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The map label for this gene is bktB [H]

Identifier: 110677609

GI number: 110677609

Start: 198181

End: 199359

Strand: Direct

Name: bktB [H]

Synonym: RD1_0201

Alternate gene names: 110677609

Gene position: 198181-199359 (Clockwise)

Preceding gene: 110677605

Following gene: 110677612

Centisome position: 4.79

GC content: 61.66

Gene sequence:

>1179_bases
ATGACCAAAGAGATCGTAATTCTGGACGGCGCGCGCACGGCAATCGGCACGTTTGGTGGCGCATTGGCCGCAACGTCCCC
CATTGATCTCGCCACCGTGGCCAGCAAGGCGGCATTGGAACGGTCAGGCGTCGAGGGGGCGCAGATCGGGCATGTTGCCT
TTGGTCATGTCATCAACACCGAACCGAAGGACATGTACCTGAGCCGTGTGGCCGCGATGCAGGCGGGCGTGCCTGAAACG
GTCCCGGCGATGAACGTCAATCGTCTGTGCGGCTCAGGGGCGCAGGCGATTGTCTCGGTCATTCAGTCTCTTATGCTGGG
TGATGCGGATTTCGCCCTTGCGGGTGGCGCCGAGAACATGTCGCGTTCGCCCTTCATCATCCCGCAACAGCGTTGGGGTG
CAAAAATGGGGGACGTCAAGACGCTGGATATGATGCTGGGCGCGCTGAATTGTCCGTTCGGAACGGGGCATATGGGCGTC
ACAGCTGAAAACGTCGCGGCAGAGCATGACATCACCCGTGCTCAACAGGACGCATTCGCCCTGCAAAGCCAGCAGCGGGC
AGCAGATGCCATCGCGGCGGGGTATTTCAAATCGCAAATCACGCCCGTTGAGGTCCGGGTAAAACGGGACATGGTGGCCT
TCGAGGTGGATGAGCACCCCAAGGCGACAACTCTTGAGGCCTTGTCGGGGCTGCGCGCCGTGTTCCAGAAAGACGGGTCT
GTGACCGCAGGCAATGCCAGCGGCATCAATGATGGTGCTGCCGCGATTGTGTTGGCAACGGGTGACGCTGCGCAAAAGGC
CGGATTGAAACCAAAGGCGCGCGTTCTGGGCTATGCGCATGCAGGCGTGCGCCCCGAAGTGATGGGCATCGGCCCGGTGC
CCGCGGTTCAGAACCTGCTGGCGCGCACGGGCCTGTCGGTCGCGGATTTTGACGTTGTGGAAAGCAACGAGGCCTTTGCC
GCGCAGGCGCTGGCCGTCAGTCAGGAACTGGGCCTGGGTGCTGCCAAGGTGAACCCGAACGGCGGCGCAATCGCGTTGGG
TCATCCGGTTGGAGCGACAGGCGCGATCATCACCCTCAAGGCGATGTATGAATTGGAACGGATCGGCGGCAAACGGGCGT
TGATTACCATGTGCATCGGCGGTGGTCAGGGCATCGCGCTCGCGATTGAGCGACTTTAA

Upstream 100 bases:

>100_bases
CAGGACGATGTCAACAAATGACGTAACATCAGCATAACTCCTTGCTGACAATCCGATGTGACACCCGCATAGTGGCCGCC
ACAAGCAAGCGGAGGGCATC

Downstream 100 bases:

>100_bases
CCGCCGCGCTCAAAAGAACATCAGATCAACCGCGATCAGGGTCAGGGACCCCGATACCCCGATCGTGACCCCGAGAATCA
GCCCGCCCACAATCCACTTG

Product: beta-ketothiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTKEIVILDGARTAIGTFGGALAATSPIDLATVASKAALERSGVEGAQIGHVAFGHVINTEPKDMYLSRVAAMQAGVPET
VPAMNVNRLCGSGAQAIVSVIQSLMLGDADFALAGGAENMSRSPFIIPQQRWGAKMGDVKTLDMMLGALNCPFGTGHMGV
TAENVAAEHDITRAQQDAFALQSQQRAADAIAAGYFKSQITPVEVRVKRDMVAFEVDEHPKATTLEALSGLRAVFQKDGS
VTAGNASGINDGAAAIVLATGDAAQKAGLKPKARVLGYAHAGVRPEVMGIGPVPAVQNLLARTGLSVADFDVVESNEAFA
AQALAVSQELGLGAAKVNPNGGAIALGHPVGATGAIITLKAMYELERIGGKRALITMCIGGGQGIALAIERL

Sequences:

>Translated_392_residues
MTKEIVILDGARTAIGTFGGALAATSPIDLATVASKAALERSGVEGAQIGHVAFGHVINTEPKDMYLSRVAAMQAGVPET
VPAMNVNRLCGSGAQAIVSVIQSLMLGDADFALAGGAENMSRSPFIIPQQRWGAKMGDVKTLDMMLGALNCPFGTGHMGV
TAENVAAEHDITRAQQDAFALQSQQRAADAIAAGYFKSQITPVEVRVKRDMVAFEVDEHPKATTLEALSGLRAVFQKDGS
VTAGNASGINDGAAAIVLATGDAAQKAGLKPKARVLGYAHAGVRPEVMGIGPVPAVQNLLARTGLSVADFDVVESNEAFA
AQALAVSQELGLGAAKVNPNGGAIALGHPVGATGAIITLKAMYELERIGGKRALITMCIGGGQGIALAIERL
>Mature_391_residues
TKEIVILDGARTAIGTFGGALAATSPIDLATVASKAALERSGVEGAQIGHVAFGHVINTEPKDMYLSRVAAMQAGVPETV
PAMNVNRLCGSGAQAIVSVIQSLMLGDADFALAGGAENMSRSPFIIPQQRWGAKMGDVKTLDMMLGALNCPFGTGHMGVT
AENVAAEHDITRAQQDAFALQSQQRAADAIAAGYFKSQITPVEVRVKRDMVAFEVDEHPKATTLEALSGLRAVFQKDGSV
TAGNASGINDGAAAIVLATGDAAQKAGLKPKARVLGYAHAGVRPEVMGIGPVPAVQNLLARTGLSVADFDVVESNEAFAA
QALAVSQELGLGAAKVNPNGGAIALGHPVGATGAIITLKAMYELERIGGKRALITMCIGGGQGIALAIERL

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=44.6428571428571, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=43.2225063938619, Blast_Score=313, Evalue=1e-85,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=39.5465994962217, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI4557237, Length=398, Percent_Identity=38.1909547738693, Blast_Score=241, Evalue=7e-64,
Organism=Homo sapiens, GI4504327, Length=424, Percent_Identity=30.188679245283, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=30.9462915601023, Blast_Score=145, Evalue=9e-35,
Organism=Escherichia coli, GI1788554, Length=397, Percent_Identity=47.8589420654912, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1787663, Length=400, Percent_Identity=46, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=43.4782608695652, Blast_Score=308, Evalue=3e-85,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=40.5, Blast_Score=236, Evalue=1e-63,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=31.9512195121951, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=47.0588235294118, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=35.4591836734694, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=36.9620253164557, Blast_Score=228, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=32.2274881516588, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17535917, Length=397, Percent_Identity=27.9596977329975, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6325229, Length=399, Percent_Identity=36.3408521303258, Blast_Score=226, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6322031, Length=347, Percent_Identity=38.0403458213257, Blast_Score=201, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=45.0127877237852, Blast_Score=337, Evalue=9e-93,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=46.4285714285714, Blast_Score=330, Evalue=1e-90,
Organism=Drosophila melanogaster, GI24640423, Length=396, Percent_Identity=38.1313131313131, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI17137578, Length=426, Percent_Identity=30.9859154929577, Blast_Score=171, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40158; Mature: 40026

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEIVILDGARTAIGTFGGALAATSPIDLATVASKAALERSGVEGAQIGHVAFGHVINT
CCCEEEEECCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCEECCEEECCEECC
EPKDMYLSRVAAMQAGVPETVPAMNVNRLCGSGAQAIVSVIQSLMLGDADFALAGGAENM
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
SRSPFIIPQQRWGAKMGDVKTLDMMLGALNCPFGTGHMGVTAENVAAEHDITRAQQDAFA
CCCCEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LQSQQRAADAIAAGYFKSQITPVEVRVKRDMVAFEVDEHPKATTLEALSGLRAVFQKDGS
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
VTAGNASGINDGAAAIVLATGDAAQKAGLKPKARVLGYAHAGVRPEVMGIGPVPAVQNLL
EECCCCCCCCCCCEEEEEEECCHHHHCCCCCHHHEEEEECCCCCCEEEECCCHHHHHHHH
ARTGLSVADFDVVESNEAFAAQALAVSQELGLGAAKVNPNGGAIALGHPVGATGAIITLK
HHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCEEEHH
AMYELERIGGKRALITMCIGGGQGIALAIERL
HHHHHHHCCCCEEEEEEEECCCCEEEEEEECC
>Mature Secondary Structure 
TKEIVILDGARTAIGTFGGALAATSPIDLATVASKAALERSGVEGAQIGHVAFGHVINT
CCEEEEECCCCHHHHHCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCEECCEEECCEECC
EPKDMYLSRVAAMQAGVPETVPAMNVNRLCGSGAQAIVSVIQSLMLGDADFALAGGAENM
CHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCC
SRSPFIIPQQRWGAKMGDVKTLDMMLGALNCPFGTGHMGVTAENVAAEHDITRAQQDAFA
CCCCEEEEHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LQSQQRAADAIAAGYFKSQITPVEVRVKRDMVAFEVDEHPKATTLEALSGLRAVFQKDGS
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
VTAGNASGINDGAAAIVLATGDAAQKAGLKPKARVLGYAHAGVRPEVMGIGPVPAVQNLL
EECCCCCCCCCCCEEEEEEECCHHHHCCCCCHHHEEEEECCCCCCEEEECCCHHHHHHHH
ARTGLSVADFDVVESNEAFAAQALAVSQELGLGAAKVNPNGGAIALGHPVGATGAIITLK
HHCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCCCEEEECCCCCCCCCEEEHH
AMYELERIGGKRALITMCIGGGQGIALAIERL
HHHHHHHCCCCEEEEEEEECCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]