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The map label for this gene is idnD [H]

Identifier: 110678443

GI number: 110678443

Start: 1059989

End: 1061020

Strand: Reverse

Name: idnD [H]

Synonym: RD1_1108

Alternate gene names: 110678443

Gene position: 1061020-1059989 (Counterclockwise)

Preceding gene: 110678446

Following gene: 110678442

Centisome position: 25.67

GC content: 61.92

Gene sequence:

>1032_bases
ATGAAATCGCTTGTTATCCACGCCGCGCATGATCTGCGCATCGAAGAGCATGAGCCACAGGCCCTTGGTGCCGGACAGGT
TCGGATCGCGCTGGCGACCGGGGGCATCTGCGGATCGGATCTGCACTACTATCACAATGGTGGCTTTGGCACGGTACGCC
TCAAGGAACCCATGGTGCTGGGTCATGAAGTATCCGGGCATATCACAGCACTTGGGGCGGGGGTCAGCGGGCTTGAGGTC
GGGCAGTTGGTGGCGGTGTCACCCTCGCGCCCCTGTGGCACCTGCAGCTATTGTGCTGAAGGGATGCGCAACCAATGCCT
GAACATGCGGTTTTACGGCTCCGCCATGCCGTTGCCACATATTCAGGGGGCATTCCGGCAGGTTCTGGTCGCGGATGCTG
CGCAATGTGCCGTGGCCGACGGTTTATCCGCTGGCGAAGCTGCCATGGCCGAACCCCTGGCCGTCTGTCTGCATGCCGCC
AGTCAGGCTGGCCCGCTGCTCGGCAAGCGCGTGTTGGTGACAGGCTGCGGCCCCATCGGGTTGCTGAGCATTCTGGTTGC
CCGCCGCGCGGGTGCGACGGAAATCGTCGCGACGGACCTGACCGATTTCACGCTGCAAATGGCCGCCGCACAGGGGGCGG
ATGTCACGATCAACGGCGCGACCGATCCCGACAGATTGGCGACCTATCAAGCGGGCAAGGGCACCTTTGACGTGCTGTTT
GAATGCACGGGCGTGGCCGCCGCACTGGCTGGCGGGATCGCAGCCCTGCGTCCGGGTGGCATCATTGTGCAACTGGGGTT
GGGCGGAGACATGACCCTACCGGTGCAGGCATTGACGGCCAAGGAGTTGCAACTGCGCGGCTCGTTCCGCTTTCATGAGG
AGTTCTTTACAGGTGTGACGCTGATGCAAAAGGGGCTGATTGACGTAAAGCCCCTGATCACGCAAACGCTGCCGCTGGCA
GATGCCATTGCCGCCTTTGATCTGGCCAGCGACAGAACACAGTCGATGAAGGCTCAGATCAGTTTTGCCTGA

Upstream 100 bases:

>100_bases
TGTGCTCGACAATTGCGATCTGTCCCGCTTATTTTACCCCCAACCCTCAGAGTCAAGGACGCCGGGCAACCCGCCCCTTG
AACAGCCCAAAGAGACCTCT

Downstream 100 bases:

>100_bases
CTTCCTGACATCCTTGCGCGCACCAAGCAGTGTTGCGAGCCGCTGCCCGGCGTGGAACGGGTAAACGATGGACCTGACAA
TGCTCATCGTGATCGCGGGC

Product: L-idonate 5-dehydrogenase, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MKSLVIHAAHDLRIEEHEPQALGAGQVRIALATGGICGSDLHYYHNGGFGTVRLKEPMVLGHEVSGHITALGAGVSGLEV
GQLVAVSPSRPCGTCSYCAEGMRNQCLNMRFYGSAMPLPHIQGAFRQVLVADAAQCAVADGLSAGEAAMAEPLAVCLHAA
SQAGPLLGKRVLVTGCGPIGLLSILVARRAGATEIVATDLTDFTLQMAAAQGADVTINGATDPDRLATYQAGKGTFDVLF
ECTGVAAALAGGIAALRPGGIIVQLGLGGDMTLPVQALTAKELQLRGSFRFHEEFFTGVTLMQKGLIDVKPLITQTLPLA
DAIAAFDLASDRTQSMKAQISFA

Sequences:

>Translated_343_residues
MKSLVIHAAHDLRIEEHEPQALGAGQVRIALATGGICGSDLHYYHNGGFGTVRLKEPMVLGHEVSGHITALGAGVSGLEV
GQLVAVSPSRPCGTCSYCAEGMRNQCLNMRFYGSAMPLPHIQGAFRQVLVADAAQCAVADGLSAGEAAMAEPLAVCLHAA
SQAGPLLGKRVLVTGCGPIGLLSILVARRAGATEIVATDLTDFTLQMAAAQGADVTINGATDPDRLATYQAGKGTFDVLF
ECTGVAAALAGGIAALRPGGIIVQLGLGGDMTLPVQALTAKELQLRGSFRFHEEFFTGVTLMQKGLIDVKPLITQTLPLA
DAIAAFDLASDRTQSMKAQISFA
>Mature_343_residues
MKSLVIHAAHDLRIEEHEPQALGAGQVRIALATGGICGSDLHYYHNGGFGTVRLKEPMVLGHEVSGHITALGAGVSGLEV
GQLVAVSPSRPCGTCSYCAEGMRNQCLNMRFYGSAMPLPHIQGAFRQVLVADAAQCAVADGLSAGEAAMAEPLAVCLHAA
SQAGPLLGKRVLVTGCGPIGLLSILVARRAGATEIVATDLTDFTLQMAAAQGADVTINGATDPDRLATYQAGKGTFDVLF
ECTGVAAALAGGIAALRPGGIIVQLGLGGDMTLPVQALTAKELQLRGSFRFHEEFFTGVTLMQKGLIDVKPLITQTLPLA
DAIAAFDLASDRTQSMKAQISFA

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=330, Percent_Identity=35.4545454545455, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=26.3013698630137, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI4501929, Length=352, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI34577061, Length=352, Percent_Identity=25.8522727272727, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=24.6575342465753, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=24.6575342465753, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI71565152, Length=368, Percent_Identity=23.3695652173913, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI71565154, Length=354, Percent_Identity=24.0112994350282, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790718, Length=317, Percent_Identity=44.1640378548896, Blast_Score=268, Evalue=4e-73,
Organism=Escherichia coli, GI1788073, Length=318, Percent_Identity=30.8176100628931, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1787863, Length=352, Percent_Identity=31.5340909090909, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790045, Length=327, Percent_Identity=30.5810397553517, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI226510992, Length=346, Percent_Identity=29.7687861271676, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1788075, Length=341, Percent_Identity=28.7390029325513, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788407, Length=331, Percent_Identity=30.2114803625378, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786825, Length=388, Percent_Identity=25, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081918, Length=294, Percent_Identity=27.5510204081633, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082125, Length=295, Percent_Identity=28.4745762711864, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=24.9322493224932, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI87082401, Length=307, Percent_Identity=28.0130293159609, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17562876, Length=339, Percent_Identity=36.283185840708, Blast_Score=209, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17562878, Length=339, Percent_Identity=36.8731563421829, Blast_Score=195, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6322619, Length=341, Percent_Identity=34.8973607038123, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6319955, Length=341, Percent_Identity=34.8973607038123, Blast_Score=192, Evalue=7e-50,
Organism=Saccharomyces cerevisiae, GI6323099, Length=320, Percent_Identity=33.4375, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319257, Length=375, Percent_Identity=27.4666666666667, Blast_Score=123, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6319258, Length=349, Percent_Identity=28.6532951289398, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=286, Percent_Identity=25.5244755244755, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=356, Percent_Identity=25.561797752809, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319621, Length=262, Percent_Identity=25.9541984732824, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=273, Percent_Identity=24.1758241758242, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17737897, Length=329, Percent_Identity=34.3465045592705, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI17137530, Length=329, Percent_Identity=31.6109422492401, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550770, Length=312, Percent_Identity=25.3205128205128, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI45551930, Length=312, Percent_Identity=25.3205128205128, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI221457811, Length=312, Percent_Identity=25.3205128205128, Blast_Score=85, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17737895, Length=374, Percent_Identity=25.668449197861, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 35459; Mature: 35459

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLVIHAAHDLRIEEHEPQALGAGQVRIALATGGICGSDLHYYHNGGFGTVRLKEPMVL
CCCEEEEEHCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCEEEEEECCCEEE
GHEVSGHITALGAGVSGLEVGQLVAVSPSRPCGTCSYCAEGMRNQCLNMRFYGSAMPLPH
EEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCHH
IQGAFRQVLVADAAQCAVADGLSAGEAAMAEPLAVCLHAASQAGPLLGKRVLVTGCGPIG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHH
LLSILVARRAGATEIVATDLTDFTLQMAAAQGADVTINGATDPDRLATYQAGKGTFDVLF
HHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEECCCCHHHHEEECCCCCCEEEEE
ECTGVAAALAGGIAALRPGGIIVQLGLGGDMTLPVQALTAKELQLRGSFRFHEEFFTGVT
EHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHH
LMQKGLIDVKPLITQTLPLADAIAAFDLASDRTQSMKAQISFA
HHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECC
>Mature Secondary Structure
MKSLVIHAAHDLRIEEHEPQALGAGQVRIALATGGICGSDLHYYHNGGFGTVRLKEPMVL
CCCEEEEEHCCCEEECCCCCCCCCCCEEEEEEECCCCCCCCEEEECCCEEEEEECCCEEE
GHEVSGHITALGAGVSGLEVGQLVAVSPSRPCGTCSYCAEGMRNQCLNMRFYGSAMPLPH
EEECCCEEEEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCHH
IQGAFRQVLVADAAQCAVADGLSAGEAAMAEPLAVCLHAASQAGPLLGKRVLVTGCGPIG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHH
LLSILVARRAGATEIVATDLTDFTLQMAAAQGADVTINGATDPDRLATYQAGKGTFDVLF
HHHHHHHHCCCCCEEEEECCHHHHHHHHHCCCCCEEEECCCCHHHHEEECCCCCCEEEEE
ECTGVAAALAGGIAALRPGGIIVQLGLGGDMTLPVQALTAKELQLRGSFRFHEEFFTGVT
EHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHHH
LMQKGLIDVKPLITQTLPLADAIAAFDLASDRTQSMKAQISFA
HHHCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]