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The map label for this gene is gyaR [H]

Identifier: 110678494

GI number: 110678494

Start: 1124841

End: 1125812

Strand: Direct

Name: gyaR [H]

Synonym: RD1_1164

Alternate gene names: 110678494

Gene position: 1124841-1125812 (Clockwise)

Preceding gene: 110678493

Following gene: 110678495

Centisome position: 27.22

GC content: 58.23

Gene sequence:

>972_bases
ATGGTCAAGCCAAGTGTCCTCGTCACACGTCGCTGGCCCAAGATCGTCGAGCGCCAGCTGTCGGAAAAATACAACGTGCA
GCTCAACCGGACGGACCGCCCCCTGACCCCTGAAGAGTTTCGCGAGGCGATTGCCAAATATGATGCTGTTTTGCCGACCG
TTACGGACAAGATCCGGGCGGACGCGCTCGATGCGCGCAATGTGCAAACCAAAATATTGGCCAACTACGGTGTCGGATAT
ACGCATATCGACGTTGATGTTGCCAAAACCCAAGGGATAGCGATCACCAACACGCCTGATGTTCTGTCCGAATGCACCGC
AGATCTGGCCATGACGCTGATGTTGATGGCGGCGCGGCGTGCTGGCGAGGGAGAGCGCGAGTTGCGCGCTGGTGACTGGT
CCGGCTGGCGTCCGACGCATCTGATGGGCACGAAGGTTTCAGGCAAAGTGCTTGGCATTGTTGGCTTTGGGCGGATCGGG
CAAGAGGTGGCGCGCCGTGCACATCATGGCTTTGGTATGAAGATCGTCGTCTTCAATCGTTCGAAGGTTGCGCCCGATGT
TTTGGCGCAATTCAACGCGCAACAGGTCGCAACGCTGGATGATCTGATGCCGCTTTGTGATTTCGTCTCGTTGCATTGCC
CCGGCGGACAGGAAAACCGCCATATGATCAACGCGAACCGGCTGAACCTGATGAAGGAAGACGCATTCCTGATCAATACT
GCGCGCGGCGAAGTCGTGAATGAACACGCGCTGGCACAGGCTTTGATGTTCGACACCATCGGCGGCGCCGCGCTGGACGT
GTTTGATGGCGAGCCACGGATCAACCCGACGCTGGCGCAATGCGACAATCTTGTCATGCTGCCACATTTGGGCAGTGCCA
CACGCGAAGCGCGCGAGGCGATGGGGTTTCGCGTGCTGGACAATCTTGCCGACTTCTTTGACGGGCGCACACCACGCGAC
CGCGTCGCATAA

Upstream 100 bases:

>100_bases
CGAGCGAAAAGGTCGAAATCCTGTCGGCGGCAGGCGTCACGGTTGCCGAAAACCCGGCTGTCATCGGTGAGACAATCGCC
AAAGTGATGGAGGCCGCGTG

Downstream 100 bases:

>100_bases
TCATTCGACATTTCACAACAAACAGATTGGAGGCGGCGATGAACGCGCTTGACCGAAACACTTCTACCTTCTTTACGTCC
AGCCTTGCACAAACGGACCC

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MVKPSVLVTRRWPKIVERQLSEKYNVQLNRTDRPLTPEEFREAIAKYDAVLPTVTDKIRADALDARNVQTKILANYGVGY
THIDVDVAKTQGIAITNTPDVLSECTADLAMTLMLMAARRAGEGERELRAGDWSGWRPTHLMGTKVSGKVLGIVGFGRIG
QEVARRAHHGFGMKIVVFNRSKVAPDVLAQFNAQQVATLDDLMPLCDFVSLHCPGGQENRHMINANRLNLMKEDAFLINT
ARGEVVNEHALAQALMFDTIGGAALDVFDGEPRINPTLAQCDNLVMLPHLGSATREAREAMGFRVLDNLADFFDGRTPRD
RVA

Sequences:

>Translated_323_residues
MVKPSVLVTRRWPKIVERQLSEKYNVQLNRTDRPLTPEEFREAIAKYDAVLPTVTDKIRADALDARNVQTKILANYGVGY
THIDVDVAKTQGIAITNTPDVLSECTADLAMTLMLMAARRAGEGERELRAGDWSGWRPTHLMGTKVSGKVLGIVGFGRIG
QEVARRAHHGFGMKIVVFNRSKVAPDVLAQFNAQQVATLDDLMPLCDFVSLHCPGGQENRHMINANRLNLMKEDAFLINT
ARGEVVNEHALAQALMFDTIGGAALDVFDGEPRINPTLAQCDNLVMLPHLGSATREAREAMGFRVLDNLADFFDGRTPRD
RVA
>Mature_323_residues
MVKPSVLVTRRWPKIVERQLSEKYNVQLNRTDRPLTPEEFREAIAKYDAVLPTVTDKIRADALDARNVQTKILANYGVGY
THIDVDVAKTQGIAITNTPDVLSECTADLAMTLMLMAARRAGEGERELRAGDWSGWRPTHLMGTKVSGKVLGIVGFGRIG
QEVARRAHHGFGMKIVVFNRSKVAPDVLAQFNAQQVATLDDLMPLCDFVSLHCPGGQENRHMINANRLNLMKEDAFLINT
ARGEVVNEHALAQALMFDTIGGAALDVFDGEPRINPTLAQCDNLVMLPHLGSATREAREAMGFRVLDNLADFFDGRTPRD
RVA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=307, Percent_Identity=34.5276872964169, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI23308577, Length=299, Percent_Identity=32.1070234113712, Blast_Score=161, Evalue=7e-40,
Organism=Homo sapiens, GI61743967, Length=259, Percent_Identity=36.6795366795367, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557497, Length=259, Percent_Identity=36.6795366795367, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI145580578, Length=254, Percent_Identity=35.0393700787402, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557499, Length=254, Percent_Identity=35.0393700787402, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580575, Length=240, Percent_Identity=37.0833333333333, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI87082289, Length=322, Percent_Identity=36.0248447204969, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789279, Length=258, Percent_Identity=32.5581395348837, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1787645, Length=330, Percent_Identity=25.7575757575758, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17532191, Length=280, Percent_Identity=31.4285714285714, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=32.1705426356589, Blast_Score=114, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=312, Percent_Identity=29.8076923076923, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6322116, Length=312, Percent_Identity=29.4871794871795, Blast_Score=140, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324055, Length=238, Percent_Identity=33.1932773109244, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6324964, Length=266, Percent_Identity=23.6842105263158, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6321253, Length=275, Percent_Identity=26.5454545454545, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=175, Percent_Identity=29.7142857142857, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=186, Percent_Identity=24.7311827956989, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28571528, Length=270, Percent_Identity=38.1481481481481, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45552429, Length=272, Percent_Identity=36.0294117647059, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45551003, Length=271, Percent_Identity=36.1623616236162, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574284, Length=271, Percent_Identity=36.1623616236162, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24585514, Length=271, Percent_Identity=36.1623616236162, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574282, Length=271, Percent_Identity=36.1623616236162, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI28574286, Length=267, Percent_Identity=35.9550561797753, Blast_Score=151, Evalue=7e-37,
Organism=Drosophila melanogaster, GI24585516, Length=284, Percent_Identity=30.2816901408451, Blast_Score=135, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19921140, Length=307, Percent_Identity=29.3159609120521, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24646446, Length=226, Percent_Identity=36.7256637168142, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646448, Length=226, Percent_Identity=36.7256637168142, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646452, Length=226, Percent_Identity=36.7256637168142, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646450, Length=226, Percent_Identity=36.7256637168142, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI62472511, Length=226, Percent_Identity=36.7256637168142, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35715; Mature: 35715

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKPSVLVTRRWPKIVERQLSEKYNVQLNRTDRPLTPEEFREAIAKYDAVLPTVTDKIRA
CCCCCEEEECCCHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALDARNVQTKILANYGVGYTHIDVDVAKTQGIAITNTPDVLSECTADLAMTLMLMAARR
HHHCCCCHHHHEEECCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
AGEGERELRAGDWSGWRPTHLMGTKVSGKVLGIVGFGRIGQEVARRAHHGFGMKIVVFNR
CCCCCHHHCCCCCCCCCCCEEECCCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEEEECC
SKVAPDVLAQFNAQQVATLDDLMPLCDFVSLHCPGGQENRHMINANRLNLMKEDAFLINT
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEEECHHHHHHHHCCEEEEEC
ARGEVVNEHALAQALMFDTIGGAALDVFDGEPRINPTLAQCDNLVMLPHLGSATREAREA
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCEEEECCCCHHHHHHHHH
MGFRVLDNLADFFDGRTPRDRVA
HHHHHHHHHHHHHCCCCCHHCCC
>Mature Secondary Structure
MVKPSVLVTRRWPKIVERQLSEKYNVQLNRTDRPLTPEEFREAIAKYDAVLPTVTDKIRA
CCCCCEEEECCCHHHHHHHHHHHHCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DALDARNVQTKILANYGVGYTHIDVDVAKTQGIAITNTPDVLSECTADLAMTLMLMAARR
HHHCCCCHHHHEEECCCCCEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHH
AGEGERELRAGDWSGWRPTHLMGTKVSGKVLGIVGFGRIGQEVARRAHHGFGMKIVVFNR
CCCCCHHHCCCCCCCCCCCEEECCCCCCEEEEEEECHHHHHHHHHHHHCCCCEEEEEECC
SKVAPDVLAQFNAQQVATLDDLMPLCDFVSLHCPGGQENRHMINANRLNLMKEDAFLINT
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHEEECCCCCCCCEEECHHHHHHHHCCEEEEEC
ARGEVVNEHALAQALMFDTIGGAALDVFDGEPRINPTLAQCDNLVMLPHLGSATREAREA
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHCCCEEEECCCCHHHHHHHHH
MGFRVLDNLADFFDGRTPRDRVA
HHHHHHHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA