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The map label for this gene is pepA [H]

Identifier: 110677717

GI number: 110677717

Start: 302192

End: 303574

Strand: Direct

Name: pepA [H]

Synonym: RD1_0314

Alternate gene names: 110677717

Gene position: 302192-303574 (Clockwise)

Preceding gene: 110677716

Following gene: 110677718

Centisome position: 7.31

GC content: 61.24

Gene sequence:

>1383_bases
ATGACTTCCCTGTTTGCTGATGCTGACGATCAGACAATTCCGCTGCACATCATAGATGAAGACTCGCTTGAGGCGTGGCT
GGGCGACCAGTCGCAGACGGTTCAGGCATGGGTGCGCGCGAATGGGTTCGCGGCCCGGATCGGTCAGGCCTTGCTGGTCC
CGTCTGATACAGGTTTGCCGGTGATGGCGCTTGCAGGCTTTGGCACAGCGAAATCGCGGGCACGGGGGCGGTTTCACCTT
GCGGCGGCTGCCAGTAAACTGCCCGCTGCCTGTTATGCGATTGCCTCGGGCCTGCCGCAGGCGCAGTCCGACATGGAAGT
TCTGGGCTGGCTGCTGGCCGCCTATCGGTTTGGCCGCTACAGCGAGACCGGCGCGATGGGAGCAAGGCTCGCGCGGCCCG
AAGGGCTGGATACCGCACGGCTGGAAATCCTCGCGCAAGCCGAGACGCTGACCCGTGATTTGATCAATACGCCCGCAAAT
GACATGGGACCCCCGGATCTTGAAGCCGCAGCGCAGGATCTCGCCCAACAGCATGGTGCATCGATCGAGGTTGTTCTTGG
CGATGATCTGCTGGCGCAGGATTTTCCGTTGATCCACACGGTCGGGCGCGCTGCGGATCGCGCGCCGCGCCTGATCGACA
TGAAATGGGGTGACAGGGGCCCCAAGATCACCTTGGTTGGCAAGGGCGTGTGCTTTGATACTGGCGGGCTGAATCTGAAA
CCGGGCGCGTCGATGGGGCTGATGAAAAAGGATATGGGCGGGGCGGCCAATGTTCTGGGGCTGGCGCATATGATAATGGC
CTTGCAACCCCGGATCAGTCTGCGCGTTCTTATTCCGGCCGTGGAAAACTCGGTGGCTGGCAATGCATTCCGGCCGGGCG
ATATCCTGCCGTCGCGCAAGGGTCTGAGCGTCGAGATCAACAATACCGACGCAGAGGGGCGGCTGGTTCTGGCCGACGCA
TTGGCTTATGCACAGGAAGACGCACCAGACCTCATCATCTCGATGGCGACGCTGACGGGGGCCGCGCGCGTTGCGGTTGG
TCCTGATCTGGCGCCCTATTATTGCGATGATCCTGATTTTGTCACAGCGCTCGAAAACGCTGCTACGCATCAATGCGACC
CGGTTTGGCGCATGCCGTTTCACACGCCCTATGAATCGATGATTGAACCGGGGATCGCGGATCTGGACAACGCGCCAAAG
GGCGGATTTGCCGGATCCATCACCGCAGCGCTTTTCCTGCGACGGTTTGTGGACGAAAGCGTCTACGCACATTTTGACGT
CTATGGCTGGAACCCGAGCGATGCGCCGGGACGCCCGAAGGGTGGCGCAGGTCAGGCAACCCGCGCCTTGCTGGGGGTTA
TCGAAGCCATGCAGACGTCATGA

Upstream 100 bases:

>100_bases
AAGCGCTATATGGGACCTGCAAGACATCACGATCTGATGCCTTGCACCGCCATCAGATCAGACTAGGCTGCGAGGGCGAT
TTTGTGAAAGGCGCCCTCTT

Downstream 100 bases:

>100_bases
CGGATCGGCGGGTGACGCCTGATCCGACCCATGTGACGCTGGACATACCGGCGCAAGTTACTGGGCCCATCGCCGACTTG
CGTCAAAGCCCTGCGGGACC

Product: leucine aminopeptidase, putative

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTSLFADADDQTIPLHIIDEDSLEAWLGDQSQTVQAWVRANGFAARIGQALLVPSDTGLPVMALAGFGTAKSRARGRFHL
AAAASKLPAACYAIASGLPQAQSDMEVLGWLLAAYRFGRYSETGAMGARLARPEGLDTARLEILAQAETLTRDLINTPAN
DMGPPDLEAAAQDLAQQHGASIEVVLGDDLLAQDFPLIHTVGRAADRAPRLIDMKWGDRGPKITLVGKGVCFDTGGLNLK
PGASMGLMKKDMGGAANVLGLAHMIMALQPRISLRVLIPAVENSVAGNAFRPGDILPSRKGLSVEINNTDAEGRLVLADA
LAYAQEDAPDLIISMATLTGAARVAVGPDLAPYYCDDPDFVTALENAATHQCDPVWRMPFHTPYESMIEPGIADLDNAPK
GGFAGSITAALFLRRFVDESVYAHFDVYGWNPSDAPGRPKGGAGQATRALLGVIEAMQTS

Sequences:

>Translated_460_residues
MTSLFADADDQTIPLHIIDEDSLEAWLGDQSQTVQAWVRANGFAARIGQALLVPSDTGLPVMALAGFGTAKSRARGRFHL
AAAASKLPAACYAIASGLPQAQSDMEVLGWLLAAYRFGRYSETGAMGARLARPEGLDTARLEILAQAETLTRDLINTPAN
DMGPPDLEAAAQDLAQQHGASIEVVLGDDLLAQDFPLIHTVGRAADRAPRLIDMKWGDRGPKITLVGKGVCFDTGGLNLK
PGASMGLMKKDMGGAANVLGLAHMIMALQPRISLRVLIPAVENSVAGNAFRPGDILPSRKGLSVEINNTDAEGRLVLADA
LAYAQEDAPDLIISMATLTGAARVAVGPDLAPYYCDDPDFVTALENAATHQCDPVWRMPFHTPYESMIEPGIADLDNAPK
GGFAGSITAALFLRRFVDESVYAHFDVYGWNPSDAPGRPKGGAGQATRALLGVIEAMQTS
>Mature_459_residues
TSLFADADDQTIPLHIIDEDSLEAWLGDQSQTVQAWVRANGFAARIGQALLVPSDTGLPVMALAGFGTAKSRARGRFHLA
AAASKLPAACYAIASGLPQAQSDMEVLGWLLAAYRFGRYSETGAMGARLARPEGLDTARLEILAQAETLTRDLINTPAND
MGPPDLEAAAQDLAQQHGASIEVVLGDDLLAQDFPLIHTVGRAADRAPRLIDMKWGDRGPKITLVGKGVCFDTGGLNLKP
GASMGLMKKDMGGAANVLGLAHMIMALQPRISLRVLIPAVENSVAGNAFRPGDILPSRKGLSVEINNTDAEGRLVLADAL
AYAQEDAPDLIISMATLTGAARVAVGPDLAPYYCDDPDFVTALENAATHQCDPVWRMPFHTPYESMIEPGIADLDNAPKG
GFAGSITAALFLRRFVDESVYAHFDVYGWNPSDAPGRPKGGAGQATRALLGVIEAMQTS

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=318, Percent_Identity=33.9622641509434, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI47155554, Length=309, Percent_Identity=33.0097087378641, Blast_Score=130, Evalue=2e-30,
Organism=Escherichia coli, GI87082123, Length=289, Percent_Identity=39.7923875432526, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1790710, Length=301, Percent_Identity=34.5514950166113, Blast_Score=162, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17556903, Length=284, Percent_Identity=35.9154929577465, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17565172, Length=226, Percent_Identity=34.070796460177, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21355725, Length=318, Percent_Identity=32.3899371069182, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24661038, Length=318, Percent_Identity=31.7610062893082, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI21357381, Length=205, Percent_Identity=41.4634146341463, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI221379063, Length=205, Percent_Identity=41.4634146341463, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI221379062, Length=205, Percent_Identity=41.4634146341463, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI20129969, Length=290, Percent_Identity=30.6896551724138, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI21355645, Length=290, Percent_Identity=28.2758620689655, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662223, Length=290, Percent_Identity=28.2758620689655, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662227, Length=290, Percent_Identity=27.9310344827586, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI19922386, Length=290, Percent_Identity=27.9310344827586, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161077148, Length=290, Percent_Identity=28.9655172413793, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20130057, Length=290, Percent_Identity=28.9655172413793, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24646701, Length=269, Percent_Identity=31.2267657992565, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24646703, Length=269, Percent_Identity=31.2267657992565, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21358201, Length=269, Percent_Identity=31.2267657992565, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI20129963, Length=288, Percent_Identity=26.7361111111111, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 48652; Mature: 48521

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLFADADDQTIPLHIIDEDSLEAWLGDQSQTVQAWVRANGFAARIGQALLVPSDTGLP
CCCCCCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHCCCHHHHCCCEEEEECCCCCC
VMALAGFGTAKSRARGRFHLAAAASKLPAACYAIASGLPQAQSDMEVLGWLLAAYRFGRY
EEEEECCCCHHHHCCCCEEEEHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
SETGAMGARLARPEGLDTARLEILAQAETLTRDLINTPANDMGPPDLEAAAQDLAQQHGA
CCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
SIEVVLGDDLLAQDFPLIHTVGRAADRAPRLIDMKWGDRGPKITLVGKGVCFDTGGLNLK
EEEEEECCCHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCEEEECCCCCCC
PGASMGLMKKDMGGAANVLGLAHMIMALQPRISLRVLIPAVENSVAGNAFRPGDILPSRK
CCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCC
GLSVEINNTDAEGRLVLADALAYAQEDAPDLIISMATLTGAARVAVGPDLAPYYCDDPDF
CCEEEECCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
VTALENAATHQCDPVWRMPFHTPYESMIEPGIADLDNAPKGGFAGSITAALFLRRFVDES
HHHHHHHCCCCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYAHFDVYGWNPSDAPGRPKGGAGQATRALLGVIEAMQTS
HEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSLFADADDQTIPLHIIDEDSLEAWLGDQSQTVQAWVRANGFAARIGQALLVPSDTGLP
CCCCCCCCCCEEEEEEECCCCHHHHCCCCHHHHHHHHHCCCHHHHCCCEEEEECCCCCC
VMALAGFGTAKSRARGRFHLAAAASKLPAACYAIASGLPQAQSDMEVLGWLLAAYRFGRY
EEEEECCCCHHHHCCCCEEEEHHHHHCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
SETGAMGARLARPEGLDTARLEILAQAETLTRDLINTPANDMGPPDLEAAAQDLAQQHGA
CCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
SIEVVLGDDLLAQDFPLIHTVGRAADRAPRLIDMKWGDRGPKITLVGKGVCFDTGGLNLK
EEEEEECCCHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCCEEEEEECCEEEECCCCCCC
PGASMGLMKKDMGGAANVLGLAHMIMALQPRISLRVLIPAVENSVAGNAFRPGDILPSRK
CCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCC
GLSVEINNTDAEGRLVLADALAYAQEDAPDLIISMATLTGAARVAVGPDLAPYYCDDPDF
CCEEEECCCCCCCEEEEHHHHHHHCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHH
VTALENAATHQCDPVWRMPFHTPYESMIEPGIADLDNAPKGGFAGSITAALFLRRFVDES
HHHHHHHCCCCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
VYAHFDVYGWNPSDAPGRPKGGAGQATRALLGVIEAMQTS
HEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA