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The map label for this gene is munIM [H]

Identifier: 110678417

GI number: 110678417

Start: 1034399

End: 1035049

Strand: Reverse

Name: munIM [H]

Synonym: RD1_1079

Alternate gene names: 110678417

Gene position: 1035049-1034399 (Counterclockwise)

Preceding gene: 110678418

Following gene: 110678415

Centisome position: 25.04

GC content: 48.08

Gene sequence:

>651_bases
ATGACGAATGCGGCCGATGACATGCTGAAAGAATTGGGAAGCAGTAAGTTTCAGACAATTCTGGCCGATCCTCCGTGGCA
GTTTCAAAACCGGACTGGAAAGATGGCCCCAGAGCATAAGCGCCTAGCCCGATATCCGACGATGTCTTTGGACGATATTT
GTGACCTGCCGGTTGAGGCAATAGCAGGAGATCCCGCGCATTTGTATTTGTGGGTACCGAATGCGCTTTTGCCTGAGGGG
CTCAAAGTAATGGAACACTGGGGCTTCAAGTATAAGAGCAATATTATTTGGTACAAAATTCGCAAGGATGGAGGTCCTGA
TCGCCGTGGCGTTGGGTTCTACTTCAGAAATGTCACCGAAATTTTACTGTTTGGCGTTCGTGGCAAAAATGCGCGAACAC
TGGCACCTGGCAGATCACAAGAGAATATAATTTCAACGCAAAAACGAGAACATAGCAGAAAGCCCGACGAACAATACAAG
TTGATTGAAGACTGTAGTTTCGGAAACCGGCTGGAACTCTTTGCAAGGGGTCCTCGCGCTGGGTGGACTGTCTGGGGTAA
TCAGTCCGATCATTATGTGCCCACTTGGAATACTTATGTAAATCACTCCCAAGCAAACGTAGTGCCATTACGCAAAGCCG
AGACTGGATAA

Upstream 100 bases:

>100_bases
ATATGTCGAAGCTCGTACCACGGATCGAAGGTGGTGGGGCCGGTGGATGCCCGATTTTAACTTTTGGCATCAAACCCAGC
CTGTACAGGGAGAATGAATA

Downstream 100 bases:

>100_bases
AGGTTCAAAAGGAGTCACAGCGTTTCGACAAAGGCTTGAGACATCGCACGCTGCATCTCTGCCGCCGCCACATTGCCCGA
GCGCAGCACTTCGCCAAAGG

Product: DNA methyltransferase

Products: NA

Alternate protein names: Adenine-specific methyltransferase MunI; M.MunI [H]

Number of amino acids: Translated: 216; Mature: 215

Protein sequence:

>216_residues
MTNAADDMLKELGSSKFQTILADPPWQFQNRTGKMAPEHKRLARYPTMSLDDICDLPVEAIAGDPAHLYLWVPNALLPEG
LKVMEHWGFKYKSNIIWYKIRKDGGPDRRGVGFYFRNVTEILLFGVRGKNARTLAPGRSQENIISTQKREHSRKPDEQYK
LIEDCSFGNRLELFARGPRAGWTVWGNQSDHYVPTWNTYVNHSQANVVPLRKAETG

Sequences:

>Translated_216_residues
MTNAADDMLKELGSSKFQTILADPPWQFQNRTGKMAPEHKRLARYPTMSLDDICDLPVEAIAGDPAHLYLWVPNALLPEG
LKVMEHWGFKYKSNIIWYKIRKDGGPDRRGVGFYFRNVTEILLFGVRGKNARTLAPGRSQENIISTQKREHSRKPDEQYK
LIEDCSFGNRLELFARGPRAGWTVWGNQSDHYVPTWNTYVNHSQANVVPLRKAETG
>Mature_215_residues
TNAADDMLKELGSSKFQTILADPPWQFQNRTGKMAPEHKRLARYPTMSLDDICDLPVEAIAGDPAHLYLWVPNALLPEGL
KVMEHWGFKYKSNIIWYKIRKDGGPDRRGVGFYFRNVTEILLFGVRGKNARTLAPGRSQENIISTQKREHSRKPDEQYKL
IEDCSFGNRLELFARGPRAGWTVWGNQSDHYVPTWNTYVNHSQANVVPLRKAETG

Specific function: This methylase recognizes the double-stranded sequence CAATTG, causes specific methylation on A-3 on both strands, and protects the DNA from cleavage by the MunI endonuclease [H]

COG id: COG4725

COG function: function code TK; Transcriptional activator, adenine-specific DNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MT-A70-like family [H]

Homologues:

Organism=Homo sapiens, GI21361827, Length=179, Percent_Identity=31.8435754189944, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321246, Length=178, Percent_Identity=29.2134831460674, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21355141, Length=179, Percent_Identity=32.9608938547486, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002052
- InterPro:   IPR007757 [H]

Pfam domain/function: PF05063 MT-A70 [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 24745; Mature: 24614

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS00092 N6_MTASE ; PS51143 MT_A70

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAADDMLKELGSSKFQTILADPPWQFQNRTGKMAPEHKRLARYPTMSLDDICDLPVEA
CCCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCHHH
IAGDPAHLYLWVPNALLPEGLKVMEHWGFKYKSNIIWYKIRKDGGPDRRGVGFYFRNVTE
HCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCEEEEEEECCCCCCCCCCHHHHHHHHH
ILLFGVRGKNARTLAPGRSQENIISTQKREHSRKPDEQYKLIEDCSFGNRLELFARGPRA
HHEECCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCC
GWTVWGNQSDHYVPTWNTYVNHSQANVVPLRKAETG
CEEEECCCCCCCCCCCHHHCCCCCCCEEEECCCCCC
>Mature Secondary Structure 
TNAADDMLKELGSSKFQTILADPPWQFQNRTGKMAPEHKRLARYPTMSLDDICDLPVEA
CCHHHHHHHHHCCCCEEEEECCCCHHHCCCCCCCCCHHHHHHHCCCCCHHHHHCCCHHH
IAGDPAHLYLWVPNALLPEGLKVMEHWGFKYKSNIIWYKIRKDGGPDRRGVGFYFRNVTE
HCCCCCEEEEECCCCCCHHHHHHHHHCCCEEECCEEEEEEECCCCCCCCCCHHHHHHHHH
ILLFGVRGKNARTLAPGRSQENIISTQKREHSRKPDEQYKLIEDCSFGNRLELFARGPRA
HHEECCCCCCCEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEECCCCC
GWTVWGNQSDHYVPTWNTYVNHSQANVVPLRKAETG
CEEEECCCCCCCCCCCHHHCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8181741 [H]