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The map label for this gene is ald [H]

Identifier: 110678376

GI number: 110678376

Start: 1000161

End: 1001279

Strand: Reverse

Name: ald [H]

Synonym: RD1_1033

Alternate gene names: 110678376

Gene position: 1001279-1000161 (Counterclockwise)

Preceding gene: 110678379

Following gene: 110678372

Centisome position: 24.23

GC content: 62.56

Gene sequence:

>1119_bases
ATGATCATCGGGTGCCCAAAAGAGATCAAACCACAGGAATTTCGCGTCGGCCTGACACCAAACGCCGCCCGCGAGGCCGT
GTCACACGGGCACCGGGTTTTGATCGAAACGAACGCAGGCGCCGGTGCCGGGTTTGAGGATGCGGATTACACAGCGGCAG
GTGCTCAGGTTCTGGAGACCGCCGCAGAGATATTCGCAACCGCCGAGATGATCGTGAAGGTCAAGGAACCACAGGCCGGT
GAGCGTAAAATGCTGCGCGCGGGCCAGGTACTGTTTACCTATCTGCACCTTGCGCCGGATCCGGATCAGACCCATGACCT
TTTGGCCTCCGGTGCGACGTGCATTGCCTATGAAACGGTGACGGATGCTCAGGGCGGCTTGCCGCTTTTGGCCCCGATGT
CAGAGGTTGCAGGGCGGCTTGCGCCACAGGTCGGGGCATGGACCCTGCAAAAGGCCAACGGCGGGCGTGGCGTCTTGATG
GGCGGGGTGCCCGGCGTCGGGCCTGCCCGTGTTGTGGTGATCGGCGGGGGTGTCGTCGGCACCCATGCCGCCAGAATTGC
GGCCGGTATGGGCGCGGATGTCACGGTTCTGGATCGGTCGCTGGCACGCCTGCGGTATCTGGATGACGTCTTTGGCGGTC
AGTTCAAGACCTCCTATGCCTCTGCTGGCAATACGCTGGAACTGGCGCAGGCCGCCGATCTGATCATCGGTGCAGTCCTC
ATTCCCGGTGCCGCCGCGCCCAAGCTGATCAGCCGGGCGCAGCTTGCAACGCTCAAACCCGGTGCGGCGCTGGTGGATGT
GGCCATTGATCAGGGCGGCTGCTTTGAAACCTCAAAGGCCACGACCCACAGTGACCCGGTTTATGACGTGGACGGAATCA
TGCATTACTGCGTGGCGAACATGCCCGGCGCCGTGGCGCGCACGTCAACGATTGCGCTTGGCAACGCCACGATGCCCTTC
ATGCTGGCCCTGGCCGACAAGGGCTGGCGACAAGCCTGCATTGATGATCCGCACCTGTTGAACGGCTTGAACGTGCACGC
AGGCCAGCTGACCTATTACGCCGTTGGCAAGGCGCTGGGGCTGGATGTCATCTCACCCACCGTTGCGATCAGGCAATAG

Upstream 100 bases:

>100_bases
TTCTTTCAATAAATCAACTAGAGGCAAGGTTTATTTCGCGCCTATTTGCGCCAAAGACTTCGTATGTTTCGGCCATAATG
CAACGGAGGAGGAGTGCATC

Downstream 100 bases:

>100_bases
GGCGCAAGAGGGTTTGGCGACGCGGCTTGCGCGTCTGCCACGCTCCCCAGCATAGAGGCGCGCGGCCCGACTCAGAGCCC
GCCAACCCCCAGATTCTCCA

Product: alanine dehydrogenase

Products: NA

Alternate protein names: 40 kDa antigen; TB43 [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MIIGCPKEIKPQEFRVGLTPNAAREAVSHGHRVLIETNAGAGAGFEDADYTAAGAQVLETAAEIFATAEMIVKVKEPQAG
ERKMLRAGQVLFTYLHLAPDPDQTHDLLASGATCIAYETVTDAQGGLPLLAPMSEVAGRLAPQVGAWTLQKANGGRGVLM
GGVPGVGPARVVVIGGGVVGTHAARIAAGMGADVTVLDRSLARLRYLDDVFGGQFKTSYASAGNTLELAQAADLIIGAVL
IPGAAAPKLISRAQLATLKPGAALVDVAIDQGGCFETSKATTHSDPVYDVDGIMHYCVANMPGAVARTSTIALGNATMPF
MLALADKGWRQACIDDPHLLNGLNVHAGQLTYYAVGKALGLDVISPTVAIRQ

Sequences:

>Translated_372_residues
MIIGCPKEIKPQEFRVGLTPNAAREAVSHGHRVLIETNAGAGAGFEDADYTAAGAQVLETAAEIFATAEMIVKVKEPQAG
ERKMLRAGQVLFTYLHLAPDPDQTHDLLASGATCIAYETVTDAQGGLPLLAPMSEVAGRLAPQVGAWTLQKANGGRGVLM
GGVPGVGPARVVVIGGGVVGTHAARIAAGMGADVTVLDRSLARLRYLDDVFGGQFKTSYASAGNTLELAQAADLIIGAVL
IPGAAAPKLISRAQLATLKPGAALVDVAIDQGGCFETSKATTHSDPVYDVDGIMHYCVANMPGAVARTSTIALGNATMPF
MLALADKGWRQACIDDPHLLNGLNVHAGQLTYYAVGKALGLDVISPTVAIRQ
>Mature_372_residues
MIIGCPKEIKPQEFRVGLTPNAAREAVSHGHRVLIETNAGAGAGFEDADYTAAGAQVLETAAEIFATAEMIVKVKEPQAG
ERKMLRAGQVLFTYLHLAPDPDQTHDLLASGATCIAYETVTDAQGGLPLLAPMSEVAGRLAPQVGAWTLQKANGGRGVLM
GGVPGVGPARVVVIGGGVVGTHAARIAAGMGADVTVLDRSLARLRYLDDVFGGQFKTSYASAGNTLELAQAADLIIGAVL
IPGAAAPKLISRAQLATLKPGAALVDVAIDQGGCFETSKATTHSDPVYDVDGIMHYCVANMPGAVARTSTIALGNATMPF
MLALADKGWRQACIDDPHLLNGLNVHAGQLTYYAVGKALGLDVISPTVAIRQ

Specific function: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer [H]

COG id: COG0686

COG function: function code E; Alanine dehydrogenase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=357, Percent_Identity=28.2913165266106, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI122939153, Length=357, Percent_Identity=28.2913165266106, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1787887, Length=377, Percent_Identity=28.9124668435013, Blast_Score=112, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17550456, Length=374, Percent_Identity=30.2139037433155, Blast_Score=128, Evalue=5e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886
- InterPro:   IPR008141 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.4.1.1 [H]

Molecular weight: Translated: 38424; Mature: 38424

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00837 ALADH_PNT_2 ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGCPKEIKPQEFRVGLTPNAAREAVSHGHRVLIETNAGAGAGFEDADYTAAGAQVLET
CEECCCCCCCCCCEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
AAEIFATAEMIVKVKEPQAGERKMLRAGQVLFTYLHLAPDPDQTHDLLASGATCIAYETV
HHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCEEEEEEEE
TDAQGGLPLLAPMSEVAGRLAPQVGAWTLQKANGGRGVLMGGVPGVGPARVVVIGGGVVG
CCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCEEEEEECCCCHH
THAARIAAGMGADVTVLDRSLARLRYLDDVFGGQFKTSYASAGNTLELAQAADLIIGAVL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCEEHHHHHHHHHHHHHH
IPGAAAPKLISRAQLATLKPGAALVDVAIDQGGCFETSKATTHSDPVYDVDGIMHYCVAN
CCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
MPGAVARTSTIALGNATMPFMLALADKGWRQACIDDPHLLNGLNVHAGQLTYYAVGKALG
CCCCHHCCEEEEECCCCHHHHEEECCCCHHHHCCCCCHHHCCCCCCCCCEEEEEHHHHHC
LDVISPTVAIRQ
HHHHCCCEEECC
>Mature Secondary Structure
MIIGCPKEIKPQEFRVGLTPNAAREAVSHGHRVLIETNAGAGAGFEDADYTAAGAQVLET
CEECCCCCCCCCCEEECCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHH
AAEIFATAEMIVKVKEPQAGERKMLRAGQVLFTYLHLAPDPDQTHDLLASGATCIAYETV
HHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCHHHHHHHCCCEEEEEEEE
TDAQGGLPLLAPMSEVAGRLAPQVGAWTLQKANGGRGVLMGGVPGVGPARVVVIGGGVVG
CCCCCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCEEEEEECCCCHH
THAARIAAGMGADVTVLDRSLARLRYLDDVFGGQFKTSYASAGNTLELAQAADLIIGAVL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHCCCCEEHHHHHHHHHHHHHH
IPGAAAPKLISRAQLATLKPGAALVDVAIDQGGCFETSKATTHSDPVYDVDGIMHYCVAN
CCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
MPGAVARTSTIALGNATMPFMLALADKGWRQACIDDPHLLNGLNVHAGQLTYYAVGKALG
CCCCHHCCEEEEECCCCHHHHEEECCCCHHHHCCCCCHHHCCCCCCCCCEEEEEHHHHHC
LDVISPTVAIRQ
HHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1587598; 9634230; 12218036; 7822223 [H]