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The map label for this gene is serA [H]

Identifier: 110677605

GI number: 110677605

Start: 193514

End: 195109

Strand: Direct

Name: serA [H]

Synonym: RD1_0197

Alternate gene names: 110677605

Gene position: 193514-195109 (Clockwise)

Preceding gene: 110677604

Following gene: 110677609

Centisome position: 4.68

GC content: 58.33

Gene sequence:

>1596_bases
ATGGCTCCCAAAGTACTTATTTCCGACAAACTGTCACCCGCCGCTGTTCAGATCTTCAAGGACCGGGGCATTGACGTGGA
TTTCCAACCGGATGTTGGAAAAGACAAGGACAAGCTGGCCGAGATCATCGGCGATTACGACGGCCTCGCCATCCGCTCTG
CGACCAAGGCGACCGCGAAGATCATCGCCGCGGCAACCAACCTCAAGGTGATCGGGCGTGCCGGGATCGGCACCGACAAC
ATCGACAAGGATGCAGCCTCCAAGAAAGGCATCATCGTGATGAACACGCCCTTCGGCAACATGATCACGACGGCCGAACA
CGCCATTGCGATGATGTTCGCGGTGGCGCGCCAGATTCCCGAGGCCTCCGCTTCGACCCACGCGGGCAAATGGGAAAAGT
CGAAATTCATGGGCGTTGAATTGACGGGCAAGACACTTGGCGTGATCGGGGCCGGGAACATCGGTGGCATCGTCTGCGAC
CGCGCAAAGGGCCTCAAGATGAAGGTTGTCGCCTACGATCCGTTTCTGGGCGAGGAAAAAGCCAAGAAGATGGGCGTAGA
AAAGGTTGAACTTGACGCGCTTTTGGCACGCGCGGATTTCATCACCCTGCATGTGCCATTCACCGACCAGACGGCGAATA
TCCTGAGCGCTGAAGCGATAGCGAAGATGAGACCCGGTGTGCGGATCATCAACTGCGCGCGCGGCGGTCTGGTGGATGAA
GAGGCGCTGGCCGCAGCCCTCAAATCGGGCCATGTGGCAGGGGCCGCCTTTGACGTGTTCTCGCAGGAACCGGCGACGGA
AAACCCGTTGTTCAATCTGCCCAATGTCGTCTGCACCCCGCATCTGGGCGCGGCGACCAGCGAGGCACAGGAAAACGTCG
CCCTTCAGGTGGCCGAACAAATGTCCGACTATCTGCTGACCGGCGCGGTGAGCAACGCGCTCAACATGCCATCCGTCACC
GCCGAAGAGGCCAAGGTGATGGGCCCTTGGCTCAAACTGTCCGGGCATCTGGGCGCGTTTATCGGTCAGATGACGGATGA
GCCGATCAAGGCGATCAACATCCTCTATGACGGGTCCGTGGCCGAAATGAACCTCTCCGCGCTGAATTGCGGTGTGATTG
CGGGCATCATGAAAAAGGCGAACCCGGATGTGAACATGGTGTCGGCCCCCGTCATCGCACAGGAACGCGGCATCACGATC
TCGACCACGAACCAAAGCAAGTCCGGCGTATTTGATGGATACATCAAGGTGACGGTCGTTACCGACAAGCGCGAGCGTTC
CATCGCAGGCACCGTGTTTTCGGACGGCAAGCCCCGGTTTATCCAGATCAAGGGCATTCAGATTGACGCCGAAGTCGGTG
CGCATATGCTCTATACCACCAACGAGGACGTGCCGGGTATCATCGGCACGCTGGGCCAGACCATGGGCGAAAACGGCGTG
AACATTGCGAACTTTACGCTGGGGCGTGCCGAAGCAAAGGGCGAAGCCATTGCGTTGCTCTATGTGGATGATCAGGTGCC
GGCGCCGGTCATCAAAAAGCTGGAAAAAACGGGCATGTTCACGCAGGTGAAACCGCTGATTTTTGACGTCGCATAA

Upstream 100 bases:

>100_bases
CATCACCGCAATGCTGCCTTGGCTCGCGTGGGCCTTCGAAGCCGAAATCAACGCGTAACGCGCGCAACACCATTCCAGAC
TTCAAAAAAGGACCAACAAG

Downstream 100 bases:

>100_bases
ATTGCGCGTTTCAGGGTGAGGCAGGGGCGCTTTGATGCCTTTGCCTTGCCCATTGGTTTGCGGGTCAAGCGGTCGTCCAG
TCCAGCACAACCTTGCCTGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MAPKVLISDKLSPAAVQIFKDRGIDVDFQPDVGKDKDKLAEIIGDYDGLAIRSATKATAKIIAAATNLKVIGRAGIGTDN
IDKDAASKKGIIVMNTPFGNMITTAEHAIAMMFAVARQIPEASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCD
RAKGLKMKVVAYDPFLGEEKAKKMGVEKVELDALLARADFITLHVPFTDQTANILSAEAIAKMRPGVRIINCARGGLVDE
EALAAALKSGHVAGAAFDVFSQEPATENPLFNLPNVVCTPHLGAATSEAQENVALQVAEQMSDYLLTGAVSNALNMPSVT
AEEAKVMGPWLKLSGHLGAFIGQMTDEPIKAINILYDGSVAEMNLSALNCGVIAGIMKKANPDVNMVSAPVIAQERGITI
STTNQSKSGVFDGYIKVTVVTDKRERSIAGTVFSDGKPRFIQIKGIQIDAEVGAHMLYTTNEDVPGIIGTLGQTMGENGV
NIANFTLGRAEAKGEAIALLYVDDQVPAPVIKKLEKTGMFTQVKPLIFDVA

Sequences:

>Translated_531_residues
MAPKVLISDKLSPAAVQIFKDRGIDVDFQPDVGKDKDKLAEIIGDYDGLAIRSATKATAKIIAAATNLKVIGRAGIGTDN
IDKDAASKKGIIVMNTPFGNMITTAEHAIAMMFAVARQIPEASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCD
RAKGLKMKVVAYDPFLGEEKAKKMGVEKVELDALLARADFITLHVPFTDQTANILSAEAIAKMRPGVRIINCARGGLVDE
EALAAALKSGHVAGAAFDVFSQEPATENPLFNLPNVVCTPHLGAATSEAQENVALQVAEQMSDYLLTGAVSNALNMPSVT
AEEAKVMGPWLKLSGHLGAFIGQMTDEPIKAINILYDGSVAEMNLSALNCGVIAGIMKKANPDVNMVSAPVIAQERGITI
STTNQSKSGVFDGYIKVTVVTDKRERSIAGTVFSDGKPRFIQIKGIQIDAEVGAHMLYTTNEDVPGIIGTLGQTMGENGV
NIANFTLGRAEAKGEAIALLYVDDQVPAPVIKKLEKTGMFTQVKPLIFDVA
>Mature_530_residues
APKVLISDKLSPAAVQIFKDRGIDVDFQPDVGKDKDKLAEIIGDYDGLAIRSATKATAKIIAAATNLKVIGRAGIGTDNI
DKDAASKKGIIVMNTPFGNMITTAEHAIAMMFAVARQIPEASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCDR
AKGLKMKVVAYDPFLGEEKAKKMGVEKVELDALLARADFITLHVPFTDQTANILSAEAIAKMRPGVRIINCARGGLVDEE
ALAAALKSGHVAGAAFDVFSQEPATENPLFNLPNVVCTPHLGAATSEAQENVALQVAEQMSDYLLTGAVSNALNMPSVTA
EEAKVMGPWLKLSGHLGAFIGQMTDEPIKAINILYDGSVAEMNLSALNCGVIAGIMKKANPDVNMVSAPVIAQERGITIS
TTNQSKSGVFDGYIKVTVVTDKRERSIAGTVFSDGKPRFIQIKGIQIDAEVGAHMLYTTNEDVPGIIGTLGQTMGENGVN
IANFTLGRAEAKGEAIALLYVDDQVPAPVIKKLEKTGMFTQVKPLIFDVA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=403, Percent_Identity=40.9429280397022, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI61743967, Length=261, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4557497, Length=261, Percent_Identity=33.3333333333333, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI145580578, Length=280, Percent_Identity=33.9285714285714, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI4557499, Length=280, Percent_Identity=33.9285714285714, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI145580575, Length=280, Percent_Identity=33.9285714285714, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI6912396, Length=246, Percent_Identity=34.5528455284553, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789279, Length=292, Percent_Identity=41.7808219178082, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI87082289, Length=281, Percent_Identity=33.0960854092527, Blast_Score=158, Evalue=7e-40,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=31.6, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081824, Length=263, Percent_Identity=26.615969581749, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=27.3408239700375, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=302, Percent_Identity=45.0331125827815, Blast_Score=265, Evalue=4e-71,
Organism=Caenorhabditis elegans, GI25147481, Length=250, Percent_Identity=33.2, Blast_Score=143, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=331, Percent_Identity=37.1601208459215, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=36.2537764350453, Blast_Score=215, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6324055, Length=255, Percent_Identity=29.8039215686275, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=27.037037037037, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=112, Percent_Identity=34.8214285714286, Blast_Score=71, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324980, Length=196, Percent_Identity=26.0204081632653, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=302, Percent_Identity=43.046357615894, Blast_Score=253, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24646446, Length=248, Percent_Identity=35.4838709677419, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646448, Length=248, Percent_Identity=35.4838709677419, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646452, Length=248, Percent_Identity=35.4838709677419, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24646450, Length=248, Percent_Identity=35.4838709677419, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI62472511, Length=248, Percent_Identity=35.4838709677419, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI28574286, Length=299, Percent_Identity=28.0936454849498, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24585516, Length=289, Percent_Identity=28.0276816608997, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=31.6981132075472, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24585514, Length=238, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574282, Length=238, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45551003, Length=238, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574284, Length=238, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45552429, Length=238, Percent_Identity=29.4117647058824, Blast_Score=114, Evalue=2e-25,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 56063; Mature: 55932

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3 ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPKVLISDKLSPAAVQIFKDRGIDVDFQPDVGKDKDKLAEIIGDYDGLAIRSATKATAK
CCCCEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEECHHHHHHH
IIAAATNLKVIGRAGIGTDNIDKDAASKKGIIVMNTPFGNMITTAEHAIAMMFAVARQIP
HEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
EASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCDRAKGLKMKVVAYDPFLGEEK
CCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEECCCCCEEEEEEECCCCCHHH
AKKMGVEKVELDALLARADFITLHVPFTDQTANILSAEAIAKMRPGVRIINCARGGLVDE
HHHCCCCHHHHHHHHEECCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCH
EALAAALKSGHVAGAAFDVFSQEPATENPLFNLPNVVCTPHLGAATSEAQENVALQVAEQ
HHHHHHHHCCCCCEEEEHHHCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
MSDYLLTGAVSNALNMPSVTAEEAKVMGPWLKLSGHLGAFIGQMTDEPIKAINILYDGSV
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEECCCHHHHHHHCCCCCEEEEEEEECCCE
AEMNLSALNCGVIAGIMKKANPDVNMVSAPVIAQERGITISTTNQSKSGVFDGYIKVTVV
EEEEHHHHHHHHHHHHHHHCCCCCEEEECCEEECCCCEEEEECCCCCCCCEEEEEEEEEE
TDKRERSIAGTVFSDGKPRFIQIKGIQIDAEVGAHMLYTTNEDVPGIIGTLGQTMGENGV
ECCCCCCEEEEEECCCCCCEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCC
NIANFTLGRAEAKGEAIALLYVDDQVPAPVIKKLEKTGMFTQVKPLIFDVA
EEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECCEEEECC
>Mature Secondary Structure 
APKVLISDKLSPAAVQIFKDRGIDVDFQPDVGKDKDKLAEIIGDYDGLAIRSATKATAK
CCCEEEECCCCHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEECHHHHHHH
IIAAATNLKVIGRAGIGTDNIDKDAASKKGIIVMNTPFGNMITTAEHAIAMMFAVARQIP
HEEEECCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCC
EASASTHAGKWEKSKFMGVELTGKTLGVIGAGNIGGIVCDRAKGLKMKVVAYDPFLGEEK
CCCCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCEEEECCCCCEEEEEEECCCCCHHH
AKKMGVEKVELDALLARADFITLHVPFTDQTANILSAEAIAKMRPGVRIINCARGGLVDE
HHHCCCCHHHHHHHHEECCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCH
EALAAALKSGHVAGAAFDVFSQEPATENPLFNLPNVVCTPHLGAATSEAQENVALQVAEQ
HHHHHHHHCCCCCEEEEHHHCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHH
MSDYLLTGAVSNALNMPSVTAEEAKVMGPWLKLSGHLGAFIGQMTDEPIKAINILYDGSV
HHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEECCCHHHHHHHCCCCCEEEEEEEECCCE
AEMNLSALNCGVIAGIMKKANPDVNMVSAPVIAQERGITISTTNQSKSGVFDGYIKVTVV
EEEEHHHHHHHHHHHHHHHCCCCCEEEECCEEECCCCEEEEECCCCCCCCEEEEEEEEEE
TDKRERSIAGTVFSDGKPRFIQIKGIQIDAEVGAHMLYTTNEDVPGIIGTLGQTMGENGV
ECCCCCCEEEEEECCCCCCEEEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCCC
NIANFTLGRAEAKGEAIALLYVDDQVPAPVIKKLEKTGMFTQVKPLIFDVA
EEEEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEEECCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]