGRRYYGGCQHVD
VAENLAIERACKLFGCDFANVQPNSGSQANQGVFQAVLKPGDTILGMSLDAGGHLTHGAAPNQSGKWFNAVQYGVRKDTL
DVDYDQLEALALEHKPQMIIAGGSAIPRTLDFARFRAIADKVGAYLLADIAHYAGLIATGHYPSPFPHVHVATTTTHKTL
RGPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALEPDFERYQAQVIKNAQAMADELIKGGLDIVTGG
TDTHLMLVDLRPKGVKGNVAEKALGRAHITCNKNGIPFDTEKPMITSGLRLGSPAGTTRGFTETEFRQIAGWIVEVVDGI
ARHGPEENGEVEAGVRAKVQALCDAFPIY

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=452, Percent_Identity=44.0265486725664, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=44.0265486725664, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=44.0265486725664, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=44.0265486725664, Blast_Score=345, Evalue=5e-95,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=43.141592920354, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI22547186, Length=404, Percent_Identity=47.5247524752475, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI22547189, Length=387, Percent_Identity=45.4780361757106, Blast_Score=295, Evalue=6e-80,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=55.8752997601918, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI25144732, Length=422, Percent_Identity=46.4454976303318, Blast_Score=355, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI25144729, Length=422, Percent_Identity=46.4454976303318, Blast_Score=355, Evalue=2e-98,
Organism=Saccharomyces cerevisiae, GI6323087, Length=411, Percent_Identity=44.5255474452555, Blast_Score=340, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6319739, Length=417, Percent_Identity=42.4460431654676, Blast_Score=332, Evalue=8e-92,
Organism=Drosophila melanogaster, GI24640005, Length=405, Percent_Identity=47.1604938271605, Blast_Score=357, Evalue=9e-99,
Organism=Drosophila melanogaster, GI221329721, Length=405, Percent_Identity=47.1604938271605, Blast_Score=356, Evalue=2e-98,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45982; Mature: 45982

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNALDRNTSTFFTSSLAQTDPEIASAVALELKRQRDEIELIASENIVSQAVIEAQGSVMT
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHCHHHHHHHHHHCCCCHH
NKYAEGYPGRRYYGGCQHVDVAENLAIERACKLFGCDFANVQPNSGSQANQGVFQAVLKP
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
GDTILGMSLDAGGHLTHGAAPNQSGKWFNAVQYGVRKDTLDVDYDQLEALALEHKPQMII
CCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEE
AGGSAIPRTLDFARFRAIADKVGAYLLADIAHYAGLIATGHYPSPFPHVHVATTTTHKTL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEECCHHHH
RGPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALEPDFERYQAQVIK
CCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
NAQAMADELIKGGLDIVTGGTDTHLMLVDLRPKGVKGNVAEKALGRAHITCNKNGIPFDT
HHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCC
EKPMITSGLRLGSPAGTTRGFTETEFRQIAGWIVEVVDGIARHGPEENGEVEAGVRAKVQ
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ALCDAFPIY
HHHHHCCCC
>Mature Secondary Structure
MNALDRNTSTFFTSSLAQTDPEIASAVALELKRQRDEIELIASENIVSQAVIEAQGSVMT
CCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHCHHHHHHHHHHCCCCHH
NKYAEGYPGRRYYGGCQHVDVAENLAIERACKLFGCDFANVQPNSGSQANQGVFQAVLKP
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCC
GDTILGMSLDAGGHLTHGAAPNQSGKWFNAVQYGVRKDTLDVDYDQLEALALEHKPQMII
CCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEE
AGGSAIPRTLDFARFRAIADKVGAYLLADIAHYAGLIATGHYPSPFPHVHVATTTTHKTL
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEEEEEECCHHHH
RGPRGGMILTNDEALAKKFNSAIFPGIQGGPLMHVIAAKAVAFGEALEPDFERYQAQVIK
CCCCCCEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
NAQAMADELIKGGLDIVTGGTDTHLMLVDLRPKGVKGNVAEKALGRAHITCNKNGIPFDT
HHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCCHHHHHCCCEEEEECCCCCCCCC
EKPMITSGLRLGSPAGTTRGFTETEFRQIAGWIVEVVDGIARHGPEENGEVEAGVRAKVQ
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
ALCDAFPIY
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA