Click here to switch to the map view.

The map label for this gene is msrA-1 [H]

Identifier: 110677814

GI number: 110677814

Start: 408854

End: 409516

Strand: Direct

Name: msrA-1 [H]

Synonym: RD1_0419

Alternate gene names: 110677814

Gene position: 408854-409516 (Clockwise)

Preceding gene: 110677812

Following gene: 110677817

Centisome position: 9.89

GC content: 61.39

Gene sequence:

>663_bases
ATGCTGAACATTTCATCCCTTAAAACCTATGCTTTGGCCGGTATGATTGCCCTCGGCCTGTGTGTGCACGGCACGCAGAG
CCACGCGGCTGAGCTTGAGACGATCACCGTCGCCGGCGGGTGTTTCTGGTGTGTCGAATCGGATTTCGAACGCGTGACCG
GCGTGACAGAAGCCGTATCGGGGTTCATGGGGGGGTCCGTTTCAAACCCCACCTACAAGGAAGTCACCAGCGGCGGCACC
GGCCATTACGAGGCTGTGCAGATCACCTTCGACCCCGATGTGGTCAGCCGCGATACGCTTTACGCGATGTTCTTTCGGTC
AGTTGACCCGACGGACGCAGGCGGGCAGTTTTGCGACCGGGGTGACAGCTACCGCACCGCGATATTTGCCGAAACACCTG
CACAGGCCGCTGCGGCGAAGGCCGCCAAGGCAAATGCTGCCGCAGCCCTGGGCGTGCCGGTTGTGACGCCCGTGTTGGAC
GCCTCGACCTTTTATCCGGCAGAAGCCTATCATCAGGATTACTACAAAGGCACGCGGTTGGTGATCACCCGATTTGGCCC
CAAACGACAGGCGTCTGCATACAAGGCCTATCGCGAAGCCTGCGGGCGTGACGCCCGCGTCAGGGAACTCTGGGGCGCGG
CTGCTCCCTTTGCGGGCGGCTAA

Upstream 100 bases:

>100_bases
GCTTCAAGATGTAAACTGTCATCACCACCGCGTGAAAGGGCATGAATGCCCATTGCGCGATGATCGCAATCCCGTCACCT
TTGCTTTGAGGAGACATATG

Downstream 100 bases:

>100_bases
CCTAAGCGCATGTCCTGAATTTCCTTTAGGTCGGGAATGACATCTGCCGTTCCAACCCGCGTCACCATCAACGCCGCCGC
CCGCGTGGCAAGATCAATCG

Product: methionine-S-sulfoxide reductase, putative

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MLNISSLKTYALAGMIALGLCVHGTQSHAAELETITVAGGCFWCVESDFERVTGVTEAVSGFMGGSVSNPTYKEVTSGGT
GHYEAVQITFDPDVVSRDTLYAMFFRSVDPTDAGGQFCDRGDSYRTAIFAETPAQAAAAKAAKANAAAALGVPVVTPVLD
ASTFYPAEAYHQDYYKGTRLVITRFGPKRQASAYKAYREACGRDARVRELWGAAAPFAGG

Sequences:

>Translated_220_residues
MLNISSLKTYALAGMIALGLCVHGTQSHAAELETITVAGGCFWCVESDFERVTGVTEAVSGFMGGSVSNPTYKEVTSGGT
GHYEAVQITFDPDVVSRDTLYAMFFRSVDPTDAGGQFCDRGDSYRTAIFAETPAQAAAAKAAKANAAAALGVPVVTPVLD
ASTFYPAEAYHQDYYKGTRLVITRFGPKRQASAYKAYREACGRDARVRELWGAAAPFAGG
>Mature_220_residues
MLNISSLKTYALAGMIALGLCVHGTQSHAAELETITVAGGCFWCVESDFERVTGVTEAVSGFMGGSVSNPTYKEVTSGGT
GHYEAVQITFDPDVVSRDTLYAMFFRSVDPTDAGGQFCDRGDSYRTAIFAETPAQAAAAKAAKANAAAALGVPVVTPVLD
ASTFYPAEAYHQDYYKGTRLVITRFGPKRQASAYKAYREACGRDARVRELWGAAAPFAGG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=139, Percent_Identity=41.0071942446043, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI208609995, Length=139, Percent_Identity=41.0071942446043, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI208609993, Length=99, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1790665, Length=148, Percent_Identity=41.8918918918919, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320881, Length=153, Percent_Identity=31.3725490196078, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=30.9859154929577, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=30.8823529411765, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23310; Mature: 23310

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNISSLKTYALAGMIALGLCVHGTQSHAAELETITVAGGCFWCVESDFERVTGVTEAVS
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCEEEEECCHHHHHHHHHHHHH
GFMGGSVSNPTYKEVTSGGTGHYEAVQITFDPDVVSRDTLYAMFFRSVDPTDAGGQFCDR
HHCCCCCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHCC
GDSYRTAIFAETPAQAAAAKAAKANAAAALGVPVVTPVLDASTFYPAEAYHQDYYKGTRL
CCCEEEEEEECCCHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEE
VITRFGPKRQASAYKAYREACGRDARVRELWGAAAPFAGG
EEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLNISSLKTYALAGMIALGLCVHGTQSHAAELETITVAGGCFWCVESDFERVTGVTEAVS
CCCHHHHHHHHHHHHHHHHHHHCCCCHHHHEEEEEEEECCEEEEECCHHHHHHHHHHHHH
GFMGGSVSNPTYKEVTSGGTGHYEAVQITFDPDVVSRDTLYAMFFRSVDPTDAGGQFCDR
HHCCCCCCCCCHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHCC
GDSYRTAIFAETPAQAAAAKAAKANAAAALGVPVVTPVLDASTFYPAEAYHQDYYKGTRL
CCCEEEEEEECCCHHHHHHHHHHCCCHHHCCCCHHHHHHCCCCCCCHHHHHHHHHCCCEE
VITRFGPKRQASAYKAYREACGRDARVRELWGAAAPFAGG
EEEECCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]